检索结果-南通市图书馆

Traditional Chinese Medicine Formula Liu-wei-Die-huang-Wan in the Treatment of Knees Osteoarthritis:A Double Blind Randomized Placebo-Controlled Clinical Trial

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Traditional Chinese Medicine Formula Liu-Wei-Die-Huang-Wan i...

Application of Dorzagliatin in peritoneal dialysis patients with type 2 diabetes mellitus:A case report

第十四届全国中药和天然药物学术研讨会

作者： Wuu-Tsun Perng James Cheng-Chung wei Chung Shan Medical University Hospital

＜正＞Aim This study compared the efficacy of an herbal formula OA2（Liu-wei-Die-huang-Wan）to placebo in relieving the pain and stiffness of *** This trial was a 8 weeks’randomized,double-blind,placebo-controlled *** study was approved by the IRB of Chung Shan Medical University hospital,and signed informed consent

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

World Journal of Diabetes 2025年第1期16卷 204-210页

作者： Fang Chen Bo An Wen-Cheng An Gang Fu wei huang Hui-Xian Yan Department of Endocrinology Beijing Haidian HospitalBeijing 100080China Department of Nephrology Beijing Haidian HospitalBeijing Haidian Section of Peking University Third HospitalBeijing 100080China

BACKGROUND Treating diabetes in dialysis patients remains a challenge,with many hypoglycemic drugs requiring dose adjustments or avoidance in these *** SUMMARY This report describes an 83-year-old female patient with a 30-year history of type 2 diabetes(T2DM)who had struggled to control her blood sugar for more than a *** had a history of high blood pressure for 30 years,had undergone continuous ambulatory peritoneal dialysis for more than two years,was 163 cm tall,weighed 77 kg,and had a body mass index of 28.98 kg/*** intensive insulin therapy at a daily dose of 150 units,adding Dorzagliatin at a dosage of 75 mg orally twice daily led to immediate blood sugar improvement and a gradual reduction in insulin *** one month of follow-up,the fasting plasma glucose was 6-8 mmol/L,and the 2-hour postprandial glucose was 8-12 mmol/*** To our knowledge,this report is the first to use Dorzagliatin to treat type 2 diabetes peritoneal dialysis patients with challenging glucose ***,a novel glucokinase activator primarily metabolized by the liver,exhibits no pharmacokinetic differences among patients with varying degrees of chronic kidney *** has a high plasma protein binding rate and may not be cleared by peritoneal dialysis,potentially offering a new glycemic control option for Type 2 diabetic patients on peritoneal dialysis.

关键词： Dorzagliatin Type 2 diabetes mellitus Peritoneal dialysis Glucokinase activator Glucose control Case report

Protein nanoparticles as potent delivery vehicles for polycytosine RNA-binding protein one

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2025年第1期16卷 222-225页

作者： Zi-Yu Zhao Pei-Li Luo Xia Guo Zheng-wei huang State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative DrugsCollege of PharmacyJinan UniversityGuangzhou 511436Guangdong ProvinceChina

Ma et al recently reported in the World Journal of Diabetes that ferroptosis occurs in osteoblasts under high glucose conditions,reflecting diabetes *** condition could be protected by the upregulation of the gene encoding polycytosine RNA-binding protein 1(PCBP1).Additionally,Ma et al used a lentivirus infection system to express *** the authors’method of administration can be improved in terms of stability and cost,we propose delivering PCBP1 to treat type 2 diabetic osteoporosis by encapsulating it in protein ***,PCBP1 is small and ***,intravenous injection can help deliver PCBP1 across the mucosa while avoiding acid and enzyme-catalyzed ***,incorporating PCBP1 into nanoparticles prevents its interaction with water or oxygen and protects PCBP1’s structure and ***,the safety of the protein materials and the industrialization techniques for large-scale production of protein nanoparticles must be comprehensively investigated before clinical application.

关键词： Polycytosine RNA-binding protein 1 Protein nanoparticle Osteoblast Ferroptosis Diabetes

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu wei huang Jiayi Wen Xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

维普期刊数据库

耳穴压豆联合穴位贴敷治疗老年股骨粗隆间骨折术后便秘临床观察

在线全文

学校读者我要写书评

暂无评论

中国中医药现代远程教育 2025年第1期23卷 134-136,143页

作者：黄伟江西省南城县中医院骨科江西南城344700

目的分析行股骨近端防旋髓内钉内固定术的老年股骨粗隆间骨折患者,应用耳穴压豆联合穴位贴敷治疗的效果及对术后便秘的影响。方法回顾性选取2020年2月—2022年2月南城县中医院行股骨近端防旋髓内钉内固定术的老年股骨粗隆间骨折患者70例... 详细信息

目的分析行股骨近端防旋髓内钉内固定术的老年股骨粗隆间骨折患者,应用耳穴压豆联合穴位贴敷治疗的效果及对术后便秘的影响。方法回顾性选取2020年2月—2022年2月南城县中医院行股骨近端防旋髓内钉内固定术的老年股骨粗隆间骨折患者70例,分为联合治疗组和常规治疗组,各35例。联合治疗组行耳穴压豆联合穴位贴敷治疗,常规治疗组行常规治疗,观察临床效果。结果联合治疗组术后便秘发生率为8.57%(3/35),低于常规治疗组的31.43%(11/35);各围术期指标均优于常规治疗组;治疗总有效率为91.43%(32/35),高于常规治疗组的71.43%(25/35);术后并发症发生率为2.86%(1/35),低于常规治疗组的25.71%(9/35)(P<0.05)。治疗后,联合治疗组便秘患者症状自评量表(PAC-SYM)评分、视觉模拟量表(VAS)评分、焦虑评分、抑郁评分均低于常规治疗组,骨折断端骨痂生长评分、Harris评分均高于常规治疗组(P<0.05)。结论行股骨近端防旋髓内钉内固定术的老年股骨粗隆间骨折患者应用耳穴压豆联合穴位贴敷治疗,效果显著,术后便秘发生率明显降低。

关键词：股骨粗隆间骨折便秘股骨近端防旋髓内钉内固定术耳穴压豆疗法穴位贴敷疗法

NMDA receptor regulation by Liu-wei-Di-huang Decoction accounts for its enhancement of LTP in SAMP8 hippocampal slices

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

NMDA receptor regulation by Liu-Wei-Di-Huang Decoction accou...

