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Analysis of Sea Surface Temperature Cooling in Typhoon Events Passing the Kuroshio Current

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Journal of Ocean University of China 2024年第2期23卷 287-303页

作者： HU Yuyi SHAO weizeng SHEN wei ZUO Juncheng JIANG tao HU Song College of Marine Sciences Shanghai Ocean UniversityShanghai 201306China East China Sea Environment Monitoring Ministry of Natural ResourcesShanghai 201206China China Waterborne Transport Research Institute Ministry of TransportBeijing 100088China

The aim of this study is to investigate the sea surface temperature(SST) cooling as typhoons pass the Kuroshio Current.A numerical circulation model,denoted as the Stony Brook Parallel Ocean Model(sbPOM),was used to simulate the SST,which includes four wave-induced effect terms(i.e.,radiation stress,nonbreaking waves,Stokes drift,and breaking waves) simulated using the third-generation wave model,called WAVEWATCH-Ⅲ(WW3).The significant wave height(SWH) measurements from the Jason-2 altimeter were used to validate the WW3-simulated results,yielding a root mean square error(RMSE) of less than 0.50 m and a correlation coefficient(COR) of approximately *** water temperature measured from the Advanced Research and Global Observation Satellite was applied to validate the model ***,the RMSE of the SST is 0.92℃ with a COR of approximately *** revealed in the sbPOM-simulated SST fields,a reduction in the SST at the Kuroshio Current region was observed as a typhoon passed,although the water temperature of the Kuroshio Current is relatively *** variation of the SST is consistent with that of the current,whereas the maximum SST lagged behind the occurrence of the peak ***,the Stokes drift plays an important role in the SST cooling after analyzing four wave-induced terms in the background of the Kuroshio *** sensitivity experiment also showed that the accuracy of the water temperature was significantly reduced when including breaking waves,which play a negative role in the inside part of the *** variation in the mean mixing layer depth(MLD) showed that a typhoon could enhance the mean MLD in the Kuroshio Current area in September and October,whereas a typhoon has little influence on the mean MLD in the Kuroshio Current area in ***,the mean MLD rapidly decreased with the weakening of the strong wind force and wave-induced effects when a typhoon crossed the Kuroshio Current.

关键词： typhoon wave sea surface temperature Kuroshio Current

Micropillar compression using discrete dislocation dynamics and machine learning

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Theoretical & Applied Mechanics Letters 2024年第1期14卷 39-47页

作者： Jin tao Dean wei Junshi Yu Qianhua Kan Guozheng Kang Xu Zhang School of Mechanics and Aerospace Engineering Southwest Jiaotong UniversityChengdu 610031China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China

Discrete dislocation dynamics(DDD)simulations reveal the evolution of dislocation structures and the interaction of *** study investigated the compression behavior of single-crystal copper micropillars using fewshot machine learning with data provided by DDD *** types of features are considered:external features comprising specimen size and loading orientation and internal features involving dislocation source length,Schmid factor,the orientation of the most easily activated dislocations and their distance from the free *** yielding stress and stress-strain curves of single-crystal copper micropillar are predicted well by incorporating both external and internal features of the sample as separate or combined *** is found that the machine learning accuracy predictions for single-crystal micropillar compression can be improved by incorporating easily activated dislocation features with external ***,the effect of easily activated dislocation on yielding is less important compared to the effects of specimen size and Schmid factor which includes information of orientation but becomes more evident in small-sized ***,incorporating internal features,especially the information of most easily activated dislocations,improves predictive capabilities across diverse sample sizes and orientations.

