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Acta Pharmaceutica Sinica B 2024年第6期14卷 2716-2731页

作者： yang Tong Pei An Puxian Tang Rui Mu Yuteng Zeng hang Sun Mei Zhao Ziyan Lv Pan Wang Wanjun Han Chunshan Gui Xuechu Zhen Liang Han Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development Soochow UniversitySuzhou 215123China

Lipogenesis is often highly upregulated in breast cancer brain metastases to adapt to intracranial low lipid *** inhibitors hold therapeutic potential but their intra-tumoral distribution is often blocked by the blood-tumor barrier(BTB).BTB activates its Wnt signaling to maintain barrier properties,e.g.,Mfsd2a-mediated BTB low ***,we reported VCAM-1-targeting nano-wogonin(W@V-NPs)as an adjuvant of nano-orlistat(O@V-NPs)to intensify drug delivery and inhibit lipogenesis of brain metastases.W@V-NPs were proven to be able to inactivate BTB Wnt signaling,downregulate BTB Mfsd2a,accelerate BTB vesicular transport,and enhance tumor accumulation of O@*** the ability to specifically kill cancer cells in a lipid-deprived environment with IC_(50) at 48 ng/mL,W@V-NPs plus O@V-NPs inhibited the progression of brain metastases with prolonged survival of model *** combination did not induce brain edema,cognitive impairment,and systemic toxicity in healthy *** Wnt signaling could safely modulate the BTB to improve drug delivery and metabolic therapy against brain metastases.

关键词： Lipogenesis Brain metastases Blood-tumor barrier Wnt signaling Drug delivery Fatty acid synthase Nanoparticles Combination therapy

General anesthetic agents induce neurotoxicity through astrocytes

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Neural Regeneration Research 2024年第6期19卷 1299-1307页

作者： Yanchang yang Tiantian Liu Jun Li Dandan Yan Yuhan Hu Pin Wu Fuquan Fang Patrick M.McQuillan wenxin hang Jianhang Leng Zhiyong Hu Department of Anesthesiology The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Anesthesiology Ningbo Women and Children’s HospitalNingboZhejiang ProvinceChina Department of Anesthesiology Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhouZhejiang ProvinceChina Cell Biology Department Yale UniversityNew HavenCTUSA Department of Anesthesiology Penn State Hershey Medical CentrePenn State College of MedicineHersheyPAUSA Department of Central Laboratory Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Neuroscientists have recognized the importance of astrocytes in regulating neurological function and their influence on the release of glial *** studies,however,have focused on the effects of general anesthetic agents on neuroglia or *** can also be an important target of general anesthetic agents as they exert not only sedative,analgesic,and amnesic effects but also mediate general anesthetic-induced neurotoxicity and postoperative cognitive ***,we analyzed recent advances in understanding the mechanism of general anesthetic agents on astrocytes,and found that exposure to general anesthetic agents will destroy the morphology and proliferation of astrocytes,in addition to acting on the receptors on their surface,which not only affect Ca^(2+)signaling,inhibit the release of brain-derived neurotrophic factor and lactate from astrocytes,but are even involved in the regulation of the pro-and anti-inflammatory processes of *** would obviously affect the communication between astrocytes as well as between astrocytes and neighboring neurons,other neuroglia,and vascular *** this review,we summarize how general anesthetic agents act on neurons via astrocytes,and explore potential mechanisms of action of general anesthetic agents on the nervous *** hope that this review will provide a new direction for mitigating the neurotoxicity of general anesthetic agents.

