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Pien Tze Huang Inhibits Proliferation of Colorectal Cancer Cells through Suppressing PNO1 Expression and Activating p53/p21 Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第6期30卷 515-524页

作者： CAO liu-jing liU li-ya CHEN You-qin HAN Yu-ying wei li-hui YAO Meng-ying FANG Yi WU Mei-zhu CHENG Ying Thomas J.Sferra liU hui-xin li li PENG Jun SHEN A-ling Clinical Research Institute the Second Affiliated Hospital&Academy of Integrative MedicineFujian University of Traditional Chinese MedicineFuzhou350122China Fujian Key Laboratory of Integrative Medicine in Geriatrics Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Pediatrics Case Western Reserve University School of MedicineUH Rainbow Babies and Children’s HospitalClevelandOH44106USA Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Health Management Fujian Provincial HospitalShengli Clinical College of Fujian Medical UniversityFuzhou000000China

ObjectiveTo explore the regulatory effect of Pien Tze Huang (PZH) on targeting partner of NOB1 (PNO1) and it’s down-stream mediators in colorectal cancer (CRC) *** polymerase chain reaction was performed to determine mRNA levels of PNO1, TP53, and CDKN1A. Western blotting was performed to determine protein levels of PNO1, p53, and p21. HCT-8 cells were transduced with a lentivirus over-expressing PNO1. Colony formation assay was used to detect cell survival in PNO1 overexpression of HCT-8 cells after PZH treatment. Cell-cycle distribution, cell viability and cell apoptosis were performed to identify the effect of PNO1 overexpression on cell proliferation and apoptosis of HCT-8 cells after PZH treatment. Xenograft BALB/c nude mice bearing HCT116 cells transduced with sh-PNO1 or sh-Ctrl lentivirus were evaluated. Western blot assay was performed to detect PNO1, p53, p21 and PCNA expression in tumor sections. Terminal deoxynucleotidyl transferase dUTP nick end labling (TUNEL) assay was used to determine the apoptotic cells in *** treatment decreased cell viability, down-regulated PNO1 expression, and up-regulated p53 and p21 expressions in HCT-8 cells (Plity, cell cycle arrest and cell apoptosis in vitro (Pliminated the effects of PZH treatment on tumor growth, inhibiting cell proliferation inhibition and apoptosis induction in vivo (Pliferative effect is at least in part by regulating the expression of PNO1 and its downstream targets p53 and p21.

关键词： colorectal cancer Pien Tze Huang Chinese medicine partner of NOB1 proliferation p53/p21 pathway

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超高分子量聚α-烯烃的高效合成及其减阻性能研究

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高分子学报 2024年第4期55卷 419-427页

作者：姜子豪李鑫源回立为康宇泽王菲蔡浩潘莉李悦生天津大学材料科学与工程学院天津300350 廊坊开发区中油科新化工有限责任公司廊坊065000

利用第四代Ziegler-Natta催化体系——负载在MgCl_(2)上的TiCl_(4)为主催化剂,三乙基铝(Et_(3)Al)为助催化剂,甲基环己基二甲氧基硅烷(CHMDMS)为外给电子体,在磁力搅拌和机械搅拌2种条件下催化1-辛烯和1-癸烯共聚合,制得了一系列高减阻... 详细信息

利用第四代Ziegler-Natta催化体系——负载在MgCl_(2)上的TiCl_(4)为主催化剂,三乙基铝(Et_(3)Al)为助催化剂,甲基环己基二甲氧基硅烷(CHMDMS)为外给电子体,在磁力搅拌和机械搅拌2种条件下催化1-辛烯和1-癸烯共聚合,制得了一系列高减阻性能聚α-烯烃(Poly-alpha-olefin,PAO)类减阻剂.利用高温凝胶渗透色谱仪测得聚合物的重均分子量(M_(w))在3×10^(6)以上,分子量分布指数(PDI)基本在3.04以内.进一步通过低温机械搅拌可实现更窄的聚合物分子量分布(1.27~1.90).通过核磁共振(^(13)C-NMR)对聚合物进行分子结构表征,结果表明得到了目标产物、无单体残留,且聚合物中单体比例与投料比基本一致.示差扫描量热法(DSC)和X射线衍射(XRD)测试结果表明,成功合成了无结晶行为的聚合物.热重分析(TGA)结果表明,该聚合物在氮气气氛下的热分解温度在300℃以上,远高于使用温度.环路管道循环实验表明,随着聚合物分子量增加,减阻效率整体呈增加趋势,共聚物的减阻效率大于均聚物;随着单体与催化剂的摩尔比增加,减阻效率先升高后降低.相较已有报道,减阻性能有较大提升,最高减阻率可达50%.

