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Gastrointestinal metabolic surgery for the treatment of type 2 diabetes mellitus

World Journal of Gastroenterology 2014年第39期20卷 14315-14328页

作者： Eng-Hong Pok wei-jei lee Division of Upper GI Surgery Department of Surgery University Malaya Medical Center University of Malaya Kuala Lumpur 50603 Malaysia Department of Surgery Min-Sheng General Hospital National Taiwan University

Medical therapy for type 2 diabetes mellitus is ineffective in the long term due to the progressive nature of the disease, which requires increasing medication doses and polypharmacy. Conversely, bariatric surgery has emerged as a cost-effective strategy for obese diabetic individuals; it has low complication rates and results in durable weight loss, glycemic control and improvements in the quality of life, obesity-related co-morbidity and overall survival. The finding that glucose homeostasis can be achieved with a weight loss-independent mechanism immediately after bariatric surgery, especially gastric bypass, has led to the paradigm of metabolic surgery. However, the primary focus of metabolic surgery is the alteration of the physio-anatomy of the gastrointestinal tract to achieve glycemic control, metabolic control and cardio-metabolic risk reduction. To date, metabolic surgery is still not well defined, as it is used most frequently for less obese patients with poorly controlled diabetes. The mechanism of glycemic control is still incompletely understood. Published research findings on metabolic surgery are promising, but many aspects still need to be defined. This paper examines the proposed mechanism of diabetes remission, the efficacy of different types of metabolic procedures, the durability of glucose control, and the risks and complications associated with this procedure. We propose a tailored approach for the selection of the ideal metabolic procedure for different groups of patients, considering the indications and prognostic factors for diabetes remission.

关键词： Metabolic surgery Gastrointestinal surgery Type-2 diabetes mellitus Glucolipotoxicity Efficacy Prognostic factor

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Impairment of gastrointestinal quality of life in severely obese patients

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World Journal of Gastroenterology 2014年第22期20卷 7027-7033页

作者： Po-Jui Yu Ju-Juin Tsou wei-jei lee Kuo-Ting lee Yi-Chih lee Department of Nursing National Taiwan University Department of Surgery Min-Sheng General Hospital Department of Surgery National Cheng-Kung University Hospiyal Department of International Business Chien Hsin University of Science and Technology

AIM: To investigate the common gastro-intestinal symptoms and quality of life in severely obese subjects.

关键词： Severe obesity Quality of life Gastro-intestinal symptoms Glycosylated hemoglobin

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Do different bariatric surgical procedures influence plasma levels of matrix metalloproteinase-2,-7,and-9 among patients with type 2 diabetes mellitus?

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World Journal of Diabetes 2020年第6期11卷 252-260页

作者： Wen-Chi Wu wei-jei lee Tzong-His lee Shu-Chun Chen Chih-Yen Chen Department of Medicine Taipei Veterans General HospitalTaipei 11217Taiwan Department of Surgery Min-Sheng General HospitalTaoyuan 330Taiwan Taiwan Society for Metabolic and Bariatric Surgery Taipei 11031Taiwan Division of Gastroenterology and Hepatology Department of Internal MedicineFar Eastern Memorial HospitalNew Taipei City 220Taiwan Department of Nursing Chang-Gung Institute of TechnologyGuishanTaoyuan 333Taiwan Division of Gastroenterology and Hepatology Department of MedicineTaipei Veterans General HospitalTaipei 11217Taiwan Faculty of Medicine and Institute of Emergency and Critical Medicine National Yang-Ming University School of MedicineTaipei 11221Taiwan Association for the Study of Small Intestinal Diseases GuishanTaoyuan 33305Taiwan Chinese Taipei Society for the Study of Obesity Taipei 110Taiwan