关键词： astrocytes brain-derived neurotrophic factor general anesthetic agents neuron neurotoxicity N-methyl-D-aspartate receptor perioperative neurocognition Toll-like receptor γ-aminobutyric acid receptor

Strength and ductility optimization of HPDC AlSi8MgCuZn2 alloys by modifying pre-aging treatment

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China Foundry 2024年第4期21卷 343-351页

作者： Yuan-hang Jiang Hui-ting Zheng Fei Liu Hai-dong Zhao National Engineering Research Center of Near-net Shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510641China

Considering the components produced by high pressure die casting(HPDC)process usually with ultra-large sizes and complex morphologies,high temperature solid solution treatment is not a suitable method to further improve their mechanical *** this study,two-stage aging treatment with different pre-aging times was designed and employed to further improve the mechanical properties of HPDC Al8SiMgCuZn *** characteristics of precipitates were evaluated by a transmission electron microscope(TEM),and the precipitation strengthening mechanism was *** results reveal that the strengthening is mainly contributed by the precipitation ofβ″phase after two-stage aging,and the number density and size of the precipitates are significantly depended on the pre-aging *** number density of precipitates is increased with the pre-aging time prolonged from 0 h to 4 h,and then decreases with the further increase of pre-aging time from 4 h to 6 *** precipitates with the highest density and smallest size are observed after pre-aging for 4 *** pre-aged at 100℃for 4 h and then artificial aged at 200℃for 30 min,the yield strength of 207 MPa,ultimate tensile strength of 325 MPa and elongation of 7.6%are achieved.

关键词： high pressure die cast aluminum alloy microstructural heterogeneity mechanical properties precipitation strengthening two-stage aging

Effect of Cr_(2)O_(3) on properties of CaO-SiO_(2)-Fe_(t)O-MgO system and dissolution behavior of lime

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Journal of Iron and Steel Research International 2024年第4期31卷 870-881页

作者： Shan-nan Li Jian-li Li Yue Yu hang-yu Zhu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina

The productivity of the chrome-containing semi-steel converter smelting process is directly affected by the slag-forming speed during the converter preliminary *** effects of Cr_(2)O_(3) content on the physicochemical properties of the CaO-SiO_(2)-Fe_(t)O-MgO system,such as melting temperature,solidification behavior,mineral composition,and lime dissolution rate,were *** results showed that the slag was an amorphous phase at 1500℃.When Cr_(2)O_(3) was added,Ca(Fe,Mg)Si_(2)O_(6) and spinel were formed in the *** the increase in Cr_(2)O_(3) content,the amount of spinel precipitation increased,and the dendritic FegO_(4) crystal gradually changed into the granular(Fe,Mg)(Fe,Cr)2O_(4) *** the Cr_(2)O_(3) content increased from O to 2.91 wt.%,the melting temperature of the slag rose,and the melting range of the slag expanded slightly,but the lime dissolution rate did not *** the Cr_(2)O_(3) content further increased to 9.09 wt.%,the melting temperature continued to rise,the melting range rapidly expanded,and the lime dissolution rate decreased.

关键词： Cr_(2)O_(3) Vanadium-titanium magnetite Converter Slag Lime dissolution

Predicting the evolution of electrochemical trepanning for inner blisks with a chamfer structure at blade tip

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Chinese Journal of Aeronautics 2024年第9期37卷 560-576页

作者： Erhao JIAO Dong ZHU Penghui WANG hang ZUO Liyong CHEN College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Electrochemical trepanning(ECTr)is an effective electrochemical machining(ECM)technique that can be used to manufacture the integral components of aero-engine *** study focused on the dynamic evolution of ECTr for production of inner blisks(bladed disks)with a special chamfer structure at blade *** to the existence of chamfer,the ECTr process of inner blades is in a non-equilibrium state during the early stages,and the physical field changes in the machining gap are complex,making it difficult to predict the forming *** this paper,a dynamic evolution model(DEM)of inner blade ECTr with a special chamfer at blade tip structure is proposed,and an ECTr multi-physical fields simulation study was carried *** evolution of the chamfer at blade tip was analyzed and data related to chamfer were predicted based on the dependence of anode boundary properties with machining time and feed *** addition,the dis-tributions of current density,electrolyte flow rate,bubble volume fraction,temperature rise,and electrolyte conductivity in the machining area at different times were obtained by combining them with the multi-physical fields simulation ***,a series of ECTr experiments were conducted,in which,as the feed rate increased,the surface quality and machining accuracy of the inner blades were *** with the simulation results,the error in machining accu-racy of the chamfer profile is controlled within±2%,and the machining accuracy of the blade full profile was controlled within±0.2 mm,indicating that the model proposed in this study was effec-tive in predicting the evolution of inner blades ECTr with chamfer structures at blade tip.

