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Separation of growth-stimulating peptides for Bifidobacterium from soybean conglycinin

World Journal of Gastroenterology 2005年第37期11卷 5801-5806页

作者： wei-Yong Zuo wei-Hua chen si-Xiang Zou Key Laboratory of Animal Physiology and Biochemistry Ministry of Agriculture College of Veterinary Medicine Nanjing Agricultural University Nanjing 210095 Jiangsu Province China

AIM： To isolate and identify the soybean conglycinin peptides that selectively stimulates the growth of bifidobacteria in vitro, and to investigate the effect of soybean conglycinin peptides on intestinal ecosystem in vivo. METHODS： Soybean conglycinin was purified from soybean seeds by gel filtration （Sepharose-CL-6B）. These proteins were submitted to hydrolysis by pepsin. Several growth-stimulating peptides for bifidobacteria were isolated chromatographically from pepsin hydrolysis of soybean conglycinin and identified by means of matrixassisted laser desorption ionization time of flight mass spectrometry （MALDI-TOF-MS）. Parallel to in vitro study, in vivo experiments with soybean conglycinin peptides were performed in mice. Ninety male KM mice were randomly assigned into five groups of 16 mice each, and each group was administered for 21d intragastrically with physiological saline （control）, conglycinin, pepsin-treated conglycinin （PTC）, the most active fraction which isolated from pepsin-treated conglycinin （P2-PTC） and HCl-full hydrolysis of conglycinin （HCl-FHC）, respectively. Intestinal microflora were evaluated by standard microbiologic methods and biochemical assays of cecal content samples after treatment. RESULTS： The results showed that the peptides which were isolated from soybean conglycinin could stimulate the growth of bifidobacteria in vitro, and the molecular mass of purified peptides with MALDI-TOF-MS ranged from 693.32 to 1829.55. Compared with control group, in vivo experiments showed that P2-PTC group decreased cecal pH （7.08±0.08 vs7.21±0.09, P〈0.05） and enterococcicounts （5.38±0.26 log10CFU/g vs 5.78±0.19 log10CFU/g, P〈0.05）, significantly increased sigA level （172.08±35.40 ng/g vs 118.27±33.93 ng/g, P〈0.01） and β-galactosidase activity （1.28±0.23 U/g vs 1.82±0.58 U/g, P〈0.05） CONCLUsiON： The results have shown that conglycinin is good source for enzyme-mediated production of peptides which stimulate the growth of bifidobacteria. These peptid

关键词： Conglycinin pepsin peptides bifidobacteria

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Research progress of traditional medicine to improve colorectal tumor from the perspective of intestinal flora

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Microenvironment & Microecology Research 2022年第3期4卷 19-26页

作者： wei-chen si School of Acupuncture-Moxibustion and Tuina Shanghai University of Traditional Chinese MedicineShanghai 201203China

Colorectal cancer(CRC)is one of the cancers with a high mortality *** and more scientific researches have found that intestinal flora can directly interact with *** can also be involved in the development of CRC by regulating metabolites such as bile acids,short-chain fatty acid and amino *** traditional medicine has unique advantages in the treatment of CRC by correcting microbiome,restoring intestinal microecology,improving intestinal immune function and enhancing intestinal barrier *** author combines the global scientific research in this direction for analysis and report,to make a summary.

关键词： colorectal cancer intestinal flora traditional Chinese medicine pathogenesis therapeutic mechanism

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Research progress on the mechanism of Zuojin Pill in inhibiting cancer

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Drug Combination Therapy 2022年第3期4卷 18-20页

作者： wei-chen si School of Acupuncture-Moxibustion and Tuina Shanghai University of Traditional Chinese MedicineShanghai 201203China

Background Zuojin wan first appeared in the mind art of dan xi,and it is recorded in the original text:“Zuojin wan is for treating liver fire”–for the first time illustrates the Zuojin *** author of the book is Jin Yuan Zhu Danxi said four *** evodia rutaecarpa and the coptis chinensis in the prescription form the Zuojin Pill according to the ratio of 6:1,the main medicine in the prescription is coptis chinensis with cold nature,which can clear liver fire and purge stomach fire,and the other evodia rutaecarpa has a mild and warm nature,which can warm the liver and dispel cold,*** prescription has obvious medication characteristics.

关键词： prescription stomach inhibiting

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Discussion on pathogenesis of colorectal cancer based on the theory of rheumatic fever in traditional Chinese medicine

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Medical Theory and Hypothesis 2022年第4期5卷 6-10页

作者： wei-chen si School of Acupuncture-Moxibustion and Tuina Shanghai University of Traditional Chinese MedicineShanghai 201203China.

Rheumatic fever is a disease according to the theory of traditional Chinese medicine(TCM),and its main clinical manifestations include coma and confusion of eyes and head,severe limb drowsiness,fever without consciousness,sticky and greasy stool,short and blood urine,red tongue with yellow and greasy coating,and slippery rapid *** cancer is a common malignant tumor in the digestive *** to the theory of TCM,rheumatic fever is the main etiology and pathogenesis of colorectal cancer,which is the common syndrome of colorectal *** method of antipyretic and removing dampness has been widely used in TCM treatment for colorectal cancer which is *** the perspective of rheumatic fever,the article summarizes the material basis of colorectal cancer from the perspectives of gene,protein,metabolism,and microorganism,discussing the potential mechanism of rheumatic fever in the occurrence and development of colorectal cancer combined with the theory of TCM,summarizing the defects of the research direction at this stage,in order to better guide the prevention and treatment of colorectal cancer.

