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Retrospective analysis of patients with hepatocellular carcinoma complicated with human immunodeficiency virus infection after hepatectomy

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3851-3864页

作者： Jia-Jie Lu Shuai yan Lin Chen Lin-Ling Ju wei-hua Cai Jin-Zhu Wu Department of Hepatobiliary Surgery Nantong Third People's HospitalMedical School of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Medical School Nantong UniversityNantong 226300Jiangsu ProvinceChina Institute of Liver Disease Nantong Third People’s HospitalAffiliated Nantong Hospital 3 of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Hepatobiliary Surgery Affiliated Nantong Hospital 3 of Nantong UniversityNantong 226006Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the third leading cause of cancer death worldwide,with a 5-year relative survival rate of approximately 18%.The similarity between incidence and mortality(830000 deaths per year)underscores the bleak prognosis associated with the *** is the fourth most common malignancy and the second leading cause of cancer death in *** patients with HCC have a history of chronic liver disease such as chronic hepatitis B virus(HBV)or hepatitis C virus(HCV)infection,alcoholism or alcoholic steatohepatitis,nonalcoholic fatty liver disease,or nonalcoholic *** diagnosis and effective treatment are the keys to improving the prognosis of patients with *** the total number of human immunodeficiency virus(HIV)-infected patients is declining globally the incidence of HCC is increasing in HIVinfected patients,especially those who are coinfected with HBV or *** a result,people infected with HIV still face unique challenges in terms of their risk of developing *** To investigate the survival prognosis and clinical efficacy of surgical resection in patients with HCC complicated with HIV *** The clinical data of 56 patients with HCC complicated with HIV admitted to the Third Affiliated Hospital of Nantong University from January 2013 to December 2023 were retrospectively *** these,27 patients underwent hepatectomy(operation group)and 29 patients received conservative treatment(nonoperation group).All patients signed informed consents in line with the provisions of medical *** general data,clinicopathological features and prognoses for the patients in the two groups were analyzed and the risk factors related to the prognoses of the patients in the operation group were *** The median disease-free survival(DFS)and overall survival(OS)of HIV-HCC patients in the surgical group were 13 months and 17 months,respectively,and the median OS of patients in the nonsurgic

关键词： Hepatocellular carcinoma Human Immunodeficiency virus Liver resection Retrospective analysis Prognosis

Research progress on temperature field evolution of hot reservoirs under low-temperature tailwater reinjection

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Journal of Groundwater Science and Engineering 2024年第2期12卷 205-222页

作者： Xin Wang Guo-qiang Zhou yan-guang Liu Ying-nan Zhang Mei-hua wei Kai Bian School of Earth science and Engineering Hebei University of EngineeringHandan 056038HebeiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Technology Innovation Center of Geothermal&Hot Dry Rock Exploration and Development Ministry of Natural ResourcesShijiazhuang 050061China Shanxi Key Laboratory for Exploration and Exploitation of Geothermal Resources Taiyuan 030024China Shanxi Geological Engineering Exploration Institute Taiyuan 030024China

This paper focuses on the study of the evolutionary mechanism governing the temperature field of geothermal reservoir under low-temperature tailwater reinjection conditions,which is crucial for the sustainable geothermal energy *** advancing exploitation of geothermal resources deepens,precise understanding of this mechanism becomes paramount for devising effective reinjection strategies,optimizing reservoir utilization,and bolstering the economic viability of geothermal energy *** article presents a comprehensive review of temperature field evolution across diverse heterogeneous thermal reservoirs under low-temperature tailwater reinjection conditions,and analyzes key factors influ-encing this *** evaluates existing research methods,highlighting their strengths and *** study identifies gaps in the application of rock seepage and heat transfer theories on a large scale,alongside the need for enhanced accuracy in field test results,particularly regarding computational effi-ciency of fractured thermal reservoir models under multi-well reinjection *** address these shortcomings,the study proposes conducting large-scale rock seepage and heat transfer experiments,coupled with multi-tracer techniques for field testing,aimed at optimizing fractured thermal reservoir models'computational efficiency under multi-well reinjection ***,it suggests integrat-ing deep learning methods into research *** initiatives are of significance in deepening the understanding of the evolution process of the temperature field in deep thermal reservoirs and enhancing the sustainability of deep geothermal resource development.

