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NecAB family of neuronal calcium-binding proteins in health and disease

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NecAB1–3) constitute a family of predominantly neuronal proteins charac.erized by the presence of at least one eF-hand calcium-binding domain and a functionally less we.l charac.erized c-terminal antibiotic biosynthesis monooxygenase domain. All three family members we.e initially discovered due to their interactions with other proteins. NecAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesic.e exocytosis. NecAB2 interacts with predominantly striatal G-protein-coupled receptors, while NecAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NecAB proteins exhibit distinct subcellular localizations: NecAB1 is found in the nuc.eus and cytosol, NecAB2 resides in endosomes and the plasma membrane, and NecAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily anc.ent component, is akin to atypical heme oxygenases in prokaryotes but is not we.lcharac.erized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NecAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. Howe.er, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NecAB proteins by controlling the availability of protein–protein interaction domains situated betwe.n the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Dynamics of air transport networks：A review from a complex systems perspective

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chinese Journal of Aeronautics 2017年第2期30卷 469-478页

作者： Luis e.c.Rocha Department of Public Health Sc.ences Karolinska Institutet Stockholm 17177 Sweden Department of Mathematics University of Namur 5000 Belgium

Air transport systems are highly dynamic at temporal scales from minutes to *** dynamic behavior not only charac.erizes the evolution of the system but also affect the system＇s *** the evolutionary mechanisms is thus fundamental in order to better design optimal air transport networks that benefits companies,passengers and the *** this review,we.briefly present and discuss the state-of-the-art on time-evolving air transport *** distinguish the structural analysis of sequences of network snapshots,ideal for long-term network evolution（*** evolution）,and temporal paths,preferred for short-term dynamics（*** evolution）.we.emphasize that most previous research focused on the first modeling approach（***-term） whereas only a few studies look at high-resolution temporal *** conclude the review highlighting that much research remains to be done,both to apply already available methods and to develop new measures for temporal paths on air transport *** particular,we.identify that the study of delays,network resilience and optimization of resources（aircraft and c.ew） are critical topics.

关键词： Air transport Airport network complex network Dynamic network Temporal network

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聚合过程

聚合过程

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作者： (美)c.e席尔奈希特 I.斯凯斯特唐士培杨新源等译

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effects of Different combinations of Two Spices:clove and Nutmeg Seed extracts on Antioxidants Levels in African catfish(clarias gariepinus)

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Journal of Fisheries Sc.ence 2021年第2期3卷 36-44页

作者： Akinrotimi O.A Okenwa U Stephen M.U eze B.U Onwujiariri c.e African Regional Aquaculture center/Nigerian Institute for Oceanography and Marine Research AluuPort HarcourtRivers StateNigeria Department of Fisheries and Aquatic.environment Faculty of AgricultureRivers State UniversityNkpoluOroworukwoPortharcourtRivers StateNigeria

The effect of different combinations of botanical spices such as clove and nutmeg in different proportion on the antioxidants activities which include lipid peroxidation(LPO),superoxide dismutase(SOD),catalase(cAT),glutathione-S-transferase(GST)and glutathione peroxide(GPX)in juveniles and adults sizes of clarias gariepinus was investigated using different combinations of clove(c),and nutmeg(c.N 0:0-control 0%of clove and Nutmeg;c.N 1:3-25%clove and 75%Nutmeg;c.N 3:1-75%clove and 25%Nutmeg;c.N 2:2-50%clove and 50%Nutmeg;c.4-100%clove;N4-100%)in *** results from the study indicated that the anaesthetic caused a substantial(pcations in the five antioxidants under *** highest deviations in the studied antioxidants we.e observed in the fish exposed to c4 combination of the anaesthetics and the lowe.t in the *** results from this work therefore suggest that the anaesthetics can alter antioxidants levels in the fish which was more noticeable in the fish exposed to c.N 3:1-75%clove and 25%Nutmeg;c.N 2:2-50%clove and 50%Nutmeg;c.4-100%clove;N4-100%.Hence fish farmers and sc.entists are advised to take caution when combining these plant extracts for use in aquaculture.

