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World Journal of Acupuncture-Moxibustion 2020年第2期30卷 158-162页

作者： Hao-cheng TANG wei-hua ZHANG School of Acupuncture-Moxibustion and Tuina Shaanxi University of Traditional Chinese MedicineXianyang 712046Shaanxi ProvinceChina Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine Xianyang 712000Shaanxi ProvinceChina

The professor wei-hua ZHANG’s experiences in treatment of primary dysmenorrhea with"warmingunblocking needling method"was introduced in this *** believes that obstruction is the crucial in pathogenesis of primary dysmenorrhea no matter of the excess or the deficiency *** and unblocking principle is the essential in ***,an unique therapeutic method is innovated,named warming-unblocking needling method,including three-layer and two-direction warming needling technique at Sanyinjiao(三阴交SP6),two-layer rotating warming-unblocking technique at Zhongji(中极CV3)and one-layer and two-direction warming needling technique at Ciliao(次髎BL32).In this set of needling procedure,acupoint is viewed as a three-dimensional hierarchical structure.A layered and multidirectional needling technique is adopted at main acupoints to enhance the sensations of diqi and to generate heat effect in the ***,moxibustion is combined to intensify warming and unblocking ***,the supplementary acupoints are used in response to *** of the acupoints coordinately warm up the uterus,promote meridian circulation and stop ***,this therapeutic method achieves relatively excellent effect and deserves to be promoted in practice.

关键词： Famous doctor’s clinical experiences Primary dysmenorrhea Warming-unblocking method wei-hua ZHANG

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang Yi Jiang hua-wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

Flow units as dynamic defects in metallic glassy materials

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National Science Review 2019年第2期6卷 304-323页

作者： Zheng Wang wei-hua Wang Institute of Physics Chinese Academy of Sciences

In a crystalline material, structural defects such as dislocations or twins are well defined and largely determine the mechanical and other properties of the material. For metallic glass(MG) with unique properties in the absence of a long-range lattice, intensive efforts have focused on the search for similar 'defects'. The primary objective has been the elucidation of the flow mechanism of MGs. However,their atomistic mechanism of mechanical deformation and atomic flow response to stress, temperature, and failure, have proven to be challenging. In this paper, we briefly review the state-of-the-art studies on the dynamic defects in metallic glasses from the perspective of flow units. The characteristics, activation and evolution processes of flow units as well as their correlation with mechanical properties, including plasticity,strength, fracture, and dynamic relaxation, are introduced. We show that flow units that are similar to structural defects such as dislocations are crucial in the optimization and design of metallic glassy materials via the thermal, mechanical and high-pressure tailoring of these units. In this report, the relevant issues and open questions with regard to the flow unit model are also introduced and discussed.

关键词： metallic glass flow unit flow glass transition mechanical deformation property optimization

Symplectic Structures of Two Kinds of Nonsymmetric Differential Operators

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Acta Mathematicae Applicatae Sinica 2015年第2期31卷 543-556页

作者： wei-hua YANG School of Mathematics and Physics Beijing University of Technology

Non-self-adjoint quasi-differential expression M and its formal adjoint M＋may generate nonsymmetric ordinary differential operators. Although minimal operators T0, T＋0 generated by M, M＋are not symmetric, they form an adjoint pair. In this paper, author studies regularly solvable operators with respect to the adjoint pair T0, T＋0 in two kinds of conditions and give their geometry description in the corresponding ways.

关键词： regularly solvable operators symplectic space self-adjoint operator pair

Least-Squares Seismic Inversion with Stochastic Conjugate Gradient Method

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Journal of Earth Science 2015年第4期26卷 463-470页

作者： wei huang hua-wei Zhou Department of Earth & Atmospheric Sciences University of Houston College of Marine Geosciences Ocean University of China

With the development of computational power, there has been an increased focus on data-fitting related seismic inversion techniques for high fidelity seismic velocity model and image, such as full-waveform inversion and least squares migration. However, though more advanced than conventional methods, these data fitting methods can be very expensive in terms of computational cost. Recently, various techniques to optimize these data-fitting seismic inversion problems have been implemented to cater for the industrial need for much improved efficiency. In this study, we propose a general stochastic conjugate gradient method for these data-fitting related inverse problems. We first prescribe the basic theory of our method and then give synthetic examples. Our numerical experiments illustrate the potential of this method for large-size seismic inversion application.

关键词： least-squares seismic inversion stochastic conjugate gradient method data fitting,Kirchhoff migration.

Expression analysis of GSK-3β in diapause pupal brains in the cotton bollworm, Helicoverpa armigera

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Insect Science 2015年第5期22卷 597-605页

作者： wei Chen wei-hua Xu Guangdong Province Key Laboratory for Biotechnology Drug Candidates School of Biosciences and Biopharmaceutics Guangdong Pharmaceutical University and State Key Laboratory of Biocontrol School of Life Sciences Sun Yat-sen University Guangzhou China

Diapause is an adaptive response to adverse environmental conditions, but the molecular mechanisms are unclear. Some signaling molecules have been identified in the regulation of diapause. GSK-3β is an important signaling protein involved in sev- eral signaling pathways. In this study, GSK-3β from the cotton bollworm, Helicoverpa armigera, was cloned using reverse transcription polymerase chain reaction and rapid am- plification of complementary DNA （cDNA） ends techniques. Sequence analysis showed that the full-length cDNA was 1447 bp containing a 292 bp 5＇-untranslated region （UTR）, a 162 bp 3＇-UTR and a 993 bp open reading frame （ORF）. The deduced Har-GSK-3β pro- tein has high identity to other known GSK-3β, as determined by Basic Local Alignment Search Tool analysis. Developmental expression of total GSK-3/3 and p-GSK-3β （Ser9） in diapause and non-diapanse pupal brains was investigated by Western blotting. Results indicated that the activity of GSK-3β is down-regulated in diapause pupal brains, which is further confirmed by Western blotting after diapause break. These finding suggest that the down-regulation of Har-GSK-3β activity may be important for pupal diapause.