关键词： Geothermal reinjection Seepage heat transfer Tracer test Numerical simulation Thermal breakthrough

An Accelerated Proximal Gradient Algorithm for Hankel Tensor Completion

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Journal of the Operations Research Society of China 2024年第2期12卷 461-477页

作者： Chuan-Long Wang Xiong-wei Guo Xi-Hong yan Key Laboratory of Engineering and Computational Science Shanxi Provincial Department of EducationJinzhong 030619ShanxiChina Department of Mathematics Taiyuan Normal UniversityJinzhong 030619ShanxiChina

In this paper,an accelerated proximal gradient algorithm is proposed for Hankel tensor completion *** our method,the iterative completion tensors generated by the new algorithm keep Hankel structure based on projection on the Hankel tensor ***,due to the special properties of Hankel structure,using the fast singular value thresholding operator of the mode-s unfolding of a Hankel tensor can decrease the computational ***,the convergence of the new algorithm is discussed under some reasonable ***,the numerical experiments show the effectiveness of the proposed algorithm.

关键词： Hankel tensor Tensor completion Accelerated proximal gradient algorithm

Development status and prospect of underground thermal energy storage technology

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Journal of Groundwater Science and Engineering 2024年第1期12卷 92-108页

作者： Ying-nan Zhang yan-guang Liu Kai Bian Guo-qiang Zhou Xin Wang Mei-hua wei School of Earth science and Engineering Hebei University of EngineeringHandan 056038Hebei ProvinceChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Technology Innovation Center of Geothermal&Hot Dry Rock Exploration and Development Ministry of Natural ResourcesShijiazhuang 050061China Shanxi Key Laboratory for Exploration and Exploitation of Geothermal Resources Taiyuan 030024China Shanxi Geological Engineering Exploration Institute Taiyuan 030024China

Underground Thermal Energy Storage(UTES)store unstable and non-continuous energy underground,releasing stable heat energy on *** effectively improve energy utilization and optimize energy *** UTES technology advances,accommodating greater depth,higher temperature and multi-energy complementarity,new research challenges *** paper comprehensively provides a systematic summary of the current research status of *** categorized different types of UTES systems,analyzes the applicability of key technologies of UTES,and evaluate their economic and environmental ***,this paper identifies existing issues with UTES,such as injection blockage,wellbore scaling and corrosion,seepage and heat transfer in cracks,*** suggests deepening the research on blockage formation mechanism and plugging prevention technology,improving the study of anticorrosive materials and water treatment technology,and enhancing the investigation of reservoir fracture network characterization technology and seepage heat *** recommendations serve as valuable references for promoting the high-quality development of UTES.

关键词： Aquifer thermal energy storage Borehole thermal energy storage Cavern thermal energy storage Thermal energy storage technology Benefit evaluation

On the longitudinal shifts of the Agulhas retroflection point

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Acta Oceanologica Sinica 2024年第5期43卷 16-29页

作者： weiwei Zhang Xiaoyi yang wei Zhuang Xiaohai yan State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361002China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China Center for Remote Sensing College of EarthOcean and EnvironmentUniversity of DelawareNewarkDE 19716USA Joint Center for Remote Sensing University of Delaware-Xiamen UniversityNewarkDE 19716USA and Xiamen 361002China

The Agulhas system is the strongest western boundary current system in the Southern Hemisphere and plays an important role in modulating the Indian-to-Atlantic Ocean water exchange by the Agulhas *** is difficult to measure in situ transport of the Agulhas leakage as well as the Agulhas retroflection position due to their intermittent *** this study,an innovative kinematic algorithm was designed and applied to the gridded altimeter observational data,to ascertain the longitudinal position of Agulhas retroflection,the stability of Agulhas jet stream,as well as its *** results show that the east-west shift of retroflection is related neither to the strength of Agulhas current nor to its *** analysis uncovers the connection between the westward extension of Agulhas jet stream and an anomalous cyclonic circulation at its northern side,which is likely attributed to the local wind stress curl *** confirm the effect of local wind forcing on the east-west shift of retroflection,numerical sensitivity experiments were *** results show that the local wind stress can induce a similar longitudinal shift of the retroflection as altimetry *** statistical and case study indicates that whether an Agulhas ring can continuously migrate westward to the Atlantic Ocean or re-merge into the main flow depends on the retroflection ***,the westward retroflection may contribute to a stronger Agulhas leakage than the eastward retroflection.