BACKGROUND Bariatric surgery is an efficient strategy for body weight and type 2 diabetes mellitus(T2 DM) management. Abnormal lipid deposition in visceral organs,especially the pancreas and liver, might cause beta-cell dysfunction and insulin resistance. Extracellular matrix(ECM) remodeling allows adipose expansion, and matrix metalloproteinases(MMPs) play essential roles in ECM ***-2 and MMP-9 are the substrates of MMP-7. Different studies have reported that MMP-2,-7, and-9 increase in patients with obesity and metabolic syndromes or T2 DM and are considered biomarkers in obesity and hyperglycemia *** prospectively investigate whether MMP-2, MMP-7, and MMP-9 differ after two bariatric surgeries: Gastric bypass(GB) and sleeve gastrectomy(SG).METHODS We performed GB in 23 and SG in 19 obese patients with T2 DM. We measured body weight, waist circumference, body mass index(BMI), and serum concentrations of total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting blood sugar(FBS),hemoglobin A1 c(Hb A1 c), C-peptide, homeostasis model assessments of insulin resistance, and MMP-2, MMP-7, and MMP-9 levels at baseline and at 3, 12, and 24 mo *** Twenty-three patients aged 44.7 ± 9.7 years underwent GB, and 19 patients aged40.1 ± 9.1 years underwent SG. In the GB group, BMI decreased from 30.3 ± 3.4 to24.4 ± 2.4 kg/m2, Hb A1 c decreased from 9.2% ± 1.5% to 6.7% ± 1.4%, and FBS decreased from 171.6 ± 65.0 mg/d L to 117.7 ± 37.5 mg/d L 2 years post-operation(P < 0.001). However, the MMP-2, MMP-7, and MMP-9 levels pre-and post-GB were similar even 2 years post-operation(P = 0.107, 0.258, and 0.466,respectively). The SG group revealed similar results: BMI decreased from 36.2 ±5.1 to 26.9 ± 4.7 kg/m2, Hb A1 c decreased from 7.9% ± 1.7% to 5.8% ± 0.6%, and FBS decreased from 138.3 ± 55.6 mg/d L to 95.1 ± 3.1 mg/d L(P < 0.001). The serum MMP-2,-7, and-9 levels pre-and post-SG we

关键词： Matrix metalloproteinases Extracellular matrix Obesity Type 2 diabetes mellitus Gastric bypass Sleeve gastrectomy

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Recent advances in bariatric/metabolic surgery:appraisal of clinical evidence

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The Journal of Biomedical Research 2015年第2期29卷 98-104页

作者： wei-jei lee Abdullah Almulaifi Department of Surgery Min-Sheng General HospitalNational Taiwan University

Obesity and associated type 2 diabetes mellitus（T2DM） are becoming a serious medical issue *** surgery has been shown to be the most effective and durable therapy for the treatment of morbid obese *** data indicates bariatric surgery as metabolic surgery is an effective and novel therapy for not well controlled obese T2 DM *** review of recent developments in bariatric/metabolic surgery covers 4major fields.1） Improvement of safety：recent advances in laparoscopic/metabolic surgery has made this minimal invasive surgery more than ten times safer than a decade *** safety profile of laparoscopic/metabolic surgery is compatible with that of laparoscopic cholecystectomy now.2） New bariatric/metabolic surgery：laparoscopic sleeve gastrectomy（LSG） is becoming the leading bariatric surgery because of its simplicity and *** new procedures,such as gastric plication,banded plication,single anastomosis（mini） gastric bypass and Duodeno-jejunal bypass with sleeve gastrectomy have all been accepted as treatment modalities for bariatric/metabolic surgery.3）Mechanism of bariatric/metabolic surgery：Restriction is the most important mechanism for bariatric *** regain after bariatric surgery is usually associated with loss of *** studies demonstrated that gut hormone,microbiota and bile acid changes after bariatric surgery may play an important role in durable weight loss as well as in T2 DM ***,weight loss is still the cornerstone of T2 DM remission after metabolic surgery.4） Patient selection：patients who may benefit most from bariatric surgery was found to be patients with insulin *** Asian T2 DM patients,the indication of metabolic surgery has been set to those with not well2controlled（Hb A1 c.7.5%） disease and with their BMI.27.5 Kg/m.A novel diabetes surgical score,ABCD score,is a simple system for predicting the success of surgical therapy for T2 DM.

