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价值工程 2019年第14期38卷 169-172页

作者：李魏瀚中国铁路上海局集团公司徐州221000

为了均衡提高铁路设备质量,对京沪铁路各种检查数据进行深入分析,提出了多种检查数据综合分析运用的方法,为科学合理指导线路的养护维修提供了依据。

关键词：铁路工务线路检查线路维修综合分析

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膨体聚四氟乙烯密封材料在民机上的应用

装备制造技术 2017年第6期 211-213页

作者：李韦翰上海飞机设计研究院上海201210

民用飞机受经济效益影响的推动,在研发时对重量指标的要求愈加严苛,对维护时间与维护便利性的需求也越来越高。考虑到膨体聚四氟乙烯(e PTFE)用作密封材料具有许多优良的性能,近年来广泛运用于国外民用飞机的接触面密封以满足重量与维... 详细信息

民用飞机受经济效益影响的推动,在研发时对重量指标的要求愈加严苛,对维护时间与维护便利性的需求也越来越高。考虑到膨体聚四氟乙烯(e PTFE)用作密封材料具有许多优良的性能,近年来广泛运用于国外民用飞机的接触面密封以满足重量与维护性的需求。基于此,简述了膨体聚四氟乙烯密封材料在民机应用上的发展优势,给出国内民机常见应用范围。

关键词：膨体聚四氟乙烯民用飞机密封材料复材面板维护性

Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin han Lanxin Luo Caiyan wei Yaru Qiao Jiming Xie Xianchao Pan Juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

盐胁迫下匍匐翦股颖高光谱分析与电解质渗透率反演

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光谱学与光谱分析 2016年第11期36卷 3630-3636页

作者：肖国增吴雪莲滕珂晁跃辉李伟涛韩烈保北京林业大学草坪研究所北京100083 长江大学园艺园林学院湖北荆州434025 华中农业大学经济管理学院湖北武汉430070 滁州学院地理信息与旅游学院安徽滁州239000

叶片电解质渗透率是反映植物细胞渗透性的一个重要指标,对草坪草遭受盐胁迫的研究有重要意义。针对叶片电解质渗透率传统检测方法,耗时长,损伤叶片,无法大面积监测等弊端,探讨了用高光谱快速无损检测叶片电解质渗透率的方法。以匍匐翦股... 详细信息

叶片电解质渗透率是反映植物细胞渗透性的一个重要指标,对草坪草遭受盐胁迫的研究有重要意义。针对叶片电解质渗透率传统检测方法,耗时长,损伤叶片,无法大面积监测等弊端,探讨了用高光谱快速无损检测叶片电解质渗透率的方法。以匍匐翦股颖(Agrostis stolonifera)为对象,在温室中水培两周后进行浓度分别为0(对照),100和200mmol·L-1的盐处理,7d后按间隔7d取样3次,共72个样。每次取样时先测量样品的光谱值,然后采用电导率法测定叶片电解质渗透率。分析匍匐翦股颖三种盐处理与光谱反射率之间的关系和差异,对三种盐处理的光谱反射率计算归一化植被指数和差值植被指数,采用差分法计算光谱反射率的一阶微分,同时计算出蓝、绿和红光的三边参数,分析叶片电解质渗透率与光谱反射率、归一化植被指数、差值植被指数和三边参数的相关性。利用叶片电解质渗透率和各光谱数据相关程度高的数据,对校正集采用一元线性回归、多元线性回归和偏最小二乘回归法构建叶片电解质渗透率反演模型,用预测集检验反演模型。结果表明:盐胁迫与叶片高光谱在450~700nm波段呈正相关;叶片电解质渗透率与450~732nm波段反射率在0.01水平上显著相关;三边参数中绿边幅值和绿边面积与叶片电解质渗透率显著相关;采用偏最小二乘回归法建立的反演模型精度最好,建模和反演预测的决定系数分别达到了0.681和0.758,均方根误差分别为7.124和7.079。偏最小二乘法构建的反演模型实现了盐胁迫下匍匐翦股颖叶片电解质渗透率的快速无损检测,也为采用高光谱实时监测盐胁迫对匍匐翦股颖及其同类植物的伤害提供了依据和理论参考。

关键词：高光谱盐胁迫草坪草匍匐翦股颖电解质渗透率反演模型

Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue Tong Shi Chenhui han Heng Zhang Fenrong liu Haorun li Yan Wang Xiaojun Gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Oxygen vacancy Hydrocarbon production Reaction mechanism

STUDY OF CAPILLARY ELECTROPHORESIS ON MICROCHIP BASED ON MEMS

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Journal of Electronics(China) 2002年第4期19卷 375-377页

作者： Wang Ming li wei han Jinghong Cui Dafu (State Key Lab. of Transducer Tech., Inst. of Electron., Chinese Academy of Sci., Beijing 100080) State Key Lab. of Transducer Tech. Inst. of Electron. Chinese Academy of Sci. Beijing

Using a standard photolithographical procedure, chemical wet etching and thermal diffusion bonding technology, a chemical analysis device for Capillary Electrophoresis(CK) has been microfabricated on a planar glass substrate with a cross-column geometry. The channels on the microchip substrate are about 50μm deep and 150μm wide. By employing amino acids derived from 2,4-DiNitroFluoroBenzeri (DNFB) on CE chip channels, the sample manipulating system is studied based on the principle of electrodynamics.

