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Chylous ascites in colorectal surgery:A systematic review

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World Journal of Gastrointestinal Surgery 2021年第6期13卷 585-596页

作者： Zi Qin ng Margaret han han Nien Beh Simon Keelan Department of General Surgery St John of God Midland HospitalMidland 6056Western AustraliaAustralia Department of General Surgery Joondalup Health CampusJoondalup 6027Western AustraliaAustralia

BACKGROUND Chylous ascites is a rare complication in colorectal surgery with limited *** To systematically review all available evidence to describe the incidence,clinical presentation,risk factors and management *** The systematic review was performed through PubMed,MEDLINE,EMBASE and Cochrane and cross-checked up to November *** data collated included:Demographics,indications(benign vs malignant),site of disease,surgical approach,extent of lymphadenectomy,day to and method of diagnosis of chylous ascites and management *** A total of 28 studies were included in the final analysis(426 cases).Patient age ranged from 31 to 89 *** except one case were performed for *** the 426 cases,195 were right-colonic,121 left-colonic,103 pelvic surgeries and 7 *** majority were diagnosed during the same inpatient stay by recognition of typical drain appearance and increased *** cases were diagnosed during outpatient visits with increased abdominal distention and subsequently underwent *** cases were managed successfully non-operatively(fasting with prolonged drainage,total parenteral nutrition,somatostatin analogues or a combination of these).Only three cases required surgical intervention after failing conservative management and subsequently resolved *** factors identified include:Right-colonic surgery/tumour location,extent of lymphadenectomy and number of lymph nodes *** Chylous ascites after colorectal surgery is a relatively rare *** the majority of cases resolved without surgical intervention,preventative measures should be undertaken such as meticulous dissection and clipping of lymphatics during lymphadenectomy to prevent morbidity.

关键词： Chylous Chyle Ascites Leak Colon Rectum Lymphadenectomy

2017~2018年冬季菏泽大气PM_(2.5)中金属元素特征及健康风险评估

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环境科学 2024年第3期45卷 1361-1370页

作者：杜虹萱任丽红赵明升韩慧霞徐义生中国环境科学研究院大气环境研究所北京100012 兰州理工大学石油化工学院兰州730050

于山东省菏泽市采集了2017年10月15日至2018年1月31日期间菏泽学院、华润制药和污水处理厂共3个采样点的大气PM_(2.5)样品,利用电感耦合等离子体质谱仪(ICP-MS)测定PM_(2.5)中21种金属元素的浓度,并讨论元素富集程度、评估重金属的健康... 详细信息

于山东省菏泽市采集了2017年10月15日至2018年1月31日期间菏泽学院、华润制药和污水处理厂共3个采样点的大气PM_(2.5)样品,利用电感耦合等离子体质谱仪(ICP-MS)测定PM_(2.5)中21种金属元素的浓度,并讨论元素富集程度、评估重金属的健康风险和潜在生态风险.结果表明,采样期间3个采样点中ρ(PM_(2.5))范围为26.7~284.1μg·m^(-3)且浓度值差别不大,均处于较高污染水平;3个采样点金属元素中K浓度最高,分别占总量的31.03%、39.47%和38.43%,主要由于菏泽作为较大农业城市,其秋冬季生物质燃烧贡献率较高;3个采样点微量元素中ρ(Zn)最高,分别为89.70、84.21和67.68 ng·m^(-3).富集因子结果表明,Zn、Pb、Sn、Sb、Cd和Se的富集因子值均高于100,其中Cd和Se的富集因子分别高于2 000和4 000,受人为活动影响显著,可能与工业生产、金属冶炼、道路源和燃煤排放等有关.健康风险结果表明,As存在一定的潜在非致癌风险(儿童和成人HQ>0.1),3个采样点对儿童和成人均存在综合潜在非致癌风险(HI>0.1)和一定的潜在致癌风险(CRT>1×10^(-6)),其中污水处理厂对成人的致癌风险较为显著(CRT>1×10^(-4)),成人的致癌风险略高于儿童可能与成人室外活动时间较长和PM_(2.5)暴露量更高有关.潜在生态风险值最高的元素为Cd、As和Pb,其中Cd表现为极高的潜在生态风险,应引起重视;3个采样点均呈现出极高的综合潜在生态风险,强度在空间上表现为:菏泽学院>华润制药>污水处理厂.

