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Research progress in drug therapy of juvenile idiopathic arthritis

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World Journal of Pediatrics 2022年第6期18卷 383-397页

作者： Wen-Jia Zhao jiang-hong Deng Cai-Feng Li Department of Rheumatology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthNo.56Nan Li Shi RoadBeijing100045China

Background Juvenile idiopathic arthritis(JIA)is the most common chronic rheumatic disease in *** the gradual expansion of the incidence of JIA in the population,the pathogenesis and treatment of JIA were further explored and analyzed,and JIA has achieved some success in drug *** sources A systemic literature search was conducted on PubMed,Cochrane Library,EMBASE,ISI Web of Science,the US National Institutes of Health Ongoing Trials Register,and the EU Clinical Trials *** the searching of clinical trials of JIA in recent years,we summarized the progress of the clinical treatment of *** The main treatment drugs for JIA include non-steroidal anti-inflammatory drugs,glucocorticoids,disease-modifying antirheumatic drugs and biological *** far,a variety of biological agents targeting the cytokines and receptors involved in its pathogenesis have been gradually approved for JIA in many *** application of biological agents in JIA showed good efficacy and safety,bringing unprecedented experience to children and adolescents with *** The potential and advantages of biologic agents in the treatment of JIA are significant,and the application of biologic agents in the treatment of JIA will be more and more common.

关键词： Juvenile idiopathic arthritis Progress Treatment

Preseismic deformation in the seismogenic zone of the Lushan MS7.0 earthquake detected by GPS observations

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Science China Earth Sciences 2015年第8期58卷 1592-1601页

作者： LIU XiaoXia WU YanQiang jiang ZaiSen ZHAN wei LI Qiang wei WenXin ZOU ZhenYu Institute of Geology China Earthquake Administration Key Laboratory of Earthquake Prediction China Earthquake Administration First Crust Monitoring and Application Center China Earthquake Administration

A continuous GPS array across the southern segment of the Longmenshan fault zone recorded the deformation during the process of the Lushan MS7.0 earthquake that occurred on April 20, 2013. Such data can provide meaningful information regarding the dynamic evolution of crustal deformation in the seismogenic zone. Our studies have shown that the occurrence of the Wenchuan earthquake led to the loading of compressive and sinistral shearing strain on the southern segment of the Maoxian-Wenchuan fault, whereby the extrusion strain accumulated at a greater rate than before the Wenchuan earthquake. The strain time series in the seismogenic zone revealed that the principal compression strain rates decreased from west to east in the direction of N30°–45°W. Furthermore, the area to the east of Beichuan-Yingxiu fault behaved as a zone of compressive deformation with obvious sinistral shearing deformation. The surface strain and the first shearing strain time series decreased with time, while the area to the west of the Beichuan-Yingxiu fault behaved as a zone of dextral shear deformation that increased with time. Furthermore, the regional deformation field before the Lushan earthquake showed that the rate of extrusion strain accumulation in the southern segment of the Longmenshan fault zone was obviously larger than before the Wenchuan earthquake. Moreover, the sinistral shearing strain accumulated in the area of the southern segment of the Maoxian-Wenchuan fault. Based on the above analysis, we consider that the eastward movement of the Bayan Har block increased considerably following the Wenchuan earthquake, which enhanced the accumulation of compression strain in the southern segment of the Longmenshan fault zone.

关键词： Lushan Ms7.0 earthquake GPS observations GPS baseline time series strain time series

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从霍布斯到马克思:近代市民社会思想的发展历程

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黑龙江社会科学 2024年第5期 28-34,144页

作者：江蓓蕾王朋伟中央文化和旅游管理干部学院北京102600 国家教育行政学院北京102617

近代市民社会思想经历了一个不断丰富、反思和超越自身的发展过程。以洛克、霍布斯为代表的社会契约论思想家讨论了市民社会的自然状态和国家形式,加速了市民社会与政治国家的分离,在“发现国家”的同时划定市民社会的形成范围;以休谟... 详细信息

近代市民社会思想经历了一个不断丰富、反思和超越自身的发展过程。以洛克、霍布斯为代表的社会契约论思想家讨论了市民社会的自然状态和国家形式,加速了市民社会与政治国家的分离,在“发现国家”的同时划定市民社会的形成范围;以休谟、斯密为代表的苏格兰启蒙运动思想家植根经验,构建出一套逻辑严密的社会本体论,在“发现社会”的过程中确定市民社会的运行规范;黑格尔则在深刻揭示和反思市民社会的基础上,精心设计了国家决定市民社会的伦理体系。最终,马克思超越传统市民社会思想,从理论上得出市民社会必然灭亡的结论,并确定了无产阶级这一现实实践主体。