关键词： Chamfer structure Inner blisk Electrochemical trepanning(ECTr) Dynamic evolution model Forming prediction Multiphysics Machining quality

Coupled strategy based on regulator manipulation and medium optimization empowers the biosynthetic overproduction of lincomycin

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Synthetic and Systems Biotechnology 2024年第1期9卷 134-143页

作者： Xinlu Cai Wanlian Xu yang Zheng Sendi Wu Rundong Zhao Nian Wang Yaqian Tang Meilan Ke Qianjin Kang Linquan Bai Buchang Zhang hang Wu School of Life Sciences Institute of Physical Science and Information TechnologyAnhui UniversityHefei230601China State Key Laboratory of Microbial Metabolism Shanghai Jiao Tong UniversityShanghai200240China

The biosynthesis of bioactive secondary metabolites,specifically antibiotics,is of great scientific and economic *** control of antibiotic production typically involves different processes and molecular *** numerous efforts to improve antibiotic yields,joint engineering strategies for combining genetic manipulation with fermentation optimization remain *** A(Lin-A),a lincosamide antibiotic,is industrially fermented by Streptomyces ***,the leucine-responsive regulatory protein(Lrp)-type regulator SLCG_4846 was confirmed to directly inhibit the lincomycin biosynthesis,whereas indirectly controlled the transcription of SLCG_2919,the first reported repressor in *** of SLCG_4846 in the high-yield *** LA219X(LA219XΔ4846)increases the Lin-A production and deletion of SLCG_2919 in LA219XΔ4846 exhibits superimposed yield *** the effect of the double deletion on cellular primary metabolism of ***,Plackett-Burman design,steepest ascent and response surface methodologies were utilized and employed to optimize the seed medium of this double mutant in shake flask,and Lin-A yield using optimal seed medium was significantly increased over the *** strategies were performed in a 15-L *** maximal yield of Lin-A in LA219XΔ4846-2919 reached 6.56 g/L at 216 h,55.1%higher than that in LA219X at the parental cultivation(4.23 g/L).This study not only showcases the potential of this strategy to boost lincomycin production,but also could empower the development of high-performance actinomycetes for other antibiotics.

关键词： Streptomyces Transcription factor Genetic engineering Fermentation optimization Lincomycin

New insight into Ca^(2+)-permeable channel in plant immunity

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Journal of Integrative Plant Biology 2024年第3期66卷 623-631页

作者： wei Wang hang-Yuan Cheng Jian-Min Zhou State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hainan Yazhou Bay Seed Laboratory Sanya 572025China

Calcium ions(Ca^(2+)) are crucial intracellular second messengers in eukaryotic cells. Upon pathogen perception, plants generate a transient and rapid increase in cytoplasmic Ca^(2+)levels, which is subsequently decoded by Ca^(2+)sensors and effectors to activate downstream immune responses. The elevation of cytosolic Ca^(2+)is commonly attributed to Ca^(2+)influx mediated by plasma membranelocalized Ca^(2+)–permeable channels. However, the contribution of Ca^(2+)release triggered by intracellular Ca^(2+)-permeable channels in shaping Ca^(2+)signaling associated with plant immunity remains poorly understood. This review discusses recent advances in understanding the mechanism underlying the shaping of Ca^(2+)signatures upon the activation of immune receptors, with particular emphasis on the identification of intracellular immune receptors as non-canonical Ca^(2+)-permeable channels. we also discuss the involvement of Ca^(2+)release from the endoplasmic reticulum in generating Ca^(2+)signaling during plant immunity.