关键词： PM_(2.5) 重金属富集因子健康风险评估潜在生态风险

Room temperature Ⅲ–Ⅴ nanolasers with distributed Bragg reflectors epitaxially grown on(001) silicon-on-insulators

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Photonics Research 2019年第9期7卷 1081-1086页

作者： YU han WAI KIT ng YIng XUE KAM SIng WOng KEI MAY LAU Department of Electronic and Computer Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Department of Physics and William Mong Institute of Nano Science and Technology Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Efficient, scalable, bufferless, and compact Ⅲ–V lasers directly grown on(001)-oriented silicon-on-insulators(SOIs) are preferred light sources in Si-photonics. In this article, we present the design and operation of Ⅲ–V telecom nanolaser arrays with integrated distributed Bragg reflectors(DBRs) epitaxially grown on industry-standard(001) SOI wafers. We simulated the mirror reflectance of different guided modes under various mirror architectures, and accordingly devised nanoscale DBR gratings to support high reflectivity around1500 nm for the doughnut-shaped TE01 mode. Building from InP/IngaAs nanoridges grown on SOI, we fabricated subwavelength DBR mirrors at both ends of the nanoridge laser cavities and thus demonstrated room-temperature low-threshold InP/IngaAs nanolasers with a 0.28 μm^2 cross-section and a 20 μm effective cavity length. The direct growth of these bufferless nanoscale Ⅲ–V light emitters on Si-photonics standard(001) SOI wafers opens future options of fully integrated Si-based nanophotonic integrated circuits in the telecom wavelength regime.

关键词： IngaAs InP SOI nanolasers with distributed Bragg reflectors epitaxially grown on Room temperature silicon-on-insulators Bragg

Unravelling charge carrier dynamics in protonated g-C3N4 interfaced with carbon nanodots as co-catalysts toward enhanced photocatalytic CO2 reduction： A combined experimental and first-principles DFT study

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Nano Research 2017年第5期10卷 1673-1696页

作者： wee-Jun Ong Lutfi Kurnianditia Putri Yoong-Chuen Tan Lling-Lling Tan Neng Li Yun Hau ng Xiaoming Wen Siang-Piao Chai Institute of Materials Research and Engineering (IMRE) Agency for Science Technology and Research (A'STAR) 2 Fusionopolis Way Innovis Singapore 138534 Singapore Multidisciplinary Platform of Advanced Engineering Chemical Engineering Discipline School of Engineering Monash University Jalan Lagoon Selatan Bandar Sunway 47500 Selangor Malaysia Chemical Engineering School of Engineering and Physical Sciences Heriot-Watt University Jalan Venna PS/2 Precinct 5 62200 Putrajaya Malaysia State Key Laboratory of Silicate Materials for Architectures Wuhan University of Technology 122 Luoshi Road Wuhan 430070 China Particles and Catalysis Research Group (PARTCAT) School of Chemical Engineering The University of New South Wales Sydney New South Wales 2052 Australia Australian Centre for Advanced Photovoltaics School of Photovoltaic and Renewable Energy Engineering The University of New South Wales Sydney New South Wales 2052 Australia