Neuroprotective effect of Liu wei Di huang Tang on adult hippocampal neurogenesis in mice

第二届世界天然药物和传统药物药理学学术会议

作者： Yan huang,He-Ping ZHANG,Zeng-Yao HU,Gang LIU,Sheng YANG,Wen-Xia ZHOU~* Yong-Xiang ZHANG~* (Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China)

AIMPrevious pharmacological studies demonstrated that LW could ameliorate the decline of the learning and memory in senescence accelerated mouse/prone 8(SAMP8),but the mechanism has not been well ***-containing serum(LWCS) was used in this study to elucidate the possible *** 6-month-old SAMP8 was used in this study to investigate the effect of LWCS on the induction of long-term potentiation(LTP).Primary cultured hippocampal neurons were used in this study to investigate the effects of LWCS on[Ca];I and N-methyl-D-aspartate(NMDA)-evoked currents.[Ca],was imaged using Fluo-3 and whole-cell patch recordings were applied to study the I and NMDA-evoked *** We find that LWCS facilitates the induction of LTP in hippocampal slices of 6-month-old *** primary cultured hippocampal neurons,LWCS increases intracellular[Ca],the I is suppressed by LWCS,and NMDA-evoked currents are *** These results indicate that LW improves the synaptic plasticity by inhibiting voltage-dependent caiciumchannels and promoting the function of NMDA *** improvement might be one of the mechanisms contributing to cognitive improvement effect of LW.

关键词： Liu-wei-Di-huang Decoction long-term potentiation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国药理学与毒理学杂志 2018年第4期32卷 312-312页

作者： Ming-xiao wei Tian-yao SHI Wen-xia ZHOU Zhong-lin ZHOU Jing-jing JIA Yong-xiang ZHANG Department of Neuroimmunopharmacology Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical countermeasures Beijing 100850 China

OBJECTIVE To explore the effect and mechanisms of LW-AFC,a new formula derived fromLiu wei Di huang Tang,on irradiation-induced reduction of mice adult hippocampal *** C57 BL/6 J mice were randomly divided into seven groups(n=10):control group,LW-AFC group(1.6 g·kg^(-1)),Liu wei Di huang Tang(LW) group(10 g·kg^(-1)),brain derived neurotrophic factor(BDNF) group,irradiation group,irradiation + LW group,and irradiation + LW-AFC *** of mice adult hippocampal neurogenesis was induced by cranial ***-AFC was administered by oral gavage for 30 d after cranial irradiation *** and Nissl′s staining were performed for histological morphology ***(BrdU) staining was used in the detection of proliferation *** peripheral blood and hippocampal homogenate were collected to measure the content of tumor necrosis factor-α(TNF-α),interferon-gamma(INF-γ),interleukin-1β(IL-1β),IL-4 and *** hippocampal homogenate was used for Western blot to detect the BDNFTrkB signal pathway,including extracellular regulated protein kinases1/2(ERK1/2) and BDNF target *** water maze and new object recognition test were performed to examine the cognitive function of *** mice forced swimming and tail suspension test were used to assess alteration in depressive *** term potentiation was used to examine the synaptic plasticity change of *** Adult hippocampal neurogenesis was significantly reduced after irradiation of 20 Gray dose(10 Gray per day,total 2 d).LW-AFC treatment increased the BrdU number of irradiated mice(P<0.05).In Morris water maze test,LW-AFC group showed decreased escape latency in the learning period(P<0.05),while increased the number of crossing the platform in the memory ***-AFC can also reduce the immobility time of mice in the tail suspension test(P<0.01).*** LW-AFC modulates adult neurogenesis to ameliorate cognitive impairment and reduce d

关键词：六味地黄汤海马神经治疗方法临床分析

维普期刊数据库

Zeolites as host matrix for luminescent carbon dots:a newclass of thermally activated delayed fluorescence materials with 350 ms delayed decay time

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2017年第9期60卷 1147-1148页

作者： wei huang Institute of Advanced Materials Nanjing Tech UniversityNanjing 211816China

Organic light-emitting diodes （OLEDs） have attractedconsiderable attentions from both academia and industryfor decades because of their potential applications in fullcolor fiat-panel displays and solid state lightings. Since2009 [1], thermally activated delayed fluorescence （TADF）OLEDs have drawn intense attention due to the utilizationof low-cost organic luminogens by harvesting all singletand triplet excitons to theoretically reach 100% internalquantum efficiency.

关键词：中国科学化学英文版

维普期刊数据库

Advancing basic research towards making China a world leader in science and technology

在线全文

学校读者我要写书评

暂无评论

National Science Review 2018年第2期5卷 126-128页

作者： wei huang Ministry of Science and Technology of the People’s Republic of China

INTRODUCTION Basic research is the bedrock of science and technology(S&T)progress and industrial transformation,and the cornerstone to making China a world leader in S&*** the new round of the technological and industrial revolution,basic research is assuming an increasingly prominent *** at becoming a world leader in S&T by 2050,China should

关键词： SCIENCE RESEARCH CHINA