关键词：减阻剂聚α-烯烃减阻率 Ziegler-Natta催化剂

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Sleep disturbances and psychomotor retardation in the prediction of cognitive impairments in patients with major depressive disorder

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World Journal of Psychiatry 2024年第10期14卷 1474-1483页

作者： Mi Wang Wen-Tao Chen Hao-Ting Wang Bang-Shan liu Yu-Meng Ju Qiang-li Dong Xiao-Wen Lu Jin-Rong Sun liang Zhang Hua Guo Fu-Tao Zhao wei-hui li li Zhang Ze-Xuan li Mei liao Yan Zhang Jin liu ling-Jiang li Department of Mental Health Center Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina National Clinical Research Center of Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Psychiatry National Clinical Research Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Department of Psychiatry Zhumadian Psychiatric HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Symptoms of depression and comorbid anxiety are known risk factors for cognitive impairment in major depressive disorder(MDD).Understanding their relationships is crucial for developing targeted interventions to mitigate cognitive impairments in MDD *** expect that the severity of sleep disturbances and other depressive symptoms will be positively correlated with the degree of cognitive *** also hypothesize that anxiety symptoms,especially psychic anxiety,is a key factor in predicting cognitive performance in MDD patients and may indirectly contribute to cognitive impairment by affecting sleep disturbances and other potential *** To determine which dimension of the depressive and anxiety symptoms predicts cognitive impairment during a depressive *** A comprehensive neurocognitive test battery assessed executive function,attention,processing speed,and memory in 162 medication-free MDD patients and 142 matched healthy *** 24-item Hamilton Depression Rating Scale was used to assess depressive symptoms,and the 14-item Hamilton Anxiety Scale was used to assess anxiety *** regression analyses and mediation analyses were conducted to evaluate the impact of depressive and anxiety symptoms,as well as their interactions,on cognitive *** Among the depressive symptoms,sleep disturbances were associated with poorer executive function(P=0.004),lower processing speed(P=0.047),and memory impairments(P<0.001),and psychomotor retardation(PR)was associated with lower processing speed in patients with MDD(P=0.019).Notably,PR was found to mediate the impact of sleep disturbances on the processing *** anxiety symptoms,psychic anxiety,rather than somatic anxiety,was associated with cognitive impairments in all *** disturbances mediated the effect of psychic anxiety on executive function[β=-0.013,BC CI(-0.027,-0.001)]and memory[β=-0.149,BC CI(-0.237,-0.063)],while PR mediated its ef

关键词： Major depressive disorder Cognitive impairment Depressive symptoms Anxiety symptoms Sleep disturbance Psychomotor retardation

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Statistical study of EUV and X-ray transient brightenings

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Research in Astronomy and Astrophysics 2010年第7期10卷 696-706页

作者： Jing-wei li hui li Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China

Using the visual inspection and base difference method and data from the X-ray Telescope （XRT） onboard Hinode and TRACE with improved spatial and temporal resolution, we selected 48 X-ray transient brightenings （XTBs） and 237 EUV transient brightenings （ETBs） to study the connection between these two types of transient brightenings （TBs）. These ETBs and XTBs have smaller areas （8.42 Mm^2 and 36.3 Mm^2, respectively, on average） and shorter durations （9.0 min and 6.9 min, respectively, on average） than previous studies. These XTBs show three types of morphological structure： point-like, single-loop and multiple-loop. We find only 20% of the ETBs have corresponding XTBs while the other 80% have no X-ray signatures at all. This is presumably due to the small amount of released energy, which is not enough to heat the plasma to coronal temperatures which produce X-ray emission rather than being due to the limitation of spatial resolution and temperature sensitivity of the X-ray instrument. These small ETBs may significantly contribute to the coronal heating.

关键词： Sun X-rays, gamma rays -- Sun UV radiation -- Sun corona

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Assessment of Rice Cultivars in China for Field Resistance to Aphelenchoides besseyi

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Journal of Integrative Agriculture 2014年第10期13卷 2221-2228页

作者： FENG hui wei li-hui liN Mao-song ZHOU Yi-jun College of Plant Protection Nanjing Agricultural University Institute of Plant Protection Jiangsu Academy of Agricultural Sciences

The effect ofAphelenchoides besseyi on 27 cultivars of rice （23japonica and 4 indica） was assessed in the field for two seasons during 2010 and 2011. The vigorous pathogenic nematodes culturing on Botrytis cinerea were used for this experiment. Inoculation was carried out at the tilling stage; the growth parameters and nematode population were recorded at the end of growth of rice plants. The results showed that the cultivars differed in their response to infection. Most of cultivars were lack of the characteristic symptom of white tip, which was seen less frequently than the other two symptoms, namely small grains and erect panicles; moreover, the expression of symptoms was probably hereditary. The infection lowered the values of all the measured biological parameters, namely length of the stem and of the panicle, the number of filled grains per panicle, and 100-grain weight, in all the cultivars. The final nematode population indicated that the threshold of economic damage had also been exceeded in 10 cultivars, and none of them was immune. Three japonica cultivars proved most vulnerable whereas Tetep, an indica type, showed a level of resistance potentially useful in controlling A. besseyi.

