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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

第十四届全国中药和天然药物学术研讨会

作者： Wuu-Tsun Perng James Cheng-Chung wei Chung Shan Medical University Hospital

＜正＞Aim This study compared the efficacy of an herbal formula OA2（Liu-wei-Die-huang-Wan）to placebo in relieving the pain and stiffness of *** This trial was a 8 weeks’randomized,double-blind,placebo-controlled *** study was approved by the IRB of Chung Shan Medical University hospital,and signed informed consent

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu wei huang Jiayi Wen Xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

耳穴压豆联合穴位贴敷治疗老年股骨粗隆间骨折术后便秘临床观察

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中国中医药现代远程教育 2025年第1期23卷 134-136,143页

作者：黄伟江西省南城县中医院骨科江西南城344700

目的分析行股骨近端防旋髓内钉内固定术的老年股骨粗隆间骨折患者,应用耳穴压豆联合穴位贴敷治疗的效果及对术后便秘的影响。方法回顾性选取2020年2月—2022年2月南城县中医院行股骨近端防旋髓内钉内固定术的老年股骨粗隆间骨折患者70例... 详细信息

目的分析行股骨近端防旋髓内钉内固定术的老年股骨粗隆间骨折患者,应用耳穴压豆联合穴位贴敷治疗的效果及对术后便秘的影响。方法回顾性选取2020年2月—2022年2月南城县中医院行股骨近端防旋髓内钉内固定术的老年股骨粗隆间骨折患者70例,分为联合治疗组和常规治疗组,各35例。联合治疗组行耳穴压豆联合穴位贴敷治疗,常规治疗组行常规治疗,观察临床效果。结果联合治疗组术后便秘发生率为8.57%(3/35),低于常规治疗组的31.43%(11/35);各围术期指标均优于常规治疗组;治疗总有效率为91.43%(32/35),高于常规治疗组的71.43%(25/35);术后并发症发生率为2.86%(1/35),低于常规治疗组的25.71%(9/35)(P<0.05)。治疗后,联合治疗组便秘患者症状自评量表(PAC-SYM)评分、视觉模拟量表(VAS)评分、焦虑评分、抑郁评分均低于常规治疗组,骨折断端骨痂生长评分、Harris评分均高于常规治疗组(P<0.05)。结论行股骨近端防旋髓内钉内固定术的老年股骨粗隆间骨折患者应用耳穴压豆联合穴位贴敷治疗,效果显著,术后便秘发生率明显降低。

关键词：股骨粗隆间骨折便秘股骨近端防旋髓内钉内固定术耳穴压豆疗法穴位贴敷疗法

NMDA receptor regulation by Liu-wei-Di-huang Decoction accounts for its enhancement of LTP in SAMP8 hippocampal slices

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NMDA receptor regulation by Liu-Wei-Di-Huang Decoction accou...

Neuroprotective effect of Liu wei Di huang Tang on adult hippocampal neurogenesis in mice

第二届世界天然药物和传统药物药理学学术会议

作者： Yan huang,He-Ping ZHANG,Zeng-Yao HU,Gang LIU,Sheng YANG,Wen-Xia ZHOU~* Yong-Xiang ZHANG~* (Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China)

AIMPrevious pharmacological studies demonstrated that LW could ameliorate the decline of the learning and memory in senescence accelerated mouse/prone 8(SAMP8),but the mechanism has not been well ***-containing serum(LWCS) was used in this study to elucidate the possible *** 6-month-old SAMP8 was used in this study to investigate the effect of LWCS on the induction of long-term potentiation(LTP).Primary cultured hippocampal neurons were used in this study to investigate the effects of LWCS on[Ca];I and N-methyl-D-aspartate(NMDA)-evoked currents.[Ca],was imaged using Fluo-3 and whole-cell patch recordings were applied to study the I and NMDA-evoked *** We find that LWCS facilitates the induction of LTP in hippocampal slices of 6-month-old *** primary cultured hippocampal neurons,LWCS increases intracellular[Ca],the I is suppressed by LWCS,and NMDA-evoked currents are *** These results indicate that LW improves the synaptic plasticity by inhibiting voltage-dependent caiciumchannels and promoting the function of NMDA *** improvement might be one of the mechanisms contributing to cognitive improvement effect of LW.

