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Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients

Chinese Medical Journal 2013年第12期126卷 2276-2280页

作者： zheng ying CAI guang-yan chen Xiang-mei FU Ping chen jiang-hua DING Xiao-qiang YU xue-qing liN Hong-li liu jian XIE Ru-juan WANG li-ning NI Zhao-hui liu Fu-you YIN Ai-ping XING Chang-ying WANG li SHI wei liu jian-she HE ya-ni DING guo-hua li Wen-ge WU guang-li MIAO li-ning chen Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang gu Yong BAI Yun-kai LUO Hui-min liN Shan chen Meng-hua GONG li yanG Yi-bin yanG Xiao-ping li ying WAN jian-xin WANG Nian-song li Hai-ying XI Chun-sheng HAO li XU yan fang Jing-ai liu Bi-cheng li Rong-shan WANG Rong ZHANG Jing-hong WANG jian-qin LOU Tan-qi SHAO Feng-min MEI Feng liu Zhi-hong YUAN wei-jie SUN Shi-ren ZHANG ling ZHOU Chun-hua chen qin-kai JIA Shun-lian GONG Zhi-feng guAN guang-ju XIA Tian ZHONG liang-bao Department of Nephrology State key Laboratory of Kidney Disease Chinese PLA General Hospital Beijing 100853 China Nephrology Institute of the Chinese People's liberation Army Chinese People's Liberation Army Key Laboratory of Nephrology Beijing 100853 China Department of Nephrology West China Hospital of Sichuan University Chengdu Sichuan 610041 China Department of Nephrology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China Department of Nephrology Zhongshan Hospital Fudan University Shanghai 200032 China Department of Nephrology First Affiiated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China Department of Nephrology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China Department of Nephrology First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China Department of Nephrology First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Nephrology First Afftiated Hospital of China Medical University Shenyang Liaoning 110001 China Department of Nephrology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China Department of Nephrology Second Xiangya Hospital Central South University Changsha Hunan 410000 China Department of Nephrology First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Nephrology First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital) Nanjing Jiangsu 210029 China Department of Nephrology Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China Department of Nephrology Guangdong Provincial People's Hospital Guangzhou Guangdong 510030 China Department of Nephrology Affliated Xiehe Hospital Tongji Medical College Huazhong Science and Technology University Wuhan Hubei 430022 China Department of Nephrology Daping Hospital Third Military Medi

Background Data on the epidemiology of hypertension in Chinese non-dialysis chronic kidney disease （CKD） patients are *** aim of the present study was to investigate the prevalence,awareness,treatment,and control of hypertension in the non-dialysis CKD patients through a nationwide,multicenter study in *** The survey was performed in 61 tertiary hospitals in 31 provinces,municipalities,and autonomous regions in China （except Hong Kong,Macao,and Taiwan）.Trained physicians collected demographic and clinical data and measured blood pressure （BP） using a standardized *** was defned as systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg,and/or use of antihypertensive *** 〈140/90 mmHg and 〈130/80 mmHg were used as the 2 thresholds of hypertension *** multivariate logistic regression with adjustment for sex and age,we analyzed the association between CKD stages and uncontrolled hypertension in non-dialysis CKD *** The analysis included 8927 non-dialysis CKD *** prevalence,awareness,and treatment of hypertension in non-dialysis CKD patients were 67.3%,85.8%,and 81.0%,*** hypertensive CKD patients,33.1% and 14.1% had controlled BP to 〈140/90 mmHg and 〈130/80 mmHg,*** successive CKD stages,the prevalence of hypertension in non-dialysis CKD patients increased,but the control of hypertension decreased （P〈0.001）.When the threshold of BP 〈130/80 mmHg was considered,the risk of uncontrolled hypertension in CKD 2,3a,3b,4,and 5 stages increased 1.3,1.4,1.4,2.5,and 4.0 times compared with CKD 1 stage,respectively （P〈0.05）.Using the threshold of 〈140/90 mmHg,the risk of uncontrolled hypertension increased in advanced stages （P〈0.05）.Conclusions The prevalence of hypertension Chinese non-dialysis CKD patients was high,and the hypertension control was *** successive CKD stages,the risk of uncontrolled hypertension increased.

