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Nano Research 2024年第3期17卷 1818-1826页

作者： kun Chen Shengqiu Liu Yujun wei South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou 510641China Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing South China University of TechnologyGuangzhou 510641China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou 510641China

Obesity is closely related with insulin resistance and chronic ***,we report that unsaturated lipid-modified polyoxovanadates(ULPOVs)can restrict weight gain of diet-induced obese mice and improve their glycemic control and obesity-associated *** administration of the sub-nanosized ULPOVs at a low dosage for 7 weeks reduces the body weight and almost normalizes the blood glucose levels of obese mice fed on a high-fat *** treatment increases the activity of the nuclear receptor peroxisome proliferator-activated receptorγ(PPARγ)and reduces intestinal caloric intake,which may be the main reason for blood sugar and body weight *** addition to insulin-sensitizing,PPARγactivation induced by ULPOV treatment in obese mice with atopic dermatitis(AD)promotes the type 2 T helper(TH_(2))cell selective responses and therapeutic effects on immune dysregulation caused by *** data suggest sub-nanosized polyoxovanadate clusters as a class of potential candidates to relieve symptoms accompanied by diet-induced obesity.

关键词： polyoxovanadates lipid modification glucose homeostasis obesity inflammatory disease peroxisome proliferator-activated receptorγ(PPARγ)

Editable semiconductor photo-electrodes for sustainable ammonia synthesis

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Nano Research 2024年第4期17卷 3107-3112页

作者： Ning Lan kun Du Erling Zhao wei Zhao Tao Ling Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education Institute of New-EnergySchool of Materials Science and EngineeringTianjin UniversityTianjin 300072China School of Materials Science and Engineering Tianjin Chengjian UniversityTianjin 300384China

Powered by an inexhaustible supply of solar energy,photoelectrochemical(PEC)nitrogen reduction reaction(NRR)provides an ideal solution for the synthesis of green ammonia(NH_(3)).Although great efforts have been made in the past decades,there are still significant challenges in increasing the NH_(3) yields of the PEC-NRR *** addition to the issues of low activity and selectivity similar to electrochemical NRR,the progress of PEC-NRR is also impeded by the limited increase in NH_(3) yields as the electrode is ***,we propose an editable electrode design strategy that parallels unit photo-electrodes to achieve a linear increase in NH_(3) yields with electrode active *** demonstrate that the editable electrode design strategy minimizes the electrode charge transfer resistance,allowing more photo-generated carriers to reach the electrode surface and promote the catalytic *** believe that this editable electrode design strategy provides an avenue to achieve sustainable PEC NH_(3) production.

关键词： editable electrode photoelectrochemical nitrogen reduction reaction parallel electrode ZnSe

Coupling analysis method of grouting construction with deformation response of adjacent existing tunnel

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Underground Space 2024年第2期15卷 312-330页

作者： Ping-wei Jiang Zhi-hong Zhang Hong Zheng Jin-kun Huang Key Laboratory of Urban Security and Disaster Engineering of China Ministry of Education Beijing University of TechnologyBeijing 100124China China MCC17 Group Co.LTD MaanshanAnhui 243000China School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

In the new tunnel under close distance through the existing tunnel risk source,the grouting scheme developed to compensate for stratum losses is still based on empirical methods,relying on the overburden thickness of existing *** can potentially lead to an excessively high or low probability of uplift of existing *** a coupled deformation analysis method between the grouting construction and adjacent existing tunnels is of great theoretical significance for developing grouting *** order to reasonably limit the design parameters of grouting construction,based on the theory of fluid–solid coupling elastic pore-column expansion and the theory of random media,the calculation method of stratum displacement which simultaneously considers the coexistence of grout compaction expansion and permeability diffusion mode is derived,and the accuracy of the calculation method is verified by engineering *** accuracy of this calculation method was verified through engineering *** with the deformation coordination condition,the existing tunnel is regarded as an elastic Euler-Bernoulli continuous beam,and the finite element coupling balance equation of the interaction between the existing tunnel and the surrounding soil is *** on this,a coupling calculation model of the grouting construction and the deformation response of the adjacent existing tunnel is *** with three times of grouting construction examples in the shield tunneling project of Beijing Metro Line 12 under the existing airport line,the reliability of the coupling calculation model to determine the grouting construction parameters is *** calculation parameters in the coupling calculation model have clear physical meanings,which can provide a theoretical basis for the grouting design of similar risk source projects.