关键词： Aphelenchoides besseyi rice symptom expression yield loss resistance assessment

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Scutellaria barbata *** Inhibits Colorectal Cancer Growth via Suppression of Wnt/β-Catenin Signaling Pathway

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Chinese Journal of Integrative Medicine 2017年第11期23卷 858-863页

作者： wei li-hui liN Jiu-mao CHU Jian-feng CHEN Hong-wei li Qing-yu PENG Jun Academy of Integrative Traditional Chinese Medicine.Medicine Fujian University of Fuzhou(350122)China Fujian Key Laboratory of Integrative Medicine on Geriatrics Fujian University of Traditional Chinese MedicineFuzhou(350122)China

Objective： To investigate the effect of the ethanol extract of Scutellaria barbata D. Don（EESB） on colorectal cancer（CRC） growth and Wnt/β-catenin signaling pathway in vivo and in vitro. Methods： In vivoexperiment, CRC xenograft mouse model was constructed with injection of HT-29 cells. Following xenograft implantation, twenty mice were randomly divided into EESB-treated group（n=10） and control group（n=10） by a random number table, and were given with intra-gastric administration of 2 g/kg EESB or saline, 5 days a week for 16 days, respectively. At the end of experiment, tumors were removed and weighed by electronic scales. The proliferation biomarker Ki-67 of tumor was evaluated by immunohistochemistry（IHC） assay. In vitro study, HT-29 cells were treated with 0, 0.5, 1.5, 2.5 mg/m L EESB for 24 h. At the end of the treatment, the viability and survival of HT-29 cells were determined by methylthiazolyldiphenyl-tetrazolium bromide（MTT） assay and colony formation assay, respectively. The m RNA expression of c-Myc, Survivin and adenomatous polyposis coli（APC） was examined by reverse transcription-polymerase chain reaction（RT-PCR） both in tumor tissues of CRC xenograft mice and HT-29 cells. Protein expression of c-Myc, Survivin, APC, and β-catenin as well as β-catenin phosphorylation level were evaluated by IHC assay or Western blotting. Results： EESB significantly reduced tumor weight in CRC xenografts mice, compared with the control group（P〈0.05）. IHC assay showed that EESB significantly inhibited protein expression of Ki-67 in tumor tissues（P〈0.05）. MTT assay showed that EESB significantly reduced HT-29 cell viability in a dose-dependent manner（P〈0.05）. Colony formation assay showed that EESB dose-dependently decreased the survival of HT-29 cells（P〈0.05）. In addition, RT-PCR assay showed that EESB decreased the m RNA expression of c-Myc and Survivin and increased APC expression, both in tumor tissues of CRC xenograft mice and HT-29 cells（P〈0.05）. IHC assay or Western

关键词： Scutellaria barbata D.Don colorectal cancer proliferation Wnt/β-catenin pathway

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Commwarrior worm propagation model for smart phone networks

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The Journal of China Universities of Posts and Telecommunications 2008年第2期15卷 60-66页

作者： XIA wei li Zhao-hui CHEN Zeng-qiang YUAN Zhu-zhi College of Information Technical Science Nankai UniversityTianjin 300071 China

Commwarrior worm is capable of spreading through both Bluetooth and multimedia messaging service （MMS） in smart phone networks. According to the propagation characteristics of Bluetooth and MMS, we built the susceptibleexposed-infected-recovered-dormancy （SEIRD） model for the Bluetooth and MMS hybrid spread mode and performed the stability analysis. The simulation results show good correlation with our theoretical analysis and demonstrate the effectiveness of this dynamic propagation model. On the basis of the SEIRD model, we further discuss at length the influence of the propagation parameters such as user gather density in groups, moving velocity of smart phone, the time for worm to replicate itself, and other interrelated parameters on the propagation of the virus. On the basis of these analytical and simulation results, some feasible control strategies will be proposed to restrain the spread of mobile worm such as commwarrior on smart phone network.

