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Enhancing electrochemical capacity and interfacial stability of lithium-ion batteries through side reaction modulation with ultrathin carbon nanotube film and optimized lithium cobalt oxide particle size

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Nano Research 2024年第8期17卷 7230-7241页

作者： wei Xi xiaogang xia Jiacheng Zhu Dehua Yang Sishen Xie Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Advanced Passivation Technology Lab College of Physics Science and TechnologyHebei UniversityBaoding 071002China

Lithium cobalt oxide(LCO),the first commercialized cathode active material for lithium-ion batteries,is known for high voltage and ***,its application has been limited by relatively low capacity and stability at high *** particle size is considered one of the most straightforward and effective strategies to enhance ion transfer,thus increasing the rate ***,side reactions are simultaneously enhanced as the specific surface area ***,we investigate the impact of LCO particles with varying size distributions and optimize the particle *** modulate the side reactions associated with particle size reduction,an ultrathin carbon nanotube film(UCNF)is introduced to coat the cathode *** this simple process and optimized particle size,the rate performance improves significantly,normal commercial LCO achieves 118 mA·h·g^(−1)at 3.0–4.3 V and 20 C(0.72 mA·h·cm^(−2)),corresponding to power density of 8732 W·kg^(−1).This method is applied to high voltage as well,152 mA·h·g^(−1)at 3.0–4.6 V and 20 C(0.99 mA·h·cm^(−2))was achieved with high-voltage LCO(HVLCO),corresponding to power density of 11,552 W·kg^(−1).The cycling stability is also enhanced,with the capacity retention maintaining more than 96%after 100 cycles at 0.1 *** the first time,UCNF is demonstrated to suppress the excessive decomposition of the electrolytes and solvents by blocking electron injection/extraction between LCO and electrolyte *** findings provide a simple method for improving LCO rate performance,especially at high C-rates.

关键词： lithium-ion batteries lithium cobalt oxides carbon nanomaterials side reactions

Drug repurposing for cancer therapy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1981-2013页

作者： Ying xia Ming Sun Hai Huang wei-Lin Jin Center for Clinical Laboratories The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004PR China The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550001PR China School of Clinical Laboratory Science Guizhou Medical UniversityGuiyang 550004PR China Division of Gastroenterology and Hepatology Department of Medicine andDepartment of OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21287USA Institute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhou 730000PR China

Cancer,a complex and multifactorial disease,presents a significant challenge to global *** significant advances in surgical,radiotherapeutic and immunological approaches,which have improved cancer treatment outcomes,drug therapy continues to serve as a key therapeutic ***,the clinical efficacy of drug therapy is often constrained by drug resistance and severe toxic side effects,and thus there remains a critical need to develop novel cancer *** promising strategy that has received widespread attention in recent years is drug repurposing:the identification of new applications for existing,clinically approved *** repurposing possesses several inherent advantages in the context of cancer treatment since repurposed drugs are typically cost-effective,proven to be safe,and can significantly expedite the drug development process due to their already established safety *** light of this,the present review offers a comprehensive overview of the various methods employed in drug repurposing,specifically focusing on the repurposing of drugs to treat *** describe the antitumor properties of candidate drugs,and discuss in detail how they target both the hallmarks of cancer in tumor cells and the surrounding tumor *** addition,we examine the innovative strategy of integrating drug repurposing with nanotechnology to enhance topical drug *** also emphasize the critical role that repurposed drugs can play when used as part of a combination therapy *** conclude,we outline the challenges associated with repurposing drugs and consider the future prospects of these repurposed drugs transitioning into clinical application.

关键词： drugs integrating spite

Urinary metabolic profiles during Helicobacter pylori eradication in chronic gastritis

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World Journal of Clinical Cases 2024年第5期12卷 951-965页

作者： Wen-Ting An Yu-xia hao Hong-xia Li Xing-Kang Wu Department of Pharmacy Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Department of Gastroenterology Shanxi Provincial People's HospitalTaiyuan 030012Shanxi ProvinceChina Department of Oncology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006Shanxi ProvinceChina

BACKGROUND Helicobacter pylori(***)infection is a major risk factor for chronic gastritis,affecting approximately half of the global *** eradication is a popular treatment method for ***-positive chronic gastritis,but its mecha-nism remains *** metabolomics has been used to elucidate the mechanisms of gastric disease ***,no clinical study has been conducted on urinary metabolomics of chronic *** To elucidate the urinary metabolic profiles during *** eradication in patients with chronic *** We applied LC–MS-based metabolomics and network pharmacology to in-vestigate the relationships between urinary metabolites and ***-positive chronic gastritis via a clinical follow-up *** Our study revealed the different urinary metabolic profiles of ***-positive chronic gastritis before and after *** *** metabolites regulated by *** eradication therapy include cis-aconitic acid,isocitric acid,citric acid,L-tyrosine,L-phenylalanine,L-tryptophan,and hippuric acid,which were involved in four metabolic pathways:(1)Phenylalanine metabolism;(2)phenylalanine,tyrosine,and tryptophan biosynthesis;(3)citrate cycle;and(4)glyoxylate and dicarboxylate *** metabolomics and network pharmacology revealed that MPO,COMT,TPO,TH,EPX,CMA1,DDC,TPH1,and LPO were the key proteins involved in the biological progress of *** eradication in chronic *** Our research provides a new perspective for exploring the significance of urinary metabolites in evaluating the treatment and prognosis of ***-positive chronic gastritis patients.