关键词： bariatric surgery metabolic surgery type 2 diabetes mellitus advances

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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun lee Dan Cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

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Development and application prospect of stem cell combined with 3D printing technology for oral disease

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BIOCELL 2025年第1期49卷 45-59页

作者： YIXIAN YOU YIHUNG lee YUSHIN HU YOUHUI XU JOUCHEN CHEN wei JIANG CHANGHAI LIU ENQIANG CHEN HONG TANG HUA ZHANG DONGBO WU Center of Infectious Diseases West China Hospital of Sichuan UniversityChengdu610041China West China College of Stomatology Sichuan UniversityChengdu610041China West China School of Medicine Sichuan UniversityChengdu610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengdu610041China

With organ transplantation facing many dilemmas,tissue and organ regeneration as an alternative has bright *** regenerative medicine,Three-dimensional(3D)printing technology and stem cells has been widely applied to the treatment of diseases related to tissue or organ replacement in dentistry,***,there are very few studies on the combination of the two,and even fewer clinical studies have been reported in *** this review,the current oral tissue engineering in vivo and in vitro based on 3D printing and stem cell technology will be summarized,and the discussion on the development prospects of this research direction will be ***,the working principles and advantages&disadvantages of several types of 3D printers,as well as the mechanism of stem cells in tissue engineering will be *** review provides clinicians and researchers with the current state of research and trends in the combination of stem cells and 3D printing technology to treat oral-related *** the future,3D bioprinters are poised for ongoing innovation with the advancement of relevant technologies,catalyzing an increase in clinical studies focused on treating oral diseases using stem cells and 3D ***,these developments will further advance the field of oral tissue engineering.

关键词： Stem cells 3D printing Tissue engineering Oral diseases

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A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning

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Nano-Micro Letters 2025年第2期17卷 417-431页

作者： Yunjian Guo Kunpeng Li wei Yue Nam‑Young Kim Yang Li Guozhen Shen Jong‑Chul lee Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Radio Frequency Integrated Circuit(RFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China State Key Laboratory of Integrated Chips and Systems Fudan UniversityShanghai 200433People’s Republic of China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband Self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction

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Advancements in Passive Wireless Sensing Systems in Monitoring Harsh Environment and Healthcare Applications

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Nano-Micro Letters 2025年第5期17卷 145-192页

作者： wei Yue Yunjian Guo Jong‐Chul lee Enkhzaya Ganbold Jia-Kang Wu Yang Li Cong Wang Hyun Soo Kim Young-Kee Shin Jun-Ge Liang Eun-Seong Kim Nam-Young Kim RFIC Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Jiangnan UniversityWuxi 214122People’s Republic of China School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China School of Electronics and Information Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China Department of Electronics Engineering Kwangwoon UniversitySeoul 01897South Korea Laboratory of Molecular Pathology and Cancer Genomics Department of Molecular Medicine and Biopharmaceutical SciencesGraduate School of Convergence Science and TechnologySeoul National UniversitySeoul 08826South Korea

Recent advancements in passive wireless sensor technology have significantly extended the application scope of sensing,particularly in challenging environments for monitoring industry and healthcare *** systems are equipped with battery-free operation,wireless connectivity,and are designed to be both miniaturized and *** features enable the safe,real-time monitoring of industrial environments and support high-precision physiological measurements in confined internal body spaces and on wearable epidermal *** the exploration into diverse application environments,the development of a systematic and comprehensive research framework for system architecture remains elusive,which hampers further optimization of these *** review,therefore,begins with an examination of application scenarios,progresses to evaluate current system architectures,and discusses the function of each component—specifically,the passive sensor module,the wireless communication model,and the readout module—within the context of key implementations in target sensing ***,we present case studies that demonstrate the feasibility of proposed classified components for sensing scenarios,derived from this systematic *** outlining a research trajectory for the application of passive wireless systems in sensing technologies,this paper aims to establish a foundation for more advanced,user-friendly applications.

关键词： Wireless sensing Passive detection Harsh environment Biomedical monitoring Flexible sensors

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A comprehensive framework for the delimitation of species within the Bemisia tabaci cryptic complex, a global pest-species group

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INSECT SCIENCE 2025年第1期32卷 321-342页

