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maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun ma Peng-Peng Li Hai-wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-Jian Tang Yuan-Ming Pan wei Li Rui-Qiong ma Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

Microencapsulated ammonium polyphosphate by polyurethane with segment of dipentaerythritol and its application in flame retardant polypropylene

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Chinese Journal of Chemical Engineering 2019年第7期27卷 1735-1743页

作者： shouwu Yu Shujuan Xiao Zewen Zhao Xiaowen Huo Junfu wei School of material Science and Engineering Tianjin Polytechnic UniversityTianjin 300387China College of materials Science and Engineering North China University of Science and TechnologyTangshan 063009China

Dipentaerythritol(DPER),4,40-diphenylmethanediisocyanate(MDI)and melamine(MEL)are used as raw materials to microencapsulate ammonium polyphosphate(maPP)in situ *** maPP is characterized by Fourier transform infrared(FT-IR),scanning electron microscopy(SEM),transmission electron microscopy(TEM)and thermal gravimetric analysis(TGA).The results show that the coating operation can effectively improve water resistance of ammonium polyphosphate(APP),and maPP has higher residual rate than that of APP after *** flame retardant action of maPP and APP in polypropylene(PP)is investigated by the limited oxygen index(LOI),vertical burning test(UL-94),TGA,SEM,and cone calorimeter test(CCT).The LOI value of the PP/maPP composite at the same loading is higher than that of PP/APP *** 94 ratings of PP/maPP composites are raised to V-0 at 20 wt%*** results of CCT also show that maPP is more efficient than *** morphological structures observed by digital photos and SEM demonstrated that maPP could be promoted to form the continuous and compact intumescent char *** flame retardant mechanism of PP/maPP is also discussed.

关键词： Microencapsulation Solubility Ammonium polyphosphate Pyrolysis Flame retardant Stability

Metastable seed-crystals: epitaxial growth of branched-array organic heterostructure nanowires

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Science China Chemistry 2025年

作者： Jin Feng Zhen-Yu Geng Ting-Yao Song Ying-Xin ma Chuan-Zeng Wang wei Zhang Hong-Tao Lin Jin Zhou Shu-Ping Zhuo Shu-Hai Chen Xue-Dong Wang School of Chemistry and Chemical Engineering Shandong University of Technology Institute of Functional Nano & Soft materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & DevicesSoochow University College of Chemistry and Chemical Engineering Hunan Normal University

Tunable light–matter interactions are exhibited by organic low-dimensional crystals, making these crystals a promising platform for organic photonics. However, the precise synthesis of organic low-dimensional crystals remains challenging due to the stochastic nature of molecular nucleation processes. Herein, the directed nucleation process is driven by the introduction of metastable seed-crystals as the trunk, which ultimately leads to branched-array organic heterostructures. The successful formation of organic heterostructures with high-density branched arrays is attributed to the highest attachment energy (Eatt（023）=-104.25 kcal mol-1) of the exposed （023） crystal plane during the seed-crystal growth route. Significantly, these as-prepared heterostructures inherently have an ultralow lattice mismatch ratio η of 0.7%between trunk and branch, which contributes to the multi-channel photon transportation. Therefore, this work provides valuable insights into a versatile synthetic strategy for accessing low-dimensional heterostructures for integrated optoelectronics.

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在线测流成果的整合与数据库入库方法研究

水利技术监督 2025年第1期 70-72,178页

作者：马维安徽省芜湖水文水资源局安徽芜湖241000

为提高水文数据整编效率,提出利用Excel函数、水文精简软件及5.0水文资料整编系统处理自动化设备高频次采集测流数据的方法。文章通过长江流域青弋江水阳江水系大砻坊水文站的案例,研究了基于流速率定的在线测流成果数据的精简、匹配及... 详细信息

为提高水文数据整编效率,提出利用Excel函数、水文精简软件及5.0水文资料整编系统处理自动化设备高频次采集测流数据的方法。文章通过长江流域青弋江水阳江水系大砻坊水文站的案例,研究了基于流速率定的在线测流成果数据的精简、匹配及转换流程,确保数据符合5.0系统整编标准。结果表明,复合工具法不仅提供了便捷的数据处理方式,还极大地提高了水文工作的效率,总时间节省率超过90%。通过此方法,不仅有效解决了自动化设备高频次采集数据所带来的处理难题,也为未来水文信息化的发展提供了新的方法参考。

关键词：在线测流数据整合 Excel函数 5.0水文资料整编系统精简软件

Facile synthesis of hollow Ti_(3)AlC_(2)microrods in molten salts via Kirkendall effect

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Journal of Advanced Ceramics 2022年第9期11卷 1491-1497页

