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Intracellular redox potential-driven live-cell synthesis of CdSe quantum dots in Staphylococcus aureus

Science China Chemistry 2024年第3期67卷 990-999页

作者： Cai-Qin Wu An-An Liu Xu Li Jia-wei tu Juan Kong Ling-Ling Yang Jian-Hong Jia Chuan Wang Bin Hu Zhi-Xiong Xie Dai-Wen Pang The Institute for Advanced Studies College of Chemistry and Molecular SciencesCollege of Life SciencesHubei Key Laboratory of Cell HomeostasisWuhan UniversityWuhan 430072China Research Center for Analytical Sciences College of ChemistryState Key Laboratory of Medicinal Chemical BiologyTianjin Key Laboratory of Biosensing and Molecular RecognitionFrontiers Science Center for New Organic MatterFrontiers Science Center for Cell Responsesand Haihe Laboratory of Sustainable Chemical TransformationsNankai UniversityTianjin 300071China

Biosynthesized semiconductor quantum dots(QDs) have bright fluorescence,adjustable particle sizes,and environmental friendliness,endowing them with convenience and potential for biological *** to the unclear mechanism of the cellular environment on the live-cell synthesis of QDs,it is still difficult to regulate their optical ***,the critical role of the intracellular redox environment in regulating the fluorescence properties of biosynthesized CdSe QDs in Staphylococcus aureus(***) has been *** glutathione peroxidase(GPx) activity directly affects the intracellular H_(2)O_(2) produced in the SeO_(3)^(2-) reduction,which further manipulates the glutathione redox cycle to determine the content of low-valence *** a result,the fluorescence intensity of the synthesized CdSe QDs increases by 60% in the GPx overexpressed *** cellular redox potential that is controlled by the GSH redox cycle provides the driving force for the reduction of SeO_(3)^(2-),facilitating the synthesis of CdSe QDs in *** *** proposed mechanism of the cellular redox state provides a new perspective for regulating the synthesis of semiconductor nanomaterials in live cells.

关键词： redox H_(2)O_(2) peroxidase quantum dot Staphylococcus aureus

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Aryl hydrocarbon receptor:Linking environment to aging process in elderly patients with asthma

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Chinese Medical Journal 2024年第4期137卷 382-393页

作者： Tianrui Yang Rongjun Wan wei tu Sai Nithin Avvaru Peisong Gao Division of Allergy and Clinical Immunology Department of MedicineJohns Hopkins University School of MedicineBaltimoreMD 21224USA Department of Geriatric Medicine The First People’s Hospital of Yunnan ProvinceKunmingYunnan 650032China Department of Respiratory Medicine Xiangya HospitalCentral South UniversityChangshaHunan 410008China The State Key Laboratory of Respiratory Disease for Allergy Shenzhen Key Laboratory of Allergy and ImmunologyShenzhen University School of MedicineShenzhenGuangdong 518055China

Aging is a significant risk factor for various diseases,including asthma,and it often leads to poorer clinical outcomes,particularly in elderly *** is recognized that age-related diseases are due to a time-dependent accumulation of cellular damage,resulting in a progressive decline in cellular and physiological functions and an increased susceptibility to chronic *** effects of aging affect not only the elderly but also those of younger ages,posing significant challenges to global ***,understanding the molecular mechanisms associated with aging in different diseases is *** intriguing factor is the aryl hydrocarbon receptor(AhR),which serves as a cytoplasmic receptor and ligand-activated transcription factor and has been linked to the aging ***,we review the literature on several major hallmarks of aging,including mitochondrial dysfunction,cellular senescence,autophagy,mitophagy,epigenetic alterations,and microbiome ***,we provide an overview of the impact of AhR on these hallmarks by mediating responses to environmental exposures,particularly in relation to the immune ***,we explore how aging hallmarks affect clinical characteristics,inflammatory features,exacerbations,and the treatment of *** is suggested that AhR signaling may potentially play a role in regulating asthma phenotypes in elderly populations as part of the aging process.

关键词： Aging Environment Reactive oxygen species Senescence Aryl hydrocarbon receptor Asthma

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桥梁实景三维高斯辐射场建模

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测绘学报 2024年第9期53卷 1694-1705页

作者：马威涂强潘建平赵立都涂伟李清泉重庆交通大学智慧城市学院重庆400074 自然资源部国土空间规划监测评估预警重点实验室重庆400074 自然资源部智能城市时空信息与装备工程技术创新中心重庆401121 深圳大学建筑与城市规划学院城市空间信息工程系广东深圳518060 空间信息智能感知与服务深圳市重点实验室广东深圳518060 广东省城市空间信息工程重点实验室广东深圳518060 自然资源部大湾区地理环境监测重点实验室广东深圳518060

