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Chinese Journal of Chemistry 2024年第4期42卷 343-350页

作者： Na Yao Juan Zhu Hongnan Jia Hengjiang Cong wei luo College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei430072 China

Developing highly efficient and low-cost electrocatalysts towards oxygen evolution reaction(OER)is essential for practical application in water electrolyzers and rechargeable metal-air batteries.Although Fe-based oxyhydroxides are regarded as state-of-the-art non-noble OER electrocatalysts,the origin of performance enhancement derived from Fe doping remains a hot topic of considerable discussion.Herein,we demonstrate that in situ generated Fe vacancies in the pristine CoFeOOH catalyst through a pre-conversion process during alkaline OER result from dynamic Fe dissolution,identifying the origin of Fe-vacancy-induced enhanced OER kinetics.Density functional theory(DFT)calculations and experimental results including X-ray absorption fine-structure spectroscopy,in situ UV-Vis spectroscopy,and in situ Raman spectroscopy reveal that the Fe vacancies could significantly promote the d-band center and valence states of adjacent Co sites,alter the active site from Fe atom to Co atom,accelerate the formation of high-valent active Co^(4+)species,and reduce the energy barrier of the potential-determining step,thereby contribute to the significantly enhanced OER performance.

关键词： CoFe oxyhydroxide Oxygen evolution reaction Fe vacancy Electrocatalysis Kinetics Reaction mechanisms

Enhancing the electrocatalytic performance of nitrate reduction to ammonia by in-situ nitrogen leaching

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Chinese Chemical Letters 2024年第2期35卷 564-569页

作者： Mimi Fu Yini Mao Hua Wang wei luo Yimin Jiang wei Shen Ming Li Rongxing He College of Chemistry and Chemical Engineering Southwest UniversityChongqing 400715China

Electrochemical nitrate reduction reaction (NITRR) is regarded as a “two birds-one stone” method for the treatment of nitrate contaminant in polluted water and the synthesis of valuable ammonia, which is retarded by the lack of highly reactive and selective electrocatalysts .Herein, for the first time, nickel foam supported Co_(4) N was designed as a high-performance NITRR catalyst by an in-situ nonmetal leaching-induced strategy.At the optimal potential, the Co_(4) N/NF catalyst achieves ultra-high Faraday efficiency and NH_(3) selectivity of 95.4% and 99.4%, respectively.Ex situ X-ray absorption spectroscopy (XAS), together with other experiments powerfully reveal that the nitrogen vacancies produced by nitrogen leaching are stable and play a key role in boosting nitrate reduction to ammonia.Theoretical calculations confirm that Co_(4) N with abundant nitrogen vacancies can optimize the adsorption energies of NO_(3)^(-) and intermediates, lower the free energy (Δ G ) of the potential-determining step (*NH_(3) to NH_(3) ) and inhibit the formation of N-containing byproducts.In addition, we also conclude that the nitrogen vacancies can stabilize the adsorbed hydrogen, making H_(2) quite difficult to produce, and lowering ΔG from *NO to *NOH, which facilitates the selective reduction of nitrate.This study reveals significant insights about the in-situ nonmetal leaching to enhance the NITRR activity.

关键词： Co4N Nitrate reduction In-situ nonmetal leaching Nitrogen vacancy Mechanism

Metastable face-centered cubic ruthenium-based binary alloy for efficient alkaline hydrogen oxidation electrocatalysis

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Journal of Energy Chemistry 2024年第5期92卷 207-215页

作者： Yunbo Li Jianchao Yue Chaoyi Yang Hongnan Jia Hengjiang Cong wei luo College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072HubeiChina

Metastable nanostructured electrocatalyst with a completely different surface environment compared to conventional phase-based electrocatalyst often shows distinctive catalytic property.Although Ru-based electrocatalysts have been widely investigated toward hydrogen oxidation reaction(HOR)under alkaline electrolytes,these studies are mostly limited to conventional hexagonal-close-packed(hcp)phase,mainly arising from the lack of sufficient synthesis strategies.In this study,we report the precise synthesis of metastable binary RuW alloy with face-centered-cubic(fcc)phase.We find that the introduction of W can serve as fcc phase seeds and reduce the formation energy of metastable fcc-RuW alloy.Impressively,fcc-RuW exhibits remarkable alkaline HOR performance and stability with the activity of 0.67 mA cm_(Ru)^(-2)which is almost five and three times higher than that of hcp-Ru and commercial Pt/C,respectively,which is attributed to the optimized binding strength of adsorbed hydroxide intermediate derived from tailored electronic structure through W doping and phase engineering.Moreover,this strategy can also be applied to synthesize other metastable fcc-RuCr and fcc-RuMo alloys with enhanced HOR performances.

