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Multi-scale modeling for prediction of mechanical performance in brazed GH99 thin-walled structure

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Chinese Journal of Aeronautics 2024年第7期37卷 550-563页

作者： Yazhou LIU Shengpeng HU Yanyu SONG wei fu Xiaoguo SONG Ning GUO weimin LONG State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China Shandong Institute of Shipbuilding Technology Weihai 264209China China Machinery Intelligent Equipment Innovation Research Institute(Ningbo)Co. Ltd.Ningbo 315700China

Superalloy thin-walled structures are achieved mainly by brazing,but the deformation process of brazed joints is non-uniform,making it a challenging research *** paper records a thorough investigation of the effect of brazing parameters on the microstructure of joints and its mechanical properties,which mainly inquires into the deformation and fracture mechanisms in the shearing process of GH99/BNi-5a/GH99 *** macroscopic-microscopic deformation mechanism of the brazing interface during shearing was studied by Crystal Plasticity(CP)and Molecular Dynamics(MD)on the basis of the optimal brazing *** experimental results show that the brazing interface is mainly formed by(Ni,Cr,Co)(s,s)and possesses a shear strength of approximately 546 *** shearing fracture of the brazed joint occurs along the brazing seam,displaying the characteristics of intergranular *** simulations show that dislocations disassociate and transform into fine twinning with increased *** simulated the shear deformation process of the brazed *** multiscale simulation results are consistent with the experimental *** mechanical properties of thin-walled materials for brazing are predicted using MD and CP methods.

关键词： Multi-scale modeling Brazing Shear mechanisms Crystal plasticity GH99 superalloy

Low Selenium and Low Protein Exacerbate Myocardial Damage in Keshan Disease by Affecting the PINK1/Parkin-mediated Mitochondrial Autophagy Pathway

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Current Medical Science 2024年第1期44卷 93-101页

作者： Li-wei ZHANG Hong-qi FENG Song-bo fu Dian-jun SUN Center for Endemic Disease Control Chinese Center for Disease Control and PreventionHarbin Medical UniversityNHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University)Key Lab of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceHarbin 150086China

Objective Keshan disease(KD)is a myocardial mitochondrial disease closely related to insufficient selenium(Se)and protein *** induced putative kinase 1(PINK1)/Parkin mediated mitochondrial autophagy regulates various physiological and pathological processes in the *** study aimed to elucidate the relationship between PINK1/Parkin-regulated mitochondrial autophagy and KD-related myocardial *** A low Se and low protein animal model was *** hundred Wistar rats were randomly divided into 5 groups(control group,low Se group,low protein group,low Se+low protein group,and corn from KD area group).The JC-1 method was used to detect the mitochondrial membrane potential(MMP).ELISA was used to detect serum creatine kinase MB(CK-MB),cardiac troponin I(cTnI),and mitochondrial-glutamicoxalacetic transaminase(M-GOT)***-PCR and Western blot analysis were used to detect the expression of PINK1,Parkin,sequestome 1(P62),and microtubule-associated proteins1A/1B light chain 3B(MAP1LC3B).Results The MMP was significantly decreased and the activity of CK-MB,cTnI,and M-GOT significantly increased in each experimental group(low Se group,low protein group,low Se+low protein group and corn from KD area group)compared with the control group(P<0.05 for all).The mRNA and protein expression levels of PINK1,Parkin and MAP1LC3B were profoundly increased,and those of P62 markedly decreased in the experimental groups compared with the control group(P<0.05 for all).Conclusion Low Se and low protein levels exacerbate myocardial damage in KD by affecting the PINK1/Parkin-mediated mitochondrial autophagy pathway.