关键词： Helicoverpa armigera GSK-3β pupal diapauses RACE

Luminescent properties of a new Nd^(3+)-doped complex with two different carboxylic acids and pyridine derivative

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Rare Metals 2013年第5期32卷 490-495页

作者： Yun-Xia Ye Li-hua wei wei-Chen Mei Chen Yin-Qun hua School of Mechanical Engineering Jiangsu University Institute of Laser Technology Jiangsu University School of Material Engineering Jiangsu University

A new Nd3＋-doped organic complex featuring two different perfluorinated carboxylic acids as the first ligand and pyridine derivative 2-amino-3-chloro-5-（tri- fluoromethyl）pyridine as the second ligand was designed and synthesized. Successful coordination between the ligands and central rare earth ions was confirmed by Fourier transform infrared spectroscopy （FT-IR） spectra, 1H nuclear magnetic resonance （1H NMR） spectra, and UV spectra, and the synthesized complex is inferred to be eight-coordinate structure. Solution of the complex dis- solved in DMSO-d6 was prepared and then its fluorescence spectrum, UV-Vis-NIR absorption spectrum, and fluorescence decay curve were tested. The fluorescent lifetime is about 7 txs. Based on the above experimental research, Judd-Ofelt analysis was carried out, and the results indi- cate that appropriate coordination environment around Nd3＋ in this solution results in a high fluorescent quantum efficiency 2 % and a large stimulated emission cross-section about 3.2 × 10^-20 cm^2 at 1,064 nm.

关键词： Nd Organic solution Liquid laser Quantum efficiency Judd-Ofelt theory

Nonlinear magnetic network models for flux-switching permanent magnet machines

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Science China(Technological Sciences) 2016年第3期59卷 494-505页

作者： zhang gan hua wei cheng ming School of Electrical Engineering Southeast University Nanjing 210096 China

In this paper, firstly, a basic nonlinear magnetic network model considering iron saturations is proposed for a three-phase 12-stator-slot/10-rotor-pole flux-switching permanent magnet(FSPM) machine. This model is built under cylindrical coordinates and enables the open-circuit air-gap flux-density distributions, phase permanent magnet(PM) flux-linkage, and electromotive-force(EMF) to be predicted with acceptable accuracy. However, large discrepancies are found in the predictions of armature inductances. Then, the basic model is modified by taking into account the localized saturation effect. As a result, the electromagnetic performance can be predicted more accurately, especially for the air-gap flux-density distributions. Furthermore, two improved models are proposed by adding bypass-bridge branches in stator network, to enhance the calculating accuracy of both saturated and unsaturated armature inductances. Finally, the predicted results from the four magnetic network models are validated by both 2D finite element analysis(FEA) and experimental measurements on a machine prototype. Overall, comparisons indicate that the model with bypass-bridge branches between stator teeth and back irons exhibits best performances.

关键词： air-gap flux density finite element analysis flux switching nonlinear magnetic network permanent magnet

Simple and robust method for rapid cooling of 87Rb to quantum degeneracy

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Chinese Physics B 2020年第6期29卷 202-206页

作者： Chun-hua wei Shu-hua Yan State Key Laboratory of Aerodynamics China Aerodynamics Research and Development CenterMianyang 621000China Low Speed Aerodynamics Institute China Aerodynamics Research and Development CenterMianyang 621000China Interdisciplinary Center for Quantum Information National University of Defense TechnologyChangsha 410073China

We demonstrate a simple and fast way to produce 87Rb Bose–Einstein condensates. A digital optical phase lock loop(OPLL) board is introduced to lock and adjust the frequency of the trap laser, which simplifies the optical design and improves the experimental efficiency. We collect atoms in a magneto-optical trap, then compress the cloud and cut off hot atoms by rf knife in a magnetic quadrupole trap. The atom clouds are then transferred into a spatially mode-matched optical dipole trap by lowering the quadrupole field gradient. Our system reliably produces a condensate with 2 × 106 atoms every7.5 s. The compact optical design and rapid preparation speed of our system will open the gate for mobile quantum sensing.

关键词： optical phase lock loop laser cooling Bose-Einstein condensates

Water Dissociation Phenomena on a Bipolar Membrane──Current-voltage Curve in Relation with IonicTransport and Limiting Current Density

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Chemical Research in Chinese Universities 2001年第4期17卷 457-464页

作者： XU Tong-wen YANG wei-hua Department of Applied Chemistry University of Science and Technology of ChinaHefei 230026P.R.China

The water dissociation mechanism on a bipolar membrane under the electrical field was investigated and characterized in terms of ionic transport and limiting current density. It is considered that the depletion layer exists at the junction of a bipolar membrane, which is coincided with the viewpoint of the most literatures, but we also consider that the thickness and conductivity of this layer is not only related with the increase of the applied voltage but also with the limiting current density. Below the limiting current density, the thickness of the depletion layer keeps a constant and the conductivity decreases with the increase of the applied voltage; while above the limiting current density, the depletion thickness will increase with the increase of the applied voltage and the conductivity keeps a very low constant. Based on the data reported in the literatures and independent determinations, the limiting current density was calculated and the experimental curves Ⅰ-Ⅴ in the two directions were com

关键词： Bipolar membrane Water dissociation Ionic transport Limiting current density