实景三维和数字孪生已成为桥梁运维和管理的重要基础,然而面对桥梁的复杂几何结构,现有三维建模方法存在原始数据采集量大、建模效率低、模型细节缺失或变形等问题。对此,本文研究了一种基于3D高斯辐射场的桥梁实景三维重建方法。利用3... 详细信息

实景三维和数字孪生已成为桥梁运维和管理的重要基础,然而面对桥梁的复杂几何结构,现有三维建模方法存在原始数据采集量大、建模效率低、模型细节缺失或变形等问题。对此,本文研究了一种基于3D高斯辐射场的桥梁实景三维重建方法。利用3D高斯函数对采集图像生成的稀疏点云构建高斯辐射场,并基于随机梯度下降对辐射场参数进行自适应优化,通过可微光栅渲染对三维模型进行实时可视化,从而实现高质量桥梁三维重建和渲染。试验探讨了不同图像分辨率,以及各项参数变化对桥梁建模的影响,并与传统方法作对比,为进一步针对桥梁的应用提供理论和技术支撑,推动桥梁复杂结构的高效、准确实景三维重建。

关键词： 3D高斯辐射场桥梁实景三维重建随机梯度下降可微光栅渲染

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Exploring the effect and mechanisms of Epimedium on diabetic testicular injury using network pharmacology,molecular docking,and cell experiments

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TMR Modern Herbal Medicine 2024年第2期7卷 19-27页

作者： Jun-Jun wei Qiong-Yao Xu Zhao-Wen Pan Yi-wei tu wei Yu Lan Huang Wen-Liang Zha College of Pharmacy Hubei University of Science and TechnologyXianning 437100China Xianning Medical College Hubei University of Science and TechnologyXianning 437100China School of Stomatology and Ophthalmology Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China

Background:Studying the potential targets and mechanisms of Epimedium for anti-diabetic testicular injury using network pharmacology,molecular docking,and cell ***:Acquisition of major components and targets of Epimedium was based on TCMSP,TCMID,and Symmap databases and retrieval of diabetic testicular injury targets by OMIM,GeneCards,Pharmgkb,and Drugbank *** targets were obtained from the Venny 2.1.0 database and input SRTING data to construct a protein-protein interaction(PPI)network,and key targets were screened in Cytoscape 3.8.0 *** the Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses of intersecting targets were conducted through the DAVID ***,AutoDock software was used to verify docking between the main components and the core target *** addition,a Cell Counting Kit-8(CCK-8)assay was used to determine the survival effect of quercetin,the main component of Epimedium,on TM4 sertoli-like cells exposed to palmitic acid(PA).Results:Quercetin,kaempferol and luteolin in epimedium were identified as the main components in the treatment of diabetic testicular *** has core target proteins including MMP9,AKT1,and *** biological process mainly involves the regulation of the apoptotic signaling *** key pathways of KEGG are the AGE-RAGE signaling pathway in diabetic complications,PI3K-Akt and MAPK signaling *** docking results showed that quercetin had the strongest binding ability to ***,PA-challenged cells had a lower survival rate,which was alleviated by the administration of ***:Our findings suggest that Epimedium attenuates diabetes mellitus(DM)-induced testicular injury through AGE-RAGE,PI3K-Akt and MAPK signaling *** insights offer a potential therapeutic strategy for managing DM-induced testicular injury,will be the basis for future clinical research.

关键词： Epimedium diabetic testicular injury network pharmacology molecular docking

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社交媒体数据支持的城市承灾体脆弱性评估——以深圳极端天气为例

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城市规划 2024年第8期48卷 101-113页

作者：范雅婷李越凡涂伟李云深圳大学建筑与城市规划学院深圳大学亚热带建筑与城市科学全国重点实验室深圳大学建筑与城市规划学院城市空间信息工程系深圳大学建筑与城市规划学院城市规划系深圳市建筑环境优化设计研究重点实验室

世界范围内极端天气频度和强度的显著增强,对高密度城市中公众和基础设施等承灾体造成严峻威胁,揭示和评估城市承灾体脆弱性对提升城市韧性具有重大意义。相对传统数据在极端突发灾害事件中的应用局限,社交媒体数据包含了实时且丰富时... 详细信息

世界范围内极端天气频度和强度的显著增强,对高密度城市中公众和基础设施等承灾体造成严峻威胁,揭示和评估城市承灾体脆弱性对提升城市韧性具有重大意义。相对传统数据在极端突发灾害事件中的应用局限,社交媒体数据包含了实时且丰富时空信息而呈现出巨大潜力。研究以2018年“山竹”台风灾害3个时间序列阶段和深圳76个街道的空间分布为例,获取并预处理灾害期间相关微博数据后,分别基于LDA模型和SnowNLP模型训练得到公众灾害感知脆弱性和公众情绪脆弱性,并基于语料库构建进一步细分得到6种类型的基础设施脆弱性。研究发现这3种脆弱性的集中峰值呈现依次滞后的时间序列特征以及南北圈层差异和“哑铃状”的空间分布特征。最后针对性提出提升城市承灾体脆弱性时空协调性的相关建议,对城市灾害韧性提供一定规划指引。