关键词： LC-MS metabolomics chronic gastritis Helicobacter pylori urinary metabolites

A real-time calibration method based on time-to-digital converter for accelerator timing system

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Nuclear Science and Techniques 2024年第9期35卷 127-140页

作者： Qi-hao Duan Liang Ge Yan-hao Jia Jie-Yu Zhu wei Zhang Institute of modern physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

The high-intensity heavy-ion accelerator facility(HIAF)is a scientific research facility complex composed of multiple cas-cade accelerators of different types,which pose a scheduling problem for devices distributed over a certain range of 2 km,involving over a hundred *** white rabbit,a technology-enhancing Gigabit Ethernet,has shown the capability of scheduling distributed timing devices but still faces the challenge of obtaining real-time synchronization calibration param-eters with high *** study presents a calibration system based on a time-to-digital converter implemented on an ARM-based System-on-Chip(SoC).The system consists of four multi-sample delay lines,a bubble-proof encoder,an edge controller for managing data from different channels,and a highly effective calibration module that benefits from the SoC *** performance was evaluated with an average RMS precision of 5.51 ps by measuring the time intervals from 0 to 24,000 ps with 120,000 data for every *** design presented in this study refines the calibration precision of the HIAF timing *** eliminates the errors caused by manual calibration without efficiency loss and provides data support for fault *** can also be easily tailored or ported to other devices for specific applications and provides more space for developing timing systems for particle accelerators,such as white rabbits on HIAF.

关键词： HIAF White rabbit Calibration system Time-to-digital converter(TDC)

Three dimensional discrete element modelling of the conventional compression behavior of gas hydrate bearing coal

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International Journal of Coal Science & Technology 2024年第1期11卷 61-77页

作者： xia Gao Nannan Wang Baoyong Zhang Qiqi Lin Qiang Wu wei Meng xia Liu Department of Architecture and Civil Engineering Heilongjiang University of Science and TechnologyHarbin150022China School of Qilu Transportation Shandong UniversityJinan250061China Department of Safety Engineering Heilongjiang University of Science and TechnologyHarbin150022China Jining Hongxiang Highway Survey Design and Research Institute Co.Ltd Jining272000China

To analyze the relationship between macro and meso parameters of the gas hydrate bearing coal(GHBC)and to calibrate the meso-parameters,the numerical tests were conducted to simulate the laboratory triaxial compression tests by PFC3D,with the parallel bond model employed as the particle contact constitutive ***,twenty simulation tests were conducted to quantify the relationship between the macro–meso ***,nine orthogonal simulation tests were performed using four meso-mechanical parameters in a three-level to evaluate the sensitivity of the meso-mechanical ***,the calibration method of the meso-parameters were then ***,the contact force chain,the contact force and the contact number were examined to investigate the saturation effect on the meso-mechanical behavior of *** results show that:(1)The elastic modulus linearly increases with the bonding stiffness ratio and the friction coefficient while exponentially increasing with the normal bonding strength and the bonding radius *** failure strength increases exponentially with the increase of the friction coefficient,the normal bonding strength and the bonding radius coefficient,and remains constant with the increase of bond stiffness ratio;(2)The friction coefficient and the bond radius coefficient are most sensitive to the elastic modulus and the failure strength;(3)The number of the force chains,the contact force,and the bond strength between particles will increase with the increase of the hydrate saturation,which leads to the larger failure strength.

关键词： Gas hydrate bearing coal Discrete element method Triaxial compression test Macro-meso mechanical propertie

Alterations in expression and localization of POMGNT1 in the APP/PS1 mouse model of Alzheimer’s disease

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Genes & Diseases 2024年第5期11卷 55-58页

作者： Hanxiao Jiang Yuxue Feng xia hao Guiqiong He xiaofeng Li Department of Neurology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 401336China Chongqing Key Laboratory of Neurobiology Chongqing Medical UniversityChongqing 400016China Department of Anatomy Chongqing Medical UniversityChongqing 400016China Department of Neurology The Fifth People’s Hospital of ChongqingChongqing 400062China

Alzheimer’s disease(AD)is a complex and progressive neurodegenerative disorder that causes dementia in the aging *** of the characteristic pathologic hallmarks of AD is the senile plaques,composed of the accumulation of *** b-amyloid results from the cleavage of transmembrane b-amyloid precursor protein(APP)by b-secretases and g-secretases,sequentially.O-mannosylation was found essential for the normal function of APP in Saccharomyces cerevisiae.1 Protein Olinked mannose b1,2-N-acetyl-glucosaminyltransferase 1(POMGNT1)is a glycosyltransferase crucial for the elongation of O-mannosyl glycans and catalyzes the transfer of Nacetylglucosamine from uridine 50-diphosphate-N-acetylglucosamine to O-mannose of glycoproteins.