作者： Yi LIU Chuangye WANG wei LUO Liang BAI Yang XU Xiaodong HAO Jianfeng ZHU shouwu GUO School of materials Science and Engineering Shaanxi University of Science and TechnologyXi’an 710021China materials Institute of Atomic and Molecular Science Shaanxi University of Science and TechnologyXi’an 710021China Department of Electronic Engineering School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The microstructure and morphology of Ti_(3)AlC_(2)powders not only affect the preparation of Ti_(3)C_(2) MXene but also have a great influence on their potential applications,such as microwave absorbers,alloy additives,or catalytic ***,the synthesis of Ti_(3)AlC_(2)powders with desired microstructure and morphology remains a ***,hollow Ti_(3)AlC_(2)microrods were prepared for the first time in NaCl/KCl molten salts by using titanium,aluminum,and short carbon fibers as starting *** was found that the short carbon fibers not only performed as carbon source but also acted as sacrificial ***,it was revealed that TiC and Ti2AlC were initially formed on the surface of carbon *** subsequent reactions between the outer Ti,Al and the inner carbon were dominated by the Kirkendall effect which gave rise to the formation of a hollow *** on this mechanism,hollow Ti_(3)AlC_(2)microspheres and a series of hollow TiC,Ti_(2)AlC,and V_(2)AlC powders were also successfully *** work provides a facile route to synthesize hollow maX phases and may give enlightenment on preparing other hollow carbide powders via the Kirkendall effect in the molten salts.

关键词： Ti_(3)AlC_(2) molten salt synthesis(MSS) hollow structure Kirkendall effect

Frequency Distributions of Energy Deposition in a Low Energy Electron Track

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IMP & HIRFL Annual Report 1994年 179-180页

作者： Li Qiang wei zengquan ma shouwu Zhou Guaugming Dang Bingrong Han Guangwu Li Wenjian and Xie Hongmei

ＦｒｅｑｕｅｎｃｙＤｉｓｔｒｉｂｕｔｉｏｎｓｏｆＥｎｅｒｇｙＤｅｐｏｓｉｔｉｏｎｉｎａＬｏｗＥｎｅｒｇｙＥｌｅｃｔｒｏｎＴｒａｃｋ￥ＬｉＱｉａｎｇ；ＷｅｉＺｅｎｇｑｕａｎ；ＭａＳｈｏｕｗｕ；Ｚｈｏ... 详细信息

ＦｒｅｑｕｅｎｃｙＤｉｓｔｒｉｂｕｔｉｏｎｓｏｆＥｎｅｒｇｙＤｅｐｏｓｉｔｉｏｎｉｎａＬｏｗＥｎｅｒｇｙＥｌｅｃｔｒｏｎＴｒａｃｋ￥ＬｉＱｉａｎｇ；ＷｅｉＺｅｎｇｑｕａｎ；ＭａＳｈｏｕｗｕ；ＺｈｏｕＧｕａｕｇｍｉｎｇ；ＤａｎｇＢｉ...

关键词： Electron

A mild, configurable, flexible CoNi-LDH（v）/Zn battery based on H-vacancy-induced reversible Zn2+ intercalation

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Journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dingsheng Wu Hao Gao Qingqing Wang Pengfei Lv Sam S.Yoon Qufu wei Key Laboratory of Eco-textiles Ministry of Education Jiangnan University School of Mechanical Engineering Korea University

Flexible Zn-based batteries have attracted increasing research interest as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide （CoNi-LDH） as the cathode material is hampered by their poor cycling stability and the corrosiveness of alkaline ***,CoNi-LDH nanosheets enriched with H vacancies (CoNi-LDH（v）) were constructed on a flexible carbon cloth （CC） substrate via electrochemical deposition and *** Zn-based battery comprising CoNi-LDH（v）@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnSO4electrolyte （pH=4）.The battery delivered an excellent specific capacity (225 ma h g-1,0.26 ma h cm-2),acceptable cycling stability（53.9%,900 cycles）,and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn2+and the extravasation of NO3-generated channels and space for Zn2+transport and storage,together enabling an excellent Zn2+storage ***,a sandwich-structured solid-state CoNi-LDH（v）@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device

炭烧干酪的工艺优化及对其在不同成熟期蛋白质降解的研究

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食品与发酵工业 2025年第1期51卷 116-123页

作者：马晓蕊瓮亚楠陈涛魏超昆宁夏大学食品科学与工程学院宁夏银川750021 宁夏大学食品科学与工程学院宁夏食品微生物应用技术与安全控制重点实验室宁夏银川750021

为了开发干酪新品种,探究美拉德反应对炭烧干酪发酵过程中理化指标及其蛋白质降解量的影响,通过单因素和响应面法优化炭烧干酪的试验工艺条件,并对不同成熟期的炭烧干酪进行理化指标、蛋白质降解度、游离氨基酸以及蛋白酶活力的测定。... 详细信息

为了开发干酪新品种,探究美拉德反应对炭烧干酪发酵过程中理化指标及其蛋白质降解量的影响,通过单因素和响应面法优化炭烧干酪的试验工艺条件,并对不同成熟期的炭烧干酪进行理化指标、蛋白质降解度、游离氨基酸以及蛋白酶活力的测定。最终结果表明,炭烧干酪的最佳工艺条件为,葡萄糖添加量10%、加热温度95℃、加热时间3.0 h。实验结果表明,炭烧干酪在发酵过程中,pH和水分逐渐下降,蛋白质分解量和总游离氨基酸增加,蛋白酶活力和乳酸菌总数先增加后降低;在发酵中期,炭烧干酪的水分含量、脂肪以及蛋白质含量低于普通干酪,这是美拉德反应致使蛋白质和脂肪球膜蛋白发生变性,失去脂肪球膜的脂肪不稳定发生凝结,从而使得蛋白质和脂肪含量下降。

关键词：美拉德反应炭烧干酪蛋白质降解度理化指标酶活力