关键词：承灾体脆弱性社交媒体公众感知公众情绪基础设施承灾脆弱性

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Machine-learning-based models assist the prediction of pulmonary embolism in autoimmune diseases: A retrospective, multicenter study

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中华医学杂志(英文版) 2024年第15期137卷 1811-1822页

作者： Hu Ziwei Hu Yangyang Zhang Shuoqi Dong Li Chen Xiaoqi Yang Huiqin Su Linchong Hou Xiaoqiang Huang Xia Shen Xiaolan Ye Cong tu wei Chen Yu Chen Yuxue Cai Shaozhe Zhong Jixin Dong Lingli Department of Rheumatology and Immunology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Radiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Rheumatology and Immunology Jingzhou Central Hospital Yangtze University Jinzhou Hubei China Department of Rheumatology and Immunology Zhongnan Hospital Wuhan University Wuhan Hubei China Department of Rheumatology Wuhan No.Hospital Wuhan Hubei China Department of Rheumatology Minda Hospital of Hubei Minzu University Enshi Hubei China Department of Rheumatology and Immunology The First College of Clinical Medical Science China Three Gorges University Yichang Hubei China

Background: Pulmonary embolism (PE) is a severe and acute cardiovascular syndrome with high mortality among patients with autoimmune inflammatory rheumatic diseases (AIIRDs). Accurate prediction and timely intervention play a pivotal role in enhancing survival rates. However, there is a notable scarcity of practical early prediction and risk assessment systems of PE in patients with ***: In the training cohort, 60 AIIRD with PE cases and 180 age-, gender-, and disease-matched AIIRD non-PE cases were identified from 7254 AIIRD cases in Tongji Hospital from 2014 to 2022. Univariable logistic regression (LR) and least absolute shrinkage and selection operator (LASSO) were used to select the clinical features for further training with machine learning (ML) methods, including random forest (RF), support vector machines (SVM), neural network (NN), logistic regression (LR), gradient boosted decision tree (GBDT), classification and regression trees (CART), and C5.0 models. The performances of these models were subsequently validated using a multicenter validation ***: In the training cohort, 24 and 13 clinical features were selected by univariable LR and LASSO strategies, respectively. The five ML models (RF, SVM, NN, LR, and GBDT) showed promising performances, with an area under the receiver operating characteristic (ROC) curve (AUC) of 0.962-1.000 in the training cohort and 0.969-0.999 in the validation cohort. CART and C5.0 models achieved AUCs of 0.850 and 0.932, respectively, in the training cohort. Using D-dimer as a pre-screening index, the refined C5.0 model achieved an AUC exceeding 0.948 in the training cohort and an AUC above 0.925 in the validation cohort. These results markedly outperformed the use of D-dimer levels ***: ML-based models are proven to be precise for predicting the onset of PE in patients with AIIRD exhibiting clinical suspicion of *** Registration: ***: ChiCTR2200059599.

关键词： Autoimmune inflammatory rheumatic diseases Pulmonary embolism Predictive model Machine learning

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酒钢选矿厂3种铁矿石选矿试验研究

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甘肃科技 2024年第1期40卷 51-55页

作者：涂威张楠酒钢集团选矿厂甘肃嘉峪关735100 酒钢集团检验检测中心甘肃嘉峪关735100

高钙质铁白云石型铁矿石为酒钢选矿厂原料矿石之一,铁品位31.90%,CaO含量6.20%,主要铁矿物镜铁矿含量为26%,菱铁矿为11%,褐铁矿为20%,因现场使用该矿石后回收率指标大幅下降,严重影响选矿厂经济效益,为解决此问题,通过显微镜下观察以及... 详细信息

高钙质铁白云石型铁矿石为酒钢选矿厂原料矿石之一,铁品位31.90%,CaO含量6.20%,主要铁矿物镜铁矿含量为26%,菱铁矿为11%,褐铁矿为20%,因现场使用该矿石后回收率指标大幅下降,严重影响选矿厂经济效益,为解决此问题,通过显微镜下观察以及电子探针分析、强磁选试验、马弗炉还原焙烧-弱磁选试验等方法,与另外2种铁矿石桦树沟矿、黑沟矿进行对比试验研究。通过显微镜下观察以及电子探针发现高钙质铁白云石型铁矿石中的脉石矿物铁白云石Fe元素波动较大,在5.70%~15.46%,类质同象是造成尾矿Fe品位偏高、回收率偏低的主要原因;通过强磁选试验发现高钙质铁白云石型铁矿石强磁精矿中SiO2含量为11.19%,偏低,需进一步提高磁场强度以提高回收率;通过马弗炉还原焙烧-弱磁选试验发现,高钙质铁白云石型铁矿石还原焙烧温度需达到750℃时回收率才能显著提高。

