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Construction and performance test of charged particle detector array for MATE

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Nuclear Science and Techniques 2024年第8期35卷 92-100页

作者： Xiao‑Bin Li Long‑Hui Ru Zhi‑Chao Zhang bing‑Feng Lv Ning‑Tao Zhang Jin‑Long Zhang Chen‑Gui lu bing‑Shui Gao Jun‑bing Ma Fu‑Shuai Shi Satoru Terashima Xiao‑Dong Xu Zhen Bai Shi‑wei Xu Yan‑Yun Yang Hooi‑Jin Ong Xiao‑Dong Tang Institute of Modern Physics(IMP) Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Research Center for Nuclear Physics Osaka UniversityIbarakiOsaka 567‑0047Japan RIKEN Nishina Center WakoSaitama 351‑0198Japan Joint Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China

A charged particle array named MATE-PA,which serves as an auxiliary detector system for a Multi-purpose Active-target Time projection chamber used in nuclear astrophysical and exotic beam Experiments(MATE),was *** array comprised of 20 single-sided strip-silicon detectors covering approximately 10%of the solid *** detectors facilitated the detection of reaction-induced charged particles that penetrate the active volume of the *** performance of MATE-PA has been experimentally studied using an alpha source and a 36-MeV 14 N beam injected into the MATE chamber on the radioactive ion beam line in Lanzhou(RIBLL).The chamber was filled with a gas mixture of 95%4 He and 5%CO_(2) at a pressure of 500 *** results indicated good separation of light-charged particles using the forward double-layer silicon detectors of *** energy resolution of the Si detectors was deduced to be approximately 1%(σ)for an energy loss of approximately 10 MeV caused by theα*** inclusion of MATE-PA improves particle identification and increases the dynamic range of the kinetic energy of charged particles,particularly that of theαparticles,up to approximately 15 MeV.

关键词： Silicon detector array Active target Time projection chamber

Security estimation of LWE via BKW algorithms

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Cybersecurity 2024年第1期7卷 71-87页

作者： Yu wei Lei Bi Xianhui lu Kunpeng Wang SKLOIS Institute of Information EngineeringCASBeijingChina School of Cyber Security University of Chinese Academy of SciencesBeijingChina

The Learning With Errors(LWE)problem is widely used in lattice-based cryptography,which is the most promising post-quantum cryptography *** are a variety of LWE-solving methods,which can be classified into four groups:lattice methods,algebraic methods,combinatorial methods,and exhaustive *** Blum–Kalai–Wasserman(BKW)algorithm is an important variety of combinatorial algorithms,which was first presented for solving the Learning Parity With Noise(LPN)problem and then extended to solve *** this paper,we give an overview of BKW algorithms for solving *** introduce the framework and key techniques of BKW algorithms and make comparisons between different BKW algorithms and also with lattice methods by estimating concrete security of specific LWE *** also briefly discuss the current problems and potential future directions of BKW algorithms.

关键词： Post-quantum cryptography Learning with errors problem Lattice-based cryptography Security estimation

Metallosalen covalent organic frameworks for heterogeneous catalysis

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Interdisciplinary Materials 2024年第1期3卷 87-112页

作者： wei Zhou wei‐Qiao Deng Xing lu School of Chemistry and Chemical Engineering Hainan UniversityHaikouHainanChina Institute of Molecular Sciences and Engineering Shandong UniversityQingdaoShandongChina

Metallosalen covalent organic frameworks(M(salen)-COFs)have garnered significant attention as promising candidates for advanced heterogeneous catalysis,including organocatalysis,electrocatalysis,and photocatalysis,due to their unique structural advantages(combining molecules catalysts and crystalline porous materials)and tunable topological *** is essential to provide a comprehensive overview of emerging designs of M(salen)-COFs and corresponding advances in this ***,this review first summarizes the reported metallolinkers and the synthesis methods of M(salen)-*** addition,the review enumerates the excellent M(salen)-COF based heterogeneous catalysts and discusses the fundamental mechanisms behind the outstanding heterogeneous catalytic performance of M(salen)-*** mechanisms include the pore enrichment effect(enhancing local concentration within porous materials to promote catalytic reactions),the three-in-one strategy(integrating enrichment,reduction,and oxidation sites in one system),and the incorporation of a built-in electric field(implanting a built-in electric field in heterometallic phthalocyanine covalent organic frameworks).Furthermore,this review discusses the challenges and prospects related to M(salen)-COFs in heterogeneous catalysis.