关键词： Discrete dislocation dynamics simulations Machine learning Size effects Orientation effects Microstructural features

In situ tracking of the lithiation and sodiation process of disodium terephthalate as anodes for rechargeable batteries by Raman spectroscopy

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Nano Research 2024年第1期17卷 245-252页

作者： Xiu-Mei Lin Chong Han Xin-tao Yang Jia-Sheng Lin wei-Qiang Yang Hong-Xu Guo Yao-Hui wang Jin-Chao Dong Jian-Feng Li Department of Chemistry and Environment Science Fujian Province University Key Laboratory of Analytical ScienceMinnan Normal UniversityZhangzhou 363000China College of Energy College of Chemistry and Chemical EngineeringCollege of MaterialsState Key Laboratory of Physical Chemistry of Solid SurfacesiChEMXiamen UniversityXiamen 361005China Institute of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China

Organic compounds represent an appealing group of electrode materials for rechargeable batteries due to their merits of biomass,sustainability,environmental friendliness,and *** terephthalate(Na_(2)C_(8)H_(4)O_(4),Na_(2)TP),an organic salt with a theoretical capacity of 255 mAh·g^(-1),is electroactive towards both lithium and ***,its electrochemical energy storage(EES)process has not been directly observed via in situ characterization techniques and the underlying mechanisms are still under ***,in situ Raman spectroscopy was employed to track the de/lithiation and de/sodiation processes of *** appearance and then disappearance of the–COOLi Raman band at 1625 cm^(-1) during the de/lithiation,and the increase and then decrease of the–COONa Raman band at 1615 cm^(-1) during the de/sodiation processes of Na2TP elucidate the one-step with the 2Li+or 2Na+transfer *** also found that the inferior cycling stability of Na2TP as an anode for sodium-ion batteries(SIBs)than lithium-ion batteries(LIBs)could be due to the larger ion radium of Na+than Li+,which results in larger steric resistance and polarization during *** Na2TP,therefore,shows greater changes in spectra during de/sodiation than de/*** expect that our findings could provide a reference for the rational design of organic compounds for EES.

关键词： disodium terephthalate(Na_(2)C_(8)H_(4)O_(4) Na2TP) in situ Raman spectroscopy de/lithiation de/sodiation mechanisms

Genome mining of sulfonated lanthipeptides reveals unique cyclic peptide sulfotransferases

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2773-2785页

作者： Meng wang Wen-wei Li Zhe Cao Jianong Sun Jiang Xiong Si-Qin tao Tinghong Lv Kun Gao Shangwen Luo Shi-Hui Dong State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China

Although sulfonation plays crucial roles in various biological processes and is frequently utilized in medicinal chemistry to improve water solubility and chemical diversity of drug leads,it is rare and underexplored in ribosomally synthesized and post-translationally modified peptides(RiPPs).Biosynthesis of RiPPs typically entails modification of hydrophilic residues,which substantially increases their chemical stability and bioactivity,albeit at the expense of reducing water *** explore sulfonated RiPPs that may have improved solubility,we conducted co-occurrence analysis of RiPP class-defining enzymes and sulfotransferase(ST),and discovered two distinctive biosynthetic gene clusters(BGCs)encoding both lanthipeptide synthetase(LanM)and *** expressing these BGCs,we characterized the structures of novel sulfonated lanthipeptides and determined the catalytic details of LanM and *** demonstrate that SslST-catalyzed sulfonation is leader-independent but relies on the presence of A ring formed by *** LanM and ST are promiscuous towards residues in the A ring,but ST displays strict regioselectivity toward *** recognition of cyclic peptide by ST was further *** evaluation underscores the significance of the ST-catalyzed *** study sets up the starting point to engineering the novel lanthipeptide STs as biocatalysts for hydrophobic lanthipeptides improvement.

