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Biomedical and Environmental Sciences 2024年第2期37卷 196-203页

作者： WANG Dan Dan WANG An Xin ZHANG Xiao Li wei Wen Bin WU shou Ling ZHAO Xing Quan Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China China National Clinical Research Center for Neurological Diseases Beijing 100070China Beijing Tongren Eye Center Beijing Key Laboratory of Ophthalmology and Visual ScienceBeijing Tongren HospitalCapital Medical UniversityBeijing 100005China Department of Cardiology Kailuan HospitalTangshan 063001HebeiChina

Objective Cognitive impairment(CI)in older individuals has a high morbidity rate worldwide,with poor diagnostic methods and susceptible population *** study aimed to investigate the relationship between different retinal metrics and CI in a particular population,emphasizing polyvascular *** We collected information from the Asymptomatic Polyvascular Abnormalities Community Study on retinal vessel calibers,retinal nerve fiber layer(RNFL)thickness,and cognitive function of 3,785participants,aged 40 years or *** regression was used to analyze the relationship between retinal metrics and cognitive *** stratified by different vascular statuses were also *** RNFL thickness was significantly thinner in the CI group(odds ratio:0.973,95%confidence interval:0.953–0.994).In the subgroup analysis,the difference still existed in the non-intracranial arterial stenosis,non-extracranial carotid arterial stenosis,and peripheral arterial disease subgroups(Pshould be investigated in the future.

关键词： Retinal nerve fiber layer Cognitive impairment Polyvascular abnormality

Viral-mediated gene therapy in pediatric neurological disorders

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World Journal of Pediatrics 2024年第6期20卷 533-555页

作者： Jing peng wei-wei Zou Xiao-Lei Wang Zhi-Guo Zhang Ran Huo Li Yang Department of Pediatrics Clinical Research Center for Chidren Neurodevelopmental disablities of Hunan ProvinceXiangya HospitalCentral South UniversityChangsha 410008China Reproductive Medicine Center Department of Obstetrics and Gynecologythe First Affiliated Hospital of Anhui Medical UniversityHefeiChina State Key Laboratory of Reproductive Medicine Nanjing Medical UniversityNanjingChina

Background Due to the broad application of next-generation sequencing,the molecular diagnosis of genetic disorders in pediatric neurology is no longer an unachievable ***,treatments for neurological genetic disorders in children remain primarily *** the other hand,with the continuous evolution of therapeutic viral vectors,gene therapy is becoming a clinical *** this perspective,we wrote this review to illustrate the current state regarding viral-mediated gene therapy in childhood neurological *** sources We searched databases,including PubMed and Google Scholar,using the keywords"adenovirus vector,""lentivirus vector,"and"AAv"for gene therapy,and"immunoreaction induced by gene therapy vectors,""administration routes of gene therapy vectors,"and"gene therapy"with"NCL,""SMA,""DMD,""congenital myopathy,""MPS""leukodystrophy,"or"pediatric metabolic disorders".We also screened the database of *** using the keywords"gene therapy for children"and then filtered the results with the ones aimed at neurological *** time range of the search procedure was from the inception of the databases to the *** We presented the characteristics of commonly used viral vectors for gene therapy for pediatric neurological disorders and summarized their merits and drawbacks,the administration routes of each vector,the research progress,and the clinical application status of viral-mediated gene therapy on pediatric neurological *** Viral-mediated gene therapy is on the brink of broad clinical ***-mediated gene therapy will dramatically change the treatment pattern of childhood neurological disorders,and many children with incurable diseases will meet the dawn of a ***,the vectors must be optimized for better safety and efficacy.

关键词： Gene therapy Neurological disorders Pediatrics Viral vectors

Climate-growth relationships of Pinus tabuliformis along an altitudinal gradient on Baiyunshan Mountain,Central China

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Journal of Forestry Research 2024年第1期35卷 202-212页

作者： Xiaoxu wei Jianfeng peng Jinbao Li Jinkuan Li Meng peng Xuan Li Yameng Liu Jiaxin Li College of Geography and Environmental Science Henan UniversityKaifeng 475004People’s Republic of China Key Laboratory of Earth System Observation and Simulation of He’nan Province Kaifeng 475004People’s Republic of China Department of Geography University of Hong KongPokfulamHong Kong SARPeople’s Republic of China HKU Shenzhen Institute of Research and Innovation Shenzhen 518057People’s Republic of China