关键词： covalent organic frameworks heterogeneous catalysis metallosalen

Two-phase early prediction method for remaining useful life of lithium-ion batteries based on a neural network and Gaussian process regression

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Frontiers in Energy 2024年第4期18卷 447-462页

作者： Zhiyuan wei Changying LIU Xiaowen SUN Yiduo LI Haiyan lu College of Instrumentation and Electrical Engineering Jilin UniversityChangchun 130021China College of Chemistry Jilin UniversityChangchun 130012China Changsha Automobile Innovation Research Institute of Jilin University Changsha 410006China

Lithium-ion batteries(LIBs)are widely used in transportation,energy storage,and other *** prediction of the remaining useful life(RUL)of lithium batteries not only provides a reference for health management but also serves as a basis for assessing the residual value of the *** order to improve the prediction accuracy of the RUL of LIBs,a two-phase RUL early prediction method combining neural network and Gaussian process regression(GPR)is *** the initial phase,the features related to the capacity degradation of LIBs are utilized to train the neural network model,which is used to predict the initial cycle lifetime of 124 *** Pearson coefficient’s two most significant characteristic factors and the predicted normalized lifetime form a 3D *** Euclidean distance between the test dataset and each cell in the training dataset and validation dataset is calculated,and the shortest distance is considered to have a similar degradation pattern,which is used to determine the initial Dual Exponential Model(DEM).In the second phase,GPR uses the DEM as the initial parameter to predict each test set’s early RUL(ERUL).By testing four batteries under different working conditions,the RMSE of all capacity estimation is less than 1.2%,and the accuracy percentage(AP)of remaining life prediction is more than 98%.Experiments show that the method does not need human intervention and has high prediction accuracy.

关键词： lithium-ion batteries RUL prediction double exponential model neural network Gaussian process regression(GPR)

Prediction of the short-term efficacy of anti-VEGF therapy for neovascular age-related macular degeneration using optical coherence tomography angiography

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Eye and Vision 2024年第3期10卷 21-30页

作者： Huixun Jia bing lu Zhi Zhao Yang Yu Fenghua Wang Minwen Zhou Xiaodong Sun Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of Medicine100 Hai Ning RoadShanghai200080People’s Republic of China Shanghai Key Laboratory of Ocular Fundus Diseases ShanghaiChina National Clinical Research Center for Eye Diseases ShanghaiChina Shanghai Engineering Center for Visual Science and Photomedicine ShanghaiChina Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases ShanghaiChina Clinical Research Institute Shanghai Jiao Tong University School of MedicineShanghaiChina

Background To evaluate whether the specific choroidal neovascularization(CNV)characteristics measured using optical coherence tomography angiography(OCTA)can predict the 6-month prognosis of neovascular age-related macular degeneration(nAMD)after anti-vascular endothelial growth factor(anti-VEGF)*** Patients with type 1,type 2,or mixed-type neovascularization(NV)were prospectively *** underwent an initial loading phase of three consecutive monthly intravitreal injections of Conbercept(0.5 mg)and were switched to a pro re nata(PRN)treatment *** images were evaluated for eyes that underwent follow-up assessments for more than 6 *** lesions were manually segmented,and the CNV area,vessel area,greatest vascular caliber(GVC),and greatest linear dimension(GLD)were compared between responders and *** masked graders independently measured the above-mentioned parameters using OCTA,and consistency was assessed using the intraclass correlation coefficient(ICC)*** logistic regression analysis was performed to evaluate the effect of a 3-month change in the CNV area,GLD,and GVC on the 6-month response to anti-VEGF *** Among the 60 eyes of 60 patients with nAMD,39 were responders and 21 were *** proportion of CNV types was significantly different between responders and non-responders(P=0.009).Patients with type 2 or mixed NV seemed more likely to respond to the treatment(28.2%vs.0.0%,and 30.8%vs.23.8%,respectively).The change in GVC showed a significant difference between responders(−4.98±17.17μm)and non-responders(11.01±14.10μm)after three monthly intravitreal anti-VEGF *** logistic regression analysis showed that only the change in GVC remained significant after controlling for baseline GVC,injection number,and CNV type(adjusted OR=1.083;P=0.008).Conclusions Type 2 and mixed-type NV were significantly associated with a better response to anti-VEGF *** i

关键词： Age-related macular degeneration Choroidal neovascularization Optical coherence tomography angiography Anti-VEGF

Capturing and visualizing the phase transition mediated thermal stress of thermal barrier coating materials via a cross-scale integrated computational approach

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Journal of Advanced Ceramics 2024年第4期13卷 413-428页

作者： Mengdi Gan Tianlong lu wei Yu Jing Feng Xiaoyu Chong Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China

The generation and evaluation of severely high thermal stress(σ)is known to be responsible for failure of thermal barrier coatings(TBCs)during thermal *** is crucial and challenging to capture fluctuations inσcaused by the phase transition,which has motivated us to develop a high-throughput multiscale evaluation method forσin TBCs that considers the phase transition of the top ceramic materials by coupling first-principles calculations with finite element *** method quantitatively evaluates and visualizesσof the real TBC structure under thermal cycling by multifield ***,the thermophysical properties calculated by the first-principles calculations consider the effects of temperature and phase transition,which not only reduces the cost of obtaining data but also has a more physical *** this work,rare earth tantalites(RETaO_(4))are introduced as ceramic layers,and the results demonstrate thatσundergoes a rapid escalation near the phase transition temperature(T_(t)),particularly in the TBCs_GdTaO_(4) system,where it rises from 224 to 435 *** discontinuity inσmay originate from the significant alterations in Young’s modulus(increase by 27%–78%)and thermal conductivity(increase by 53%–146%)near T_(t).The TBCs_NdTaO_(4) and TBCs_SmTaO_(4) systems exhibit noteworthy temperature drop gradients and minimalσfluctuations,which are beneficial for extending service lifetime of *** approach facilitates the prediction of failure mechanisms and provides theoretical guidance for the reverse design of TBC materials to obtain low thermal stress systems.

