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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第1期12卷 55-64页

作者： wei zhang quan-wei wei zheng-chao wang wei ding wei wang fang-xiong shi Laboratory of Animal Reproduction College of Animal Science and Technology Nanjing Agricultural University Nanjing 210095 China

Objective: The present study is designed to investigate the cellular expressions and immunolocalizations of three different nitric oxide synthase (NOS) isoforms and the related nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway in the ovaries of neonatal and immature ***: The ovaries were obtained from ICR (Institute for Cancer Research) female Sprague-Dawley rats at postnatal days 1,5,7,10,and *** we carried out the histologic examination,immunohistochemistry,measurement of NOS activity,and modifications within the NO/cGMP ***: During postnatal days 1,5,7,10,and 19,all three isoforms of NOS were mainly localized to the oocytes and expressed as a gradual increase in granulosa cells and theca cells within the growing *** ovarian total NOS activities and NO levels were increased at postnatal days 7 and 10 compared with other ***: Our findings suggest that the locally produced NO and the NO/NOS signaling systems are involved in the follicular development to puberty.

关键词： Nitric oxide synthase Nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway Ovary Neonatal rats Prepuberty

Cell-specific expression and immunolocalization of nitric oxide synthase isoforms and the related nitric oxide/cyclic GMP signaling pathway in the ovaries of neonatal and immature rats

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第9期 706-706页

作者： wei zhang,quan-wei wei,zheng-chao wang,wei ding,wei wang,fang-xiong shi

Objective:To explore the effects of insulin-like growth factor-1(IGF-1) on migration,proliferation and differentiation of mesenchymal stem cells(MSCs).Methods:MSCs were obtained from Sprague-Dawley rats by a combination of gradient centrifugation and cell culture techniques and treated with IGF-1 at concentrations of 5-20 ng/*** of MSCs was determined as the mean doubling *** of CXC chemokine receptor 4(CXCR4) and migration property were determined by flow cytometry and transwell migration essay,*** expression of GATA-4 and collagen II was determined by reverse transcription-polymerase chain reaction(RT-PCR).Results:The mean doubling time of MSC proliferation was decreased,and the expression of CXCR4 on MSCs and migration of MSCs were increased by IGF-1,all in a dose-dependent manner,while the optimal concentration of IGF-1 on proliferation and migration was ***-1 did not affect the expression of GATA-4 or collagen II ***:IGF-1 dose-dependently stimulated the proliferation of MSCs,upregulated the expression of CXCR4,and accelerated *** was no apparent differentiation of MSCs to cardiomyocytes or chondrocytes after culturing with IGF-1 alone.

关键词： MSCs IGF CXCR GATA GMP

A nomogram to predict Gleason sum upgrading of clinically diagnosed localized prostate cancer among Chinese patients

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Chinese Journal of Cancer 2014年第5期33卷 241-248页

作者： Jin-You wang Yao Zhu chao-Fu wang shi-Lin zhang Bo Dai ding-wei Ye Department of Oncology Shanghai Medical CollegeFudan University Department of Urology Shanghai Medical CollegeFudan University Department of Pathology Fudan University Cancer Hospital

Although several models have been developed to predict the probability of Gleason sum upgrading between biopsy and radical prostatectomy specimens,most of these models are restricted to prostatespecific antigen screening-detected prostate *** study aimed to build a nomogram for the prediction of Gleason sum upgrading in clinically diagnosed prostate *** study cohort comprised 269 Chinese prostate cancer patients who underwent prostate biopsy with a minimum of 10 cores and were subsequently treated with radical *** all included patients,220(81.8%) were referred with clinical *** prostate-specific antigen level,primary and secondary biopsy Gleason scores,and clinical T category were used in a multivariate logistic regression model to predict the probability of Gleason sum *** developed nomogram was validated *** sum upgrading was observed in 90(33.5%) *** nomogram showed a bootstrap-corrected concordance index of 0.789 and good calibration using 4 readily available *** nomogram also demonstrated satisfactory statistical performance for predicting significant *** validation of the nomogram published by Chun et *** our cohort showed a marked discordance between the observed and predicted probabilities of Gleason sum *** summary,a new nomogram to predict Gleason sum upgrading in clinically diagnosed prostate cancer was developed,and it demonstrated good statistical performance upon internal validation.