关键词： non-dialysis chronic kidney disease chronic kidney disease stages hypertension epidemiology

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Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)

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Military Medical Research 2022年第4期9卷 389-403页

作者： Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong chen Xing chen Xiao-ming Zha Wen-Jie Dai Zhi-Jun Dai qin-Yu Feng qing-Jun Gao Run-fang Gao Bao-San Han Jin-Xuan Hou wei Hou Hai-ying liao Hong Luo zheng-Ren liu Jing-hua Lu Bin Luo Xiao-Peng Ma Jun Qian jian-Yong qin wei wei gang wei li-ying Xu Hui-Chao xue hua-wei yang wei-Ge yang Chao-Jie Zhang Fan Zhang guan-Xin Zhang Shao-Kun Zhang Shu-qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-wei Zhao Xiang-min zheng Le-wei zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu Department of Thyroid and Breast Surgery Zhongnan Hospital of Wuhan UniversityWuhan430071China Department of Pathology University of Chicago Pritzker School of MedicineChicagoIL60637USA Department of Surgical Oncology and Breast Surgery Oncology CenterFaculty of MedicineMansoura UniversityMansoura35516Egypt Department of Breast Surgery Beijing University of Chinese MedicineBeijing100700China Department of Infectious Diseases and Tropical Medicine Faculty of MedicineMashhad University of Medical SciencesMashhad***Iran Breast Department KK Women’s and Children’s Hospital100 Bukit Timah RoadSingapore229899Singapore Department of Surgery Department of Public HealthDepartment of BiostatisticsBioinformatics and Medical InformaticsInonu University Faculty of Medicine44280MalatyaTurkey Department of General Surgery Faculty of MedicineÇanakkale Onsekiz Mart University17020ÇanakkaleTurkey Department of Radiology Cancer InstituteImam Khomeini HospitalTehran University of Medical SciencesTehran***Iran Department of Surgery College of Medicine and Medical SciencesArabian Gulf University-BahrainManama26671Bahrain Department of Radiology International Faculty of MedicineIstanbul Medipol University34810IstanbulTurkey Department of General Surgery Faculty of MedicineSakarya University54050SakaryaTurkey Department of Surgery HiU Clinic170Gwongwang-roPaldal-guSuwon16488Korea Department of Radiology Faculty of MedicineAtaturk University25240ErzurumTurkey Academic Support and Education Center Hırkai Serif DistrictKececi Cesmesi StrDoktorlar BuildingB/734091IstanbulTurkey Department of General and Digestive Surgery Hospital General CastellonAvda Benicassim S/N12812004CastellónSpain Radiology Department Ankara Training and Research Hospital305018AnkaraTurkey Department of Surgery The University of Hong KongChina The University of Hong Kong-Shenzhen Hospital Shenzhen518053China University of Miami Health System and Miller School of Medicine 1475 NW 12th AvenueM

Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the *** of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and *** approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM.

关键词： Granulomatous mastitis Granulomatous lobular mastitis Idiopathic granulomatous mastitis Diagnosis Treatment

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Hec1基因表达沉默对胃癌细胞凋亡及分裂周期的影响

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上海交通大学学报（医学版） 2006年第8期26卷 852-855页

作者：瞿颖蔡劬陈雪华李建芳王运伟朱正纲刘炳亚上海交通大学医学院瑞金医院外科上海市消化外科研究所上海200025

目的研究癌症高表达(Hec1)基因表达沉默对胃癌细胞AGS分裂周期及细胞凋亡的影响。方法应用siRNA使Hec1基因表达下调,通过实时定量PCR检测Hec1mRNA表达抑制率;流式细胞仪检测细胞周期变化,经AnnexinV/PI双染色检测细胞凋亡率。结果胃癌细... 详细信息

目的研究癌症高表达(Hec1)基因表达沉默对胃癌细胞AGS分裂周期及细胞凋亡的影响。方法应用siRNA使Hec1基因表达下调,通过实时定量PCR检测Hec1mRNA表达抑制率;流式细胞仪检测细胞周期变化,经AnnexinV/PI双染色检测细胞凋亡率。结果胃癌细胞AGS转染Hec1siRNA48h后,Hec1基因表达抑制率达到90%;流式细胞仪检测发现,细胞G2/M期比例显著高于各对照组(P<0.05),细胞分裂被阻滞,出现明显凋亡;形态学检测发现,Hec1siRNA转染48h后处于分裂中期细胞高于各对照组,转染72h后细胞呈明显凋亡形态学改变。AnnexinV/PI双染色法显示Hec1基因沉默后细胞凋亡率高于对照(P<0.05)。结论抑制Hec1基因表达,可以明显阻滞细胞分裂并停留在有丝分裂中期,同时诱导细胞凋亡。