A set of standard chronologies for tree-ring width(TRW),earlywood width(EWW)and latewood width(LWW)in Pinus tabuliformis *** an altitudi-nal gradient(1450,1400,and 1350 m a.s.l.)on Baiyunshan Mountain,Central China to analyze the effect of varying temperature and precipitation on growth along the *** analyses showed that at all three altitudes and the TRW and EWW chronologies generally had signifi-cant negative correlations with mean and maximum tem-peratures in the current April and May and with minimum temperatures in the prior July and August,but significant positive correlations with precipitation in the current *** were generally significantly negative between LWW chronologies and all temperatures in the prior July and August,indicating that the prior summer temperature had a strong lag effect on the growth of *** that increased with *** correlation with the standard-ized precipitation evapotranspiration index(SPEI)confirmed that wet conditions in the current May promoted growth of TR and EW at all *** altitudinal differences were also found;at 1400 m,there were significant positive correlations between EWW chronologies and SPEI in the current April and significant negative correlations between LWW chronologies and SPEI in the current September,but these correlations were not significant at 1450 *** 1350 m,there were also significant negative correlations between the TRW and the EWW chronologies and SPEI in the prior October and the current July and between LWW chronology and SPEI in the current August,but these cor-relations were not significant at 1400 *** correlation results showed a stable response of EWW in relation to the SPEI in the current May at all three altitudes and of LWW to maximum temperature in the prior July-August at 1400 m from 2002 to *** EWW chronology at 1400 m and the LWW chronology at 1450 m were identified as more suitable for climate reconstruction.T

关键词： Tree rings Climate response Altitudinal gradient Baiyunshan Mountain Pinus tabuliformis Carr

Infrared microspectroscopy beamline BL06B at SSRF

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Nuclear Science and Techniques 2024年第1期35卷 10-17页

作者： Te Ji Hua-Chun Zhu wei-wei peng Jie Wang Hong-wei Zhao Ai-Guo Li Min Chen Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China

The infrared microspectroscopy beamline(BL06B) is a phase Ⅱ beamline project at the Shanghai Synchrotron Radiation Facility(SSRF). The construction and optical alignment of BL06B were completed by the end of 2020. By 2021, it became accessible to users. The synchrotron radiation infrared(SRIR) source included edge radiation(ER) and bending magnet radiation(BMR). The extracted angles in the horizontal and vertical directions were 40 and 20 mrad, respectively. The photon flux, spectral resolution, and focused spot size were measured at the BL06B endstation, and the experimental results were consistent with theoretical calculations. SRIR light has a small divergence angle, high brightness, and a wide wavelength range. As a source of IR microscopy, it can easily focus on a diffraction-limited spatial resolution with a high signal-to-noise ratio(SNR). The BL06B endstation can be applied in a wide range of research fields, including materials, chemistry, biology, geophysics, and pharmacology.

关键词： Synchrotron radiation Infrared beamline Infrared microspectroscopy

Controllable Exciton Diffusion Length and Ultrafast Charge Generation in Ternary Organic Solar Cells

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Chinese Journal of Chemistry 2024年第11期42卷 1275-1283页

作者： Sixuan Cheng Jiawei Qiao peng Lu wei Qin Xiaotao Hao School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinanShandong250100 China School of Physics National Demonstration Center for Experimental Physics EducationShandong UniversityJinanShandong250100 China ARC Centre of Excellence in Exciton Science School of ChemistryThe University of MelbourneParkvilleVictoria3010 Australia

Charge generation,a critical process in the operation of organic solar cell(OSC),requires thorough investigation in an ultrafast *** work demonstrates that the utilization of alloy model for the non-fullerene acceptor(NFA)component can regulate the crystallization properties of active layer films,which in turn affects exciton diffusion and hole transfer(HT),ultimately influencing the charge generation *** incorporating BTP-eC7 as a third component,without expanding absorption range or changing molecular energy levels but regulating the ultrafast exciton diffusion and HT processes,the power conversion efficiency(PCE)of the optimized PM6:BTP-eC9:BTP-eC7 based ternary OSC is improved from 17.30%to 17.83%,primarily due to the enhancement of short-circuit current density(JSC).Additionally,the introduction of BTP-eC7 also reduces the trap state density in the photoactive layer which helps to reduce the loss of *** study introduces a novel approach for employing ternary alloy models by incorporating dual acceptors with similar structures,and elucidates the underlying mechanism of charge generation and JSC in ternary OSCs.