关键词： Liu-wei-Di-huang Decoction long-term potentiation

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中国药理学与毒理学杂志 2018年第4期32卷 312-312页

作者： Ming-xiao wei Tian-yao SHI Wen-xia ZHOU Zhong-lin ZHOU Jing-jing JIA Yong-xiang ZHANG Department of Neuroimmunopharmacology Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical countermeasures Beijing 100850 China

OBJECTIVE To explore the effect and mechanisms of LW-AFC,a new formula derived fromLiu wei Di huang Tang,on irradiation-induced reduction of mice adult hippocampal *** C57 BL/6 J mice were randomly divided into seven groups(n=10):control group,LW-AFC group(1.6 g·kg^(-1)),Liu wei Di huang Tang(LW) group(10 g·kg^(-1)),brain derived neurotrophic factor(BDNF) group,irradiation group,irradiation + LW group,and irradiation + LW-AFC *** of mice adult hippocampal neurogenesis was induced by cranial ***-AFC was administered by oral gavage for 30 d after cranial irradiation *** and Nissl′s staining were performed for histological morphology ***(BrdU) staining was used in the detection of proliferation *** peripheral blood and hippocampal homogenate were collected to measure the content of tumor necrosis factor-α(TNF-α),interferon-gamma(INF-γ),interleukin-1β(IL-1β),IL-4 and *** hippocampal homogenate was used for Western blot to detect the BDNFTrkB signal pathway,including extracellular regulated protein kinases1/2(ERK1/2) and BDNF target *** water maze and new object recognition test were performed to examine the cognitive function of *** mice forced swimming and tail suspension test were used to assess alteration in depressive *** term potentiation was used to examine the synaptic plasticity change of *** Adult hippocampal neurogenesis was significantly reduced after irradiation of 20 Gray dose(10 Gray per day,total 2 d).LW-AFC treatment increased the BrdU number of irradiated mice(P<0.05).In Morris water maze test,LW-AFC group showed decreased escape latency in the learning period(P<0.05),while increased the number of crossing the platform in the memory ***-AFC can also reduce the immobility time of mice in the tail suspension test(P<0.01).*** LW-AFC modulates adult neurogenesis to ameliorate cognitive impairment and reduce d

关键词：六味地黄汤海马神经治疗方法临床分析

Zeolites as host matrix for luminescent carbon dots:a newclass of thermally activated delayed fluorescence materials with 350 ms delayed decay time

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Science China Chemistry 2017年第9期60卷 1147-1148页

作者： wei huang Institute of Advanced Materials Nanjing Tech UniversityNanjing 211816China

Organic light-emitting diodes （OLEDs） have attractedconsiderable attentions from both academia and industryfor decades because of their potential applications in fullcolor fiat-panel displays and solid state lightings. Since2009 [1], thermally activated delayed fluorescence （TADF）OLEDs have drawn intense attention due to the utilizationof low-cost organic luminogens by harvesting all singletand triplet excitons to theoretically reach 100% internalquantum efficiency.

关键词：中国科学化学英文版

Advancing basic research towards making China a world leader in science and technology

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National Science Review 2018年第2期5卷 126-128页

作者： wei huang Ministry of Science and Technology of the People’s Republic of China

INTRODUCTION Basic research is the bedrock of science and technology(S&T)progress and industrial transformation,and the cornerstone to making China a world leader in S&*** the new round of the technological and industrial revolution,basic research is assuming an increasingly prominent *** at becoming a world leader in S&T by 2050,China should

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The lithology and composition of lunar mantle modified by ilmenite bearing cumulate:A thermodynamic model

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Acta Geochimica 2024年第5期43卷 856-875页

作者： wei huang wei Du State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China Center for Excellence in Comparative Planetology Chinese Academy of SciencesHefei 230026China

