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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui jiang Hui-Li Kang Yi jiang Hua-wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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CFRP布加固无腹筋混凝土梁的抗剪作用试验研究

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土木与环境工程学报（中英文） 2025年第1期47卷 118-129页

作者：金浏蒋轩昂杜修力北京工业大学城市与工程安全减灾教育部重点实验室北京100124

对12根几何相似的CFRP加固无腹筋钢筋混凝土简支梁进行剪切破坏试验,分析梁深、配纤率对梁剪切破坏模式与失效机制的影响,获得了CFRP条带的全过程应变分布情况,讨论梁深和CFRP配纤率对CFRP条带抗剪贡献的定量影响,进而提出CFRP抗剪贡献... 详细信息

对12根几何相似的CFRP加固无腹筋钢筋混凝土简支梁进行剪切破坏试验,分析梁深、配纤率对梁剪切破坏模式与失效机制的影响,获得了CFRP条带的全过程应变分布情况,讨论梁深和CFRP配纤率对CFRP条带抗剪贡献的定量影响,进而提出CFRP抗剪贡献的计算公式,并与试验结果及规范计算结果等进行对比分析。结果表明,梁深对CFRP布抗剪贡献影响明显,即梁深增大时,CFRP布名义抗剪强度显著降低。梁高由300 mm变化至1200 mm时,CFRP名义抗剪强度下降约50%,具有明显的尺寸效应;不同尺寸下,CFRP布名义抗剪强度均随着配纤率的增大而增大,但名义抗剪强度增大幅度随着配纤率的增大而减小,呈现出非线性增长趋势;建立的CFRP抗剪承载力计算公式能较准确地预测不同配纤率及截面尺寸下的CFRP抗剪承载能力。

关键词：混凝土梁配纤率梁深剪切破坏抗剪贡献试验研究

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Tuning the porosity of {Co12IICo8III（μ3-OH）24（X）}11+ supramolecular frameworks by reaction time for D2/H2 separation

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Science China Chemistry 2025年

作者： Zhuozhou Xie Zhu Zhuo Zi-Ang Nan Qing Li Xiufang Li Zi-Xiu Lu Linzhe Lü jin Liu Luyao Liu Wenjing Wang wei Wang Daqiang Yuan You-Gui Huang State Key Laboratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of Sciences State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical EngineeringXiamen University

Systematicly tuning the porosities of porous materials is crucial for targeted gas mixture separation,yet it remains a longstanding *** a common strategy,altering the phenylene ring count in the organic building units has been exploited to adjust pore apertures in metal organic frameworks （MOFs） and covalent organic frameworks （COFs）,resulting in only a stepwise pore size variation of approximately 2.8?.Unlike MOFs and COFs,the porosities for supramolecular assembly frameworks are highly dependent on the packings of the molecular building units in the *** above strategy cannot be applied to supramolecular assembly frameworks and other strategies are required to adjust pore apertures in supramolecular frameworks,especially to achieve porous materials with the optimal pore size for D2/H2separation （～3?）.Here,we successfully modulate the porosity of supramolecular frameworks of[CoII1+12CoIII8L12（μ3-OH）24（X）]1clusters （L=mono-deprotonated 1-iminoisoindole-3-amine,X=ClO?4or Cl?） by controlling the duration of self-assembly *** simply adjusting the reaction time,we obtain three[CoII12CoIII8L12（μ3-OH）24（X）]11+supramolecular frameworks:[CoII12CoIII8（μ3-OH）24（ClO4）L12)]·（Cl）4·（HCO2）7（1）,[CoII12CoIII8L12（μ3-OH）24（Cl）]·（ClOI4）4·（Cl）6·（HCO2）·（H2O）10（2）,and[CoI12CoIII8L12（μ3-OH）24（Cl）]·（Cl）11·（H2O）12（3）.The different stacking patterns of the[CoII12CoIII8L12（μ3-OH）24（X）]11+clusters in these frameworks lead to significantly varied stabilities and *** 1 exhibits permanent porosity with interconnected channels and maintains stability under harsh *** contrast,compound 2 is nearly nonporous,and compound 3 becomes unstable upon *** pores of compound 1 show higher affinity to D2than H2,and the pore aperture diameter of compound 1 （～3.06?） meets the optimal porosity for D2/***,compound 1 demonstrates moderate D2/H2separation at 77 K (retention time:～7 min/g for D2/H2/Ne （10/10/80 vol%） in a flow of 5 mL

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The Effect of Topologies and Refilling Short-chain PEG on Protein Adsorption

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Chinese Journal of Polymer Science 2023年第12期41卷 1879-1888,I0007页

作者： Chi Li Jia-Ning Zhang jing jin wei jiang State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

