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Age-specific distribution of oculometric parameters and myopia in children aged 8-12y

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1887-1897页

作者： Tao Tang Si-Tong Chen Heng zhao Kai wang Ming-wei zhao Department of Ophthalmology&Clinical Centre of Optometry Peking University People’s HospitalBeijing 100044China Institute of Medical Technology Peking University Health Science CenterBeijing 100083China College of Optometry Peking University Health Science CenterBeijing 100083China Eye Disease and Optometry Institute Peking University People’s HospitalBeijing 100044China beijing Key Laboratory of the Diagnosis and Therapy of Retinal and Choroid Diseases Beijing 100044China National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To describe the distribution of ocular biometrics and to evaluate its associations with refractive error and to assess the contribution from ocular parameters to refractive error among chinese myopic ***:This cross-sectional study evaluated subjects aged ***,ocular biometry,and cycloplegic autorefraction were performed on each *** equivalent refraction(SER)and ocular biometrics were assessed as a function of age and *** Pearson correlation analysis between SER and ocular biometrics was carried *** linear regression was performed to analyze the association between SER and ocular ***:A total of 689 out of 73. participants(3.1 boys,48.1%)were analyzed,with a mean SER of-2.98±1.47 diopter(D).Axial length(AL),anterior chamber depth(ACD),corneal radius of curvature(CR),horizontal visible iris diameter(HVID),central corneal thickness(CCT)and lens power(LP)showed normal *** AL,AL/CR ratio,ACD and CR increased from 8 to 12y of age,while SER and LP decreased,HVID and CCT remained *** was no difference in *** decreased by 0.929 D for every 1 mm increase in AL and decreased by 1.144 D for every 0.1 increase in AL/CR *** Pearson correlation coefficient between SER and AL was-0.53.(P29.0%,AL/CR ratio explained 55.7%,while AL,CR,ACD and LP explained 99.3.after adjusting for age and ***:The AL,CR,ACD and LP are the most important determinants of myopic refractive error during myopia progression.

关键词： myopia ocular biometry refractive error population-based study

Tuning the product selectivity of dimethyl oxalate hydrogenation over WO_(x) modified Cu/SiO_(2) catalysts

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Journal of Energy Chemistry 2024年第10期97卷 128-138,I0004页

作者： zheng Li Zhuo Ma Yihui Li Ziang zhao Yuan Tan Ziyin Liu Xingkun Chen Nian Lei Huigang wang {3. Lu Hejun Zhu Yunjie Ding Hangzhou Institute of Advanced Studies Zhejiang Normal UniversityHangzhou 311231ZhejiangChina Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of chinese academy of sciences Beijing 100049China Shaanxi Key Laboratory of Clean Energy Technology Utilization Yulin BranchDalian National Laboratory For Clean EnergyCASYulin 719199ShaanxiChina State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Product selectivity and reaction pathway are highly dependent on surface structure of heterogeneous *** vapor-phase hydrogenation of dimethyl oxalate(DMO),"EG route"(DMO→methyl glycolate(MG)ethylene glycol(EG)→ethanol(ET))and"MA route"(DMO→MG→methyl acetate(MA))were proposed over traditional Cu based catalysts and Mo-based or Fe-based catalysts,***,tunable yield of ET(93.7%)and MA(72.1%)were obtained through different reaction routes over WO_(x) modified Cu/SiO_(2) catalysts,and the corresponding reaction route was further proved by kinetic study and in-situ DRIFTS *** studies demonstrated that H_(2) activation ability,acid density and Cu-WO_(x) interaction on the catalysts were tuned by regulating the surface W density,which resulted in the different reaction pathway and product ***'s more,high yield of MA produced from DMO hydrogenation was firstly reported with the H_(2) pressure as low as 0.5 MPa.

关键词： Ethanol Dimethyl oxalate Selective hydrogenation Methyl acetate WCu/SiO_(2)catalyst

Single-atom-mediated electron islands boost photocatalytic CO_(2)chemical fixation

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Science china Chemistry 2024年第7期67卷 2292-2299页

作者： Shu Shang Lei Li Xin He Hui wang Lirong zheng wei Shao Xiaodong Zhang Yi Xie Hefei National Research Center for Physical sciences at the Microscale University of Science and Technology of ChinaHefei 230026China Institute of Energy Hefei Comprehensive National Science CenterHefei 230031China beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Chemistry and Chemical Engineering Hefei Normal UniversityHefei 230031China

Photocatalytic cycloadditions of CO_(2)with epoxides are emerging as a significant platform for the green synthesis of valuable carbonates,where efficient catalytic systems with spatially separated charge carriers are ***,a single p-block metal atom is proposed to be a candidate for photogenerated electron localization on a metal oxide *** taking the Bi single-atom supported on ZnO nanosheet(Bi1/ZnO)as an example,we show that the Bi atom plays the role of an electron island in the sea of delocalized holes within ***,the as-formed electron island could readily promote the rate-determining ring-opening process of cycloaddition *** from the unique spatially separated electrons and holes,the Bi1/ZnO achieves a high yield of cyclic carbonates with almost 100%*** study provides a pioneering strategy for enhancing the performances of photocatalytic CO_(2)chemical fixation.

