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宣肺调肠方联合西药治疗老年脓毒症致急性呼吸窘迫综合征临床研究

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新中医 2024年第6期56卷 68-72页

作者：胡孝刚吴晗魏燕斌康润芳丽水市第二人民医院浙江丽水323000

目的:观察宣肺调肠方联合西药治疗老年脓毒症致急性呼吸窘迫综合征(ARDS)饮停夹热证的临床疗效。方法:选取92例老年脓毒症致ARDS饮停夹热证患者,按照随机数字表法分为观察组和对照组,每组46例。对照组给予西医综合治疗,观察组在对照组... 详细信息

目的:观察宣肺调肠方联合西药治疗老年脓毒症致急性呼吸窘迫综合征(ARDS)饮停夹热证的临床疗效。方法:选取92例老年脓毒症致ARDS饮停夹热证患者,按照随机数字表法分为观察组和对照组,每组46例。对照组给予西医综合治疗,观察组在对照组基础上给予宣肺调肠方治疗。2组均治疗14d。比较2组临床疗效、中医证候积分、血气分析指标及炎症因子水平。结果:治疗后,观察组总有效率95.65%,高于对照组82.61%(P2组主症、次症积分及中医证候总分均较治疗前降低(P2组动脉血氧分压(PaO_(2))及PaO_(2)/吸入气中的氧浓度分数(FiO_(2))均较治疗前升高(P2))均较治疗前降低(P2)及PaO_(2)/FiO_(2)均高于对照组(P2)低于对照组(P2组血清白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)水平均较治疗前降低(P<0.05),观察组血清IL-6、IL-10、TNF-α水平均低于对照组(P<0.05)。结论:宣肺调肠方联合西药治疗老年脓毒症致ARDS饮停夹热证疗效确切,可有效改善患者的临床症状,提高氧合功能,减轻炎症反应程度。

关键词：脓毒症急性呼吸窘迫综合征老年人饮停夹热证宣肺调肠方血气分析炎症反应

贵州织金县以那地区龙潭组煤质特征及其沉积环境指示

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地质与勘探 2023年第5期59卷 974-984页

作者：赵凌云郭志军韩思杰魏元龙张斌斌周培明吴章利徐虎自然资源部复杂构造区非常规天然气评价与开发重点实验室贵州贵阳550081 贵州省油气勘查开发工程研究院贵州贵阳550081 中国矿业大学江苏省煤基温室气体减排与资源化利用重点实验室江苏徐州221008 中国矿业大学碳中和研究院江苏徐州221008

成煤环境与煤质特征关系紧密,泥炭沼泽期陆源输入强度、海水进退以及氧化还原条件对煤中元素分布和组成具有重要影响。本次研究利用贵州织金县以那地区三个煤矿勘查区共46口钻孔主采煤层的煤质分析结果,分析了龙潭组自下而上煤质参数分... 详细信息

成煤环境与煤质特征关系紧密,泥炭沼泽期陆源输入强度、海水进退以及氧化还原条件对煤中元素分布和组成具有重要影响。本次研究利用贵州织金县以那地区三个煤矿勘查区共46口钻孔主采煤层的煤质分析结果,分析了龙潭组自下而上煤质参数分布特征,并在此基础上探讨了硫分和灰成分指数对成煤环境的指示作用。研究结果表明:(1)以那地区无烟煤全硫分含量较低,平均为2.19%,以无机硫为主,煤灰分中主量元素以SiO_(2)为主,Al_(2)O_(3)和Fe_2O_(3)次之,其他含量较低;(2)各煤层全硫含量、有机/无机硫在全硫中占比、主量元素组合(Fe_2O_(3)+CaO+MgO和SiO_(2)+Al_(2)O_(3))含量呈现相互匹配的变化规律,煤灰成分指数变化规律不明显;(3)以那地区龙潭组自下而上经历了三期海水进退过程,发育潮坪下三角洲平原、三角洲分流间湾和潮坪-瀉湖三种成煤环境,硫分与灰成分指数在成煤环境指示作用上具有较好的一致性。

关键词：龙潭组无烟煤硫分含量灰成分指数成煤环境以那地区织金县贵州

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua Cai Wenyong Cai wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen hua-Xing Chen huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhu&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

1995至2021年河南省食管癌高发区早期食管癌占比变化趋势

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郑州大学学报（医学版） 2023年第4期58卷 445-448页