关键词：癌症高表达蛋白凋亡细胞周期 siRNA 胃癌

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Chinese expert consensus on the management of hypertension in the very elderly

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Journal of Geriatric Cardiology 2016年第12期13卷 945-953页

作者： Jing li Yi-Xin HU Wen WANG Ning-Yuan fang Xin-zheng LU lin PI Mei-lin liu wei-min li yan-fang li Peng qu Qi hua qing HE Hai-ying WU Yuan-ming ZHANG Xiao-Ping chen Lu-Yuan chen li FAN Xing-Sheng ZHAO Zhi-ming zhu Yi-Nong jianG Yi-fang guO Hong YUAN Ping-Jin GAO Xin-Juan XU Jun CAI liang-Di XIE Xuan Wu Hospital Capital Medical University Beijing China Chinese PLA General Hospital Beijing China Chinese Academy of Medical Science Fuwai Hospital Beijing China Renji Hospital Medical College of Shanghai Jiao Tong University ShanghaL China jiang Su Province People's Hospital jiangsu China Beijing Chui yang liu Hospital Beijing China Peking University First Hospital Beijing China First Affiliated Hospital of Harbin Medical University Heilongjiang China Beijing An Zhen Hospital Capital Medical University Beijing China The Second Affiliated Hospital of Dalian Medical University Liaoning China Beijing Hospital Beijing China The First Hospital of Xinjiang Medical University Xinjiang Uygur Autonomous Region China West China Hospital Sichuan University Sichuan China The People's Hospital of guangdong Province Guangdong China Inner Mongolia Autonomous Region People's Hospital Inner Mongolia Autonomous Region China Daping Hospital the Third Military Medical University Chongqing China The First Affiliated Hospital of Dalian Medical University Liaoning China Hebei Province People's Hospital Hebei China Xiangya Third Hospital Central South University Hunan China Shanghai Hypertension Research Institute Shanghai China The First Hospital of Fujian Medical University Fujian China

Population aging has become a major challenge for the healthcare in China. More than 23 million Chinese are cur- rently ≥ 80 years, with an annual increase of 5%. The Chi- nese population of 80 years or older is expe... 详细信息

关键词： Consensus Geriatric Hypertension Octogenarians

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Consensus statement on layout and delivery of automatic external defibrillator in China

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Journal of Hainan Medical University 2020年第15期26卷 18-23页