关键词： Hydrogen oxidation reaction Metastable phase Face-centered cubic(fcc) Ru Phase engineering

Icariin ameliorates viral myocarditis by inhibiting TLR4-mediated ferroptosis

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 106-114,I0002-I0005页

作者： wei luo Yi Lu Jun-Hua Deng Peng Liu Yan Huang Wan-Xi Liu Chun-Li Huang Laboratory of the Atherosclerosis and Ischemic Cardiovascular Diseases Department of CardiologyAffiliated Hospital of Youjiang Medical University for NationalitiesYoujiang Medical University for NationalitiesBaiseGuangxi 533000China Department of Critical Care Medicine Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxi 533000China Department of Respiratory and Critical Care Medicine Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxi 533000China Postgraduate School of Youjiang Medical University for Nationalities BaiseGuangxi 533000China Department of Neonatology Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxi 533000China Department of Nephrology People’s Hospital of PubeiQinzhouGuangxi 535300China Urban Community Health Service Center of Youjiang District BaiseGuangxi 533000China

Objective:To explore the mechanism by which icariin alleviates viral myocarditis.Methods:CVB3-induced cardiomyocytes were used as an in vitro model of viral myocarditis to assess the effects of icariin treatment on cell viability,inflammation,and apoptosis.Moreover,the effects of icariin on ferroptosis and TLR4 signaling were assessed.After AC16 cells were transfected with TLR4 overexpression plasmids,the role of TLR4 in mediating the regulatory effect of icariin in viral myocarditis was investigated.Results:Icariin significantly elevated cell viability and reduced inflammatory factors TNF-α,IL-1β,IL-6,and IL-18.Flow cytometry revealed that icariin decreased apoptosis rate,and the protein expression of Bax and cleaved caspase 3 and 9 in CVB3-induced cardiomyocytes.Additionally,it suppressed ferroptosis including lipid peroxidation and ferrous ion,as well as the TLR4 signaling.However,TLR4 overexpression abrogated the modulatory effects of icariin.Conclusions:Icariin mitigates CVB3-induced myocardial injury by inhibiting TLR4-mediated ferroptosis.Further animal study is needed to verify its efficacy.

关键词： Viral myocarditis CVB3 TLR4 Ferroptosis Icariin

Residual alkali-evoked cross-linked polymer layer for anti-air-sensitivity LiNi_(0.89)Co_(0.06)Mn_(0.05)O_(2)cathode

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Journal of Energy Chemistry 2024年第5期92卷 450-458页

作者： Chao Zhao Xuebao Li Yun Zhao Jingjing He Yuanpeng Cao wei luo Ding Wang Jianguo Duan Xianshu Wang Baohua Li National and Local Joint Engineering Research Center of Lithium-ion Batteries and Materials Preparation Technology Key Laboratory of Advanced Battery Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093YunnanChina School of Materials Science and Engineering Central South UniversityChangsha 410083HunanChina Institute of Materials Research Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055Guangdong China City College Kunming University of Science and TechnologyKunming 650051YunnanChina

High-energy density lithium-ion batteries(LIBs)with layered high-nickel oxide cathodes(LiNi_(x)Co_(y)Mn_(1-x-y)O_(2),x≥0.8)show great promise in consumer electronics and vehicular applications.However,LiNi_(x)Co_(y)Mn_(1-x-y)O_(2)faces challenges related to capacity decay caused by residual alkalis owing to high sensitivity to air.To address this issue,we propose a hazardous substances upcycling method that fundamentally mitigates alkali content and concurrently induces the emergence of an anti-air-sensitive layer on the cathode surface.Through the neutralization of polyacrylic acid(PAA)with residual alkalis and then coupling it with 3-aminopropyl triethoxysilane(KH550),a stable and ion-conductive cross-linked polymer layer is in situ integrated into the LiNi_(0.89)Co_(0.06)Mn_(0.05)O_(2)(NCM)cathode.Our characterization and measurements demonstrate its effectiveness.The NCM material exhibits impressive cycling performance,retaining 88.4%of its capacity after 200 cycles at 5 C and achieving an extraordinary specific capacity of 170.0 mA h g^(-1) at 10 C.Importantly,this layer on the NCM efficiently suppresses unfavorable phase transitions,severe electrolyte degradation,and CO_(2)gas evolution,while maintaining commendable resistance to air exposure.This surface modification strategy shows widespread potential for creating air-stable LiNi_(x)Co_(y)Mn_(1-x-y)O_(2)cathodes,thereby advancing high-performance LIBs.