关键词： Lanthipeptides Sulfotransferases Sulfonation Biosynthesis Genome mining

Update on evidence-based clinical application of sodium-glucose cotransporter inhibitors:Insight to uncommon cardiovascular disease scenarios in diabetes

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World Journal of Diabetes 2024年第7期15卷 1461-1476页

作者： Shi-Bing tao Xi Lu Zi-wei Ye Nan-wei Tong Department of Endocrinology and Metabolism West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Research Centre for Diabetes and Metabolism West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Endocrinology and Metabolism Ziyang Central HospitalZiyang 641300Sichuan ProvinceChina

In this paper,we concentrate on updating the clinical research on sodium-glucose cotransporter inhibitors(SGLTis)for patients with type 2 diabetes who have heart failure with a preserved injection fraction,acute heart failure,atrial fibrillation,primary prevention of atherosclerotic cardiovascular disease/cardiovascular disease,and acute myocardial *** searched the data of randomized controlled trials and meta-analyses of SGLTis in patients with diabetes from PubMed between January 1,2020 and April 6,2024 for our *** to our review,certain SGLTis(empagliflozin,dapagliflozin,canagliflozin,and tofogliflozin),but not sodium-glucose cotransporter 1 inhibitor(SGLT1i),exhibit relatively superior clinical safety and effectiveness for treating the abovementioned *** utilization of SGLTis in these patients can foster clinical improvement and offer an alternative medication ***,clinical trials involving SGLTis for certain diseases have relatively small sample sizes,brief intervention durations,and conclusions based on weak evidence,necessitating additional *** findings are significant and valuable for providing a more comprehensive reference and new possibilities for the clinical utilization and scientific exploration of SGLTis.

关键词： Sodium-glucose cotransporter inhibitors Diabetes Heart failure Atrial fibrillation Atherosclerosis Cardiovascular disease Acute myocardial infarction

Mitochondria-targeted Janus mesoporous nanoplatform for tumor photodynamic therapy

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Chinese Chemical Letters 2024年第2期35卷 544-547页

作者： Min Dong Rui Tang Jing Li Jiajia Zhao Yu wang Lin Ouyang wei Lu Jun tao Meng Dang Yuxia Tang Zhaogang Teng Key Laboratory for Organic Electronics & Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced MaterialsJiangsu National Synergetic Innovation Centre for Advanced MaterialsNanjing University of Post and TelecommunicationsNanjing 210023China Laboratory of Molecular Imaging Department of RadiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Radiology The 909th HospitalSoutheast HospitalSchool of MedicineXiamen UniversityZhangzhou 363000China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsDonghua UniversityShanghai 201620China

Photodynamic therapy(PDT)is an effective treatment method for *** the specifically accumulated of photosensitizer was very difficult in the tumor site,which greatly limited the efficacy of ***,mitochondria-targeted Janus mesoporous nanoplatform(JPMO-Pt-CTPP-ZnPc)for PDT was prepared,the nanoplatform has uniform size(275 nm)and good dispersion and *** confocal laser scanning microscopy(CLSM)revealed the signal of ZnPc of JPMO-Pt-CTPP-ZnPc were higher than JPMO-Pt-ZnPc in tumor cells,and flow cytometry results showed the cell uptake efficiency of JPMO-Pt-CTPP-ZnPc was 2.5-fold higher than that of *** revealed the modification of CTPP significantly improves the targeting ability of the *** vitro anti-tumor experiment showed the JPMO-Pt-CTPP-ZnPc significantly inhibited the growth of tumor cells upon the irradiation of low-power laser,and the survival rate of cells incubated with 60μg/mL JPMO-Pt-CTPP-ZnPc was only 3%.Simultaneously,compared with JPMO-Pt-ZnPc(not modified with mitochondria targeting molecules CTPP),the PDT efficacy of JPMO-Pt-CTPP-ZnPc was significantly better,as it has targeted mitochondria in cells.

关键词： Mesoporous materials Janus particle Photodynamic therapy Mitochondria targeting Tumor treatment

Aggregation of CeAlO_(3) inclusions in heavy ingot of a steel containing 0.007% aluminum

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Journal of Iron and Steel Research International 2024年第8期31卷 1960-1972页

作者： Qiu-yue Zhou Jun-tao Ba Lun Zhang wei Chen Ying Ren Li-feng Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004HebeiChina School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144China