作者： Yu Cao Song chen yan-Fen Chai Xiao-Hui chen Yu-guo chen Shao-Wen cheng Wen-wei cheng Bang-Han Ding yang Deng Jie Fu Bang-jiang fang Mai-ying Fan li gui Ping Gong wei guo Shu-Bin guo liang huang Ji-Yuan Han Zhong Ji Xian-Fei Ji Xin-Cai Ji Hong-Xu Jin Xin-Jun jiang Wang-Xiang jiang Jia-liang liu Xiao-Ran liu Zhi liu Chuan-zhu Lv Feng Lu Tan-Shi li Xin li Yong li Shang-Lun li Shuang-ming li Xiao-gang li Bao-Jun li Pei-Wu li Chun-Sheng li Zhi-Jun li Chang-Luo li Xiang-min li Yin-Ping li Zong-Jun Lu Zu-Xun Lu Zhong-Qiu Lu Zhi-Qian Luo Xiao-Xing liao jian-Bo Lei Tao Ma Yu Ma Yue-Feng Ma qing-Bian Ma lin-Hao Ma Jun-Qi Ma Shi-Nan Nie Jie-Miao Ou-yang Peng Peng Qiao Pei Shu-ming Pan guo-Zhong qing li-Jie qin Wu-ying Qiao Fei Shao wei Song Xing-Yue Song Zhen-Ju Song Rong-Ju Sun De-ya Shang Du-Juan Sha gui-Lan Tao guo-gang Tian ying-Ping Tian jian-guang Tian Chao-yang Tong Zi-Ren Tang Meng-Xiong Tang guo-Ping Wu Zhi Wan Tao Wang Xin Wang Peng Wang Zhong Wang Tong Wang Ri-Xing Wang Yi-Xin Wang Xiao-Dan Wang ling Wu wei wei hua Xiang Feng Xu Jun Xu Jie Xu Miao-Rong Xie Shuo-gui Xu Tie Xu Feng Yu Wen Yi li-Shan yang Shi-Jiao yan Jin-jian yao Shou-Chun yan xue-Zhong Yu Xian-Zhi Ye Xian-liang yan Fu-bing Zhou Rong-Bin Zhou ming Zhou Qiang Zhou Jin Zhou Ping Zhou Chang-Ju zhu hua-Dong zhu Ji-Hong zhu Hong Zhang Mao Zhang hua Zhang Na Zhang guo-Qiang Zhang guo-Xiu Zhang Jin-Song Zhang Wen-Wu Zhang Wen-Zhong Zhang jian-Feng Zhang Yi-min zhu Jun Zeng Yuan zheng Zhi-Jie zheng Shen Zhao yan Zhao min Zhao Bin Zhao Xiao-Dong Zhao Xiao-Jing Zhao Hong-Ke Zeng Sheng-Qiang Zou The Chinese Society of Emergency Medicine Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical University Key Laboratory of Emergency and Trauma of ministry of Education Hainan Medical UniversityHaikouHainanChina Emergency and Trauma College Hainan Medical UniversityHaikouHainanChina Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikouHainanChina Key Laboratory of Hainan Trauma and Disaster Rescue Key Laboratory of Trauma of Hainan Medical University

*** Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac *** is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2].

关键词： cardiac death respiratory

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肿瘤抗原相关基因MPS-1在胃癌中的表达及其临床意义

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中华胃肠外科杂志 2005年第6期8卷 503-506页

作者：王运伟朱正纲刘炳亚顾琴龙李建芳瞿颖陈雪华林言箴上海第二医科大学附属瑞金医院普通外科上海消化外科研究所 200025

目的探讨肿瘤抗原相关基因MPS-1在胃癌组织和细胞中的表达及其临床意义。方法采用逆转录聚合酶链反应(RT-PCR)和Western印迹,检测42例胃癌组织及其相应正常黏膜组织以及AGS、MKN-45、SGC7901、KATOⅢ、N-87和SNU-16株胃癌细胞中MPS-1的... 详细信息

目的探讨肿瘤抗原相关基因MPS-1在胃癌组织和细胞中的表达及其临床意义。方法采用逆转录聚合酶链反应(RT-PCR)和Western印迹,检测42例胃癌组织及其相应正常黏膜组织以及AGS、MKN-45、SGC7901、KATOⅢ、N-87和SNU-16株胃癌细胞中MPS-1的表达情况。结果MPS-1mRNA在胃癌组织和细胞株中均有表达。MPS-1mRNA在胃癌组织中的表达水平为1.37±0.87,明显高于其在相应正常黏膜组织中的表达(0.99±0.67,P<0.01)。MPS-1的表达与肿瘤的临床分期相关,TNM分期为Ⅲ、Ⅳ期标本中的表达明显高于Ⅰ、Ⅱ期的标本(P<0.05);但与肿瘤患者的性别、年龄、肿瘤大小和分化程度无关。同时,MPS-1在6株胃癌细胞中的表达高于胃正常黏膜上皮细胞GES-1,RT-PCR与Western印迹结果一致。结论胃癌抗原相关基因MPS-1可能在胃癌的恶性转变中发挥一定的作用,为今后胃癌免疫治疗提供了又一新的靶点。

关键词：胃肿瘤肿瘤抗原免疫疗法胃癌组织相关基因肿瘤抗原临床意义 Western印迹逆转录聚合酶链反应胃癌细胞黏膜上皮细胞 PCR)

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2018--2019年广东省城市居民慢性病前瞻性队列设计和基线特征

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中华疾病控制杂志 2021年第9期25卷 1060-1066页