关键词： electron islands CO_(2)photofixation photogenerated charge carriers

Highly efficient three-dimensional solar evaporator for zero liquid discharge desalination of high-salinity brine

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Carbon Energy 2024年第9期6卷 52-65页

作者： Meichun Ding Demin zhao Panpan Feng Baolei wang Zhenying Duan Rui wei Yuxi zhao Chen-Yang Liu Chenwei Li School of Chemistry and Pharmaceutical Engineering Shandong First Medical University&Shandong Academy of Medical SciencesJinanChina Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinanChina Institut de Chimie Radicalaire Aix Marseille UniverisityMarseilleFrance CAS Key Laboratory of Engineering Plastics CAS Research/Education Center for Excellence in Molecular SciencesInstitute of Chemistrythe Chinese Academy of SciencesBeijingChina

Solar-driven interfacial evaporation is a promising technology for freshwater production from seawater,but salt accumulation on the evaporator surface hinders its performance and *** this study,we report a simple and green strategy to fabricate a three-dimensional porous graphene spiral roll(3.SR)that enables highly efficient solar evaporation,salt collection,and water production from near-saturated brine with zero liquid discharge(ZLD).The 3.SR design facilitates energy recovery,radial brine transport,and directional salt crystallization,thereby resulting in an ultrahigh evaporation rate of 9.05 kg m^(-2) h^(-1)6 in 25 wt%brine under 1-sun illumina-tion for 48 h ***,the directional salt crystallization on its outer surface not only enlarges the evaporation area but also achieves an ultrahigh salt collection rate of 2.92 kg m^(-2) h^(-1),thus enabling ZLD ***,3.SR exhibits a record-high water production rate of 3.14 kg m^(-2) h^(-1) in an outdoor *** innovative solution offers a highly efficient and continuous solar desalination method for water production and ZLD brine treatment,which has great implications for addressing global water scarcity and environmental issues arising from brine disposal.

关键词： graphene aerogels graphene composites solar desalination solar-driven interfacial evaporation

Unveiling the therapeutic potential:KBU2046 halts triple-negative breast cancer cell migration by constricting TGF-β1 activation in vitro

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Oncology Research 2024年第11期32卷 1791-1802页

作者： JINXIA CHEN SULI DAI GENG ZHANG SISI wei XUETAO zhao YANG zheng YAOJIE {3. XIAOHAN {3. YUNJIANG LIU LIANMEI zhao Research Center The Fourth Hospital of Hebei Medical UniversityShijiazhuang050000China Key Laboratory of Tumor Gene Diagnosis Prevention and TherapyClinical Oncology Research CenterShijiazhuang050000China Department of Blood Transfusion The Fourth Hospital of Hebei Medical UniversityShijiazhuang050000China Breast Center Fourth Hospital of Hebei Medical UniversityShijiazhuang050000China Hebei Provincial Key Laboratory of Tumor Microenvironment and Drug Resistance Hebei Medical UniversityShijiazhuang050000China

Background:Triple-negative breast cancer(TNBC)is a heterogeneous,recurring cancer characterized by a high rate of metastasis,poor prognosis,and lack of efficient ***2046,a small molecule inhibitor,can inhibit cell motility in malignant tumors,including breast ***,the specific targets and the corresponding mechanism of its function remain ***:In this study,we employed(3.(4,5-dimethylthiazol-2-yl)-5-(3.carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H tetrazolium)(MTS)assay and transwell assay to investigate the impact of KBU2046 on the proliferation and migration of TNBC cells in ***-Seq was used to explore the targets of KBU2046 that inhibit the motility of ***,confirmed the predicted important signaling pathways through RT-qPCR and western ***:In this study,we found that KBU2046 functioned as a novel transforming growth factor-β(TGF-β1)inhibitor,effectively suppressing tumor cell motility in ***,it directly down-regulated leucine-rich repeat-containing 8 family,member E(LRRC8E),latent TGFβ-binding protein 3.LTBP3.,dynein light chain 1(DNAL1),and MAF family of bZIP transcription factors(MAFF)genes,along with reduced protein expression of the integrin ***,KBU2046 decreased phosphorylation levels of Raf and *** deactivation of the ERK signaling pathway impeded cancer invasion and ***:In summary,these findings advocate for the utilization of TGF-β1 as a diagnostic and prognostic biomarker and as a therapeutic target in ***,our data underscore the potential of KBU2046 as a novel therapeutic strategy for combating cancer metastasis.