关键词：前列腺癌预测概率临床诊断列线图 logistic回归模型患者中国特异性抗原

A Novel Ursane Triterpene from Rubus swinhoei

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Chinese Chemical Letters 2001年第3期12卷 245-246页

作者： wei quan ZHAO Li Sheng ding Qiang zhang Ming Kui wang Chengdu Institute of Biology Chinese Academy of SciencesChengdu 610041 West China University of Medical Sciences Chengdu 610041

A novel ursane triterpene, named swinhoeic acid, was isolated from the roots of Rubus swinhoei. Its structure was elucidated as 18, 19-seco, 2 alpha, 3 beta -dihydroxy-19-oxo-urs-11, 13(18)-dien-28-oic acid by means o... 详细信息

关键词： Rubus swinhoei swinhoeic acid

Tailor-made microstructures lead to high-performance robust PEO membrane for CO_(2)capture via green fabrication technique

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Green Energy & Environment 2023年第5期8卷 1389-1397页

作者： wei-shi Sun Ming-Jie Yin Wen-Hai zhang Shuo Li Naixin wang quan-Fu An Beijing Key Laboratory for Green Catalysis and Separation Department of Environmental and Chemical EngineeringBeijing University of TechnologyBeijing100124China

Emerging excessive greenhouse gas emissions pose great threats to the ecosystem,which thus requires efficient CO_(2)capture to mitigate the disastrous *** this report,large molecular size bisphenol A ethoxylate diacrylate(BPA)was employed to crosslink poly(ethylene glycol)methyl ether acrylate(PEGMEA)via the green and rapid UV polymerization *** microstructure of such-prepared membrane could be conveniently tailored by tuning the ratio of the two prepolymers,aiming at obtaining the optimized microstructures with suitable mesh size and PEO sol content,which was approved by a novel low-field nuclear magnetic resonance *** optimum membrane overcomes the tradeoff challenge:dense microstructures lower the gas permeability while loose microstructures lower high-pressure-resistance capacity,realizing a high CO_(2)permeability of 1711 Barrer and 100-h long-term running stability under 15 *** proposed membrane fabrication approach,hence,opens a novel gate for developing high-performance robust membranes for CO_(2)capture.

关键词： CO_(2)capture PEO membrane Membrane microstructures PEO sol Photo-crosslinking

Dihydromyricetin ameliorates chronic liver injury by reducing pyroptosis

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World Journal of Gastroenterology 2020年第41期26卷 6346-6360页

作者： quan-Cheng Cheng Jing Fan Xin-wei Deng Huai-Cun Liu Hui-Ru ding Xuan fang Jian-wei wang Chun-Hua Chen wei-Guang zhang Department of Anatomy Histology and EmbryologySchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Xin Hua Hospital Shanghai Jiaotong University School of MedicineShanghai 202155China