关键词： Agulhas system Agulhas leakage retroflection position local wind stress curl

Mechanism of interfacial effects in sodium-ion storage devices

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Nano Research 2024年第3期17卷 1313-1326页

作者： Yifan wei Lingxing Zan Huicong Xia Wenfu yan Jia-Nan Zhang College of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Key Laboratory of Advanced Energy Catalytic and Functional Material Preparation of Zhengzhou City Zhengzhou 450001China Key Laboratory of Chemical Reaction Engineering of Shaanxi Province College of Chemistry&Chemical EngineeringYan’an UniversityYan’an 716000China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry and College of Chemistry Jilin UniversityChangchun 130012China

Rechargeable sodium-ion batteries(SIBs)are considered as the next-generation secondary *** performance of SIB is determined by the behavior of its electrode surface and the electrode–electrolyte interface during charging and ***,the characteristics of these surfaces and interfaces should be analyzed to realize large-scale energy storage systems with high energy density and long-cycle *** various studies have investigated the properties of electrode materials,few studies have focused on the construction of stable and efficient SIB interfaces,and even fewer have explored the mechanisms of interfacial effects;however,the strategies of regulating interfacial effects are yet to be completely ***,the results obtained thus far are insufficient to draw systematic *** present study reviews the literature on the mechanism of interfacial effects in Na+storage *** interfaces in a sodium-ion storage device include a heterogeneous interface between electrode materials,a solid electrolyte interphase,and a cathode electrolyte *** interfacial effects during the intercalation,transformation,and alloy reactions and the resulting overall battery performance were theoretically *** this review,we aim to provide a theoretical basis for optimizing the structures of electrode surface and electrode–electrolyte interface to optimize the performance of *** addition,the challenges of investigating interfacial effects and several possible helpful methods and opportunities for studying the mechanisms of interfacial effects in SIBs will be presented.

关键词： sodium-ion storage interfacial effects solid electrolyte interphase cathode electrolyte interphase

Integrated multi-omics analysis reveals liver metabolic reprogramming by fish iridovirus and antiviral function of alpha-linolenic acid

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Zoological Research 2024年第3期45卷 520-534页

作者： Lin Liu Ya Zhang Meng-Di Yuan Dong-Miao Xiao wei-hua Xu Qi Zheng Qi-wei Qin You-hua huang Xiao-Hong huang College of Marine Sciences South China Agricultural UniversityGuangdong Laboratory for Lingnan Modern AgricultureGuangzhouGuangdong 510642China Nansha-South China Agricultural University Fishery Research Institute GuangzhouGuangdong 511464China Southern Marine Science and Engineering Guangdong Laboratory ZhuhaiGuangdong 519082China

Iridovirus poses a substantial threat to global aquaculture due to its high mortality rate;however,the molecular mechanisms underpinning its pathogenesis are not well ***,a multi-omics approach was applied to groupers infected with Singapore grouper iridovirus(SGIV),focusing on the roles of key *** showed that SGIV induced obvious histopathological damage and changes in metabolic enzymes within the ***,SGIV significantly reduced the contents of lipid droplets,triglycerides,cholesterol,and *** analysis indicated that the altered metabolites were enriched in 19 pathways,with a notable down-regulation of lipid metabolites such as glycerophosphates and alpha-linolenic acid(ALA),consistent with disturbed lipid homeostasis in the *** of transcriptomic and metabolomic data revealed that the top enriched pathways were related to cell growth and death and nucleotide,carbohydrate,amino acid,and lipid metabolism,supporting the conclusion that SGIV infection induced liver metabolic *** integrative transcriptomic and proteomic analysis indicated that SGIV infection activated crucial molecular events in a phagosome-immune depression-metabolism dysregulation-necrosis signaling *** note,integrative multi-omics analysis demonstrated the consumption of ALA and linoleic acid(LA)metabolites,and the accumulation of L-glutamic acid(GA),accompanied by alterations in immune,inflammation,and cell death-related *** experimental data showed that ALA,but not GA,suppressed SGIV replication by activating antioxidant and anti-inflammatory responses in the ***,these findings provide a comprehensive resource for understanding host response dynamics during fish iridovirus infection and highlight the antiviral potential of ALA in the prevention and treatment of iridoviral diseases.