关键词： Ca^(2+)-permeable channels endoplasmic reticulum phosphorylation plant immunity resistosome

Role of micro-Ca/In alloying in tailoring the microstructural characteristics and discharge performance of dilute Mg-Bi-Sn-based alloys as anodes for Mg-air batteries

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Journal of Magnesium and Alloys 2024年第1期12卷 251-266页

作者： Fei-er Shangguan wei-li Cheng Yu-hang Chen Ze-qin Cui Hui Yu Hong-xia Wang Li-fei Wang hang Li Hua Hou School of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China School of Materials Science and Engineering Hebei University of TechnologyTianjin 300132China School of Materials Science and Engineering North University of ChinaTaiyuan 030051China

The influence of micro-Ca/In alloying on the microstructural charac teristics,electrochemical behaviors and discharge properties of extruded dilute Mg-0.5Bi-0.5Sn-based(wt.%)alloys as anodes for Mg-air batteries are *** grain size and texture intensity of the Mg-Bi-Sn-based alloys are significantly decreased after the Ca/In alloying,particularly for the In-containing *** that,in addition to nanoscale Mg_(3)Bi_(2)phase,a new microscale Mg_(2)Bi_(2)Ca phase forms in the Ca-containing *** electrochemical test results demonstrate that Ca/In micro-alloying can enhance the electrochemical *** In to alloy the Mg-Bi-Sn-based alloy is effective in restricting the cathodic hydrogen evolution(CHE)kinetics,leading to a low self-corrosion rate,while severe CHE occurred after Ca *** micro-alloying of Ca/In to Mg-Bi-Sn-based alloy strongly deteriorates the compactness of discharge products film and mitigates the"chunk effect"(CE),hence the cell voltage,anodic efficiency as well as discharge capacity are greatly *** In-containing alloy exhibits outstanding discharge performance under the combined effect of the modified microstructure and discharge products,thus making it a potential anode material for primary Mg-air battery.

关键词： Mg-air batteries Mg-Bi-Sn based alloys Electrochemical behaviors Discharge properties

Sonoafterglow luminescence for in vivo deep-tissue imaging

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Chinese Chemical Letters 2024年第10期35卷 9-10页

作者： Shihong Wu Ronghui Zhou hang Zhao Peng Wu State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Analytical&Testing Center Sichuan UniversityChengdu 610064China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

Optical imaging is a key technique to study the pathological process and disease diagnosis,but there is still a great challenge to achieve highly sensitive in vivo deep-tissue *** interferences from the intrinsic autofluorescence and light scattering and re-absorption are typically observed in biological tissues,which severely impair target signal sensing and *** address the above issues,using of afterglow luminescence for imaging has been *** to its long lifetime,the images can be collected after ceasing the excitation,thus could eliminate the ***,the current afterglow luminescence still requires photoexcitation(mainly ultraviolet or visible light),the penetration depth of which is still limited for deeptissue imaging.

关键词： scattering luminescence excitation

Density-Functional Theories for Polyelectrolyte Systems

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Chinese Journal of Polymer Science 2024年第9期42卷 1302-1312,I0006页

作者： Jia-wei Zhang Yu-hang Zhang Bao-Hui Li Qiang Wang School of Physics Nankai UniversityTianjin90001China Department of Chemical and Biological Engineering Colorado State University1370 Campus DeliveryFort CollinsCO80523-1370USA

Polymer density-functional theories(PDFTs)have distinct advantages in the study of polyelectrolyte(PE)systems over experiments and molecular *** we give an introductory review of some PDFTs recently developed for PE *** start with a general formalism of PDFTs and its relation to the widely used polymer self-consistent field theory(SCFT),then explain the various correlations that are neglected in SCFT but can be accounted for in PDFTs,including those due to the excluded-volume interaction and chain connectivity of uncharged polymers,the electrostatic correlations of small ions,and the chain correlations in *** also list some applications of PDFTs for PE systems,and finally give some perspectives on future *** hope that our review can attract more researchers to apply and further develop PDFTs as a promising class of theoretical and computational tools.

关键词： Polymer density-functional theories Polyelectrolytes Correlations