关键词： Lithium-ion batteries Nickel-rich layered cathode Residual alkalis Cross-linked polyme rmodification Airsensitivity

TEA domain transcription factor 1(TEAD1)induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1209-1220页

作者： Shuai Song Xiaokai Zhang Zihang Huang Yongchao Zhao Shuyang Lu Linqi Zeng Fengze Cai Tongyao Wang Zhiqiang Pei Xinyu Weng wei luo Hao Lu Zilun wei Jian Wu Peng Yu Li Shen Xiaochun Zhang Aijun Sun Junbo Ge Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghaiChina State Key Laboratory of Cardiology Zhongshan HospitalFudan UniversityShanghaiChina Key Laboratory of Viral Heart Diseases National Health CommissionShanghaiChina Key Laboratory of Viral Heart Diseases Chinese Academy of Medical SciencesShanghaiChina National Clinical Research Center for Interventional Medicine ShanghaiChina Department of cardiac surgery Zhongshan HospitalFudan UniversityShanghaiChina Institutes of Biomedical Sciences Fudan UniversityShanghaiChina Shanghai Institute of Hypertension Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Cardiac fibroblasts(CFs)are the primary cells tasked with depositing and remodeling collagen and significantly associated with heart failure(HF).TEAD1 has been shown to be essential for heart development and homeostasis.However,fibroblast endogenous TEAD1 in cardiac remodeling remains incompletely understood.Transcriptomic analyses revealed consistently upregulated cardiac TEAD1 expression in mice 4 weeks after transverse aortic constriction(TAC)and Ang-l infusion.Further investigation revealed that CFs were the primary cell type expressing elevated TEAD1 levels in response to pressure overload.Conditional TEAD1 knockout was achieved by crossing TEAD1-floxed mice with CFs-and myofibroblasts-specific Cre mice.Echocardiographic and histological analyses demonstrated that CFs-and myofibroblasts-specific TEAD1 deficiency and treatment with TEAD1 inhibitor,VT103,ameliorated TAC-induced cardiac remodeling.Mechanistically,RNA-seq and ChiP-seq analysis identified Wnt4 as a novel TEAD1 target.TEAD1 has been shown to promote the fibroblast-to-myofibroblast transition through the Wnt signalling pathway,and genetic Wnt4 knockdown inhibited the pro-transformation phenotype in CFs with TEAD1 overexpression.Furthermore,coimmunoprecipitation combined with mass spectrometry,chromatin immunoprecipitation,and luciferase assays demonstrated interaction between TEAD1 and BET protein BRD4,leading to the binding and activation of the Wnt4 promoter.In conclusion,TEAD1 is an essential regulator of the pro-fibrotic CFs phenotype associated with pathological cardiac remodeling via the BRD4/Wnt4 signallingpathway.

关键词： TEAD1 expression Wnt4

Interactions between myoblasts and macrophages under high glucose milieus result in inflammatory response and impaired insulin sensitivity

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World Journal of Diabetes 2024年第7期15卷 1589-1602页

作者： wei luo Yue Zhou Li-Ying Wang Lei Ai Department of Sports and Health Sciences Nanjing Sport InstituteNanjing 210014Jiangsu ProvinceChina Department of Exercise Physiology Beijing Sport UniversityBeijing 100084China Department of Sports Physiology Research Jiangsu Research Institute of Sports ScienceNanjing 210033Jiangsu ProvinceChina

BACKGROUND Skeletal muscle handles about 80% of insulin-stimulated glucose uptake and become the major organ occurring insulin resistance(IR).Many studies have confirmed the interactions between macrophages and skeletal muscle regulated the inflammation and regeneration of skeletal muscle.However,despite of the decades of research,whether macrophages infiltration and polarization in skeletal muscle under high glucose(HG)milieus results in the development of IR is yet to be elucidated.C2C12 myoblasts are well-established and excellent model to study myogenic regulation and its responses to stimulation.Further exploration of macrophages'role in myoblasts IR and the dynamics of their infiltration and polarization is warranted.AIM To evaluate interactions between myoblasts and macrophages under HG,and its effects on inflammation and IR in skeletal muscle.METHODS We detected the polarization status of macrophages infiltrated to skeletal muscles of IR mice by hematoxylin and eosin and immunohistochemical staining.Then,we developed an in vitro co-culture system to study the interactions between myoblasts and macrophages under HG milieus.The effects of myoblasts on macrophages were explored through morphological observation,CCK-8 assay,Flow Cytometry,and enzyme-linked immunosorbent assay.The mediation of macrophages to myogenesis and insulin sensitivity were detected by morphological observation,CCK-8 assay,Immunofluorescence,and 2-NBDG assay.RESULTS The F4/80 and co-localization of F4/80 and CD86 increased,and the myofiber size decreased in IR group(P0.8).In McM+HG group,F4/80+CD86+CD206-cells,monocyte chemoattractant protein 1,TNFα,IL-1βand IL-6 were increased,and F4/80+CD206+CD86-cells and IL-10 were decreased compared with Mc+HG group and McM group(P0.8).Compered to M group,myotube area,myotube number and E-MHC were increased in MMc group(P<0.