作者：骆诗韵叶咏欣陈霓璇贾胜左志刚余振陈武农孙敏英沈纪川林锦春王箭袁倩罗燕芳朱耀文李柳清李雪妍刘元桦植妙丘志成夏敏朱伟中山大学公共卫生学院营养与食品卫生学系广州510080 东莞市茶山社区卫生服务中心预防保健部东莞523381 东莞市茶山社区卫生服务中心全科医学部东莞523381 广州市疾病预防控制中心基本公共卫生服务部广州510440 深圳市罗湖医院社区健康服务管理中心深圳518001 东莞市南城社区卫生服务中心公共卫生办公室东莞523076 东莞市东城社区卫生服务中心公共卫生办公室东莞523165 东莞市松山湖社区卫生服务中心预防保健科东莞523808 广州市疾病预防控制中心毒理学检验部广州510440

目的研究广东省城市居民健康相关因素的分布情况,为进一步揭示广东省城市居民慢性非传染性疾病的流行特征及发病规律奠定基础。方法2018年3月1日―2019年10月30日在广东省广州市、东莞市及深圳市开展基线调查,包括问卷调查、体格检查、... 详细信息

目的研究广东省城市居民健康相关因素的分布情况,为进一步揭示广东省城市居民慢性非传染性疾病的流行特征及发病规律奠定基础。方法2018年3月1日―2019年10月30日在广东省广州市、东莞市及深圳市开展基线调查,包括问卷调查、体格检查、生物样本采集和实验室检测,建立了包含34764名30~84岁研究对象的基线数据库和生物样本库。结果34764名调查对象的年龄为(53.31±12.61)岁,男性占41.1%。调查对象目前吸烟率男性为34.4%,女性0.4%;有饮酒习惯的男性比例为16.7%,女性为1.9%;BMI≥24 kg/m2的男性占54.4%,女性占44.4%;男性腰围≥90 cm的比例为35.8%,女性腰围≥85 cm的比例为34.0%;调查时男性血压超过正常范围(SBP≥140 mm Hg或DBP≥90 mm Hg)的比例为34.8%,女性的比例为28.8%。结论广东省城市居民中饮食、吸烟、饮酒及肥胖等慢性非传染性疾病相关因素在不同性别和年龄人群中存在不同的分布特征。

关键词：队列研究慢性非传染性疾病基线

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内蒙古赤峰市4类精神障碍现况调查

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中国心理卫生杂志 2015年第9期29卷 678-684页

作者：李国华黄悦勤李艳祥刘肇瑞耿洪春王建伟袁瑷琳陈永丽王立杰韩雪陈艳芳李志娟韩朝娟王铸英白福臣张赫男屈风晨赤峰市安定医院内蒙古赤峰024000 北京大学第六医院北京大学精神卫生研究所卫生部精神卫生学重点实验室(北京大学) 北京100191 赤峰市精神病防治院内蒙古宁城024200

目的：描述内蒙古赤峰市≥18岁人群4类常见精神障碍的流行病学患病率及其分布特点。方法：采用多级分层容量比例概率随机抽样的方法于2010年选取赤峰市≥18岁的居民6376名，采用复合性国际诊断交谈表-3．0计算机版（CIDI-3．0-CAPI）进... 详细信息

目的：描述内蒙古赤峰市≥18岁人群4类常见精神障碍的流行病学患病率及其分布特点。方法：采用多级分层容量比例概率随机抽样的方法于2010年选取赤峰市≥18岁的居民6376名，采用复合性国际诊断交谈表-3．0计算机版（CIDI-3．0-CAPI）进行人户访谈，按美国精神障碍诊断与统计手册第4版（DSM-IV）的标准对焦虑障碍、心境障碍、物质使用障碍和冲动控制障碍进行诊断。结果：实际接受访谈4528名，焦虑障碍、心境障碍、物质使用障碍和冲动控制障碍30天调整患病率（95％CI）分别为2．5％（2．08％-2．99％）、0．9％（0．67％-1．23％）、0．5％（0．34％-0．76％）、0．6％（0．41％-0．86％）；12个月调整患病率（95％CI）分别为4．5％（3．93％～5．15％）、2．4％（2．0％-2．90％）、1．1％（0．84％-1．45％）、1．0％（0．74％-1．32％）；终生调整患病率（95％CI）分别为6．6％（5．92％-7．36％）、6．5％（5．81％～7．24％）、2．7％（2．26％～3．21％）、1．4％（1．23％～1．95％）。结论：内蒙古赤峰市4类精神障碍患病率由高到低依次为焦虑障碍、心境障碍、物质使用障碍及冲到控制障碍。

