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Epigallocatechin-3-gallate exerts antihypertensive effects and improves endothelial function in spontaneously hypertensive rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第7期13卷 287-295页

作者： Yucinda YY Khor Siew-Keah Lee Dharmani Devi M wei chih ling Department of Pre-clinical Sciences M.Kandiah Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanSelangorMalaysia Department of Pharmacology Faculty of MedicineUniversiti MalayaKuala LumpurMalaysia

Objective:To investigate the effect of epigallocatechin-3-gallate(EGCG)on endothelial dysfunction in spontaneously hypertensive rats(SHR).Methods:Wistar-Kyoto(WKY)rats and SHR were divided into four groups;WKY control,SHR control and SHR treated with EGCG(50 mg/kg/day)or losartan(10 mg/kg/day).The treatment was given daily for 4 weeks by oral gavage and the blood pressure was monitored by tail-cuff method every 3 *** endothelium-dependent relaxations were assessed in isolated phenylephrine-precontracted aortic rings at the end of *** vascular levels of reactive oxygen species,nitric oxide,tetrahydrobiopterin,and cyclic guanosine monophosphate were also ***,the expression of angiotensinⅡtype 1(AT_(1))receptor protein was ***:The systolic blood pressure was significantly decreased in SHR treated with *** impaired endothelium-dependent relaxation was significantly improved in aortic ring isolated from the EGCG-treated SHR *** also significantly increased the levels of nitric oxide,tetrahydrobiopterin,and cyclic guanosine monophosphate,while decreasing the level of reactive oxygen species and the protein expression of AT_(1)receptor in ***:EGCG attenuates endothelial dysfunction in SHR by decreasing oxidative stress and increasing vascular nitric oxide bioavailability,which may be modulated partly by inhibition of vascular AT_(1)*** increase in endothelium-dependent relaxation may contribute to a decrease in blood pressure in hypertensive animals.

关键词： Epigallocatechin-3-gallate Vascular protection Antihypertension Tetrahydrobiopterin Cyclic guanosine monophosphate Angiotensin typeⅠreceptor Spontaneously hypertensive rats

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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily Choi Michael QJiang ling wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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FFConvNeXt3D:提取中大规模目标特征的大卷积核网络

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郑州大学学报(理学版) 2025年第2期57卷 37-43页

作者：黄乾坤黄蔚凌兴宏苏州大学计算机科学与技术学院苏州大学东吴学院计算机系苏州城市学院计算科学与人工智能学院吉林大学符号计算与知识工程教育部重点实验室

目前大卷积核模型在图像领域已经证明其有效性，但是在视频领域还没有优秀的3D大卷积核模型。此外，之前的工作中忽视了时空行为检测任务主体是人的特点，其中的骨干网络只针对通用目标提取特征。针对上述原因，提出了一种含有特征融合... 详细信息

目前大卷积核模型在图像领域已经证明其有效性，但是在视频领域还没有优秀的3D大卷积核模型。此外，之前的工作中忽视了时空行为检测任务主体是人的特点，其中的骨干网络只针对通用目标提取特征。针对上述原因，提出了一种含有特征融合结构的3D大卷积核神经网络(FFConvNeXt3D)。首先，将成熟的ConvNeXt网络膨胀成用于视频领域的ConvNeXt3D网络，其中，预训练权重也进行处理用于膨胀后的网络。其次，研究了卷积核时间维度大小和位置对模型性能的影响。最后，提出了一个特征融合结构，着重提高骨干网络提取人物大小目标特征的能力。在UCF101-24数据集上进行了消融实验和对比实验，实验结果验证了特征融合结构的有效性，并且该模型性能优于其他方法。

关键词：大卷积核目标检测时空行为检测行为识别特征融合

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天然和饱水红砂岩三轴压缩蠕变变形试验研究

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三峡大学学报（自然科学版） 2025年第1期47卷 9-15页

作者：刘桃根胡凯李玲王伟湖南工学院土木与建筑工程学院湖南衡阳421002 河海大学岩土工程科学研究所南京210098 江西职业技术大学建筑工程学院江西九江332007

蠕变特性和长期强度是红砂岩地区岩体工程安全评价的关键要素,饱水软化效应对红砂岩蠕变特性和长期强度具有重要影响.采用全自动岩石三轴压缩伺服流变仪,开展天然与饱水红砂岩的三轴压缩试验和三轴压缩蠕变试验.试验结果表明:峰值强度... 详细信息

蠕变特性和长期强度是红砂岩地区岩体工程安全评价的关键要素,饱水软化效应对红砂岩蠕变特性和长期强度具有重要影响.采用全自动岩石三轴压缩伺服流变仪,开展天然与饱水红砂岩的三轴压缩试验和三轴压缩蠕变试验.试验结果表明:峰值强度、弹性模量和蠕变破坏应力因饱水软化效应而降低,围压对其降幅有削弱作用,蠕变破坏应力与峰值强度的比值在0.75~0.98之间;饱水软化效应能增强蠕变瞬时变形,减弱蠕变变形及蠕变应变速率;环向应变比轴向应变更早进入稳态蠕变阶段和加速蠕变阶段;稳态蠕变速率与偏压的变化关系符合指数函数关系;长期强度因饱水软化作用而降低,却因围压增加而增大,长期强度与峰值强度的比值在0.62~0.92之间;裂纹损伤应力与长期强度相差较大,裂纹损伤应力视为长期强度有待进一步考究.