关键词： Macrophages phenotype Myoblasts Cross-talk Glucose toxicity Chronic inflammation Insulin sensitivity

High-Order Two-Scale Asymptotic Paradigm for the Elastodynamic Homogenization of Periodic Composites

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Acta Mechanica Solida Sinica 2024年第1期37卷 124-138页

作者： wei-Zhi luo Mu He Liang Xia Qi-Chang He State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China Laboratoire Modélisation et Simulation Multi-Echelle MSME UMR 8208 CNRSUniversite Gustave Eiffel77454 Marne-la-ValléeFrance

The classical two-scale asymptotic paradigm provides macroscopic and microscopic analyses for the elastodynamic homogenization of periodic composites based on the spatial or/and temporal variable,which offers an approximate framework for the asymptotic homogenization analysis of the motion equation.However,in this framework,the growing complexity of the homogenization formulation gradually becomes an obstacle as the asymptotic order increases.In such a context,a compact,fast,and accurate asymptotic paradigm is developed.This work reviews the high-order spatial two-scale asymptotic paradigm with the effective displacement field representation and optimizes the implementation by symmetrizing the tensor to be determined.Remarkably,the modified implementation gets rid of the excessive memory consumption required for computing the high-order tensor,which is demonstrated by representative one-and two-dimensional cases.The numerical results show that(1)the contrast of the material parameters between media in composites directly affects the convergence rate of the asymptotic results for the homogenization of periodic composites,(2)the convergence error of the asymptotic results mainly comes from the truncation error of the modified asymptotic homogenized motion equation,and(3)the excessive norm of the normalized wavenumber vector in the two-dimensional inclusion case may lead to a non-convergence of the asymptotic results.

关键词： Composites Homogenization Asymptotic analysis Dynamics Dispersion

Osteopontin(OPN)alleviates the progression of osteoarthritis by promoting the anabolism of chondrocytes

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Genes & Diseases 2023年第4期10卷 1714-1725页

作者： wei luo Zili Lin Yuhao Yuan Ziyi Wu wei Zhong Qing Liu Department of Orthopaedics Xiangya HospitalCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalChangshaHunan 410008China

Osteoarthritis(OA)is a chronic debilitating joint disease,characterized by degen-eration of the cartilage and loss of the cartilage matrix,and it is clinically manifested as joint pain.Osteopontin(OPN)is a glycoprotein that is abnormally expressed in the bone and carti-lage tissues and plays a vital role in various pathological processes such as the osteoarthritic inflammatory response and endochondral ossification.The focus of our study is to investigate the therapeutic potential and specific role of OPN in OA.Using morphological comparisons,we found that the cartilage was severely worn-out and there was a significant loss of the cartilage matrix in OA.OPN,CD44,and hyaluronic acid(HA)synthase 1(HAS1)were highly expressed,and the anabolism of HA was significantly higher in the OA chondrocytes than in the control chondrocytes.Additionally,we treated the OA chondrocytes with small interfering RNA(siRNA)targeting OPN,recombinant human OPN(rhOPN),and a combination of rhOPN and anti-CD44 antibodies.Furthermore,in vivo experiments were performed in mice.We found that OPN up-regulated the expression of downstream HAS1 and increased the anabolism of HA through CD44 protein expression in OA mice compared with those in control mice.Moreover,intra-articular injection of OPN in mice with OA significantly inhibited OA progression.In summary,OPN ini-tiates an intracellular cascade via CD44 which results in an anabolic increase in HA levels,thereby inhibiting OA progression.Therefore,OPN is a promising therapeutic agent in precision treatment of OA.

关键词： Cartilage degeneration CD44 Hyaluronic acid Osteoarthritis Osteopontin

An LSTM‐based approach to precise landing of a UAV on a moving platform

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International Journal of Mechanical System Dynamics 2022年第1期2卷 99-107页

作者： wei luo Henrik Ebel Peter Eberhard Institute of Engineering and Computational Mechanics University of StuttgartStuttgartGermany

A machine learning‐based method for the precise landing of an unmanned aerial vehicle on a moving mobile platform is proposed.The proposed approach attempts to predict the mobile platform's future trajectory based on the past states of the mobile platform.To that end,it combines a long short‐term memory‐based neural network with a Kalman filter.Hence,it aims at combining the advantages of a machine learning method with those of a state estimation method from established control theory.Based on the predicted trajectory,the unmanned aerial vehicle attempts to land precisely on the moving mobile platform.The experiment is conducted in the Gazebo simulation platform with a quadrotor and an omni-directional mobile robot,and the proposed method is compared with the single‐method approaches of using only either the Kalman filter or the machine learning method alone.

关键词： Kalman filter long short‐term memory(LSTM) trajectory prediction unmanned aerial vehicle(UAV)