PEGylation is the gold standard for constructing protein resistance ***,grafting mPEG-SH and SH-PEG-SH with varied molecular weights(Mw=5K,10K,and 20K)on a gold chip,and the subsequent lysozyme adsorptions of the PEG layers are evaluated using quartzcrystal microbalance based on dissipation(QCM-D).The lysozyme resistance depends on the features of grafting density and chain conformation,i.e.,linear and looped ***,long-chain PEG(Mw≥10K)is insufficient to form a dense layer to resist protein due to large steric ***-chain PEG(Mw=1K)with linear and looped structures is used to refill onto the long-chain PEG layer to increase the grafting density of PEGs and improve protein *** refilling process and the subsequent protein adsorption depend on conformation rather than the density of the long-chain PEG ***,the long-chain PEG looped substrates significantly improve protein resistance,attributing to the high viscoelasticity of the looped substrate and an increase in grafting density after ***,refilling short-chain PEG improves protein resistance and the substrate conformation-dependence gives insight into the impact of topology,providing new ideas for how to increase chain density and select suitable topology to resist protein adsorption and demonstrating a potential application in biomedical fields.

关键词： Poly(ethylene glycol) Refilling Protein adsorption Conformation QCM-D

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Nerve growth factor affects focal cerebral cortical neuronal Bcl-2 and Bax expression in a mouse model of oxyhemoglobin-induced subarachnoid hemorrhage

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Neural Regeneration Research 2008年第8期3卷 813-816页

作者： Xianfeng jiang wei Shi jin Liang Department of Neurosurgery Affiliated Hospital of Medical College of the Chinese People＇s Armed Police Force Tianjin 300162 China Department of Neurosurgery Second Hospital of Xi＇an Jiaotong University Xi＇an 710004 Shaanxi Province China

BACKGROUND： Studies have demonstrated that oxyhemoglobin （OxyHb） can induce brain cell apoptosis in ***： To observe the effects of exogenous nerve growth factor （NGF） on cerebral cortical neuronal Bcl-2 and Bax expression in mice with OxyHb-induced subarachnoid hemorrhage. DESIGN, TIME AND SETTING： A completely randomized grouping, controlled animal experiment was performed at the Experimental Center for Biomedicine, College of Medicine, Xi＇an Jiaotong University between February and April 2005. MATERIALS： Fifty-four healthy, male, adult, ICR mice were included in this study. Subarachnoid hemorrhage was induced by a subarachnoid injection of OxyHb in 48 mice. Mouse NGF was obtained from Xiamen Beidazhilu Bioengineering Co., Ltd., ***： All 54 mice were randomly divided into three groups： control （n = 6）, injury （n = 24）, and NGF （n = 24）. The NGF group received a subarachnoidal administration of OxyHb, immediately followed by a caudal vein injection of NGF （1 μg）. The injury group was injected with OxyHb, and subsequently with physiological saline. The control group only received intravenous physiological saline. MAIN OUTCOME MEASURES： At 1,6, 24, and 48 hours following subarachnoid hemorrhage induction, expression levels of Bcl-2 and Bax were detected by immunohistochemistry in the cerebral cortex 3 mm anterior and posterior to the injection site. RESULTS： At all time points following OxyHb injection, cerebral cortical Bax levels were significantly higher in the injured group than in the control and NGF groups （P 〈 0.01）. During the first 24 hours following OxyHb injection, cerebral cortical Bcl-2 levels were significantly lower in the injury group compared to the control group （P 〈 0.05 0.01）. Between 1 and 48 hours, Bcl-2 levels were significantly higher in the NGF group than in the injury group （P 〈 0.01 ）. CONCLUSION： Exogenous NGF can inhibit increased neuronal Bax expression and decreased Bcl-2 expression in the cerebral cortex of mice wit

关键词： apoptosis Bcl-2 Bax nerve growth factor oxyhemoglobin

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Hydrogen storage properties of as-cast and annealed low-Co La1.8Ti0.2MgNi8.9Co0.1 alloys

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Rare Metals 2016年第7期35卷 559-565页

作者： wei-Qing jiang jin Guo Zheng-Cheng Zhou Yin-Yan wei College of Physics Science and Technology GuangxiUniversityNanning 530004China School of Basic Medical Sciences Youjiang Medical Universityfor NationalitiesBaise 533000China

Low-Co Lal.8Ti0.2MgNi8.9Co0.1 alloys were prepared by magnetic levitation melting followed by annealing treatment. The effect of annealing on the hydrogen storage properties of the alloys was investigated systematically by X-ray diffraction （XRD）, pressure-com- position isotherm （PCI）, and electrochemical measure- ments. The results show that all samples contain LaNi5 and LaMg2Ni9 phases. LaCo5 phase appears at 1,000 ℃. The enthalpy change of all hydrides is close to -30.6 ***1-1 H2 of LaNi5 compound. Annealing not only increases hydrogen capacity and improves cycling stability but also decreases plateau pressure at 800 and 900 ℃. After annealing, the contraction of cell volume and the increase of hydride stability cause the high rate dischargeability to reduce slightly. The optimum alloy is found to be one annealed at 900 ℃, with its hydrogen capacity reaching up to 1.53 wt%, and discharge capacity remaining 225.1 mAh·g-1 after 140 charge-discharge cycles.