关键词： Keshan disease low selenium and low protein myocardial mitochondrial injury PTEN induced putative kinase 1(PINK1)/Parkin mitochondrial autophagy

Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids

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Protein & Cell 2024年第4期15卷 285-304页

作者： Yunuo Mao wei Wang Jingwei Yang Xin Zhou Yongqu Lu Junpeng Gao Xiao Wang Lu Wen wei fu fuchou Tang School of Life Sciences Biomedical Pioneering Innovation CenterDepartment of General SurgeryThird HospitalPeking UniversityBeijing 100871China Beijing Advanced Innovation Center for Genomics(ICG) Ministry of Education Key Laboratory of Cell Proliferation and DifferentiationBeijing 100871China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100871China Peking University Third Hospital Cancer Center Beijing 100871China The Research Center of Stem Cell and Regenerative Medicine School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

Colorectal cancer(CRC)is a highly heterogeneous cancer and exploring novel therapeutic options is a pressing issue that needs to be ***,we established human CRC tumor-derived organoids that well represent both morphological and molecular heterogeneities of original *** efficiently identify repurposed drugs for CRC,we developed a robust organoid-based drug screening *** combining the repurposed drug library and computation-based drug prediction,335 drugs were tested and 34 drugs with anti-CRC effects were *** importantly,we conducted a detailed transcriptome analysis of drug responses and divided the drug response signatures into five representative patterns:differentiation induction,growth inhibition,metabolism inhibition,immune response promotion,and cell cycle *** anticancer activities of drug candidates were further validated in the established patient-derived organoids-based xenograft(PDOX)system in *** found that fedratinib,trametinib,and bortezomib exhibited effective anticancer ***,the concordance and discordance of drug response signatures between organoids in vitro and pairwise PDOX in vivo were *** study offers an innovative approach for drug discovery,and the representative transcriptome features of drug responses provide valuable resources for developing novel clinical treatments for CRC.

关键词： colorectal cancer organoids drug repurposing patient-derived organoids-based xenograft mechanism of action

Polyoxometalates-derived nanostructures for electrocatalysis application

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Rare Metals 2024年第5期43卷 1845-1866页

作者： chao-Yue Sun Wen Li Kai Wang wei-Jia Zhou Hai-Qing Wang Institute for Advanced Interdisciplinary Research(iAIR) College of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China Shandong Electrical Engineering and Equipment Group Intelligent Electric Co. Ltd.Jinan 250022China

The conversion of intermittent renewable electrical energy to chemical energy is of great importance which can not only mitigate current energy and environmental crisis but also contribute to the ongoing carbon neutrality national *** is serving as a low-carbon conversion technology that enables green and efficient energy conversion mainly through hydrogen evolution reaction(HER),carbon dioxide reduction reaction(CO_(2)RR),and nitrogen reduction reaction(NRR).The core of electrocatalysis is the design and construction of low-cost high-activity and high-stability electrocatalyst to drive reaction thermodynamics and *** employment of polyoxometalates(POMs)as platforms or precursors to construct different types of electrocatalysts has been widely ***,we systematically summarized the recent advances in POM-derived nanostructures for electrocatalysis *** strategies for precursor design and electrocatalyst synthesis were briefly *** morphology control,phase control,composite modulation,and heterostructure engineering in POM-derived nanostructures were presented in *** structure–activity relationship of POM-derived nanostructures is fully discussed for HER CO_(2)RR,and NRR ***,the current challenges and future outlooks of POM-derived nanostructures are summarized to provide insights toward high-efficiency electrocatalysts for energy conversion technologies.

关键词： Microforming Cylindrical compression Size effects Grain orientation Inhomogeneous deformation

Thermal History of Cambrian Burgess Shale-Type Deposits:New Insights from the Early Cambrian Chengjiang and Qingjiang Fossils of South China

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Journal of Earth Science 2024年第4期35卷 1215-1223页

作者： Yuheng Qiao Linhao Cui Guangyuan Xing Dongjing fu chao Chang Robert Gaines Xingliang Zhang State Key Laboratory of Continental Dynamics Shaanxi Key laboratory of Early Life and EnvironmentsDepartment of GeologyNorthwest UniversityXi’an710069China Department of Geology Pomona CollegeClaremontCA91711USA