关键词：市民社会国家马克思霍布斯

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基于工业余热与可再生能源耦合的赤峰市低碳供热研究

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暖通空调 2024年第3期54卷 144-149页

作者：方豪黄伟江亿朱旭内蒙古富龙供热工程技术有限公司赤峰024000 清华大学北京

以赤峰市大温差供热工程实践为例,介绍了赤峰市低碳供热方案的设计理念和实施步骤。从赤峰市供热热源紧缺,城区周边电厂乏汽余热、工业余热和弃风电力转化热量潜力估算,降低一次网回水温度必要性,大温差供热推进和分阶段实施过程,各阶... 详细信息

以赤峰市大温差供热工程实践为例,介绍了赤峰市低碳供热方案的设计理念和实施步骤。从赤峰市供热热源紧缺,城区周边电厂乏汽余热、工业余热和弃风电力转化热量潜力估算,降低一次网回水温度必要性,大温差供热推进和分阶段实施过程,各阶段热平衡等5个方面进行了详细说明。根据规划,至2035年赤峰市中心城区供热热量来源于非供暖季储存弃风电力转化热量和工业余热,以及供暖季工业余热和燃煤调峰电厂热量,单位供热面积的二氧化碳排放强度是现状的1/30。

关键词：低碳供热零碳热源工业余热弃风电力大温差供热跨季节储热回水温度

猪萨佩罗病毒聚合酶链式反应检测方法的建立及应用

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浙江理工大学学报（自然科学版） 2024年第5期51卷 718-724页

作者：张伟韩寅卓姜永厚浙江理工大学生命科学与医药学院杭州310018

猪萨佩罗病毒(Porcine sapelovirus,PSV)是引发猪腹泻的重要病毒之一。为开发一种能快速、准确检测PSV的聚合酶链式反应检测方法,针对PSV的保守区3D基因设计了一对特异性引物,优化了聚合酶链式反应退火温度,分析聚合酶链式反应检测方法... 详细信息

猪萨佩罗病毒(Porcine sapelovirus,PSV)是引发猪腹泻的重要病毒之一。为开发一种能快速、准确检测PSV的聚合酶链式反应检测方法,针对PSV的保守区3D基因设计了一对特异性引物,优化了聚合酶链式反应退火温度,分析聚合酶链式反应检测方法特异性和灵敏度,并应用于猪场样品检测。结果表明:建立的聚合酶链式反应检测方法可特异性扩增出PSV目的片段,对其他非靶标猪腹泻病毒则无条带产生,检测低限为5拷贝/μL;在浙江地区采集的88个健康猪粪便样本中检测PSV阳性率为7.95%。该PSV聚合酶链式反应检测方法特异性强、灵敏度高,可应用于PSV前期诊断和防控。

关键词：猪萨佩罗病毒 3D基因聚合酶链式反应特异性灵敏度阳性率

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Investigations on Flanging of Aluminum Alloy Tube Under Pulsed Magnetic Force

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Journal of Iron and Steel Research International 2012年第S1期19卷 438-441页

作者： YU Hai-ping jiang hong-wei LI Chun-feng National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of Technology

In this work,the magnetic pulse forming process was used to flange the AA 3003-O aluminum alloy tube to improve the flanging formability *** results show that there are critical discharge energy values for the flanging dies with varied slope *** mechanism of magnetic pulse flanging process is the bulging in contrast to the expanding of the quasi-static *** the flanging with 90 slope degree,the limited hoop strain at the outer fringe could be up to 0.54 without rapture,to which the limit of simple tension limit is improved by 85%in *** 180 degree flanging at tube end can be achieved by one time magnetic pulse forming.

关键词： magnetic pulse forming flanging forming limit aluminum alloy tube

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六面体类桁架变密度点阵结构设计与制造研究

制造业自动化 2024年第3期46卷 54-60页

作者：易辉成易杰蒋金位复杂薄壁精密零件智能柔性加工技术湖南省工程研究中心长沙410205 湖南工业职业技术学院汽车工程学院长沙410205 湖南华翔增量制造股份有限公司长沙410205

针对类桁架变密度点阵结构设计中存在的设计流程繁复、设计变量多等问题,提出了一种新的设计方法。依据六面体网格建立六面体类桁架变密度点阵结构参数化有限元模型,简化了设计流程。通过应力匹配函数使点阵胞元的桁架尺寸与节点等效应... 详细信息