关键词： smart phone virus spreading model Bluetooth,MMS

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Robust Interval State Estimation for Distribution Systems Considering Pseudo-measurement Interval Prediction

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 179-188页

作者： Xu Zhang wei Yan Meiqing Huo hui li the School of Electrical Engineering Chongqing UniversityChongqing 400044China

Interval state estimation(ISE)can estimate state intervals of power systems according to confidence intervals of predicted pseudo-measurements,thereby analyzing the impact of uncertain pseudo-measurements on ***,predicted pseudo-measurements have prediction errors,and their confidence intervals do not necessarily contain the truth values,leading to estimation biases of the *** solve this problem,this paper proposes a pseudo-measurement interval prediction framework based on the Gaussian process regression(GPR)model,thereby improving the prediction accuracy of pseudo-measurement confidence ***,a weight assignment strategy for improving the robustness of weighted least squares(WLS)ISE is *** strategy quantifies the deviation between the pseudo-measurement intervals and their estimated intervals and assigns smaller weights to the pseudo-measurement intervals with larger deviations,thereby improving the estimation accuracy and robustness of the *** paper adopts the data from the supervisory control and data acquisition(SCADA)system of the New York Independent System Operator(NYISO).It verifies the advantages of the GPR method for pseudo-measurement interval prediction by comparing it with the quantile regression and neural network *** addition,this paper demonstrates the effectiveness of the proposed weight assignment strategy through the IEEE 14-bus ***,the differences in the estimation accuracy and the bad data identification between the robust interval state estimation and deterministic state estimation are discussed.

关键词： Interval state estimation interval analysis pseudo-measurement Gaussian process regression(GPR)

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An improved deep dilated convolutional neural network for seismic facies interpretation

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Petroleum Science 2024年第3期21卷 1569-1583页

作者： Na-Xia Yang Guo-Fa li Ting-hui li Dong-Feng Zhao wei-wei Gu State Key Laboratory of Petroleum Resources and Engineering CNPC Key Lab of Geophysical ExplorationChina University of Petroleum(Beijing)Beijing 102249China Dagang Branch Research InstituteBGPTianjin300280China

With the successful application and breakthrough of deep learning technology in image segmentation,there has been continuous development in the field of seismic facies interpretation using convolutional neural *** intelligent and automated methods significantly reduce manual labor,particularly in the laborious task of manually labeling seismic ***,the extensive demand for training data imposes limitations on their wider *** overcome this challenge,we adopt the UNet architecture as the foundational network structure for seismic facies classification,which has demonstrated effective segmentation results even with small-sample training ***,we integrate spatial pyramid pooling and dilated convolution modules into the network architecture to enhance the perception of spatial information across a broader *** seismic facies classification test on the public data from the F3 block verifies the superior performance of our proposed improved network structure in delineating seismic facies *** analysis against the traditional UNet model reveals that our method achieves more accurate predictive classification results,as evidenced by various evaluation metrics for image ***,the classification accuracy reaches an impressive 96%.Furthermore,the results of seismic facies classification in the seismic slice dimension provide further confirmation of the superior performance of our proposed method,which accurately defines the range of different seismic *** approach holds significant potential for analyzing geological patterns and extracting valuable depositional information.

关键词： Seismic facies interpretation Dilated convolution Spatial pyramid pooling Internal feature maps Compound loss function

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Resistance analysis of the rice variety Huaidao 5 against root-knot nematode Meloidogyne graminicola

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Journal of Integrative Agriculture 2023年第10期22卷 3081-3089页

作者： FENG hui ZHOU Can-rong ZHU Feng LE Xiu-hu JING De-dao Paul DALY ZHOU Dong-mei wei li-hui Institute of Plant Protection Jiangsu Academy of Agricultural SciencesNanjing 210014P.R.China Plant Protection and Quarantine Station of Jiangsu Province Nanjing 210009P.R.China School of Landscape and Ecological Engineering Hebei University of EngineeringHandan 056038P.R.China Zhenjiang Institute of Agricultural Science in Hilly Area of Jiangsu Province Jurong 212400P.R.China

Meloidogyne graminicola has emerged as one of the most destructive plant-parasitic nematodes affecting rice(Oryza sativa)production *** to *** in rice could be the most effective option for its ***,sources of germplasm with resistance to *** in rice remain ***,we describe the root attraction,gall formation and genetic analysis of the resistance to *** in the rice variety huidao 5.A nematode attraction assay showed that second-stage juveniles(J2s)of *** were attracted at the root tip of Huaidao 5 within 8 h without a significant reduction in attraction compared to the susceptible rice variety Nanjing *** observation of the infection revealed that the J2s invaded root tissues 12 h after inoculation,but their subsequent movement to the root tip was hindered in Huaidao 5,resulting in decreased nematode number compared to Nanjing ***,we used the soil and hydroponic culture systems to simulate upland and flooding conditions in the paddy fields respectively,and found that gall number was significantly reduced,and nematode development was clearly suppressed in Huaidao *** investigate the genetic basis of this resistance,cross breeding was performed between the Huaidao 5 and Nanjing 9108 *** was no reduction in the resistance of the F_(1) offspring to *** in the greenhouse or field trials,suggesting that a dominant gene could control resistance in Huaidao *** summary,this study provides a detailed characterization of a novel source of resistance to *** in rice,which is of great potential for use in crop breeding.

关键词： root-knot nematode Meloidogyne graminicola rice resistance

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