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Chinese Chemical Letters 2006年第1期17卷 1-4页

作者： wei min zhu Zhi Fang LI Yong min ZHANG Department of Chemistry Zhejiang University Xixi Campus Hangzhou 310028 State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032

Enamines, promoted by the samarium/samarium diiodide mixed reagent, were synthesized via the cross-coupling of thioamides and diarylketones in good yields.

关键词： Samarium enamines cross-coupling thioamides diarylketones.

The Reductive Addition Reaction of Substituted 2-Chloromethyl-1,3,4-oxadiazole to Aldehydes and Ketones Promoted by Samarium Diiodide

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Chinese Chemical Letters 2005年第12期16卷 1566-1568页

作者： Xiao Liang XU wei min zhu Yong min ZHANG Department of Chemistry Zhejiang University Xixi Campus Hangzhou 310028 State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032

1-（β-Hydroxyalkyl）-l,3,4-oxadiazole derivatives were synthesized via reductive addition reactions of 2-chloromethyl-l,3,4-oxadiazole with carbonyl compounds under mild conditions promoted by SmI2.

关键词： Reductive addition samarium diiodide 1-(β-hydroxyalkyl)-1 3 4-oxadiazole deriva-tives synthesize

Novel clicked tetrathiafulvalene-calix[4]arene assemblies:Synthesis and intermolecular electron transfer toward p-chloranil

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Chinese Chemical Letters 2013年第7期24卷 573-577页

作者： Bang-Tun Zhao Xiao-min zhu Xiu-Hua Chen Zhen-Ning Yan wei-min zhu College of Chemistry and Chemical Engineering Luoyang Normal University College of Chemistry and Molecular Engineering Zhengzhou University

Two tetrathiafulvalene-calix[4]arene assemblies （TTF-calix-1 and TFF-calix-2） have been synthesized by the click reaction. Both their cyclic voltammograms show, as expected, two one-electron quasi- reversible redox behavior. The UV-vis absorption spectra studies show that these two assemblies undergo progressive oxidation at the TFF moiety in presence of increasing amounts of Cu2＋ or Hg2＋. Moreover, the absorption studies show intermolecular electron transfer between compounds TrF-calix- I or TI＇F-calix-2 and p-chloranil may be promoted by specific metal ions such as Pb2＋, Sc3＋ etc.

关键词： Tetrathiafulvalene Calixarene Click reaction Chloranil lntermolecular electron transfer

Fabrication of Iron-base Alloy by Spark Plasma Sintering

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Journal of Materials Science & Technology 2006年第2期22卷 257-260页

作者： Yuanyuan LI Xiaoqiang LI Yah LONG wei XIA min zhu weiping CHEN College of Mechanical Engineering South China University of Technology Guazngzhou 510640 China

Fe-2Cu-2Ni-1Mo-0.8C （wt pct） elemental mixed powders were rapidly sintered within 6 min by spark plasma sintering, and the effects of sintering parameters on the densification degree and performance of the assintered materials were investigated. Results showed that when a proper combination of pulse electric current and constant electric current was employed for sintering, the density and bend strength of the as-sintered material reached the maxima, being 7.61×10^3 kg/m^3 and 1540 MPa, respectively. Its corresponding fracture morphology was characterized as the mix of ductile, intergranular and cleavage fractures.

关键词： Spark plasma sintering Iron-base alloy Density Microstructure and performance

Morphological and Signal Characteristics of Rotator Cuff Tears on Conventional MRI and MR Arthrography: Comparing with Gross Anatomy and Histopathology

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上海第二医科大学学报 2005年第12期25卷 1262-1262页

作者： XU Jian-rong DENG Xia HUA Jia CAI wei-min LI Lei zhu Jian-shan Department of Radiology Renfi Hospital Shanghai Second Medical University Shanghai 200001 China