针对类桁架变密度点阵结构设计中存在的设计流程繁复、设计变量多等问题,提出了一种新的设计方法。依据六面体网格建立六面体类桁架变密度点阵结构参数化有限元模型,简化了设计流程。通过应力匹配函数使点阵胞元的桁架尺寸与节点等效应力相关联,减少了设计变量。基于***和ANSYS开发了相应的有限元计算和三维建模程序,最终达到提高变密度点阵结构设计效率的目的。采用该程序设计的悬臂梁变密度点阵结构呈现出很好的等强度效果,并成功应用增材制造工艺进行了制造。

关键词：类桁架点阵变密度增材制造

Polymer Vesicles with Upper Critical Solution Temperature for Near-infrared Light-triggered Transdermal Delivery of Metformin in Diabetic Rats

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Chinese Journal of Polymer Science 2022年第2期40卷 157-165页

作者： wei Hu Ya-wei Su Yi-Kun jiang Wen-Di Fan Song-Yue Cheng Zai-Zai Tong Chao Cen Guo-Hua jiang College of Materials Science and Engineering and Institute of Smart Biomedical Materials Zhejiang Sci-Tech UniversityHangzhou 310018China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Near-infrared light(NIR)triggered transdermal drug delivery systems are of great interest due to their on-demand drug release,which enable to enhance drug treatment efficiency as well as reduce side ***,a NIR-triggered microneedle(MN)patch array has been fabricated through depositing the photothermal conversion agent and anti-diabetic drug-loaded polymer vesicles with upper critical solution temperature(UCST)into dissolvable polymer *** UCST-type polymer has a clearing point temperature of 41℃ and the drug-loaded polymer vesicles present excellent NIR-triggered and temperature responsive drug release behavior in vitro due to the disassociation of polymer vesicles upon NIR *** applying MNs to diabetic rats,significant hypoglycemic effect is achieved upon interval NIR irradiation and the blood glucose concentration can decrease to normal state for several hours,which enables to achieve the goal of on-demand drug *** work suggests that the NIR-triggered MN drug release device has a potential application in the treatment of diabetes,especially for those requiring an active drug release manner.

关键词： Diabetes Upper critical solution temperature Near-infrared light On-demand drug release Polymeric vesicles

Human thioredoxin exerts cardioprotective effect and attenuates reperfusion injury in rats partially via inhibiting apoptosis

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Chinese Medical Journal 2008年第9期121卷 819-826页

作者： WU Xiao-wei TENG Zong-yan jiang Li-hong FAN Ying ZHANG Yu-hua LI Xiu-rong ZHANG Yi-na Department of Geriatrics Second Affiliated Hospital Harbin Medical University Harbin Heilongjiang 150086 China Department of Pathology Harbin Medical University Harbin Heilongjiang 150086 China

Background Thioredoxin is one of the most important redox regulating proteins. Although thioredoxin has been shown to protect cells against different kinds of oxidative stress, the role of thioredoxin in myocardial ischemia and reperfusion injury has not been fully understood. This study was conducted to explore the protective role of human thioredoxin on myocardial ischemia and reperfusion injury and its potential mechanisms. Methods Purified human thioredoxin was injected into adult Wister rats, which were subjected to 30 minutes of myocardial ischemia followed by 2 or 24 hours of reperfusion. We detected 1） the infarct size; 2） the level of malondisldehyde （MDA） in serum; 3） the expression of caspase-9, and cytochrome c in/out of mitochondia by Western blotting; 4） apoptosis by terminal-deoxynucleotidyl transferase mediated nick end labeling （TUNEL） assay and caspase-3 and its protein by reverse transcriptase polymerase chain reaction （RT-PCR） and Western blotting; 5） the expression of bcl-2 and bax in cardium by immunohistochemical （IHC） assay. Results Human thioredoxin reduced myocardial ischemia/reperfusion injury as evidenced by significant decrease of myocardial infarct size （P〈0.01）, notable reduction of myocyte apoptosis （P 〈0.01）, lower systemic oxidative stress level （P 〈0.01） after reperfusion for 2 hours, and few inflammatory cell infiltration after reperfusion for 24 hours in rats. Furthermore, treatment with human thioredoxin significantly reduced the release of mitochonddal cytochrome C （P〈0.05） and inhibited the activity of caspase-9 （P 〈0.05） and caspase-3 （P 〈0.01 in mRNA and P 〈0.05 at protein level）. Meanwhile, human thioredoxin markedly increased bcl-2 expression （P 〈0.05）. Conclusions These results strongly suggest that human thioredoxin has cardioprotective effects on myocardial ischemia/reperfusion and its anti-apoptotic role may be mediated by modulating bcl-2 and the mitochondria-dependent apoptotic signaling pathway.

关键词： thioredoxin reperfusion cardioprotection mitochondria apoptosis