关键词： Organic photovoltaics Ternary strategy Exciton diffusion Hole transfer Trap state Kinetics Alloys Photophysics

γδT cells:Major advances in basic and clinical research in tumor immunotherapy

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Chinese Medical Journal 2024年第1期137卷 21-33页

作者： Yueqi Zhao peng Dong wei He Jianmin Zhang Hui Chen Department of Immunology CAMS Key Laboratory for T Cell and ImmunotherapyState Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijing 100005China Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy ChangzhouJiangsu 213000China Haihe Laboratory of Cell Ecosystem Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China

γδT cells are a kind of innate immune T *** have not attracted sufficient attention because they account for only a small proportion of all immune cells,and many basic factors related to these cells remain ***,in recent years,with the rapid development of tumor immunotherapy,γδT cells have attracted increasing attention because of their ability to exert cytotoxic effects on most tumor cells without major histocompatibility complex(MHC)*** increasing number of basic studies have focused on the development,antigen recognition,activation,and antitumor immune response ofγδT ***,γδT cell-based immunotherapeutic strategies are being developed,and the number of clinical trials investigating such strategies is *** review mainly summarizes the progress of basic research and the clinical application ofγδT cells in tumor immunotherapy to provide a theoretical basis for further the development ofγδT cell-based strategies in the future.

关键词： Gamma-delta T-cells T cell receptor CD1a Tumor immunotherapy Receptors,chimeric antigen Vδ1 cells αβT cells

Machine learning-based performance predictions for steels considering manufacturing process parameters:a review

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Journal of Iron and Steel Research(International) 2024年第7期31卷 1555-1581页

作者： wei Fang Jia-xin Huang Tie-xu peng Yang Long Fu-xing Yin Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology School of Materials Science and EngineeringHebei University of TechnologyTianjin 300132China Institute of New Materials Guangdong Academy of ScienceGuangzhou 510651GuangdongChina

Steels are widely used as structural materials,making them essential for supporting our lives and ***,further improving the comprehensive properties of steel through traditional trial-and-error methods becomes challenging due to the continuous development and numerous processing parameters involved in steel *** address this challenge,the application of machine learning methods becomes crucial in establishing complex relationships between manufacturing processes and steel *** review begins with a general overview of machine learning methods and subsequently introduces various performance predictions in steel *** classification of performance pre-diction was used to assess the current application of machine learning model-assisted *** important issues,such as data source and characteristics,intermediate features,algorithm optimization,key feature analysis,and the role of environmental factors,were summarized and *** insights will be beneficial and enlightening to future research endeavors in this field.

关键词： Steel Manufacturing process Machine learning Performance prediction Algorithm

Fine-tuning growth in gold nanostructures from achiral 2D to chiral 3D geometries

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Nano Research 2024年第7期17卷 6654-6660页

作者： Lili Tan Zhi Chen Chengyu Xiao Zhiyong Geng Yinran Jin Chaoyang wei Fei Teng Wenlong Fu peng-peng Wang State Key Laboratory for Mechanical Behavior of Materials Shaanxi International Research Center for Soft MatterSchool of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China

Enriching the library of chiral plasmonic structures is of significant importance in advancing their applicability across diverse domains such as biosensing,nanophotonics,and ***,employing triangle nanoplates as growth seeds,we synthesized a novel class of chiral-shaped plasmonic nanostructures through a wet chemical strategy with dipeptide as chiral inducers,including chiral tri-blade boomerangs,concave rhombic dodecahedrons,and *** structural diversity in chiral plasmonic nanostructures was elucidated through their continuous morphological evolution from two-dimensional to threedimensional *** fine-tuning of chiroptical properties was achieved by precisely manipulating crucial synthetic parameters such as the amount of chiral molecules,seeds,and gold precursor that significantly influenced chiral structure *** findings provide a promising avenue for enriching chiral materials with highly sophisticated structures,facilitating a fundamental understanding of the relationship between structural nuances and chiroptical properties.

