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血必净联合腹腔镜胆总管探查术对复杂肝外胆管结石患者血清炎性指标及肝损伤标志物的影响

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临床合理用药 2025年第2期18卷 8-11页

作者：柳扬范伟贵州省人民医院肝胆外科二部贵阳市550002

目的观察血必净联合腹腔镜胆总管探查术对复杂肝外胆管结石患者血清炎性指标及肝损伤标志物的影响。方法选择2022年3月—2023年9月贵州省人民医院收治的复杂肝外胆管结石患者92例为研究对象,采用信封法随机分为观察组和对照组,每组46例... 详细信息

目的观察血必净联合腹腔镜胆总管探查术对复杂肝外胆管结石患者血清炎性指标及肝损伤标志物的影响。方法选择2022年3月—2023年9月贵州省人民医院收治的复杂肝外胆管结石患者92例为研究对象,采用信封法随机分为观察组和对照组,每组46例。对照组采用腹腔镜胆总管探查术治疗,观察组采用血必净联合腹腔镜胆总管探查术治疗。治疗7 d后,比较2组治疗前后血清炎性指标[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-1(IL-1)、白介素-1β(IL-1β)、白介素-6(IL-6)]、肝损伤标志物[总胆汁酸(TBA)、α-谷胱甘肽S转移酶(α-GST)、嘌呤核苷磷酸化酶(PNP)、精氨酸酶Ⅰ(ArgⅠ)、谷氨酸脱氢酶(GLDH)、鸟氨酸氨甲酰基转移酶(OCT)]及术后并发症发生率。结果治疗7 d后,2组CRP、TNF-α、IL-1、IL-1β及IL-6水平均低于治疗前,且观察组低于对照组(P<0.01);2组TBA、α-GST、PNP、ArgⅠ、GLDH及OCT水平均高于治疗前,但观察组低于对照组(P<0.01)。观察组并发症总发生率低于对照组(4.35%vs.17.39%,χ^(2)=4.039,P=0.044)。结论血必净联合腹腔镜胆总管探查术用于复杂肝外胆管结石患者中效果较好,可降低血清炎性指标和肝损伤标志物水平,有助于降低术后并发症发生率。

关键词：复杂肝外胆管结石血必净腹腔镜胆总管探查术炎性指标肝损伤标志物术后并发症

Remarks on Component Factors

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Journal of the Operations Research Society of China 2023年第3期11卷 657-666页

作者： wei Gao wei-fan Wang School of Information Science and Technology Yunnan Normal UniversityKunming650500YunnanChina Department of Mathematics Zhejiang Normal UniversityJinhua321004ZhejiangChina

In this remark,we first simply survey the important results on component factors in ***,we focus on the binding number condition of component factors in some special *** main contributions in this remark are two folded:(1)we reveal that the existence of some special component factors is equal to some specific binding number conditions;(2)the parameter conditions for a graph G with a P≥3-factor are determined.

关键词： H-factor Component factor Binding number

OnFractional(g,f,n′,m)-Critical Covered Graphs

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Journal of the Operations Research Society of China 2024年第2期12卷 446-460页

作者： wei Gao wei-fan Wang School of Information Science and Technology Yunnan Normal UniversityKunming 650500YunnanChina Department of Mathematics Zhejiang Normal UniversityJinhua 321004ZhejiangChina

The main contribution in this article is threefold:(1)we show the necessary and sufficient condition for graphs to be fractional(g,f)-covered which can be expressed in different forms,and extended to fractional(g,f,m)-covered graphs;(2)the concept of fractional-critical covered graph is put forward and its necessary and sufficient condition is given;(3)we present the degree condition for a graph to be fractional(g,f,n′,m)-critical covered,and show that degree bound is sharp when m is ***,the related result in fractional(a,b,n′,m)-critical covered setting is also verified.