关键词： KBU2046 TGF-β1(transforming growth factor-β1) LRRC(leucine-rich repeat-containing) LTBP(leucine-rich repeat-containing) Breast cancer(BC) Integrinαv Integrinα6

An integrated north–south paleo-Dadu-Anning River: New insights from bulk major and trace element analyses of the Xigeda Formation

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china Geology 2024年第1期7卷 91-103页

作者： Yong zheng Hai-bing Li Jia-wei Pan Ping wang Ya Lai zheng Gong Key Laboratory of Deep-Earth Dynamics Institute of GeologyChinese Academy of Geological SciencesChina Geological SurveyMinistry of Natural ResourcesBeijing 100037China Jiangsu Donghai Continental Deep Hole Crustal Activity National Observaion and Research Station Lianyungang 222300China Southern Marine Science and Engineering Guangdong Laboratory Guangzhou 511458China Geophysical Exploration Center China Earthquake AdministrationZhengzhou 450002China Institute of Geophysics China Earthquake AdministrationBeijing 100081China

The Xianshuihe-Anninghe fault extends SE–S and constitutes the southeastern margin of the Tibetan ***,the Dadu River which is associated with the fault does not flow following the path,but makes a 90ºturn within a distance of 1 km at Shimian,heading east,and joins the Yangtze River,finally flowing into the East china *** to the abrupt turn,a low and wide pass near the Daqiao reservoir at Mianning separates the N–S course of the Dadu River from the headwater of the Anning River which then flows south into the Yunnan Province along the Anninghe ***,many previous studies assumed southward flow of the paleo-Dadu River from the Shimian to the Anning ***,evidences for the capture of the integrated N–S paleo-Dadu-Anning River,its timing,and causes are still *** study explored the paleo-drainage pattern of the Dadu and Anning Rivers based on bulk mineral and geochemical analyses of the large quantities of fluvial/lacustrine sediments along the trunk of the Dadu and Anning *** with sands in the modern Dadu River,the Xigeda sediments also exhibit a granitoid affinity with the bulk major mineral compositions of quartz(>50%),anorthite(about 10%),orthoclase(about 5%),muscovite(about 5%),and clinochlore(about 4%).Correspondingly,bulk major elements show high SiO_(2),with all samples>60%,and some of them>70%,low TiO_(2)(≤0.75%),P_(2)O_(5)(≤0.55%),FeO*(≤5%),and relatively high CaO(1.02%–8.51%),Na_(2)O(1.60%–2.52%),and K_(2)O(2.17%–2.71%),with a uniform REE ***,synthesizing all these results indicate that these lacustrine sediments have similar material sources,which are mainly derived from its course in the Songpan-Ganzi flysch block,implying that the paleo-Dadu originally flowed southward into the Anning River and provided materials to the Xigeda ancient *** rearrangement of the paleo-Dadu River appears to be closely related to the locally focused uplift driven by strong activities of the Xians

关键词： Dadu River Anninghe fault River diversion Xigeda Formation Tectonic uplift Provenance Songpan-Ganzi flysch Ancient lake Xianshuihe-Xiaojiang fault system Tibetan Plateau

Scale effects of leaf area index inversion based on environmental and disaster monitoring satellite data

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Science china Earth sciences 2010年第S1期53卷 92-98页

作者： ZHANG Hao1,LI XiaoWen1,2,CAO ChunXiang1,YANG Hua2,GAO MengXu1,3.zheng Sheng1,3.XU Min1,3.XIE DongHui2,JIA HuiCong1,JI wei1,zhao Jian1,3.CHEN wei1,3.& NI XiLiang1,3.1 State Key Laboratory of Remote Sensing Science,Jointly Sponsored by Institute of Remote Sensing Applications,chinese academy of sciences and beijing Normal University,beijing 100101,china 2 State Key Laboratory of Remote Sensing Science,Jointly Sponsored by beijing Normal University and Institute of Remote Sensing Applications of chinese academy of sciences,beijing 100875,china 3.Graduate University of chinese academy of sciences,beijing 100049,china State Key Laboratory of Remote Sensing Science Jointly Sponsored by Institute of Remote Sensing Applications Chinese Academy of Sciences and Beijing Normal University Beijing China State Key Laboratory of Remote Sensing Science Jointly Sponsored by Beijing Normal University and Institute of Remote Sensing Applications of Chinese Academy of Sciences Beijing China Graduate University of chinese academy of sciences Beijing China