Objective To study the MR characterizations of supraspinatus and infraspinatus tendon lesions by comparing with grossanatomy and histopathology. Methods The study group consisted of20 cadaver shoulders which were underwent the same imaging pro-tocols of conventional MRI and MR arthrography. Results SE-T2WI images or MR arthrography respectively possessed of high speci-ficity (95.6%, 100%), but low sensitivity (70.6%, 58.8%) for diagnosing rotator cuff tears. By uniting two images techniques,could remedy its limitations and would markedly increase the sensitivity (88.2%). There were many factors influencing the visualizationsof partial thickness tears of rotator cuff on MR images, from which uppermost factors are tear extent, ruptured synovial capsule, scar andsynovial proliferation. Conclusion MRI diagnoses of rotator cuff lesions (especially partial thickness tears) must carefully be esti-mated by combining T2WI images and MR arthrography.

关键词：形态学 MRI检查 MR检查关节造影术解剖学组织病理学

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论杜诗的虚构之境

陇东学院学报 2023年第1期34卷 134-139页

作者：韦敏珠湖北大学文学院湖北武汉430062

杜甫的诗歌不仅是记录现实的“诗史”,也有不少虚构之境;这些虚构之境既有对仙灵世界的描绘,又有对梦境的描写,还有想象中的世界。其中包含了杜甫的忠君爱国之情、对民众的同情、对自身不幸遭遇的悲叹以及对亲友的思念与牵挂之情。作为... 详细信息

杜甫的诗歌不仅是记录现实的“诗史”,也有不少虚构之境;这些虚构之境既有对仙灵世界的描绘,又有对梦境的描写,还有想象中的世界。其中包含了杜甫的忠君爱国之情、对民众的同情、对自身不幸遭遇的悲叹以及对亲友的思念与牵挂之情。作为一位集大成的诗人,杜甫善于从各个方面汲取养分,他的虚构之境的诗歌不仅受到了楚辞的影响,还受到了佛道思想的浸润,同时受到了李白的影响。研究杜诗的虚构之境有助于我们对杜诗更加全面深入的把握。

关键词：杜诗虚构之境情感意蕴艺术渊源

Magnetic resonance imaging evaluation and nuclear receptor binding SET domain protein 1 mutation in the Sotos syndrome with attention-deficit/hyperactivity disorder

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World Journal of Clinical Cases 2025年第2期13卷 5-9页

作者： wei zhu Shanghai XiRong Information Science and Technology Co. LtdNational Science and Technology ParkSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

Sotos syndrome is characterized by overgrowth features and is caused by alterations in the nuclear receptor binding SET domain protein 1 ***/hyperactivity disorder(ADHD)is considered a neurodevelopment and psychiatric disorder in *** characteristics and clinical presentation could play an important role in the diagnosis of Sotos syndrome and *** resonance imaging(MRI)has been used to assess medical images in Sotos syndrome and *** images process is considered to display in MRI while wavelet fusion has been used to integrate distinct images for achieving more complete information in single image in this *** the future,genetic mechanisms and artificial intelligence related to medical images could be used in the clinical diagnosis of Sotos syndrome and ADHD.

关键词： Sotos syndrome Attention-deficit/hyperactivity disorder Genetic mutation Magnetic resonance imaging Wavelet fusion

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di Zhao Lemei zhu Zheyu Zhang min Yi weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali Chen Yiyong wei Jin Liu Tao zhu Cheng Zhou Donghang Zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

Decreasing in intelligence of adult and old mice induced by glucocorticoid and its mechanism

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Acta Pharmacologica Sinica 1999年第5期 85-85页

作者： LI wei-Ping, CHEN min-zhu ( Department of Pharmacology, Anhui Medical University, Hefei 230032, China)

Immunosuppresion and decrease in intellgence of adult and old mice were induced by glucocorticoids (GCOR, sc, 4 mg kg-1, qd×28 d). Calcium fluoresence indicator Fura 2-AM was used to measure free intracellular calcium ([Ca2+]*** cell death (PCD) or apoptosis was measured by electron microscopy and flow *** results showed that GCOR caused immunosupression and decrease in intelligence as well as PCD of hippocaripus in mature and old *** vivo

关键词： Decreasing in intelligence of adult and old mice induced by glucocorticoid and its mechanism