关键词：精神障碍患病率复合性国际诊断交谈表现况调查

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Hedgehog信号通路在胃癌细胞中活化并通过Gli1促进MKN28细胞增殖

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中华胃肠外科杂志 2009年第6期12卷 603-606页

作者：李晓伟李建芳瞿颖蔡劬计骏聂辉陈雪华朱正纲刘炳亚上海交通大学医学院附属瑞金医院外科上海消化外科研究所 200025 上海交通大学系统生物医学研究院

目的研究Hedgehog：（HH）信号通路在胃癌细胞中的活化形式及其转录因子Gli1对胃癌细胞增殖和体外成瘤能力的影响。方法通过反转录PCR分析HH通路相关组成分子在7株细胞系中的表达情况．化学合成针对HH信号通路转录因子Gli1的siRNA并转... 详细信息

目的研究Hedgehog：（HH）信号通路在胃癌细胞中的活化形式及其转录因子Gli1对胃癌细胞增殖和体外成瘤能力的影响。方法通过反转录PCR分析HH通路相关组成分子在7株细胞系中的表达情况．化学合成针对HH信号通路转录因子Gli1的siRNA并转染胃癌MKN28细胞。通过CCK8法和体外克隆形成实验．观察GliI siRNA转染胃癌MKN28细胞后的细胞增殖能力和克隆形成能力的变化。结果在不同胃癌细胞株中．HH信号通路各相关基因的表达情况存在差异，SHH在6株胃癌细胞系中均表达上调．PTCH在KATOⅢ细胞系、SUFU在MKN28和KATOⅢ表达下调。转染Gli1 siRNA后，MKN28细胞中Gli1 mRNA表达受到明显抑制；经Gli1 siRNA作用的MKN28细胞生长明显缓于阴性对照和未处理组（P=0．014），克隆形成数目及体外克隆形成能力降低（P〈0．001）。结论HH信号通路在胃癌细胞系中被普遍激活，HH信号通路活化后可通过转录因子Gli1促进MKN28细胞增殖．

关键词：胃肿瘤 Hedgehog信号通路 MKN28细胞 RNA干扰

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针灸推拿为主治疗神经根型颈椎病:多中心随机对照研究

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中国针灸 2006年第8期26卷 537-543页

作者：周建伟蒋振亚叶锐彬李先樑袁秀丽张凡李常度李刚唐启华胡运光艾双春陈婕李春雨廖伟王琼芬罗小兵赵菁菁李安洪孔捷秦雪飞欧阳松罗建平王敏阳光李金存王芳古英高李四川省中医药研究院针灸经络研究所成都610031 成都中医药大学附属医院四川省骨科医院四川省中医药研究院中医研究所四川省绵阳市中医医院四川省中医药研究院附属医院

目的:探讨以针灸推拿为主的非药物综合方案治疗颈椎病(神经根型)的临床价值。方法:采用五中心、单盲、随机、对照研究方法,将合格受试者660例按1∶1比例随机纳入治疗组(符合方案者317例)和对照组(311例),分别给予以针灸推拿为主的非药... 详细信息

目的:探讨以针灸推拿为主的非药物综合方案治疗颈椎病(神经根型)的临床价值。方法:采用五中心、单盲、随机、对照研究方法,将合格受试者660例按1∶1比例随机纳入治疗组(符合方案者317例)和对照组(311例),分别给予以针灸推拿为主的非药物综合方案和以物理疗法为主的非药物综合方案治疗,建立证候测评表和多维的效应评价指标,评价疗效及安全性。结果:治疗组痊愈率42.9%,愈显率64.4%,优于对照组的16.7%、36.3%(P<0.01);治疗后两组临床证候得到改善,颈肩肢痛、颈项僵硬、颈部前屈异常、颈部旋转异常等指标的改善程度,治疗组优于对照组(P<0.01或P<0.05);两组起效时间和疗程,治疗组均短于对照组(P<0.01);未发现所采用治疗方法的不良反应。结论:以针灸推拿为主的非药物综合方案治疗颈椎病(神经根型),安全有效;其较之以物理疗法为主的非药物综合方案具有疗效优势。

关键词：颈椎病/针灸疗法牵引电针推拿电磁波谱治疗仪导引

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