关键词： Network Fractional factor Data transmission Fractional covered graph Fractional critical covered graph

Calculation method of ship collision force on bridge using artificial neural network

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第5期9卷 614-623页

作者： wei fan Wan-cheng YUAN Qi-wu fan State Key Laboratory for Disaster Reduction in Civil Engineering Tongji University Shanghai 200092 China Department of Civil Engineering Southwest Jiaotong University Chengdu 610031 China

Ship collision on bridge is a dynamic process featured by high nonlinearity and instantaneity. Calculating ship-bridge collision force typically involves either the use of design-specification-stipulated equivalent static load, or the use of finite element method (FEM) which is more time-consuming and requires supercomputing resources. In this paper, we proposed an alternative approach that combines FEM with artificial neural network (ANN). The radial basis function neural network (RBFNN) employed for calculating the impact force in consideration of ship-bridge collision mechanics. With ship velocity and mass as the input vectors and ship collision force as the output vector, the neural networks for different network parameters are trained by the learning samples obtained from finite element simulation results. The error analyses of the learning and testing samples show that the proposed RBFNN is accurate enough to calculate ship-bridge collision force. The input-output relationship obtained by the RBFNN is essentially consistent with the typical empirical formulae. Finally, a special toolbox is developed for calculation efficiency in application using MATLAB software.

关键词： Ship-bridge collision force Finite element method (FEM) Artificial neural network (ANN) Radial basis function neural network (RBFNN)

Geometric nonlinear formulation for thermal-rigid-flexible coupling system

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Acta Mechanica Sinica 2013年第5期29卷 728-737页

作者： wei fan Jin-Yang Liu School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong University

This paper develops geometric nonlinear hybrid formulation for flexible multibody system with large deformation considering thermal effect. Different from the conventional formulation, the heat flux is the function of the rotational angle and the elastic deformation, therefore, the coupling among the temperature, the large overall motion and the elastic deformation should be taken into account. Firstly, based on nonlinear strain-displacement relationship, varia- tional dynamic equations and heat conduction equations for a flexible beam are derived by using virtual work approach, and then, Lagrange dynamics equations and heat conduction equations of the first kind of the flexible multibody system are obtained by leading into the vectors of Lagrange multiplier associated with kinematic and temperature constraint equations. This formulation is used to simulate the thermal included hub-beam system. Comparison of the response be- tween the coupled system and the uncoupled system has re- vealed the thermal chattering phenomenon. Then, the key parameters for stability, including the moment of inertia of the central body, the incident angle, the damping ratio and the response time ratio, are analyzed. This formulation is also used to simulate a three-link system applied with heat flux. Comparison of the results obtained by the proposed formulation with those obtained by the approximate nonlinear model and the linear model shows the significance of con- sidering all the nonlinear terms in the strain in case of large deformation. At last, applicability of the approximate non- linear model and the linear model are clarified in detail.

关键词： Thermal-rigid-flexible coupling - Thermal chattering Large deformation Stability analysis

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糖尿病早期视网膜神经变性研究新进展

国际眼科杂志 2025年第1期25卷 76-81页

作者：魏凡彭立谢青中南大学湘雅医学院附属海口医院眼科海南省海口市570208

糖尿病视网膜病变(DR)是由慢性高血糖引起的晚期微神经血管并发症,可导致血-视网膜屏障受损和视网膜功能障碍。近年来研究发现,糖尿病视网膜神经变性(DN)可能是糖尿病的视网膜改变最早事件之一,主要表现包括:新诊断糖尿病患者的视网膜... 详细信息

糖尿病视网膜病变(DR)是由慢性高血糖引起的晚期微神经血管并发症,可导致血-视网膜屏障受损和视网膜功能障碍。近年来研究发现,糖尿病视网膜神经变性(DN)可能是糖尿病的视网膜改变最早事件之一,主要表现包括:新诊断糖尿病患者的视网膜电图反应缺陷;发病初期,小胶质细胞和Müller细胞在几周内自我激活并激活相关蛋白;神经递质(如DOPA/GABA)活性降低,损害神经节信号传递;早期线粒体功能障碍,如Drp1-Fis1持续裂变及mtDNA甲基化和碱基错配之间的潜在串扰等。探讨糖尿病早期视网膜神经变性的分子基础对于理解DN的发病机制及早期治疗至关重要。文章总结糖尿病早期视网膜感光功能及神经胶质细胞、神经递质、线粒体和其他因子的病理变化及机制,旨在为研究DN早期机制及靶向治疗提供理论依据。