关键词： Grouting Close-range underpass Tunnel Random medium theory Euler-Bernoulli continuous beam

Oligomeric donor with appropriate crystallinity for organic solar cells

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Chinese Chemical Letters 2024年第2期35卷 289-294页

作者： Kaiming Yang Min Lv Yanhong Chang kun Lu Zhixiang wei CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Department of Environmental Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Resource Treatment of Typical Industrial Pollutants Beijing 100083China

Improving the performance of all-small-molecule organic solar cells(ASM-OSCs)largely depends on the design and application of novel donors with appropriate *** molecular conjugation is an effective method for regulating molecular stacking and *** this work,we successfully designed and synthesized two novel acceptor-donor-donor-donor-acceptor(A-D-D-D-A)type oligomeric donors with three dithieno[2,3-d:2′,3′-d′]benzo[1,2-b:4,5-b']dithiophene(DTBDT)as the central unit,named as 3DTBDT-Cl and 3DTBDT,depending on with and without chlorine substitution on the thiophene side *** found that the introduction of chlorine atoms makes the blend films display stronger crystallinity but with large-scale phase separation morphology and more defects,which eventually leads to a power conversion efficiency(PCE)of only 10.83%,whereas the blend films based 3DTBDT with appropriate crystallinity achieved 13.74%*** with 3DTBDT-Cl/L8-BO,the 3DTBDT/L8-BO films exhibited a nanoscale bi-continuous interpenetrating network morphology with a smaller domain size and more suitable crystallinity,which guarantees the corresponding devices obtained more efficient exciton dissociation,efficient charge transport,reduced bimolecular recombination,and performed more balanced carrier *** results demonstrated that regulating the crystallinity of oligomeric donors to obtain the desired phase separation morphology in the blend films could facilitate further improving the performance of ASM-OSCs.

关键词： Linked donor unit Oligomeric donors Crystallinity regulation Organic solar cells

A neural branch-and-price for truck scheduling in cross-docks

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Science China Mathematics 2024年第6期67卷 1341-1358页

作者： Rahimeh Neamatian Monemi Shahin Gelareh Nelson Maculan wei-kun Chen Sharkey Predictim Globe Villeneuve d’Ascq59650France Département R&T IUT de BéthuneUniversitéd’ArtoisBéthuneF-62000France Federal University of Rio de Janeiro COPPE-PESCRio de JaneiroRJ 21941-972Brazil School of Mathematics and Statistics Beijing Institute of TechnologyBeijing100081China

In this paper,we address the complex problem of dock-door assignment and truck scheduling within cross-docking *** is a problem that requires frequent resolution throughout the operational day,as disruptions often invalidate the optimal *** the problem's highly combinatorial nature,finding an optimal solution demands significant computational time and ***,the distribution of data across problem instances over a lengthy planning horizon remains consistently stable,with minimal concern regarding distribution *** factors collectively establish the problem as an ideal candidate for a learn-to-optimize solution *** propose a Dantzig-Wolfe reformulation,solving it via both a conventional branch-and-price approach and a neural branch-and-price approach,the latter of which employs imitation ***,we introduce some classes of valid inequalities to enhance and refine the pricing problem through a branch-and-cut *** computational experiments demonstrate that this methodology is not only feasible but also presents a viable alternative to the traditional branch-and-price algorithms typically utilized for such challenges.

关键词： cross-docking MILP modeling Dantzig-Wolfe decomposition graph convolutional network

Micro-sized nanoaggregates:Spray-drying-assisted fabrication and applications

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Particuology 2024年第2期85卷 22-48页

作者： Dan-Lei Yang Rong-kun Liu Yan wei Qian Sun Jie-Xin Wang School of Life Sciences and Chemical Engineering Jiangsu Second Normal UniversityNanjing210013China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology School of Chemistry and Chemical EngineeringGuangxi UniversityNanning530004China

The applications of nanoparticles suffer from their extremely small size and intrinsic trend of *** nanoparticles to form micro-sized nanoaggregates(MNAs)with increased size,ordered structure,as well as controllable size,shape,and morphology is a crucial step in various fields of science and technology to maintain the unique characteristics of nanoparticles while obtaining greatly enhanced or new performance at the *** structure of MNAs prominently affects their functionality,which is determined by the arrangement of nanoparticles and the interaction between primary *** methods have been proposed to prepare the MNAs,in which spray-drying technology stands out considering the feasibility,scalability for industry,cost,and *** assembly of nanoparticles through spray-drying under tunable process parameters yields diverse physical properties and structural arrangements of nanoparticles of the MNAs,they therefore exhibit enormous potential in a wide range of application *** review presents the construction and applications of spray-dried *** factors that influence the size,morphology,and structure of the MNAs are discussed in *** addition,the outstanding application performance resulting from the tightly packed nanoparticles in regular-shaped MNAs obtained by the spray-drying process is illustrated.