关键词： Iridovirus Liver damage Metabolic reprogramming SGIV Alpha-linolenic acid Antiinflammatory

The RNA-binding domain of DCL3 is required for long-distance RNAi signaling

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aBIOTECH 2024年第1期5卷 17-28页

作者： Jie Li Bo-Sen Zhang hua-wei Wu Cheng-Lan Liu Hui-Shan Guo Jian-hua Zhao State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of the Chinese Academy of SciencesBeijing 100049China Qilu Zhongke Academy of Modern Microbiology Technology Jinan 250022China

Small RNA(sRNA)-mediated RNA silencing(also known as RNA interference,or RNAi)is a conserved mechanism in eukaryotes that includes RNA degradation,DNA methylation,heterochromatin formation and protein translation *** plants,sRNAs can move either cell-to-cell or systemically,thereby acting as mobile silencing signals to trigger noncell autonomous ***,whether and what proteins are also involved in noncell autonomous silencing have not been *** this study,we utilized a previously reported inducible RNAi plant,PDSi,which can induce systemic silencing of the endogenous PDS gene,and we demonstrated that DCL3 is involved in systemic PDS silencing through its RNA binding *** confirmed that the C-terminus of DCL3,including the predicted RNA-binding domain,is capable of binding short *** affecting RNA binding,but not processing activity,reduced systemic PDS silencing,indicating that DCL3 binding to RNAs is required for the induction of systemic *** mosaic virus infection assays showed that the RNA-binding activity of DCL3 is required for antiviral RNAi in systemically noninoculated *** findings demonstrate that DCL3 acts as a signaling agent involved in noncell autonomous silencing and an antiviral effect in addition to its previously known function in the generation of 24-nucleotide sRNAs.

关键词： RNAi signaling DCL3 RBD RNAs Cucumber mosaic virus

Hexagonal boron nitride based slippery liquid infused porous surface with anti-corrosion, anti-contaminant and anti-icing properties for protecting magnesium alloy

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Chinese Chemical Letters 2024年第4期35卷 532-538页

作者： Wenhao yan Shuaiya Xue Xuerui Zhao wei Zhang Jian Li Key Laboratory of Eco-Functional Polymer Materials of the Ministry of Education College of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China

In an era where the concept of green development is deeply rooted, magnesium(Mg) alloy as a light metal has a long-term development prospect in the process of energy saving, emission reduction and environmental improvement. However, anti-corrosion performance of Mg alloy is poor due to the high chemical activity and low equilibrium potential, which limits the development of Mg alloy ***, three-dimensional mesopore hollow polypyrrole spheres(MHPS) were prepared, and the MHPS was inserted into the middle of the stacked hexagon boron nitride(h-BN) lamellae, which allowed the hBN to be separated forming a further composite with abundant pore structure. Subsequently, the MHPS/hBN-OH composite was uniformly sprayed on the Mg alloy surface via simple spraying method to form the superhydrophobic surface(SHS). Finally, the slippery liquid infused porous surface(SLIPS) was successfully fabricated by applying drops of silicone lubricant on the superhydrophobic coating surface. After a series of characterization and testing, the results showed that the stacking of h-BN lamellae was significantly reduced after h-BN was successfully embedded by MHPS. In addition, the fabricated SLIPS have excellent self-cleaning, mechanical stability, anti-icing and anti-corrosion properties. Therefore, the method of embedding polymer microspheres not only offers a new strategy for h-BN exfoliation, but also the successful prepared SLIPS largely retards the corrosion of Mg alloy while providing new ideas for the development of SLIPS.

关键词： Anti-corrosion Mg alloy Hexagon boron nitride Polypyrrole SLIPS