关键词： TCM theory rheumatic fever colorectal cancer pathogeny

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民法典编纂视野下法定继承制度的反思与重构

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河北法学 2017年第7期35卷 2-19页

作者：陈苇董思远西南政法大学民商法学院重庆401120

针对法定继承制度的构建进行研究,考察我国各学者建议稿的观点之分歧,从法定继承人的范围、顺序、法定应继份、配偶对婚姻住房的居住权、特殊法定继承人对住房及家庭生活用品的先取权和使用权五个方面,在对法国、德国、俄罗斯、英国和... 详细信息

针对法定继承制度的构建进行研究,考察我国各学者建议稿的观点之分歧,从法定继承人的范围、顺序、法定应继份、配偶对婚姻住房的居住权、特殊法定继承人对住房及家庭生活用品的先取权和使用权五个方面,在对法国、德国、俄罗斯、英国和美国以及我国港、澳、台三地区的立法进行比较评析的基础上,根据我国内地法定继承制度的立法现状,反思、剖析其不足,进而借鉴域外立法经验,结合我国内地实际,提出重构我国内地法定继承制度的立法建议。

关键词：法定继承人范围与顺序应继份居住权与使用权立法建议

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木林子自然保护区不同群落类型主要优势种群的生态位研究

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自然资源学报 2017年第2期32卷 223-234页

作者：林勇艾训儒姚兰黄伟陈斯湖北民族学院林学园艺学院湖北恩施445000

为定量分析木林子自然保护区不同群落类型主要优势种群的生态位,以每个样地为综合资源位,采用simpson指数的倒数和Shannon-Wiener生态位宽度公式及Pianka生态位重叠公式分别对自然恢复20 a、35 a和100 a左右次生林群落主要优势种的生态... 详细信息

为定量分析木林子自然保护区不同群落类型主要优势种群的生态位,以每个样地为综合资源位,采用simpson指数的倒数和Shannon-Wiener生态位宽度公式及Pianka生态位重叠公式分别对自然恢复20 a、35 a和100 a左右次生林群落主要优势种的生态位宽度及重叠进行测度,比较分析主要优势种在不同群落类型中的生态位变化及原因,同时对种群的环境适应能力及其随自然恢复阶段的变化等方面进行探讨。结果表明:1)青冈(Cyclobalanopsis glauca)属于木林子自然保护区亚热带常绿落叶阔叶混交林的建群种,生态位宽度最大(群落ⅠB'_((SW)i)为0.750、B'_((L)i)为0.863,群落ⅡB'_((SW)i)为0.630、B'_((L)i)为0.685,群落ⅢB'_((SW)i)为0.625、B'_((L)i)为0.658),与其他种群的生态位重叠程度高,自然恢复年限越长,其优势地位越明显。2)人为干扰和光照是影响该区域不同群落类型主要优势种生态位变化的主要因子。3)不同群落类型主要优势种的平均生态位宽度值B'_((SW)i)为0.603、B'_((L)i)为0.570,平均生态位重叠值为0.564,表明各种群生态幅广,资源利用谱较宽,群落结构复杂;各种群对环境资源的利用性竞争不激烈。4)珙桐(Davidia involucrata)种群的重要值和生态位宽度值最小(IV为0.181,B'_((SW)i)为0.292,B'_((L)i)为0.109),与其他种群的生态位重叠值小或没有重叠,表明它对群落环境的适应能力及对资源的利用能力弱且与其他种群的生态位产生了一定程度分化。各优势种的生态位随群落物种组成变化而变化,揭示了优势种的生态位随自然恢复阶段的变化规律。

关键词：种群群落生态位宽度生态位重叠重要值

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SNMPv3网络管理中的安全机制研究

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山东电子 2004年第1期 32-35页

作者：何炜陈思南京邮电学院计算机科学与技术系，210003 不详

本文分析了SNMPv1存在的安全漏洞 ,并针对这些不足之处介绍了SNMPv3网络管理的基于用户的安全模型和基于视图的访问控制模型 ,详尽探讨了SNMPv3的认证、加密、时限、访问控制等安全服务机制。

关键词： SNMPv3 网络管理安全机制访问控制加密时限

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柱形和锥形移动床中气体的扩散特性

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过程工程学报 2016年第3期16卷 380-387页

作者：贾海兵李晨卫思辰范怡平卢春喜中国石油大学(北京)重质油国家重点实验室北京102249

采用脉冲氦气体示踪技术研究了柱形和锥形移动床中气相的扩散特性,并与实验结果进行对比.结果表明,在主体流动区(0.110.89),柱形床会出现向下窜气的现象,而锥形床中向下窜气量降低40%～50%,气相径向流动更趋近平推流.根据径向气流在柱... 详细信息

采用脉冲氦气体示踪技术研究了柱形和锥形移动床中气相的扩散特性,并与实验结果进行对比.结果表明,在主体流动区(0.110.89),柱形床会出现向下窜气的现象,而锥形床中向下窜气量降低40%～50%,气相径向流动更趋近平推流.根据径向气流在柱形和锥形移动床内的流动特点,用实验数据回归了气体浓度分布的无量纲经验关联式,计算值与实验值吻合较好.

关键词：柱形移动床锥形移动床气体扩散特性

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High Fe‑Loading single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： si chen Fang Huang Lijie Mao Zhimin Zhang Han Lin Qixin Yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

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NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli si Naijia Xue Yi Liu Ran Zheng Ying chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

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