关键词： Microchip Capillary elcctrophoresis MEMS

Synergistic promotion strategy of “dual-site” and “dual-path” to enhance the C–C coupling between CO2 and HCHO driven by photoelectrocatalysis

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Journal of Energy Chemistry 2025年第1期100卷 39-49页

作者： Hongqiang Yang Jianfeng Zheng Guoyu Wang Yifei Gao Yatao Yang Jia li Xiaojin han Yan Cui Zhanggen Huang National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Institute of Coal Chemistry Chinese Academy of Science University of Chinese Academy of Science Shenyang University of Chemical Technology

Photoelectrocatalytic coupling CO2and volatile organic compounds （VOCs） is a promising green strategy for the synergistic conversion of the two carbon-containing resources to *** catalytic efficiency is always at the mercy of chemical inertness of CO2and the competitive hydrogen evolution of ***,a modified g-C3N4/ZnAl-LDH Z-scheme heterojunction catalyst with dual reaction site was rationally designed and precisely *** Faraday efficiency of ethanol reached 68.67%with a corresponding formation rate of 227.3μmol *** revealed by in-situ characterizations and density functional theory calculations,CO2and HCHO were absorbed at Zn site and N site,***,*CO generated from CO2and HCHO was converted to*CH3O and*CHO on the dual-active-site *** detailed reaction mechanism experiments indicated that C–C coupling only occurred between*CO and*CH3O in electrocatalysis *** from the“*CO+*CH3O”path,another“*CO+*CHO”coupling path was also detected in photoelectrocatalytic *** selectivity of ethanol was significantly enhanced due to the synthesis of dual-site catalyst and the dual-path coupling path between CO2and HCHO simultaneously driven by light and electricity.

关键词： Photoelectrocatalysis Z-scheme C–C coupling Ethanol

Sequence-activated chemiluminescence probes: programmable illumination for high-contrast in vivo sensing and imaging

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Science China Chemistry 2025年第01期 26-34页

作者： Yutao Zhang Juan li wei-Hong Zhu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

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Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao wei Panpan Zhao Yongchun Wang Mingxi li li Sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs

Truth telling for patients with esophageal squamous cell carcinoma in Henan,China

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Cancer Biology & Medicine 2017年第1期14卷 83-89页

作者： lian-Qun Zhang Pei-Nan Chen Hai-ling Wang li Sun Xue-Ke Zhao Xin Song Min-Jie Wu Tang-Juan Zhang ling-Fen Ji wei-li han Zong-Min Fan Yuan Yuan Hai-Jun Yang Jian-Po Wang Fu-You Zhou Yi-Jun Qi li-Dong Wang Anyang Tumor Hospital Anyang 455000China Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital Zhengzhou UniversityZhengzhou 450052China The Second Affiliated Hospital of Zhengzhou University Zhengzhou 450014China The Affiliated Cancer Hospital of Zhengzhou University Zhengzhou 450008China Key Laboratory of Cellular and Molecular Immunology College of MedicineHenan UniversityKaifeng 475004China

Objective: This study aims to investigate the truth-telling status and the relevant factors of esophageal squamous cell carcinoma(ESCC) patients in Henan, ***: A cross-sectional study from April to June 2015 using questionnaires was given to 301 family members of hospitalized ESCC patients based in three affiliated hospitals of Zhengzhou University(i.e., The First Hospital, The Second Hospital, and Tumor Hospital) and Anyang Tumor ***: Among the 41.9%(126/301) hospitalized ESCC patients who knew of their true diagnoses, only 4.0% patients were informed by their corresponding responsible doctors, 39.7% by their family members, and 56.3% by themselves. Univariate analyses showed that disclosure of confirmed ESCC diagnosis to patients was correlated with gender, family history of cancer(FHC), education level, vocation, hospital administrative level, and attitudes of family members(P lized in municipal hospitals exhibited a low rate of truth ***: Truth telling for ESCC patients in Henan is not prevalent and may be improved through consultation with family members, particularly for patients with a negative FHC, poor education, manual occupation, and advanced stages.

关键词： Truth telling esophageal squamous cell carcinoma diagnosis