In this work, we demonstrated the successful construction of metal-free zero- dimensional/two-dimensional carbon nanodot （CND）-hybridized protonatedg=C3N4 （pCN）（CND/pCN） heterojunction photocatalysts b; means of electrostatic attraction. We experimentally found that CNDs with an average diameter of 4.4 nm were uniformly distributed on the surface of pCN using electron microscopy analysis. The CND/pCN-3 sample with a CND content of 3 wt.% showed thehighest catalytic activity in the CO2 photoreduction process under visible and simulated solar light. This process results in the evolution of CH4 and CO. Thetotal amounts of CH4 and CO generated by the CND/pCN-3 photocatalyst after 10 h of visible-light activity were found to be 29.23 and 58.82 molgcatalyst-1, respectively. These values were 3.6 and 2.28 times higher, respectively, than thearn＊ounts generated when using pCN alone. The corresponding apparent quantum efficiency （AQE） was calculated to be 0.076%. Furthermore, the CND/pCN-3 sample demonstrated high stability and durability after four consecutive photoreaction cycles, with no significant decrease in the catalytic activity.

关键词： protonated graphiticcarbon nitride carbon nanodots photocatalysis carbon dioxide reduction charge carrier dynamics density functional theory(DFT) calculations

Synthesis of high-performance nickel hydroxide nanosheets/gadolinium doped-α-MnO_(2) composite nanorods as cathode and Fe_(3)O_(4)/GO nanospheres as anode for an all-solid-state asymmetric supercapacitor

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Journal of Energy Chemistry 2022年第1期31卷 475-484,I0013页

作者： Milan Babu Poudel han Joo Kim Department of Convergence Engineering Technology Jeonbuk National UniversityJeonju Jeollabuk-do 54896Republic of Korea

The wide use of manganese dioxide(MnO_(2))as an electrode in all-solid-state asymmetric supercapacitors(ASCs)remains challenging because of its low electrical *** complication can be circumvented by introducing trivalent gadolinium(Gd)ions into the MnO_(2).Herein,we describe the successful hydrothermal synthesis of crystalline Gd-doped MnO_(2) nanorods with Ni(OH)_(2) nanosheets as cathode,which we combined with Fe_(3)O_(4)/GO nanospheres as anode for all-solid-state *** tests dem on strate that Gd dopi ng sign ifica ntly affected the electrochemical activities of the MnO_(2),which was further enhanced by introducing Ni(OH)_(2).The GdMnO_(2)/Ni(OH)_(2) electrode offers sufficient surface electrochemical activity and exhibits excellent specific capacity of 121.8 mA h g^(-1),at 1A g^(-1),appealing rate performance,and ultralong lifetime stability(99.3%retention after 10,000 discharge tests).Furthermore,the GdMnO_(2)/Ni(OH)_(2)//PVA/KOH//Fe_(3)O_(4)/GO solid-state ASC device offers an impressive specific energy density(60.25 W h kg^(-1))at a high power density(2332 W kg^(-1)).This investigation thus shows its large potential in developing novel approaches to energy storage devices.

关键词： Solid-state supercapacitor Manganese dioxide Gadolinium doping Nickel hydroxide nanosheets

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辛伐他汀对帕金森病大鼠神经功能的影响

中国临床药理学杂志 2024年第4期40卷 559-563页

作者：吕金凤史艳霞林艳韩博张家口学院护理学院河北张家口175000 张家口学院医学院河北张家口175000

目的探究辛伐他汀介导腺苷酸活化蛋白激酶/过氧化物酶体增殖物激活受体γ共激活因子-1α(AMPK/PGC-1α)通路对帕金森病大鼠模型神经功能的影响。方法 SD大鼠建立帕金森病大鼠模型,建模成功后分为模型组、阳性药物组(1.67 mg·kg^(-1)... 详细信息