关键词： Spices Nutmeg clove Anaesthetics Fish Antioxidants

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Alternative fuels—a new field for mine surveying

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中国有色金属学会会刊：英文版 2005年第S1期15卷 289-293页

作者： A. Preuβe c. Herzog Institute for Mine Surveying Mining Subsidence Engineering and Geophysics in Mining (IFM) RWTH Aachen University Wüllnerstr. 2 52062 Aachen GERMANYInstitute for Mine Surveying Mining Subsidence Engineering and Geophysics in Mining (IFM) RWTH Aachen University Wüllnerstr. 2 52062 Aachen GERMANY

Due to the public’s inc.eased interest in renewable energies and the “erneuerbare energien Gesetz” (eeG) from February 2000, geothermal energy and other alternative or renewable energies gain more and more importance. As far as Germany is concerned, geothermal energy and coal bed/mine methane are considered as mineral resources according to the German mining law. This demands the participation of mine surveyors/mineral resources managers from the planning to the production stage and even beyond it. The main tasks that have to be fulfilled are, among others, applications for exploration and production licences as we.l as the evaluation of the resource’s potential. This paper indicates the tasks of mine surveyors/mineral resources managers in the wide area of the renewable energies in Germany, especially concerning the use of geothermal energy and methane.

关键词： mine surveying mineral resources management renewable energies geothermal energy methane

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effect of partic.e Froude number on sub-grid effective drag,filtered and residual stresses in fluidized gas-partic.e flows

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Particuology 2024年第12期95卷 36-48页

作者： christian c.Milioli Fernando e.Milioli Department of Mechanical engineering School of Engineering of São CarlosUniversity of São Paulo13566-590São CarlosSPBrazil

Sub-grid effective drag,filtered and residual stresses in the meso-scale of gas-partic.e fluidized flows are intrinsically affec.ed by underlying micro-scale conditions as we.l as non-local effects related to macro-scale *** this work we.applied microscopic two-fluid modeling to experiment with partic.e Froude number in order to evaluate the impact of this micro-scale condition over the concerning meso-scale derived sub-grid *** performed highly resolved simulations in periodic domains for partic.e Froude numbers from 12.21 to 799.22,for a wide range of macro-scale *** we.e filtered and classified by ranges of meso-scale markers for the various partic.e Froude *** partic.e Froude number was found to considerably affect the structural refinement of the heterogeneous flow fields thereby directly impacting effective drag,filtered and residual *** of those parameters showe. systematic behaviors in relation to partic.e Froude number,thereby providing sound data for new sub-grid modeling propositions.

关键词： Fluidization Gas-partic.e flows Two-fluid model Sub-grid analysis Multiscale analysis

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A comparison of seismic response to conventional and face destress blasting during deep tunnel development

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Journal of Rock Mechanics and Geotechnical engineering 2019年第5期11卷 965-978页

作者： c.Drover e.Villaescusa WA School of Mines Curtin University

A novel design of development face destress blasting was implemented during the construction of an experimental tunnel at great depth.A second tunnel was developed nearby using conventional blasting as a *** tunnels we.e developed parallel to one another and perpendicular to a high subhorizontal *** resolution seismic monitoring was used to record and compare the seismic response generated by each *** of the seismic data from the conventionally blasted tunnel indicated that the seismogenic zone of stress-driven instability extended up to 3.6 m ahead of the *** blasting within the corresponding zone of the adjacent tunnel had the effect of reducing the rock mass stiffness,primarily due to we.kening of the pre-existing natural *** reduction in rock mass stiffness was inferred from the spatial broadening of the seismogenic zone and associated reduction in the measured spatial density of events,radiated energy and seismic potency ahead of the *** strain gradients around the unsupported portion of the conventionally blasted excavation we.e implied by the rate at which the spatial density of seismicity changed with respect to the tunnel face *** contrast,the change in the spatial density of seismicity around the destressed development face was much more *** was indicative of lowe. strain gradients in the rock there.A reduction in rock mass stiffness following destress blasting was also indicated by the much wider variety of seismic source mechanisms recorded adjacent to the destressed *** source mechanisms associated with destress blasting we.e also more c.early charac.eristic of compressive overstressing with fracture *** source mechanism data also indicated that destress blasting induced instability on all natural joint *** compared to conventional development blasting,destress blasting typically reduced violent strain energy release from the rock mass and the assoc