关键词： La-Mg-Ni-based alloy Annealing treatment Hydrogen storage Electrochemical characterization

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荣乌高速公路沥青路面车辙处治设计

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山东交通科技 2017年第3期 103-104,114页

作者：宋军赵金伟江健宏曹溯山东省交通规划设计院山东济南250031

介绍了荣乌高速公路东营界至沙洼互通段沥青路面车辙病害的情况、成因分析、处治方案和交通组织设计。

关键词：沥青路面车辙处治方案交通组织设计

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Optimal state feedback control of brushless direct-current motor drive systems based on Lyapunov stability criterion

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第12期8卷 1889-1893页

作者： WANG wei jin Ruo-jun jiang jing-ping College of Mechatronics Engineering China .Jiliang University Hangzhou 310018. China School of Electrical Engineering Zhejiang University Hangzhou 310027 China

This paper develops a unified methodology for a real-time speed control of brushless direct-current motor drive systems in the presence of measurement noise and load torque disturbance. First, the mathematical model and hardware structure of system is established. Next, an optimal state feed back controller using the Kalman filter state estimation technique is derived. This is followed by an adaptive control algorithm to compensate for the effects of noise and disturbance. Those two algorithms working together can provide a very-high-speed regulation and dynamic response over a wide range of operating conditions. Simulated responses are presented to highlight the effectiveness of the proposed control strategy.

关键词： Brushless DC motor Adaptive control Optimal state feedback

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Abnormal characteristics and effectiveness evaluation of the micro-seismic signal before the Debao MS4.8 earthquake

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Geodesy and Geodynamics 2023年第6期14卷 605-613页

作者： jin wei Huining Huang Ying jiang Ziwei Liu Key Laboratory of Earthquake Geodesy China Earthquake AdministrationWuhan 430071China Earthquake Administration of Guangxi Zhuang Autonomous Region Nanning 530022China

The Debao MS4.8 earthquake occurred in western Guangxi on August 5,2021,near where the jingxi MS5.2 earthquake occurred in *** study the increasing seismicity in western Guangxi,it is necessary to determine whether there was an anomaly related to the earthquake source near the Pingxiang gravity station,which is located approximately 100 km from the epicenter of the Debao MS4.8 *** this study,the R-value scoring method was used to analyze the anomaly and evaluate the prediction efficiency of the double frequency(DF)micro-seismic signal vertical displacement(referred to as vertical displacement,VD)and the absolute value of monthly extreme rate(referred to as the monthly rate).Results show that earthquakes larger than MS4.0 in the 350 km range from the Pingxiang station tend to coincide with yearly typhoons,and the VD of micro-seismic signals correspondingly changes from low to *** Debao MS4.8 earthquake occurred during a gradual VD increase from 0.05×10^(-6)to 0.10×10^(-6)*** discussing the relationships among R,the rate threshold,and the effective duration of prediction,the rate threshold of the micro-seismic signal converges from 0.00039×10^(-6)to 0.00031×10^(-6)m/month,the effective duration of prediction is approximately 6-10 months,and R also converges from 0.29 to *** comparing the results of three gPhone gravity stations in Guangxi,we found that the increase of short-term VD before the Debao earthquake was related to the enhancement of the DF micro-seismic signal excited by the *** the typhoon track was perpendicular to the coastline of China,the possibility of an earthquake occurring was *** study provides evidence and reference for the future occurrence period of earthquakes above MS4.0 in western Guangxi.

关键词： gPhone gravimeter ASSM Double frequency micro-seism R-value

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A comprehensive review of cavitation in valves:mechanical heart valves and control valves

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Bio-Design and Manufacturing 2019年第2期2卷 119-136页

作者： jin-yuan Qian Zhi-xin Gao Cong-wei Hou Zhi-jiang jin Institute of Process Equipment College of Energy EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027People’s Republic of China

Valves are widely used in various working conditions for their flow control functions,and the cavitation inside valves has been investigated owing to its harm to the valve itself and the connecting downstream *** paper presents a comprehensive review of the progress that has been achieved in the past years about cavitation in valves including both mechanical heart valves and control *** review is divided in the following parts,namely the location where there is a high possibility of the occurrence of cavitation,the parameters that affect cavitation intensity,and the methods to minimize cavitation *** should be noticed that although simulation has been widely used,advanced experiments are still needed in order to obtain accurate analysis of cavitation in valves and the cavitation model still needs to be improved.

关键词： Cavitation Mechanical heart valves Control valves

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