关键词：糖尿病视网膜病变糖尿病视网膜神经变性视网膜电图线粒体自噬神经胶质细胞多巴胺

Dental pulp regeneration strategies:A review of status quo and recent advances

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Bioactive Materials 2024年第8期38卷 258-275页

作者： Xin-Lu Li wei fan Bing fan The State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan University237 Luoyu Road430079WuhanChina

Microorganisms,physical factors such as temperature or mechanical injury,and chemical factors such as free monomers from composite resin are the main causes of dental pulp *** clinical treatment methods for pulp diseases include the root canal therapy,vital pulp therapy and regenerative endodontic *** endodontic therapy serves the purpose of inducing the regeneration of new functional pulp tissues through autologous revascularization or pulp tissue *** article first discusses the current clinical methods and reviews strategies as well as the research outcomes regarding the pulp *** the in vivo models,the prospects and challenges for regenerative endodontic therapy were further discussed.

关键词： Pulp regeneration Revascularization Scaffold Growth factor Cell-homing

GREEDY NON-DOMINATED SORTING IN GENETIC ALGORITHM-ⅡFOR VEHICLE ROUTING PROBLEM IN DISTRIBUTION

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Chinese Journal of Mechanical Engineering 2008年第6期21卷 18-24页

作者： wei Tian fan Wenhui XU Huayu National CIMS Engineering Research Center Tsinghua University Beijing 100084 China

Vehicle routing problem in distribution （VRPD） is a widely used type of vehicle routing problem （VRP）, which has been proved as NP-Hard, and it is usually modeled as single objective optimization problem when modeling. For multi-objective optimization model, most researches consider two objectives. A multi-objective mathematical model for VRP is proposed, which considers the number of vehicles used, the length of route and the time arrived at each client. Genetic algorithm is one of the most widely used algorithms to solve VRP. As a type of genetic algorithm （GA）, non-dominated sorting in genetic algorithm-Ⅱ （NSGA-Ⅱ） also suffers from premature convergence and enclosure competition. In order to avoid these kinds of shortage, a greedy NSGA-Ⅱ （GNSGA-Ⅱ） is proposed for VRP problem. Greedy algorithm is implemented in generating the initial population, cross-over and mutation. All these procedures ensure that NSGA-Ⅱ is prevented from premature convergence and refine the performance of NSGA-Ⅱ at each step. In the distribution problem of a distribution center in Michigan, US, the GNSGA-Ⅱ is compared with NSGA-Ⅱ. As a result, the GNSGA-Ⅱ is the most efficient one and can get the most optimized solution to VRP problem. Also, in GNSGA-Ⅱ, premature convergence is better avoided and search efficiency has been improved sharply.

关键词： Greedy non-dominated sorting in genetic algorithm-Ⅱ (GNSGA-Ⅱ) Vehicle routing problem (VRP) Multi-objective optimization

TIME-OPTIMAL INTERPOLATION FOR CNC MACHINING ALONG CURVED TOOL PATHES WITH CONFINED CHORD ERROR

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Journal of Systems Science & Complexity 2013年第5期26卷 836-870页

作者： YUAN Chunming ZHANG Ke fan wei Key Laboratory of Mathematics Mechanization Institute of Systems ScienceChinese Academy of Sciences

In this paper, two new interpolation algorithms lot CNC machining along curve^l tom pathes are proposed： a time-optimal interpolation algorithm under chord error, feedrate, and tangential acceleration bounds, and a greedy interpolation algorithm under the chord error and tangential jerk bounds. The key idea is to reduce the chord error bound to a centripetal acceleration bound which leads to a velocity limit curve, called the chord error velocity limit curve. Then, the velocity planning is to find the proper velocity curve governed by the acceleration or jerk bounds ＇~under＂ the chord error velocity limit curve. For two types of simple tool pathes, explicit formulas for the velocity curve are given and the methods are implemented in commercial CNC controllers.

关键词： Chord error CNC interpolation cubic PH curve jerk quadratic B-spline time-optimalvelocity planning velocity limit curve.