BACKGROUND Chronic liver injury(CLI) is now a worldwide disease. However, there is no effective treatment. Pyroptosis plays an essential role in CLI. Dihydromyricetin(DHM) resists oxidation and protects the liver. We hypothesize that the beneficial effect of DHM on CLI is related to its effect on the expression of pyroptosisrelated molecules. Therefore, we studied the influence of DHM on CLI and *** To study the role of pyroptosis in the pathogenesis of CLI and the therapeutic mechanism of *** Thirty-two mice were randomly divided into four groups: The control group was injected with olive oil, the carbon tetrachloride(CCl4) group was injected with CCl4, the vehicle group was injected with hydroxypropyl-β-cyclodextrin while injecting CCl4 and the DHM group was injected with DHM while injecting CCl4. After four weeks of treatment, liver tissues from the mice were stained with hematoxylin and eosin, and oil red O. Blood was collected from the angular vein for serological analysis. The severity of CLI was estimated. Some liver tissue was sampled for immunohistochemistry, Western blotting and quantitative reverse transcription PCR to observe the changes in pyroptosis-related *** Serum total cholesterol, low density lipoprotein, aspartate aminotransferase(AST) and alanine aminotransferase(ALT) in the CCl4 group were higher than those in the control group, and serum total cholesterol, low density lipoprotein, AST and ALT in the DHM group were lower than those in the vehicle group. Hematoxylin and eosin and oil red O staining showed that there were more lipid droplets in the CCl4 group than in the control group, and there were fewer lipid droplets in the DHM group than in the vehicle group. Western blotting showed that the expression of the pyroptosis-related molecules caspase-1, NOD-, LRR-and pyrin domain-containing 3(NLRP3) and gasdermin D(GSDMD)-N in the CCl4 group was higher than that in the control group, while expression of these prot

关键词： Chronic liver injury Dihydromyricetin Pyroptosis Carbon tetrachloride Pathogenesis Steatosis

Experimental Test of Contextuality Based on State Discrimination with a Single Qubit

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Chinese Physics Letters 2022年第8期39卷 1-5页

作者： Qiuxin zhang Chenhao Zhu Yuxin wang Liangyu ding Tingting shi Xiang zhang Shuaining zhang wei zhang Department of Physics Renmin University of ChinaBeijing 100872China Beijing Academy of quantum Information Sciences Beijing 100193China Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices Renmin University of ChinaBeijing 100872China

Exploring quantum phenomena beyond predictions of any classical model has fundamental importance to understand the boundary of classical and quantum descriptions of *** a typical property that a quantum system behaves distinctively from a classical counterpart,contextuality has been studied extensively and verified experimentally in systems composed of at least three levels(qutrit).Here we extend the scope of experimental test of contextuality to a minimal quantum system of only two states(qubit)by implementing the minimum error state discrimination on a single171Yb+*** observe a substantial violation of a no-go inequality derived by assuming non-contextuality,and firmly conclude that the measured results of state discrimination cannot be reconciled with any non-contextual *** also quantify the contextual advantage of state discrimination and the tolerance against quantum noises.

关键词： quantum system inequality

FTIR Characterization of Fluorine Doped Silicon Dioxide Thin Films Deposited by Plasma Enhanced Chemical Vapor Deposition

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Chinese Physics Letters 2000年第12期17卷 912-914页

作者： wang Peng-Fei ding shi-Jin zhang wei zhang Jim-Yun wang Ji-Tao wei William Lee Department of Electronic Engineering Fudan UniversityShanghai 200433 Taiwan Semiconductor Manufacturing Co. HsinchuTaiwanChina

Fluorine doped silicon dioxide (SiOF) thin films have been prepared by plasma enhanced chemical vapor deposition. The Fourier transform infrared spectrometry (FTIR) spectra of SiOF films are deliberated to reveal the structure change of SiO_(2) and the mechanism of dielectric constant reduction after doping fluorine. When F is doped in SiO_(2) films, the Si-O stretching absorption peak will have a blue-shift due to increase of the partial charge of the O atom. The FTIR spectra indicate that some Si-OH components in the thin film can be removed after doping fluorine. These changes reduce the ionic and orientational polarization, and result in the reduction in dielectric constant of the film. According to Gaussian fitting, it is found that the Si-F2 bonds will appear in the SiOF film with increase of the fluorine content. The Si-F2 structures are liable to react with water, and cause the same increase of absorbed moisture in the film.