关键词： plasmonic nanostructures geometric chirality circular dichroism fine-tuning

Fast charge transfer kinetics in Sv-ZnIn_(2)S_(4)/Sb_(2)S_(3)S-scheme heterojunction photocatalyst for enhanced photocatalytic hydrogen evolution

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Rare Metals 2024年第2期43卷 533-542页

作者： wei Li Jia-Jun Li Zhi-Fei Liu Hong-Yu Ma peng-Fei Fang Rui Xiong Jian-Hong wei Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education School of Physics and TechnologyWuhan UniversityWuhan430072China

Constructing a S-scheme heterojunction with tight interface contact and fast charge transfer is beneficial to improving the photocatalytic hydrogen evolution ***,a unique one-dimensional(1D)/two-dimensional(2D)S-scheme heterojunction containing 1D Sb_(2)S_(3) nanorods and 2D ZnIn_(2)S_(4) with affluent sulfur vacancies(denoted as Sv-ZnIn_(2)S_(4)@Sb_(2)S_(3)) was *** introduced sulfur vacancy can promote the effective adsorption of H+for the following interfacial hydrogen-evolution ***,the larger contact area and stronger electron interaction between Sb_(2)S_(3) and ZnIn_(2)S_(4) effectively inhibits the recombination of photo-generated electron–hole pairs and abridges the migration distance of *** a result,the optimal Sv-ZnIn_(2)S_(4)@Sb_(2)S_(3) sample achieves H_(2) evolution activity of 2741.3 mol·h^(−1)·g^(−1),which is 8.6 times that of pristine ZnIn_(2)S_(4) and 3.0 times that of the Sv-ZnIn_(2)S_(4) *** on the experimental result,the photo-reactivity S-scheme mechanism of hydrogen evolution from water splitting with Sv-ZnIn_(2)S_(4)@Sb_(2)S_(3) is *** work provides an effective method for developing S-scheme heterojunction composites of transition metal sulfide with high hydrogen evolution performance.

关键词： ZnIn_(2)S_(4) nanosheets S-scheme heterojunction Sulfur vacancy Charge transfer and separation Photocatalytic H_(2)evolution

Working condition recognition of sucker rod pumping system based on 4-segment time-frequency signature matrix and deep learning

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Petroleum Science 2024年第1期21卷 641-653页

作者： Yun-peng He Hai-Bo Cheng peng Zeng Chuan-Zhi Zang Qing-wei Dong Guang-Xi Wan Xiao-Ting Dong State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016LiaoningChina Key Laboratory of Networked Control Systems Chinese Academy of SciencesShenyang 110016LiaoningChina Institutes for Robotics and Intelligent Manufacturing Chinese Academy of SciencesShenyang 110169LiaoningChina University of Chinese Academy of Sciences Beijing100049China School of Artifcial Intelligence Shenyang University of TechnologyShenyang 110870LiaoningChina

High-precision and real-time diagnosis of sucker rod pumping system(SRPS)is important for quickly mastering oil well *** learning-based method for classifying the dynamometer card(DC)of oil wells is an efficient diagnosis ***,the input of the DC as a two-dimensional image into the deep learning framework suffers from low feature utilization and high computational ***,different SRPSs in an oil field have various system parameters,and the same SRPS generates different DCs at different ***,there is heterogeneity in field data,which can dramatically impair the diagnostic *** solve the above problems,a working condition recognition method based on 4-segment time-frequency signature matrix(4S-TFSM)and deep learning is presented in this ***,the 4-segment time-frequency signature(4S-TFS)method that can reduce the computing power requirements is proposed for feature extraction of DC ***,the 4S-TFSM is constructed by relative normalization and matrix calculation to synthesize the features of multiple data and solve the problem of data ***,a convolutional neural network(CNN),one of the deep learning frameworks,is used to determine the functioning conditions based on the *** on field data verify that the proposed diagnostic method based on 4S-TFSM and CNN(4S-TFSM-CNN)can significantly improve the accuracy of working condition recognition with lower computational *** the best of our knowledge,this is the first work to discuss the effect of data heterogeneity on the working condition recognition performance of SRPS.

关键词： Sucker-rod pumping system Dynamometer card Working condition recognition Deep learning Time-frequency signature Time-frequency signature matrix