目的探究辛伐他汀介导腺苷酸活化蛋白激酶/过氧化物酶体增殖物激活受体γ共激活因子-1α(AMPK/PGC-1α)通路对帕金森病大鼠模型神经功能的影响。方法 SD大鼠建立帕金森病大鼠模型,建模成功后分为模型组、阳性药物组(1.67 mg·kg^(-1)多巴丝肼)、低剂量实验组(10 mg·kg^(-1)辛伐他汀)、高剂量实验组(20 mg·kg^(-1)辛伐他汀)、抑制药组(20 mg·kg^(-1)辛伐他汀+0.25 mg·kg^(-1)的AMPK抑制药BML-275),并选择10只正常大鼠作为对照组。用酶联免疫吸附(ELISA)法检测多巴胺(DA)、3,4二羟基苯乙酸(DOPAC)、高香草酸(HVA)、5羟基吲哚乙酸(5-HIAA)、5羟色胺(5-HT)水平,用蛋白质印迹法检测酪氨酸羟化酶(TH)、AMPK/PGC-1α通路相关蛋白表达水平,用免疫组化法检测TH表达水平,用试剂盒检测丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平。结果对照组、模型组、高剂量实验组、抑制药组DA分别为(495.63±34.30)、(207.53±24.10)、(429.39±44.89)和(285.55±20.79) pg·mL^(-1),DOPAC分别为(33.38±2.48)、(17.70±1.31)、(29.12±1.72)和(20.67±1.45)ng·mL^(-1),HVA分别为(58.75±6.25)、(25.27±2.00)、(46.16±2.83)和(30.58±1.91)ng·mL^(-1),5-HT分别为(5.62±0.45)、(2.37±0.13)、(4.42±0.26)和(3.23±0.29)ng·mL^(-1),5-HIAA分别为(11.11±1.08)、(3.88±0.30)、(7.99±0.63)和(6.04±0.51)ng·mL^(-1),p-AMPK蛋白表达水平分别为0.98±0.06、0.35±0.04、0.80±0.05和0.21±0.02,PGC-1α蛋白表达水平分别为1.12±0.11、0.40±0.04、0.90±0.08和0.58±0.05。对照组上述指标与模型组比较、模型组上述指标与高剂量实验组、抑制药组比较,在统计学上差异均有统计学意义(均P<0.05)。结论辛伐他汀可通过调节AMPK/PGC-1α通路改善帕金森病大鼠模型神经功能。

关键词：辛伐他汀腺苷酸活化蛋白激酶/过氧化物酶体增殖物激活受体γ共激活因子-1α通路帕金森病神经功能

环境中阿斯巴甜的分布、来源及环境风险研究进展

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地球与环境 2024年第4期52卷 525-534页

作者：韩雪婷曹正梅郎印海李爱峰郑磊中国海洋大学环境科学与工程学院海洋环境与生态教育部重点实验室山东青岛266100 山东省青岛生态环境监测中心山东青岛266003 山东省第三地质矿产勘查院山东烟台246000

阿斯巴甜(ASP)是一种广泛应用的人工甜味剂,在环境中被频繁检出,对人类健康和水生生态系统具有潜在的不利影响,作为一种新污染物日益受到人们的关注。国际癌症研究机构将其列入可能致癌物清单,因此,研究其在自然环境中的污染水平、来源... 详细信息

阿斯巴甜(ASP)是一种广泛应用的人工甜味剂,在环境中被频繁检出,对人类健康和水生生态系统具有潜在的不利影响,作为一种新污染物日益受到人们的关注。国际癌症研究机构将其列入可能致癌物清单,因此,研究其在自然环境中的污染水平、来源和健康风险具有重要的科学意义。本文系统梳理了国内外有关人工甜味剂ASP在环境中的分布、来源和环境风险等方面的研究现状,结果表明:1)ASP在全球范围内各种环境介质中分布广泛,浓度处于ng/L或ng/g水平,属于痕量有机污染物;2)ASP易于分布在水体固相有机体系,如悬浮颗粒物、河流沉积物和污泥中,当环境条件改变时,吸附在固相中的ASP可能会重新释放到水体,导致环境水体中ASP浓度高于污水处理厂出水的现象;3)风险评估显示目前环境中ASP基本处于低风险或无风险水平;4)固相萃取和液相色谱质谱联用(SPE-LC-MS/MS)是准确定量环境样品中ASP的有效分析方法。基于现有文献分析,今后研究应重点关注ASP的生物地球化学行为、毒性效应及人体健康风险。