关键词： fluorine film dielectric

High mobility group-box 3 overexpression is associated with poor prognosis of resected gastric adenocarcinoma

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World Journal of Gastroenterology 2012年第48期18卷 7319-7326页

作者： Hua-Rong Tang Xian-Qin Luo Gang Xu Yan wang ZhiJun Feng Hui Xu Ya-wei shi Qin zhang Li-Guang Wu Chun-quan Xue Cheng-wei wang chao-Yang Wu Department of Oncology Affiliated People's Hospital of Jiangsu University

AIM:To elucidate high mobility group-box 3(HMGB3) protein expression in gastric adenocarcinoma,its potential prognostic relevance,and possible mechanism of ***:Ninety-two patients with gastric adenocarcinomas surgically removed entered the ***3 expression was determined by immunohistochemistry through a tissue microarray *** clinicopathologic characteristics of all patients were recorded,and regular follow-up was made for all *** inter-relationship of HMGB3 expression with histological and clinical factors was analyzed using nonparametric *** analysis was carried out by Kaplan-Meier(log-rank) and multivariate Cox(Forward LR) analyses between the group with overexpression of HMGB3 and the group with low or no HMGB3 ex-pression to determine the prognosis value of HMGB3 expression on overall ***,HMGB3 expression was knocked down by small hairpin RNAs(shRNAs) in the human gastric cancer cell line BGC823 to observe its influence on cell biological *** MTT method was utilized to detect gastric cancer cell proliferation changes,and cell cycle distribution was analyzed by flow ***:Among 92 patients with gastric adenocarcinomas surgically removed in this study,high HMGB3 protein expression was detected in the gastric adenocarcinoma tissues vs peritumoral tissues(P < 0.001).Further correlation analysis with patients' clinical and histology variables revealed that HMGB3 overexpression was obviously associated with extensive wall penetration(P = 0.005),a positive nodal status(P = 0.004),and advanced tumor-node-metastasis(TNM) stage(P = 0.001).But there was no correlation between HMGB3 overexpression and the age and gender of the patient,tumor localization or histologic *** Kaplan-Meier survival analysis disclosed significant differences in overall survival between the HMGB3 overexpression group and the HMGB3 no or low expression group(P = 0.006).The expected overall survival

关键词： High mobility group-box 3 Gastric adenocarcinoma Prognosis Cell proliferation Cell cycle

Two monofluoride-bridged Dy~Ⅲdimers with different magnetization dynamics

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Chinese Chemical Letters 2023年第6期34卷 454-458页

作者： Mengmeng wang Xixi Meng Ning Liu Yi-quan zhang Na Xu wei shi Peng Cheng Department of Chemistry Key Laboratory of Advanced Energy Materials Chemistry(MOE)and Renewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071China Jiangsu Key Lab for NSLSCS School of Physical Science and TechnologyNanjing Normal UniversityNanjing 210023China

As a monoatomic bridge,fluoride ion can transmit efficient magnetic interaction between lanthanide ions but its effect on tuning the magnetization dynamics has not been well ***,two monofluoride-bridged dinuclear dysprosium complexes[Dy_(2)F(bbpen)_(2)(Et OH)_(2)]Br·Et OH(1)and[Dy_(2)F(bbppy)_(2)]Br·2Et OH(2)with Dy-F-Dy angles of~178°and their diamagnetic-ion diluted analogues 1'and 2'were *** studies reveal that 1 and 1'barely show any magnetization dynamics,but 2 and 2'exhibit strong magnetization *** experimental analysis combined with ab initio calculations reveals that the different magnetization dynamics between 1 and 2 mainly originate from the effect of magnetic anisotropy by terminal ligand and bridging group of the chelating ligand,and the fluoride bridge can effectively suppress the quantum tunneling of the magnetization and turn on Orbach process in 2.

关键词： Fluoride ion bridge Dinuclear Dy~Ⅲcomplexes Magnetization dynamics Single-molecule magnet Suppressing QTM