关键词：还原焙烧菱铁矿铁矿石强磁选

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中部六省经济增长与工业三废脱钩关系

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桂林理工大学学报 2024年第2期44卷 321-329页

作者：刘嗣明涂玮胡伟博朱媛媛华中师范大学城市与环境科学学院暨中国两型社会建设改革试验区研究中心武汉430079 伊犁师范大学霍尔果斯商学院新疆伊宁835000

基于Tapio脱钩弹性系数模型,选取工业增加值、人均GDP、工业废水、工业废气、工业固体废弃物排放量等5个指标,对中部六省2005—2019年工业三废排放与工业增加值、人均GDP增长的脱钩关系进行实证研究。结果表明:时间上看,中部六省工业增... 详细信息

基于Tapio脱钩弹性系数模型,选取工业增加值、人均GDP、工业废水、工业废气、工业固体废弃物排放量等5个指标,对中部六省2005—2019年工业三废排放与工业增加值、人均GDP增长的脱钩关系进行实证研究。结果表明:时间上看,中部六省工业增加值与工业三废排放和人均GDP增长与工业三废排放的脱钩弹性系数无时序规律,但整体脱钩关系向绝对脱钩演变;工业增加值与工业三废排放量大部分处于脱钩状态,但状态不稳定,仍有少部分非脱钩状态存在;人均GDP增长与工业三废排放脱钩关系大部分处于相对脱钩和绝对脱钩状态,少部分呈扩张负脱钩和增长连结状态。空间上看,湖南省是两组脱钩关系中表现最优的省份,山西省是两组脱钩关系中表现最差的省份。

关键词：脱钩分析经济增长工业三废中部六省

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酒钢某周边铁矿石可选性试验研究

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酒钢科技 2024年第3期 1-6页

作者：赵国庆涂威酒钢集团宏兴股份公司选矿厂甘肃嘉峪关735100

酒钢某周边铁矿石通过模拟选矿厂生产流程,粉矿采用强磁工艺经过一粗两扫流程,块矿采用竖炉焙烧两段磨矿三段磁选、三段磨矿三段磁选以及弱磁精矿反浮选流程,对其可选性进行研究。结果表明:与酒钢镜铁山铁矿石相比,强磁选精矿品位高出... 详细信息

酒钢某周边铁矿石通过模拟选矿厂生产流程,粉矿采用强磁工艺经过一粗两扫流程,块矿采用竖炉焙烧两段磨矿三段磁选、三段磨矿三段磁选以及弱磁精矿反浮选流程,对其可选性进行研究。结果表明:与酒钢镜铁山铁矿石相比,强磁选精矿品位高出酒钢矿石4个百分点左右,弱磁选精矿品位低于酒钢矿石1个百分点左右,焙烧磁选铁回收率高,选矿比略低,精矿中SiO_(2)含量较高;粉矿强磁选铁回收率较低,不到70%,选矿比较高,精矿中SiO_(2)含量较高;反浮选后精矿铁品位可提高到62.92%,SiO_(2)含量下降到6.44%。由于精矿中SiO_(2)含量偏高,该矿石可以进入选矿厂选矿流程进行选别,对综精的整体指标提高及降低选比是不利的。

关键词：磁选反浮选精矿品位杂质可选性

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Strongly adaptive online learning over partial intervals

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Science China(Information Sciences) 2022年第10期65卷 107-121页

作者： Yuanyu WAN wei-wei tu Lijun ZHANG National Key Laboratory for Novel Software Technology Nanjing University 4Paradigm Inc.

To cope with changing environments, strongly adaptive algorithms that almost enjoy the optimal performance on every time interval have been proposed for online learning. However, the best regret bound of existing algorithms on each time interval with length τ is O((τlogT)1/2), and their complexities are increasing with a factor of O(log T), where T is the time horizon. In real-world applications, T could go to infinity,which means that even these logarithmic factors are unacceptable. In this paper, we propose to remove the logarithmic factors of existing algorithms by utilizing prior information of environments. Specifically, we assume a lower bound τ1and an upper bound τ2on how long the environment changes are given, and only focus on the performance over time intervals with length in [τ1, τ2]. Then, we propose a new algorithm with a refined set of intervals that can reduce the complexity and a simple weighting method that can cooperate with our interval set. Theoretical analysis reveals that the regret bound of our algorithm on any focused interval is optimal up to a constant factor. Both the regret bound and the computational cost per iteration are independent of T. Experimental results show that our algorithm outperforms the state-of-the-art algorithm.

关键词： online learning strongly adaptive changing environments weighting method regret bound

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