关键词：红砂岩蠕变特性长期强度饱水软化效应裂纹损伤应力

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Hosoya and Merrifield-Simmons Indices in Random Polyphenyl Chains

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Acta Mathematicae Applicatae Sinica 2021年第3期37卷 485-494页

作者： wei-ling YANG School of Mathematical Sciences Xiamen UniversityXiamen 361005China

The Hosoya index of a graph is the total number of matchings in *** the Merrifield-Simmons index is the total number of independent sets in *** are typical examples of graph invariants used in mathematical chemistry for quantifying relevant details of molecular *** this paper,we obtain explicit analytical expressions for the expectations of the Hosoya index and the Merrifield-Simmons index of a random polyphenyl chain.

关键词： Hosoya index Merrifield-Simmons index random polyphenyl chain

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Hosoya and Merrifield-Simmons Indices in Random Polyphenyl Chains

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Acta Mathematicae Applicatae Sinica 2018年第1期34卷 163-172页

作者： wei-ling YANG School of Mathematical Sciences Xiamen University

The Hosoya index of a graph is the total number of matchings in it. And the Merrifield-Simmons index is the total number of independent sets in it. They are typical examples of graph invariants used in mathematical chemistry for quantifying relevant details of molecular structure. In this paper, we obtain explicit analytical expressions for the expectations of the Hosoya index and the Merrifield-Simmons index of a random polyphenyl chain.

关键词： Hosoya index Merrifield-Simmons index random polyphenyl chain

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Tensile Behavior Analysis of Loess Using Digital Image Correlation Method

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Journal of Earth Science 2023年第6期34卷 1916-1919页

作者： Xin wei ling Xu Department of Civil Engineering School of Human Settlements and Civil EngineeringXi'an Jiaotong UniversityXi'an 710049China

0 *** are generally weak in *** with compression or shear strength,the tensile strength of soils is usually neglected,for example in the analysis or design of earthen ***,knowledge of the tensile strength is of great importance for interpreting cracking behaviors in soils(wei et al.,2016;Kodikara and Costa,2013).Tensile strength and tensile stress both are important parameters that are considered in desiccation cracking process.

关键词： strength cracking process.

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A Win-Win Effect for Both the Ferromagnetism and the Dopability of p-Type Doping in ZnO:(Cu+N)

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Chinese Physics Letters 2013年第8期30卷 144-147页

作者： wei ling ZHANG wei-Feng Key laboratory of Photovoltaic Techniques School of Physics&ElectronicsHenan UniversityKaifeng 475001

We investigate the electronic structures and magnetic properties of ZnO doped with N,Cu,and(Cu+N)by using a first principles method and considering the strong correlation *** is interesting to compare these three ***:N has weak p-type doping and unstable ferromagnetism,while ZnO:Cu becomes insulating due to the Jahn–Teller *** and N codoping can not only greatly improve the dopability of p-type doping accompanying the Jahn–Teller fading,but also enhance the ferromagnetism at the same *** calculation results indicate that there is a win-win effect between N and Cu dopants in the ZnO:(Cu+N)system,which could possibly find applications in spintronics besides optoelectronics.

关键词： effect dopant doping

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Community Detection in Disease-Gene Network Based on Principal Component Analysis

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Tsinghua Science and Technology 2013年第5期18卷 454-461页

作者： wei Liu ling Chen Department of Computer Science Information Science and Technology College Yangzhou University

The identification of communities is imperative in the understanding of network structures and *** community detection algorithms in biological networks, the community structure of biological networks can be determined, which is helpful in analyzing the topological structures and predicting the behaviors of biological networks. In this paper, we analyze the diseasome network using a new method called disease-gene network detecting algorithm based on principal component analysis, which can be used to investigate the connection between nodes within the same group. Experimental results on real-world networks have demonstrated that our algorithm is more efficient in detecting community structures when compared with other well-known results.

关键词： disease-gene network principal component analysis community detection

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Anesthesia management in a pediatric patient with Becker muscular dystrophy undergoing laparoscopic surgery:A case report

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World Journal of Clinical Cases 2021年第29期9卷 8852-8857页

作者： ling Peng wei wei Department of Anaesthesiology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Patients with Becker muscular dystrophy(BMD)have a high risk of developing hyperkalemia,rhabdomyolysis,and malignant hyperthermia when exposed to volatile anesthetics and depolarizing muscle *** with BMD are also prone to respiratory depression after general ***,it is extremely challenging for anesthesiologists to manage anesthesia in BMD patients,particularly in pediatric BMD ***,we present successful anesthesia management using transversus abdominis plane block(TAPB)combined with total intravenous anesthesia(TIVA)in a pediatric BMD patient undergoing laparoscopic inguinal hernia *** SUMMARY A 2-year-old boy,weighing 15 kg,with BMD,was scheduled for laparoscopic inguinal hernia *** was used for induction,and continuous infusions of short-acting intravenous anesthetics combined with TAPB were performed for anesthesia ***,TAPB provided good postoperative *** patient underwent uneventful surgery and anesthesia,and over the 17 mo follow-up period showed no anesthesia-induced *** TAPB combined with TIVA,using short-acting intravenous anesthetic agents,can provide safe and effective anesthesia management in pediatric BMD patients undergoing short-term abdominal surgery.

关键词： Transversus abdominis plane block Total intravenous anesthesia Becker muscular dystrophy Pediatric patient Case report

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