关键词： APP/PS1 Alzheimer amyloid

Evaluation of UAV spraying quality based on 1D-CNN model and wireless multi-sensors system

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Information Processing in Agriculture 2024年第1期11卷 65-79页

作者： Ziyuan hao Minzan Li wei Yang Xinze Li Key Laboratory of Smart Agriculture Systems Ministry of EducationChina Agricultural UniversityBeijing 100083PR China

The droplet deposition is a key index to evaluate the quality of unmanned aerial vehicle(UAV)*** detection of the droplet deposition is time-consuming and costly,therefore,it is difficult to achieve large-scale and rapid acquisition in the *** solve the above problems,a droplet deposition acquisition system(DDAS)was *** was composed of the multiple sensors,processing units,remote server database and Android-based software.A droplet deposition prediction model based on field experimental data was established by using a one-dimensional convolutional neural network(1D-CNN)algorithm,and the effects of different inputs on the prediction ability of the model were *** results showed that adding temperature and humidity data to the inputs can achieve higher prediction accuracy than only using UAV spraying operation parameters and wind speed data as the inputs to the *** addition,the prediction accuracy of the 1D-CNN model was the highest when compared with other models such as back propagation neural network,multiple correlation vector machine,and multiple linear *** 1D-CNN model was embedded into the DDAS,and the evaluation experiments were carried out in the *** correlation analysis was conducted between two datasets of the droplet deposition obtained by the DDAS and water sensitive paper(WSP),*** R2 was 0.924,and the RMSE was 0.026μL/*** is proved that the droplet deposition values obtained by the DDAS and WSP have high consistency,and the DDAS developed can provide an auxiliary solution for the intelligent evaluation of UAV spraying quality.

关键词： UAV Spraying quality Droplet deposition 1D-CNN model Sensor

The value of toxicological analysis in acute poisoning patients with uncertain exposure histories:a retrospective and descriptive study from an institute of poisoning

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World Journal of Emergency Medicine 2024年第2期15卷 98-104页

作者： Qifang Shi Gen Ba Zhenyu xia Zhengsheng Mao hao Sun Jinsong Zhang Institute of Poisoning Nanjing Medical UniversityNanjing 211100China Department of Emergency Medicine the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Forensic Medicine Nanjing Medical UniversityNanjing 211166China The Key Laboratory of Modern Toxicology of Ministry of Education Nanjing Medical UniversityNanjing 211166China

BACKGROUND:In clinical practice,some patients might not be able or unwilling to provide a thorough history of medication and poison *** aim of this study was to use toxicological analysis to examine the clinical characteristics of patients with acute poisoning whose exposure history was uncertain from a toxicological analysis ***:This was a retrospective and descriptive study from an institute of *** registration information and test reports spanning the period from April 1,2020 to March 31,2022,were *** with uncertain exposure histories and who underwent toxicological analysis were *** manifestations and categories of toxics were ***:Among the 195 patients with positive toxicological analysis results,the main causes of uncertain exposure history was disturbance of consciousness(62.6%),unawareness(23.6%)and unwillingness or lack of cooperation(13.8%).The predominant clinical manifestations were disturbed consciousness(62.6%),followed by vomiting and nausea(14.4%)and liver function abnormalities(8.7%).A comparison of clinical manifestations between patients with positive and negative(n=99)toxicological analyses results revealed significantly different proportions of disturbances in consciousness(63%vs.21%),dizziness(1.5%vs.5.1%),multi-organ failure(1.5%vs.7.1%),and local pain(0 vs 4%).The main categories of substances involved were psychiatric medications(23.1%),sedatives(20.5%),insecticides(13.8%),and herbicides(12.8%).CONCLUSION:The clinical manifestations of acute poisoning in patients with an uncertain exposure history are diverse and nonspecific,and toxicological analysis plays a pivotal role in the diagnosis and differential diagnosis of such patients.

关键词： Acute poisoning Toxic exposure Toxicological analysis Clinical manifestation

A Note on B-Subdifferential of Projection Operator on Polyhedral Set

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Journal of the Operations Research Society of China 2024年第3期12卷 837-845页

作者： hao-Yang Liu Jia Wu Li-wei Zhang Institute of Operations Research and Control Theory School of Mathematical SciencesDalian University of TechnologyDalian116024LiaoningChina

This note characterizes the set of Fréchet-differentiable points of the projection operator on a polyhedral set and the B-subdifferential of this projection operator at any point.

关键词： Polyhedral set Projection operator B-subdifferential Strong regularity