The distribution of inclusions at the bottom of a Ce-treated heavy steel ingot was detected and *** three-dimensional morphology and spatial distribution of CeAlOs clusters were characterized using the electrolytic extraction and Micro-CT detection.A model of inclusion collision to predict the aggregation of CeAlO_(3) inclusions in the ingot was established and validated by measured *** were mainly CeAlO_(3) and a small amount of Ce_(2)O_(2)S in the tundish after cerium *** collision and aggregation of inclusions led to the formation of large clusters in the ingot during the solidification *** slag entrainment inclusions,large CeAO_(3) clusters and small CeAlO_(3) particles were observed from the center to the edge of the ingot *** inclusions were mainly concentrated at the *** number density of inclusions larger than 200μm was 0.21 mm^(-3).The maximum diameter of CeA1O_(3) clusters was 1340μ*** the edge to the radial center and from the bottom to the top,the average diameter of inclusions gradually increased due to the longer solidification time of the ingot.

关键词： Inclusion Heavy ingot Cerium treatment Collision

IL13RA2 promotes progression of infantile haemangioma by activating glycolysis and the Wnt/β-catenin signaling pathway

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Oncology Research 2024年第9期32卷 1453-1465页

作者： ZIYONG LIU tao MA JINFANG LI wei REN ZHIXIN ZHANG Department of Cardiothoracic Surgery 970th Hospital of the People’s Liberation ArmyWeihai264209China Department of Cardiac Ultrasound Weihai Municipal HospitalWeihai264200China

Background:Interleukin 13 receptor subunit alpha 2(IL13RA2)plays an essential role in the progression of many ***,the role of IL13RA2 in infantile haemangioma(IH)is still *** and Methods:IL13RA2 expression in IH tissues was analyzed using western blot,qRT-PCR,and *** role of IL13RA2 in haemangioma-derived endothelial cells(HemECs)was determined following knockdown or overexpression of IL13RA2 using CCK-8,colony formation,apoptosis,wound healing,tubule formation,Transwell,and western ***:IL13RA2 expression was upregulated in IH ***13RA2 overexpression promoted proliferation,migration,and invasion of HemECs and induced glycolysis,which was confirmed with a glycolysis ***,IL13RA2 interacted withβ-catenin and activated the Wnt/β-catenin pathway in HemECs,which were involved in the above-mentioned effects of ***:These findings revealed that targeting IL13RA2 is a potential therapeutic approach for IH.

关键词： Infantile haemangioma IL13RA2 Glycolysis Wnt/β-catenin pathway

Linear group delay spectral interferometry for full-range precision absolute length metrology

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Photonics Research 2024年第2期12卷 313-320页

作者： JINDONG wang JINGSHENG HUANG QIHUA LIU wei DU FUMIN ZHANG tao ZHU Key Laboratory of Optoelectronic Technology&Systems(Ministry of Education) Chongqing UniversityChongqing 400044China State Key Laboratory of Precision Measuring Technology&Instruments Tianjin UniversityTianjin 300072China

The optical frequency comb serves as a powerful tool for distance measurement by integrating numerous stable optical modes into interferometric measurements,enabling unprecedented absolute measurement ***,due to the periodicity of its pulse train,the comb suffers from measurement dead zones and ambiguities,thereby impeding its practical ***,we present a linear group delay spectral interferometer for achieving precise full-range distance *** employing a carefully designed linear group delay(LGD)device for phase modulation of the comb modes,interference can occur and be easily measured at any *** approach effectively eliminates the dead zones and ambiguities in comb-based ranging,without the need for cumbersome auxiliary scanning reference devices or reliance on complex high-repetition-rate combs or high-resolution *** conducted length metrology experiments using a mode-locked comb referenced to a rubidium clock,achieving a large nonambiguity range up to 0.3 m,covering the entire measurement *** maximum deviation compared to a laser interferometer was less than 1.5μm,and the minimum Allan deviation during long-term measurements reached 5.47 nm at a 500 s averaging *** approach ensures high accuracy while maintaining a simple structure,without relying on complex external devices,thereby propelling the practical implementation of comb-based length metrology.

关键词： interferometer metrology delay