Due to their high density,the ilmenite-bearing cumulates(IBC)(with or without KREEP)formed during the late-stage lunar magma ocean solidification are thought to sink into the underlying lunar mantle and trigger lunar mantle *** evidence implied that IBC may descend deep inside the Moon and remain as a partially molten layer at the core-mantle boundary(CMB).However,partial melting may have occurred on the mixed mantle cumulates during the sinking of IBC/KREEP and the silicate melt may be positively buoyant,thus preventing the IBC/KREEP layer from sinking to the ***,we perform thermodynamic simulation on the stability of lunar mantle cumulates at different depths mixed with different amounts of IBC/KREEP from an updated LMO *** modeling results suggest that the sinking of IBC/KREEP will cause at least 5 wt%partial melting in the shallow(~120 km)and a much larger degree of partial melting in the deep lunar mantle(~420 km).Due to the density contrast with the surrounding mantle,IBC/KREEP-bearing melts could potentially decouple under certain *** modified lunar mantle by sinking of IBC/KREEP can better explain the formation of different kinds of lunar basaltic magma than the primary lunar mantle formed through differentiation of lunar magma *** of IBC/KREEP back into the lunar mantle may introduce plagioclase,clinopyroxene,garnet,and incompatible radioactive elements into the deep lunar mantle,which will further affect the thermal and chemical evolution of the lunar interior.

关键词： Ilmenite-bearing cumulate KREEP Partial melting Lunar mantle overturn pMELTS

Surface deflection-based reliability analysis of asphalt pavement design

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Science China(Technological Sciences) 2020年第9期63卷 1824-1836页

作者： huang wei LIANG SiMing wei Ya Intelligent Transportation System Research Center Southeast UniversityNanjing210096China Department of Civil Engineering Tsinghua UniversityBeijing100084China

The surface deflection of asphalt pavement reflects the strength and stiffness of the entire structure, which can be used to evaluate the rutting life of asphalt pavements. However, it is influenced by various stochastic variables including traffic loads, material properties and structural thickness of each pavement course. The uncertainty of above stochastic variables is of significance for accurately predicting the rutting life of asphalt pavement. In this study, the statistical characteristics of stochastic variables of asphalt pavement were assessed based on the field data collected from asphalt pavement projects. A unique formula with a fairly good accuracy was found using multiple linear regression based on numerical simulation results to ease the calculation of pavement deflection during the reliability analysis. It is shown that the stochastic variables of asphalt pavement can be well characterized by normal distribution or logarithmic normal distribution. The regressed formula to calculate the surface deflection of pavement has a fairly good accuracy with an error of less than 6.0% compared to the numerical method. The proposed surface deflection-based reliability analysis can be used easily to evaluate the influence of input parameters on the rutting life and to guide the structure design of asphalt pavement with required reliability.

关键词： asphalt pavement surface deflection rutting life reliability regressive model to calculate pavement deflection

Polymers for Flexible Electronics

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Chinese Journal of Polymer Science 2022年第12期40卷 1513-1514页

作者： huang wei Frontiers Science&Fundamental Research Center for Flexible Electronics Shaanxi Institute of Flexible Electronics&Institute of Biomedical Materials and EngineeringNorthwestern Polytechnical University Key Laboratory of Flexible Electronics(KLoFE)and Institute of Advanced Materials(IAM) School of Flexible Electronics(SoFE)Nanjing Tech University(NanjingTech) State Key Laboratory of Organic Electronics and Information Displays and Institute of Advanced Materials(IAM) School of Materials Science and EngineeringNanjing University of Posts&Telecommunications

The discovery of conductive polyacetylene by Heeger,MacDiarmid,and Shirakawa et *** 1977 opened a new era,which led them to win the 2000 Nobel Prize in Chem-istry for“The discovery and development of conductive polymers”.[1]In 1987,Tang and VanSlyke reported sand-wiched electroluminescence device structures,represent-ing a milestone in the field of organic electronics.[2]In 1990,Friend,Holmes,Bradley,and their coworkers from the Cavendish Laboratory and Melville Laboratory with Cambridge University developed their polymer-based electroluminescent devices,which was widely recognized as opening the door of plastic electronics.[3]Since then,the technologies of organic light-emitting diodes(OLED),organic photovoltaics(OPV),organic field-effect transist-ors(OFET),and organic solid-state lasers(OSSL),based on conductive polymers have been pushing forward quite rapidly.

关键词： conductive diodes electronics