作者： Wang, Hua-Ling Lei, Teng Wang, Xiao-wei Cameron, Stephen Navas-Castillo, Jesus Liu, Yin-Quan Maruthi, M. N. Omongo, Christopher A. Delatte, Helene lee, Kyeong-Yeoll Krause-Sakate, Renate Ng, James Seal, Susan Fiallo-Olive, Elvira Bushley, Kathryn Colvin, John Liu, Shu-Sheng Hebei Agr Univ Coll Forestry 2596 Lekainan St Baoding 071000 Hebei Province Peoples R China Zhejiang Univ Inst Insect Sci Minist Agr Key Lab Mol Biol Crop Pathogens & Insects 866 Yuhangtang Rd Hangzhou 310058 Peoples R China Univ Greenwich Nat Resources Inst Kent ME4 4TB England Taizhou Univ Coll Life Sci Taizhou Zhejiang Provin Peoples R China Purdue Univ Dept Entomol W Lafayette IN USA CSIC Inst Hortofruticultura Subtrop & Mediterranea Mayo Malaga Spain Natl Crops Resources Res Inst Kampala Uganda CIRAD UMR PVBMT CIRAD Pole Protect Plantes St Pierre France Kyungpook Natl Univ Sch Appl Biosci Daegu South Korea UNESP Fac Ciencias Agron Botucatu Brazil Univ Calif Riverside Dept Microbiol & Plant Pathol Riverside CA USA USDA Agr Res Serv Emerging Pests & Pathogens Res Unit Ithaca NY 17123 USA Zhejiang Univ Inst Insect Sci Minist Agr Key Lab Mol Biol Crop Pathogens & Insects 866 Yuhangtang Rd Hangzhou 310058 Zhejiang Peoples R China

Identifying cryptic species poses a substantial challenge to both biologists and naturalists due to morphological similarities. Bemisia tabaci is a cryptic species complex containing more than 44 putative species;several of which are currently among the world's most destructive crop pests. Interpreting and delimiting the evolution of this species complex has proved problematic. To develop a comprehensive framework for species delimitation and identification, we evaluated the performance of distinct data sources both individually and in combination among numerous samples of the B. tabaci species complex acquired worldwide. Distinct datasets include full mitogenomes, single-copy nuclear genes, restriction site-associated DNA sequencing, geographic range, host speciation, and reproductive compatibility datasets. Phylogenetically, our well-supported topologies generated from three dense molecular markers highlighted the evolutionary divergence of species of the B. tabaci complex and suggested that the nuclear markers serve as a more accurate representation of B. tabaci species diversity. Reproductive compatibility datasets facilitated the identification of at least 17 different cryptic species within our samples. Native geographic range information provides a complementary assessment of species recognition, while the host range datasets provide low rate of delimiting resolution. We further summarized different data performances in species classification when compared with reproductive compatibility, indicating that combination of mtCOI divergence, nuclear markers, geographic range provide a complementary assessment of species recognition. Finally, we represent a model for understanding and untangling the cryptic species complexes based on the evidence from this study and previously published articles.

关键词： Bemisia tabaci cryptic species phylogenetics RAD-Seq reproductive compatibility whiteflies

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Study of cerium-promoted rhodium alumina catalyst as a steam reforming catalyst for treatment of spent solvents

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Journal of Rare Earths 2014年第9期32卷 831-836页

作者： Hee-Chul Yang Min-Woo lee Ho-Sang Hwang jei-Kwon Moon Dong-Yong Chung Korea Atomic Energy Research Institute

This study attempted to develop an appropriate catalyst used for the steam reforming of gasified spent solvents. Rh2O3/ CeOE-Al2O3 catalysts with various CeO2 loadings were prepared and heated at different temperatures of 500 and 800 ℃, and their surface properties were studied using X-ray diffraction （XRD）, X-ray photoelectron spectroscopy （XPS）, transmission electron microscopy （TEM）, temperature programmed reduction （TPR） and Bmmauer-Emmett-Teller （BET） analyses. Rhodium existed in the form of Rh2O3, regardless of the sample composition as well as the heating temperature. In the tested range of cerium addition （up to 12 times the rhodium mass）, no significant changes in BET surface areas and binding energy corresponding to Rh 3d5/2 were observed. Instead, the addition of cerium led to a greatly enhanced dispersion of rhodium nanoparticles, and no agglomeration of rhodium was observed for samples heated even at 800 ℃. Honeycomb monolith rhodium catalysts promoted with cerium were fabricated and tested for the steam reforming of a gasified spent solvent, mainly consisting of butylene （C4H8）. The test results suggested that a cerium-promoted rhodium catalyst could be used as an appropriate reforming catalyst for treating low-quality non-methane hydrocarbons without the formation of coke at high temperatures of up to 900 ℃.

关键词： cerium rhodium catalyst steam reforming spent resin rare earths

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