作者：宋昕韩文莉胡景峰钟侃马琳琳王苒周福有王献增高文俊郭威李爱丽郭贵周刘志才李吉林焦新英常扶保常志军范宗民李贝韩雪娜伍玥王立东郑州大学第一附属医院省部共建食管癌防治国家重点实验室郑州450052 郑州大学基础医学院病理学与病理生理学教研室郑州450001 安阳市肿瘤医院胸外科河南安阳455000 林州市人民医院肿瘤科河南林州456550 林州市人民医院胸外科河南林州456550 林州市人民医院病理科河南林州456550 林州市肿瘤医院肿瘤科河南林州456550 林州市肿瘤医院胸外科河南林州456550 林州市食管癌医院病理科南林州456592 林州市中心医院胸外科河南林州456592 河南省人民医院消化内科郑州450000

目的:分析1995至2021年河南省食管癌高发区5家医院就诊病例中早期食管癌占比的变化,了解高发区食管癌的防治效果。方法:对来自河南省食管癌高发区27 a间5家医院收治且有明确病理诊断的127249例食管癌病例中早期癌占比进行Joinpoint回归... 详细信息

目的:分析1995至2021年河南省食管癌高发区5家医院就诊病例中早期食管癌占比的变化,了解高发区食管癌的防治效果。方法:对来自河南省食管癌高发区27 a间5家医院收治且有明确病理诊断的127249例食管癌病例中早期癌占比进行Joinpoint回归分析。结果:2009年食管癌病例数较1995年增加了2.4倍,而2009年至2021年病例数则逐年下降。Joinpoint分析结果显示,1995至2011年早期食管癌占比上升速度较慢,年度变化百分比(95%CI)为2.94%(1.53%~4.36%);2011年以后则上升速度增快,年度变化百分比(95%CI)为12.27%(9.27%~15.35%)。结论:食管癌一级预防和二级预防措施的推广使高发区食管癌病例数明显减少,早期癌检出率大幅度提升。

关键词：食管癌早期癌高发区河南省

一种抗新型冠状病毒灭活血浆的制备及质量标准的建立

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国际生物制品学杂志 2021年第1期44卷 17-21页

作者：胡勇余鼎何彦林段凯杨汇川侯继锋梁洪彭焱周志军林连珍吴晓喻剑虹韩韧梁小龙邢延涛刘莹郑宵蓓卢奎林吴强江砚芳丁亚凌李伟张勇朱晨邓志军陈克金詹骞李陶敬王泽鋆孟胜利卢佳杨晓明李策生付道兴国药集团武汉血液制品有限公司科研开发部 430207 北京天坛生物制品股份有限公司研发中心 100024 武汉生物制品研究所有限责任公司病毒性疫苗研究二室 430207 中国生物技术股份有限公司科研管理部北京100029 中国食品药品检定研究院血液制品室北京102629 成都蓉生药业有限责任公司科研开发部 610041

目的建立一种以新型冠状病毒肺炎(COVID-19)康复者恢复期血浆为原料制备抗新型冠状病毒(2019 novel coronavirus,2019-nCoV)灭活血浆的工艺及其质量标准。方法采集2020年1—3月期间中国武汉441人份COVID-19康复者捐献的恢复期血浆,开展2... 详细信息

目的建立一种以新型冠状病毒肺炎(COVID-19)康复者恢复期血浆为原料制备抗新型冠状病毒(2019 novel coronavirus,2019-nCoV)灭活血浆的工艺及其质量标准。方法采集2020年1—3月期间中国武汉441人份COVID-19康复者捐献的恢复期血浆,开展2019-nCoV、HIV和梅毒螺旋体等病原体的筛查,进行亚甲蓝光照灭活,并通过检测蛋白含量、抗2019-nCoV抗体、凝血因子Ⅷ活性等,判断亚甲蓝光照灭活对血浆的影响并建立质量标准。结果亚甲蓝光照灭活前后灭活血浆的蛋白含量没有发生明显变化,血浆的凝血因子Ⅷ含量≥0.50 IU/ml,抗体滴度未出现明显下降,各项检测结果均符合质量要求。结论确立了以COVID-19康复者恢复期血浆制备抗2019-nCoV灭活血浆的关键质量控制及工艺参数。

关键词：新型冠状病毒肺炎新型冠状病毒亚甲蓝病毒灭活