The spatial distribution of sub-pixel components has an impact on retrieval accuracy,and should be accounted for when inverting a three-dimensional adiative transfer model to retrieve leaf area index(LAI).To investigate this effect,we constructed three realistic scenarios with the same LAI values and other properties,except that the simulated plants had different *** implemented the radiosity method to subsequently produce synthetic bidirectional reflectance factor(BRF) datasets based upon these simulated *** inversion was conducted using these data,which showed that spatial distribution affects retrieval *** inversion was also conducted for LAI based on charge-coupled device(CCD) data from the Environment and Disaster Monitor Satellite(HJ-1),which depicted both forest and drought-resistant crop land *** showed that heterogeneity in coarse-resolution remote sensing data is the main error source in LAI *** spatial distribution of global fractal dimension index,which can be used to describe the area of sub-pixel components and their spatial distribution modes,shows good consistency with the coarse resolution LAI inversion error.

关键词： HJ-1 leaf area index scale effect spatial distribution

Anti-psoriasis molecular targets and active components discovery of Optimized Yinxieling Formula via affinity-purified strategy

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chinese Journal of Natural Medicines 2024年第2期22卷 127-136页

作者： wang wei LIU Lijuan YANG Zhuo LU Chuanjian TU Pengfei zhao Ruizhi ZENG Kewu State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Dampness Syndrome of chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006China

Psoriasis,a prevalent inherited skin condition,involves an inflammatory response as a key pathogenic *** Optimized Yinxieling Formula(OYF),rooted in traditional chinese medicine,is extensively utilized in clinical settings to treat *** previous studies have demonstrated OYF’s significant anti-inflammatory effects in psoriasis,its potential molecular targets and active components remain *** study aimed to unveil the anti-psoriasis molecular targets and active components of *** findings indicated that OYF extract markedly reduced the production of several inflammatory mediators,including IL-23.nitric oxide,TNF-α,and IL-1β,in LPS-induced RAW264.7 *** synthesized OYF extract-crosslinked beads to isolate pharmacological targets from RAW264.7 lysates using an affinity purification strategy,known as Target *** enriched target proteins were subsequently identified via LC-MS/MS,followed by bioinformatics analysis to map the psoriasis-associated pathway-gene *** identified a total of 76 potential target proteins,which were highly associated with mRNA transcription *** particular,pathway-gene network analysis revealed that the IL-23.inflammatory pathway was involved in the anti-psoriasis effect of OYF *** further utilized a target protein-based affinity capture strategy,combined with LC-MS and SPR analysis,to globally screen OYF’s active components,focusing on the mRNA transcription regulator,fused in sarcoma(FUS).This process led to the identification of umbelliferone,vanillic acid,protocatechuic acid,gentisic acid,and echinacoside as key compounds targeting FUS to inhibit IL-23.***,we formulated a compound cocktail(CpdC),which significantly reduced psoriasis area and severity index(PASI)scores and the expressions of IL-23.and Ki67 in an imiquimod(IMQ)-induced psoriasis mouse ***,our study elucidates the primary molecular targets and active components of OYF,offeri

关键词： Psoriasis Optimized Yinxieling Formula(OYF) FUS protein Molecular targets Affinity-purified strategy

Electrohydrodynamic printing for high resolution patterning of flexible electronics toward industrial applications

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InfoMat 2024年第2期6卷 28-56页

作者： Zhouping Yin Dazhi wang Yunlong Guo Zhiyuan zhao Liqiang Li wei Chen Yongqing Duan State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhanthe People's Republic of China Optics Valley Laboratory Wuhanthe People's Republic of China Key Laboratory for Micro/Nano Technology and System of Liaoning Province Dalian University of TechnologyDalianthe People's Republic of China beijing National Laboratory for Molecular sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijingthe People's Republic of China Institute of Molecular Aggregation sciences Tianjin UniversityTianjinthe People's Republic of China

Electrohydrodynamic(EHD)printing technique,which deposits micro/nanostructures through high electric force,has recently attracted significant research interest owing to their fascinating characteristics in high resolution(1μm),wide material applicability(ink viscosity 1–10000 cps),tunable printing modes(electrospray,electrospinning,and EHD jet printing),and compatibility with flexible/wearable *** the laboratory level of the EHD printed electronics'resolution and efficiency is gradually approaching the commercial application level,an urgent need for developing EHD technique from laboratory into industrialization have been put ***,we first discuss the EHD printing technique,including the ink design,droplet formation,and key technologies for promoting printing efficiency/*** we summarize the recent progress of EHD printing in fabrication of displays,organic field-effect transistors(OFETs),transparent electrodes,and sensors and ***,a brief summary and the outlook for future research effort are presented.

关键词： display electrohydrodynamic printing flexible electronics organic field-effect transistor printhead