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Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： wei Xiong Xuan ye Hongzhang Cheng Xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye Moon Chen Chen Nai-kui Liu Xiao-Ming Xu wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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涠西南地区地震数据叠前同步反演

河海大学学报（自然科学版） 2012年第2期40卷 180-185页

作者：刘涛樊小意方中于邓志勇任科英张宏兵魏奎烨中海油能源发展股份有限公司钻采工程研究院地球物理研究所广东湛江524000 中海石油(中国)有限公司湛江分公司研究院广东湛江524057 河海大学地球科学与工程学院江苏南京210098

针对涠西南地区复杂的地质条件,以及基于地震资料预测储层需要纵、横波阻抗及速度、密度等弹性参数,对涠西南地区开展了地震数据叠前同步反演.该反演方法使用改进的Fatti方程,可以同时获得各种弹性参数,应用预白化处理来控制反演的噪音... 详细信息

针对涠西南地区复杂的地质条件,以及基于地震资料预测储层需要纵、横波阻抗及速度、密度等弹性参数,对涠西南地区开展了地震数据叠前同步反演.该反演方法使用改进的Fatti方程,可以同时获得各种弹性参数,应用预白化处理来控制反演的噪音水平,使反演结果更稳定.使用不同子波来均衡不同角度部分叠加数据体之间振幅、频率和相位差异,使反演结果更准确.实际地震资料处理结果表明,随着角度增大,子波主频减小.精度验证结果表明,叠前同步反演精度达到了要求,其中纵波阻抗和横波阻抗反演结果精度都比较高,密度反演结果精度相对较差.

关键词：地震数据反演叠前同步反演改进的Fatti方程角度子波涠西南地区

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

A Wind Tunnel Experimental Study on the Wake Characteristics of a Horizontal Axis Wind Turbine

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Journal of Thermal Science 2025年第1期 145-158页

作者： GUO Xingduo LI Yinran LI Rennian MA Yulong wei kui College of Energy and Power Engineering Lanzhou University of Technology Key Laboratory of Fluid Machinery and Systems Gansu Provincial Technology Centre for Wind Turbines

The characteristics of wind turbine wakes are influenced by multiple factors,including the atmospheric boundary layer(ABL) wind and wind turbine operating conditions(e.g.,tip speed ratio and yaw angle).In this study,two types of ABL winds with different velocity gradients and turbulence intensities are generated in a wind tunnel through configurations of spires,baffles,and various numbers of roughness elements.A wind turbine with a rotor diameter of 0.8 m and a hub height of 0.6 m is tested under varying tip speed ratios,yaw angles,and ABL wind *** results indicate that the streamwise velocity deficit in the near-wake region becomes more pronounced with an increase in the tip speed ratio,while the far-wake velocity deficit remains largely unaffected by changes in the tip speed *** the yaw angle increases,the wake deflection becomes more prominent and the wake narrows;the offset of the wake center at various downstream positions grows linearly,reaching a maximum value of approximately half the rotor ***,the turbulence level and influence range in the wake region are reduced when the turbine is *** ABL wind conditions,high turbulence intensity in the incoming flow accelerates wake recovery,and the Reynolds stress at different lateral positions tends to become consistent with increasing longitudinal ***,turbulence has a significant impact on the meandering characteristics of the wind turbine wake,with greater fluctuations in the wake center observed under higher turbulence ***,this study provides insights that could inform the optimal operation of wind farms.

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High-temperature electrocatalysis and key materials in solid oxide electrolysis cells

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Journal of Energy Chemistry 2021年第3期30卷 736-745页

作者： Lingting ye kui Xie Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002FujianChina Key Laboratory of Design&Assembly of Functional Nanostructures Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002FujianChina

Solid oxide electrolysis cells(SOECs)can convert electricity to chemicals with high efficiency at ~600-900℃,and have attracted widespread attention in renewable energy conversion and *** operate in the inverse mode of solid oxide fuel cells(SOFCs)and therefore inherit most of the advantages of SOFC materials and energy conversion ***,the external bias that drives the electrochemical process will strongly change the chemical environments in both in the cathode and anode,therefore necessitating careful reconsideration of key materials and electrocatalysis *** importantly,SOECs provide a unique advantage of electrothermal catalysis,especially in converting stable low-carbon alkanes such as methane to ethylene with high ***,we review the state-of-the-art of SOEC research progress in electrothermal catalysis and key materials and provide a future perspective.

关键词： Electrocatalysis Solid oxide electrolysis cell Cathode Anode Electrolyte

Influence of Na_2CO_3 as Additive on Direct Reduction of Boron-bearing Magnetite Concentrate

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Journal of Iron and Steel Research International 2016年第2期23卷 103-108页

作者： Yong-li LI Jing-kui QU Guang-ye wei Tao QI National Engineering Laboratory for Hydrometallurgical Cleaner Production Technology Institute of Process EngineeringChinese Academy of Sciences Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of Sciences

Boron-bearing magnetite concentrate is typically characterized by low grade of iron and boron （wTFe = 51%- 54%, WB2O3 =6%-8%）, as well as the close intergrowth of ascharite phase and magnetite phase. A promising technology was proposed to separate iron and boron by coupling the direct reduction of iron oxides and Na activation of boron minerals together. The influence of Na2CO3 as additive on the direct reduction of boron-bearing magnetite was studied by chemical analysis, kinetic analysis, XRD analysis and SEM analysis. The results showed that the ad- dition of Na2CO3 not only activated boron minerals, but also reduced the activation energy of the reaction and pro- moted the reduction of iron oxides. Besides, the addition of Na2CO3 changed the composition and melting point of non-ferrous phase, and then promoted the growth and aggregation of iron grains, which was conducive to the subse- quent magnetic separation. Thus, the coupling of the two processes is advantageous,

关键词： ludwigite kinetic analysis direct reduction magnetic separation sodium carbonate

WAVE MAKING COMPUTATION IN TIME DOMAIN FOR MULTI-HULL SHIPS

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Journal of Hydrodynamics 2006年第2期18卷 225-230页

作者： LI Guo-an ye Heng-kui School of Traffic Science and Engineering Huazhong University of Science and Technology Wuhan 430074China

A method Green function satisfying of three-dimensional time domain linear conditions at free surface and body surface boundary was employed to analyze the wave resistance and wave profile of a displacement multi-hull ship. The wave profile induced by a moving time domain point source was compared with those by a Havelock source, and satisfactory results were obtained. The panel method based on the time domain source distribution on the ship mean wetted hull surface was used to perform the wave making com- putations tbr mono-hull ships, catamaran and trimaran. Reasonable results were also obtained. Using the numerical method the wave profile simulations of multi-hull ships for a given Froude number were conducted.

关键词： time domain Green function ship wave making mono-hull catamaran trimaran