关键词： thermal conductivity first-principles calculations thermodynamics thermal stress thermophysical properties

Emerging role of regulated cell death in intestinal failure-associated liver disease

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 228-233页

作者： Si-Yang Cheng lu Jiang Ying Wang wei Cai Department of Pediatric Surgery Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition Shanghai 200092China Shanghai Institute for Pediatric Research Shanghai 200092China Division of Pediatric Gastroenterology and Nutrition Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China

Intestinal failure-associated liver disease(IFALD)is a common complication of long-term parenteral nutrition that is associated with significant morbidity and *** is mainly characterized by cholestasis in children and steatohepatitis in ***,there is no effective approach to prevent or reverse the *** cell death(RCD)represents a fundamental biological paradigm that determines the outcome of a variety of liver *** cell death is reclassified into several types,based on the mechanisms and morphological *** evidence has linked different modes of RCD,such as apoptosis,necroptosis,ferroptosis,and pyroptosis to the pathogenesis of liver *** studies have shown that different modes of RCD are present in animal models and patients with *** the pathogenic roles of cell death may help uncover the underlying mechanisms and develop novel therapeutic strategies in *** this review,we discuss the current knowledge on how RCD may link to the pathogenesis of *** highlight examples of cell death-targeted interventions aiming to attenuate the disease,and provide perspectives for future basic and translational research in the field.

关键词： Parenteral nutrition Apoptosis Necroptosis Cholestasis Steatosis

Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids

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Protein & Cell 2024年第4期15卷 285-304页

作者： Yunuo Mao wei Wang Jingwei Yang Xin Zhou Yongqu lu Junpeng Gao Xiao Wang lu Wen wei Fu Fuchou Tang School of Life Sciences Biomedical Pioneering Innovation CenterDepartment of General SurgeryThird HospitalPeking UniversityBeijing 100871China Beijing Advanced Innovation Center for Genomics(ICG) Ministry of Education Key Laboratory of Cell Proliferation and DifferentiationBeijing 100871China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100871China Peking University Third Hospital Cancer Center Beijing 100871China The Research Center of Stem Cell and Regenerative Medicine School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

Colorectal cancer(CRC)is a highly heterogeneous cancer and exploring novel therapeutic options is a pressing issue that needs to be ***,we established human CRC tumor-derived organoids that well represent both morphological and molecular heterogeneities of original *** efficiently identify repurposed drugs for CRC,we developed a robust organoid-based drug screening *** combining the repurposed drug library and computation-based drug prediction,335 drugs were tested and 34 drugs with anti-CRC effects were *** importantly,we conducted a detailed transcriptome analysis of drug responses and divided the drug response signatures into five representative patterns:differentiation induction,growth inhibition,metabolism inhibition,immune response promotion,and cell cycle *** anticancer activities of drug candidates were further validated in the established patient-derived organoids-based xenograft(PDOX)system in *** found that fedratinib,trametinib,and bortezomib exhibited effective anticancer ***,the concordance and discordance of drug response signatures between organoids in vitro and pairwise PDOX in vivo were *** study offers an innovative approach for drug discovery,and the representative transcriptome features of drug responses provide valuable resources for developing novel clinical treatments for CRC.

关键词： colorectal cancer organoids drug repurposing patient-derived organoids-based xenograft mechanism of action

Beating the Fault-Tolerance Bound and Security Loopholes for Byzantine Agreement with a Quantum Solution

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Research 2024年第3期2023卷 445-455页

作者： Chen-Xun Weng Rui-Qi Gao Yu Bao bing-Hong Li Wen-Bo Liu Yuan-Mei Xie Yu-Shuo lu Hua-Lei Yin Zeng-bing Chen National Laboratory of Solid State Microstructures and School of Physics Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education)Renmin University of ChinaBeijing 100872China.

Byzantine agreement,the underlying core of blockchain,aims to make every node in a decentralized network reach *** Byzantine agreements unavoidably face two major *** is 1/3 fault-tolerance bound,which means that the system to tolerate f malicious players requires at least 3f+1 *** other is the security loopholes from its classical cryptography ***,we propose a Byzantine agreement framework with unconditional security to break this bound with nearly 1/2 fault tolerance due to multiparty correlation provided by quantum digital *** is intriguing that quantum entanglement is not necessary to break the 1/3 fault-tolerance bound,and we show that weaker correlation,such as asymmetric relationship of quantum digital signature,can also *** work strictly obeys two Byzantine conditions and can be extended to any number of players without requirements for multiparticle *** experimentally demonstrate three-party and five-party consensus for a digital *** work indicates the quantum advantage in terms of consensus problems and suggests an important avenue for quantum blockchain and quantum consensus networks.

关键词： methods. quantum signature