关键词：阿斯巴甜(ASP) 环境分布来源环境风险分析方法

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血清成纤维细胞生长因子21和脂肪酸结合蛋白4检测对急性ST段抬高型心肌梗死患者经皮冠状动脉介入治疗术后心力衰竭的预测价值

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中国心血管病研究 2024年第5期22卷 469-474页

作者：包美珍韩惠内蒙古医科大学附属医院心血管内科内蒙古自治区呼和浩特市010000 内蒙古医科大学附属医院呼吸科内蒙古自治区呼和浩特市010000

目的探究血清成纤维细胞生长因子21(FGF21)和脂肪酸结合蛋白4(FABP4)检测对急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入治疗(PCI)术后心力衰竭的预测价值。方法选取2020年9月至2022年9月内蒙古医科大学附属医院接诊的113例STEM... 详细信息

目的探究血清成纤维细胞生长因子21(FGF21)和脂肪酸结合蛋白4(FABP4)检测对急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入治疗(PCI)术后心力衰竭的预测价值。方法选取2020年9月至2022年9月内蒙古医科大学附属医院接诊的113例STEMI患者为研究对象,依据PCI术后1年是否发生心力衰竭(心衰),将其分为心衰组(n=32)和非心衰组(n=81)。应用ELISA法测定血清FGF21、FABP4表达水平,比较两组血清FGF21、FABP4水平,多因素logistic回归分析影响STEMI患者PCI术后发生心力衰竭的相关因素,ROC曲线评估血清FGF21、FABP4水平对STEMI患者PCI术后心力衰竭发生的预测价值。结果心衰组心率次数、C反应蛋白(CRP)、心肌肌钙蛋白(cTnI)、N末端B型利钠肽原(BNP)、利尿剂使用比例均显著高于非心衰组,左心室射血分数(LVEF)显著低于非心衰组(Png/L比(185.68±25.52)ng/L、(34.26±5.51)ng/ml比(26.87±4.67)ng/ml,t=7.345、7.195,P1,P<0.05),LVEF(95%CI 0.473~0.913)是保护因素(OR<1,P<0.05)。血清FGF21、FABP4单独及二者联合预测STEMI患者PCI术后发生心力衰竭的曲线下面积(AUC)分别为0.828、0.856、0.934,二者联合优于单一(Z二者联合-FGF21=1.971、Z二者联合-FABP4=2.417,P=0.048、P=0.015)。结论STEMI患者PCI术后发生心力衰竭血清FGF21、FABP4水平均明显升高,二者联合对STEMI患者PCI术后发生心力衰竭的风险具有更高的预测价值。

关键词：心力衰竭成纤维细胞生长因子21 脂肪酸结合蛋白4 急性ST段抬高型心肌梗死

Reproductive medicine gets a new tool

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分子细胞生物学报:英文版 2011年第6期3卷 320-321页

作者： Wei-Xia Ang Cheng-Xu Delon Toh Huck-Hui ng Yuin-han Loh Epigenetics and Cell Fates Laboratory A*STAR Institute of Medical BiologySingapore 138648Singapore NUS Graduate School for Integrative Sciences and Engineering Singapore 117597Singapore Department of Biological Sciences National University of SingaporeSingapore 117543Singapore Gene Regulation Laboratory Genome Institute of SingaporeSingapore 138672Singapore Department of Biochemistry National University of SingaporeSingapore 117597Singapore School of Biological Sciences Nanyang Technological UniversitySingapore 639798Singapore

Infertility is a problem faced by millions *** a recent paper published in Cell,Hayashi et al.(2011)provided a potential solution for male infertility through the generation of functional spermatozoa that can give ris... 详细信息

关键词： infertility offspring