Burgess Shale-type deposits provide a wealth of information on the early evolution of *** that are central to understanding the exceptional preservation of these biotas and the paleoenvironments they inhabited may be obscured by the post-depositional alteration due to metamorphism at depth and weathering near the Earth’s *** over 50 Cambrian BST biotas,the Chengjiang and Qingjiang deposits are well known for their richness of soft-bodied taxa,fidelity of preservation,and Early Cambrian *** alteration via weathering has been well-investigated,the thermal maturity of the units bearing the two biotas has not yet been *** we investigate peak metamorphic temperatures of the two deposits using two independent *** gradient analyses demonstrate that the most fossiliferous sections of the Chengjiang were buried at a maximum depth of∼8500 m in the Early Triassic,corresponding to∼300°C,while the type area of the Qingjiang biota was buried at a maximum depth of∼8700 m in the Early Jurassic,corresponding to∼240°*** geothermometer analyses of fossil carbonaceous material demonstrate that peak temperatures varied across localities with different burial *** two productive sections of the Chengjiang biota were thermally altered at a peak temperature of approximately 300°C,and the main locality of the Qingjiang biota experienced a peak temperature of 238±22°*** results from two independent methods are *** BST deposits for which thermal maturity has been documented,the Qingjiang biota is the least thermally mature,and therefore holds promise for enriching our understanding of BST deposits.

关键词： the Chengjiang Biota the Qingjiang Biota burial history Raman geothermometer thermal history Burgess Shale-type Lagerstätte

Clinical outcome and prognostic factors of T4N0M0 colon cancer after R0 resection:A retrospective study

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1869-1877页

作者： Bang Liu Zhao-Xiong Zhang Xin-Yang Nie wei-Lin Sun Yong-Jia Yan wei-Hua fu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China

BACKGROUND Paradoxically,patients with T4N0M0(stage II,no lymph node metastasis)colon cancer have a worse prognosis than those with T2N1-2M0(stage III).However,no previous report has addressed this *** To screen prognostic risk factors for T4N0M0 colon cancer and construct a prognostic nomogram model for these *** Two hundred patients with T4N0M0 colon cancer were treated at Tianjin Medical University General Hospital between January 2017 and December 2021,of which 112 patients were assigned to the training cohort,and the remaining 88 patients were assigned to the validation *** between the training and validation groups were *** training cohort was subjected to multi-variate analysis to select prognostic risk factors for T4N0M0 colon cancer,followed by the construction of a nomogram *** The 3-year overall survival(OS)rates were 86.2%and 74.4%for the training and validation cohorts,***(P=0.000),T stage(P=0.001),right hemicolon(P=0.025),irregular review(P=0.040),and carbohydrate antigen 199(CA199)(P=0.011)were independent risk factors of OS in patients with T4N0M0 colon cancer.A nomogram model with good concordance and accuracy was *** Enterostomy,T stage,right hemicolon,irregular review,and CA199 were independent risk factors for OS in patients with T4N0M0 colon *** nomogram model exhibited good agreement and accuracy.

关键词： T4N0M0 colon cancer Prognosis Multivariate analysis Nomogram Colon cancer

Experimental Study on Consolidation Properties of Hydrate-Bearing Fine-Grained Sediments Collected from the Shenhu Area of the Northern South China Sea

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Journal of Ocean University of China 2024年第4期23卷 981-990页

作者： wei Ruchun LIU Lele JIA chao DONG Xiao BU Qingtao ZHANG Yongchao LIU Changling WU Nengyou School of Water Conservancy and Environment University of JinanJinan 250022China Shandong Engineering Research Center of Marine Exploration and Conservation Ocean University of ChinaQingdao 266100China Key Laboratory of Gas Hydrate Ministry of Natural ResourcesQingdao Institute of Marine GeologyQingdao 266237China Institute of Marine Science and Technology Shandong UniversityQingdao 266232China