关键词： Destress blasting Mining-induced seismicity Rock fracture Deep mining Tunnelling

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comparison of the simulated gamma-ray attenuation c.effic.ents with the real measurements

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Nuc.ear Sc.ence and Techniques 2015年第5期26卷 53-57页

作者： e.e.ermis e.Pilicer c.celiktas ege University Faculty of Science Physics Department Uludag University Faculty of Arts and Science Physics Department

The gamma-ray linear and the mass attenuation c.effic.ents of Pb, Al, cu, and plexiglass materials we.e calculated from both experimental and theoretical(simulation) methods. For the experimental results, a spectrometer, which was consisted of a Na I(Tl) inorganic scintillation detector, was used. The theoretical attenuation values we.e calculated by means of the FLUKA Monte carlo(Mc) and XcOM programs. Obtained attenuation c.effic.ents from the experiment and the theoretical methods we.e compared with each other and literature values.

关键词：质量衰减系数 γ射线实际测量模拟理论计算方法闪烁体探测器蒙特卡罗方法玻璃材料

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A comprehensive study for mass attenuation c.effic.ents of different parts of the human body through Monte carlo methods

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Nuc.ear Sc.ence and Techniques 2016年第3期27卷 31-39页

作者： e.e.ermis F.B.Pilicer e.Pilicer c.celiktas Physics Department Faculty of ScienceEge University Physics Department Faculty of Arts and ScienceUludag University

The gamma-ray mass attenuation c.effic.ents of blood,bone,lung,eye lens,adipose,tissue,musc.e,brain and skin we.e calculated at different energies(60,80,150,400,500,600,1000,1250,1500,and 2000 keV) by various theoretical methods such as FLUKA,GeANT4 Monte carlo(Mc) methods and XcOM program in this *** c.effic.ents we.e also compared with the National Institute of Standards and Technology(NIST) *** results we.e highly in accordance with each other and NIST *** results showe. that FLUKA was quite convenient in comparison to GeANT4 in the calculation of the mass attenuation c.effic.ents of the used human body samples for low-energy photons(60,80,and 150 keV) when compared with the NIST values.

关键词：质量衰减系数蒙特卡洛方法 Geant4 部位 NIST 美国国家标准能量计算眼晶状体

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On Quasi-Reduced Quadratic Forms

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Acta Mathematica Sinica,english Series 2010年第8期26卷 1425-1448页

作者： e. DUBOIS c. LeVeSQUe eugene Dubois UMR 6138 CNRS Dep. de mathematiques et mecanique BP 5186 U. de Caen Basse-Normandie 14032 Caen France claude Levesque CICMA et Departement de mathematiques et de statistique U. Laval Quebec P. Qudbec Canada G1K 7P4

With the help of continued fractions, we.plan to list all the elements of the set Q△ = {aX2 ＋ bXY ＋ cY2 ： a,b, c ∈Z, b2 - 4ac = △ with 0 ≤ b 〈 √△}of quasi-reduced quadratic forms of fundamental discriminant △. As a matter of fact, we.show that for each reduced quadratic form f = aX2 ＋ bXY ＋ cY2 = （a, b, c） of discriminant △〉0（and of sign σ（f） equal to the sign of a）, the quadratic forms associated with f and defined by {〈a＋bu＋cu2,b＋2cu.c〉},with 1≤σ（f）u≤b/2｜c｜（whenever they exist）, 〈c,-b-2cu,a＋bu＋cu2〉 with b/2｜c｜≤σ（f）u≤[w（f）]=[b＋√△/2｜c｜], are all different from one another and build a set I（f） whose cardinality is #I（f）={1＋[ω（f）],when（2c）｜b,[ω（f）],when （2c）｜b. If f and g are two different reduced quadratic forms, we.show that I（f） ∩ I（g） = Ф. Our main result is that the set Q△ is given by the disjoint union of all I（f） with f running through the set of reduced quadratic forms of discriminant △〉0. This allows us to deduce a formula for #（Q△） involving sums of partial quotients of certain continued fractions.

关键词： Quadratic forms reduced forms equivalence of forms class numbers quadratic fields,continued fractions

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