关键词： Spray-drying Micro-sized nanoaggregates Applications

Bioinspired Additive Manufacturing of Hierarchical Materials: From Biostructures to Functions

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Research 2024年第1期2023卷 533-559页

作者： Jingjiang wei Fei Pan Hang Ping kun Yang Yanqing Wang Qingyuan Wang Zhengyi Fu Institute for Advanced Materials Deformation and Damage from Multi-Scale Institute for Advanced StudyChengdu UniversityChengdu 610106P.R.China Department of Chemistry University of BaselBasel 4058Switzerland State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070P.R.China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065P.R.China

Throughout billions of years,biological systems have evolved sophisticated,multiscale hierarchical structures to adapt to changing *** are synthesized under mild conditions through a bottom-up self-assembly process,utilizing substances from the surrounding environment,and meanwhile are regulated by genes and *** manufacturing,which mimics this natural process,provides a promising approach to developing new materials with advantageous properties similar to natural biological *** review presents an overview of natural biomaterials,emphasizing their chemical and structural compositions at various scales,from the nanoscale to the macroscale,and the key mechanisms underlying their ***,this review describes the designs,preparations,and applications of bioinspired multifunctional materials produced through additive manufacturing at different scales,including nano,micro,micro-macro,and macro levels.

关键词： materials structures utilizing

Cardiac infiltration of diffuse large B-cell lymphoma manifesting as sustained ventricular tachycardia:a case report

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Journal of Geriatric Cardiology 2024年第2期21卷 242-245页

作者： wei CHEN kun HUANG wei-wei GUO Fan ZHOU De-Ning LIAO Department of Cardiology Shanghai Jingan District Zhabei Central HospitalShanghaiChina Department of Cardiology Shanghai Changzheng HospitalShanghaiChina Department of Hematology Shanghai Jingan District Zhabei Central HospitalShanghaiChina

Cardiac tumors are ***,cardiac metastases can occur in up to 10%of patients with *** cardiac neoplasms,metastases are much more common than primary cardiac tumors.[1]Metastatic cardiac neoplasms most frequently metast... 详细信息

关键词： neoplasms sustained cardiac

Transmissive reconfigurable metasurface enabling independent control of active and passive modules through weak coupling

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Photonics Research 2024年第7期12卷 1449-1456页

作者： kun XUE HENG wei CILEI ZHANG YONGHAO ZHANG HAOLIANG SUN SHAOHUA DONG Peng Cheng Laboratory Shenzhen 518055China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore State Key Laboratory of Radio Frequency Heterogeneous Integration College of Electronics and Information EngineeringShenzhen UniversityShenzhen 518060China

Metasurfaces have demonstrated rich electromagnetic control capabilities and degrees of freedom in past years. As is well known, for passive metasurfaces, their functionalities cannot be further expanded accordingly once prototypes are established. Therefore, reconfigurable metasurfaces, utilizing active devices to replace geometric changes in passive structures, have received widespread attention, especially with the development of wireless communication recently. In reconfigurable metasurfaces, artificial meta-atoms are composed of active devices and passive structures combined together. However, these two modules are usually utilized as a whole due to the tight coupling of the active devices and the passive structures, which results in passive structures not receiving sufficient attention and being utilized as independent degrees of freedom. In this article, we propose the concept of weakly coupled reconfigurable metasurfaces in transmissive systems, enabling independent control of active and passive modules through weak coupling. As the proof of concept, a simple weakly coupled system is proposed, which can realize the transmission wavefront engineering through the geometric changes of meta-structures in passive mode, while achieving switching between transmission and reflection states in active mode, respectively. Our exploration lies in making use of the physical structure, which is easily neglected in traditional reconfigurable metasurface design, emphasizing the collaborative work of active and passive modules, exploring more available variables within the same aperture, and providing a potential solution for balancing functionality and resource consumption in practical applications.

关键词： modules coupling weakly

Advances in targeted therapy for human epidermal growth factor receptor 2 positive in advanced gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2318-2334页

作者： Ya-kun Jiang wei Li Ying-Yang Qiu Meng Yue Department of Gastroenterology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina Health Management Center Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina Yong Loo Lin School of Medicine National University of SingaporeSingapore 119077Singapore

Emerging therapeutic methods represented by targeted therapy are effective supplements to traditional first-line chemoradiotherapy *** epidermal growth factor receptor 2(HER2)is one of the most important targets in targeted therapy for gastric *** combined with chemotherapy has been used as the first-line treatment for advanced gastric *** safety and efficacy of pertuzumab and margetuximab in the treatment of gastric cancer have been ***,monoclonal antibodies,due to their large molecular weight,inability to penetrate the blood-brain barrier,and drug resistance,lead to decreased therapeutic efficacy,so it is necessary to explore the efficacy of other HER2-targeting therapies in gastric ***-molecule tyrosine kinase inhibitors,such as lapatinib and pyrrotinib,have the advantages of small molecular weight,penetrating the blood-brain barrier and high oral bioavailability,and are expected to become the drugs of choice for perioperative treatment and neoadjuvant therapy of gastric cancer after validation by large-scale clinical trials in the ***-drug conjugate,such as T-DM1 and T-DXd,can overcome the resistance of monoclonal antibodies despite their different mechanisms of tumor killing,and are a supplement for the treatment of patients who have failed the treatment of monoclonal antibodies such as ***,after more detailed stratification of gastric cancer patients,various gastric cancer drugs targeting HER2 are expected to play a more significant role.

关键词： Human epidermal growth factor receptor 2 Gastric cancer Targeted therapy Review