Mechanical properties of hydrate-bearing fine-grained sediments are crucial to effectively mitigate environmental risks caused by artificial and natural decomposition of natural gas hydrates,and the decomposition can induce laterally confined *** explore the effect of natural gas hydrates on laterally confined compression properties,consolidation tests are conducted on remolded hydrate-free and hydrate-bearing samples by using natural fine-grained sediments collected from the northern South China Sea as the host sediments,and empirical equations are developed based on the analyses of consolidation *** results show that vertical loading induces a reduction in void ratio,and the reduction increases with decreasing hydrate saturation when samples are subjected to the same vertical stress *** compression index of samples is about 0.53 whether there is hydrate or not,but the yield stress of samples increases sharply with increasing hydrate saturation once beyond the critical *** coefficient of volume compression and the coefficient of consolidation of hydrate-bearing samples both increase firstly and then decrease to a relative stable level with increasing vertical stress,and the transition occurs at 200 *** average consolidation degree with elapsed time increases rapidly under low vertical stresses,slowly under median vertical stresses,and under high vertical stresses,the consolidation increases a little faster but still slower than those under low vertical stresses.

关键词： natural gas hydrate stiffness compression index hydraulic permeability geohazard

Review on recent advances of inorganic electrode materials for potassium-ion batteries

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Tungsten 2024年第1期6卷 174-195页

作者： Jian-Zhen Xiong Ze-Cheng Yang Xin-Liang Guo Xi-Ying Wang chao Geng Zong-fu Sun An-Yong Xiao Quan-chao Zhuang Ya-Xin Chen Zhi-Cheng Ju School of Materials Science and Physics China University of Mining and TechnologyXuzhou 221116China

Rechargeable potassium-ion batteries(PIBs)have great potential in the application of electrochemical energy storage devices due to the low cost,the abundant resources and the low standard reduction potential of *** electrode materials are the key factors to determine the electrochemical performance of devices,relevant research is being carried out to build high-performance *** recent years,significant progress has been made in the study of the design of inorganic electrode ***,we review the cathode materials(Prussian blue and its analogues,layered oxides and poly anionic compounds)and the anode materials(antimony-based,selenium-based and bismuth-based compounds).On the basis of previous work,the structural design principles for improving the performance of electrode materials are reasonably *** the same time,the problems that need to be solved in the preparation of electrode materials and the direction of future research and improvement are pointed out.

关键词： Inorganic electrode materials Potassium-ion batteries Cathode materials Anode materials

Four New Terpyridine Complexes Based Polyoxometalates with[W_(10)O_(32)]^(4-) Anions as High-Efficiency Dual-Site Catalysis for Thioether Oxidation Reaction

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Chinese Journal of Chemistry 2024年第6期42卷 592-598页

作者： Yin Zhang wei-Dong Yu Fang-Qian Wang Xiangnan Wang Jiawan Zhou chao Liu Jun Yan Junior Education Department Changsha Normal UniversityChangshaHunan410100 China School of Science Hunan University of Technology and BusinessChangshaHunan410000 China College of Chemistry and Chemical Engineering Central South UniversityChangshaHunan410000 China

Polyoxometalates modified with complex cations have attracted increasing attention because of the fascinating properties and the controllable *** adjusting the synthesis conditions,four new terpyridine complexes based hybrid POMs,[(TPY-H)CuCl]_(4)[W_(10)O_(32)]·2DMF·2H_(2)O(1),[(TPY-H)Cu(DMSO)(H_(2)O)]_(2)[W_(10)O_(32)]·2H_(2)O(2),[(TPY-H)_(2)Cu]_(2)[W_(10)O_(32)]·6DMSO·8H_(2)O(3) and[(TPY-Br)CuCl(DMSO)(H_(2)O)]_(2)[(TPY-Br)CuCl]_(2)[W_(10)O_(32)]·2DMSO·4H_(2)O(4),were prepared by using‘one-pot’***-crystal X-ray diffraction analyses,infrared radiation,etc.,revealed the structural composition of compounds 1—4,which indicates that synthesis conditions have a directional regulatory effect on the compounds *** oxidation catalytic reactions show 1—4 have good catalytic activities,and powder X-ray diffraction and thermogravimetry analysis show 1—4 have superduper catalytic ***,4 has better catalytic activity because of the different structure of terpyridine ***,a possible mechanism of dual-site catalysis by both cations and anions is proposed.

关键词： Polyoxometalates Terpyridine complexes Thioether oxidation Dual-site catalysis Clusters