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Enhancing cartilage repair with optimized supramolecular hydrogel-based scaffold and pulsed electromagnetic field

Bioactive Materials 2023年第4期22卷 312-324页

作者： Yucong Li Linlong Li Ye Li Lu Feng Bin Wang Ming Wang Haixing Wang Meiling Zhu Yongkang Yang Erik IWaldorff Nianli Zhang Ingmar Viohl Sien Lin Liming Bian wayne yuk-wai lee Gang Li Department of Orthopaedics&Traumatology Stem Cells and Regenerative Medicine LaboratoryLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong Special Administrative Region Research&Clinical Affairs Orthofix Medical Inc.LewisvilleTXUSA Department of Rehabilitation Sciences Hong Kong Polytechnic UniversityHong Kong Special Administrative Region Innovation Centre for Advanced Interdisciplinary Medicine Key Laboratory of Biological Targeting DiagnosisTherapy and Rehabilitation of Guangdong Higher Education InstitutesThe Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhenPR China School of Biomedical Sciences and Engineering National Engineering Research Center for Tissue Restoration and ReconstructionKey Laboratory of Biomedical Materials and Engineering of the Ministry of EducationSouth China University of TechnologyGuangzhouPR China Department of Orthopaedics and Traumatology SH Ho Scoliosis Research LaboratoryJoint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing UniversityThe Chinese University of Hong KongHong Kong Special Administrative Region

Functional tissue engineering strategies provide innovative approach for the repair and regeneration of damaged *** is widely used because it could provide rapid defect filling and proper structure support,and is biocompatible for cell aggregation and matrix *** have been made to seek suitable scaffolds for cartilage tissue *** Alg-DA/Ac-β-CD/gelatin hydrogel was designed with the features of physical and chemical multiple crosslinking and self-healing *** time,swelling ratio,biodegradability and biocompatibility of the hydrogels were systematically characterized,and the injectable self-healing adhesive hydrogel were demonstrated to exhibit ideal properties for cartilage ***,the new hydrogel design introduces a pre-gel state before photo-crosslinking,where increased viscosity and decreased fluidity allow the gel to remain in a semi-solid *** granted multiple administration routes to the hydrogels,which brings hydrogels the ability to adapt to complex clinical *** electromagnetic fields(PEMF)have been recognized as a promising solution to various health problems owing to their noninvasive properties and therapeutic *** treatment offers a better clinical outcome with fewer,if any,side effects,and wildly used in musculoskeletal tissue *** we propose PEMF as an effective biophysical stimulation to be 4th key element in cartilage tissue *** this study,the as-prepared Alg-DA/Ac-β-CD/gelatin hydrogels were utilized in the rat osteochondral defect model,and the potential application of PEMF in cartilage tissue engineering were *** treatment were proven to enhance the quality of engineered chondrogenic constructs in vitro,and facilitate chondrogenesis and cartilage repair in *** of the results suggested that with the injectable self-healing adhesive hydrogel and PEMF treatment,this newly proposed tissue engineering strategy r

关键词： Supramolecular hydrogels Pulsed electromagnetic field Cartilage tissue engineering Mesenchymal stem cells Chondrogenesis

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O-alg-THAM/gel hydrogels functionalized with engineered microspheres based on mesenchymal stem cell secretion recruit endogenous stem cells for cartilage repair

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Bioactive Materials 2023年第10期28卷 255-272页

作者： Yucong Li Linlong Li Ming Wang Boguang Yang Baozhen Huang Shanshan Bai Xiaoting Zhang Nan Hou Haixing Wang Zhengmeng Yang Chong Tang Ye Li wayne yuk-wai lee Lu Feng Micky D.Tortorella Gang Li Stem Cells and Regenerative Medicine Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong Special Administrative Region of China Musculoskeletal Research Laboratory Department of Orthopaedics&TraumatologyFaculty of MedicineThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong Special Administrative Region of China The CUHK-ACC Space Medicine Centre on Health Maintenance of Musculoskeletal System The Chinese University of Hong Kong Shenzhen Research InstituteShenzhenPR China Department of Orthopaedics Peking University Shougang HospitalBeijingPR China Department of Rehabilitation Sciences Hong Kong Polytechnic UniversityHong Kong Special Administrative Region of China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhouChina

Lacking self-repair abilities,injuries to articular cartilage can lead to cartilage degeneration and ultimately result in *** engineering based on functional bioactive scaffolds are emerging as promising approaches for articular cartilage regeneration and *** the use of cell-laden scaffolds prior to implantation can regenerate and repair cartilage lesions to some extent,these approaches are still restricted by limited cell sources,excessive costs,risks of disease transmission and complex manufacturing *** approaches through the recruitment of endogenous cells offer great promise for in situ articular cartilage *** this study,we propose an endogenous stem cell recruitment strategy for cartilage *** on an injectable,adhesive and self-healable o-alg-THAM/gel hydrogel system as scaffolds and a biophysio-enhanced bioactive microspheres engineered based on hBMSCs secretion during chondrogenic differentiation as bioactive supplement,the as proposed functional material effectively and specifically recruit endogenous stem cells for cartilage repair,providing new insights into in situ articular cartilage regeneration.

关键词： Bioactive hydrogels Solidified secretome Adhesive hydrogels Acellular functional scaffold Cartilage repair

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Prediction of performance and evaluation of flexible pavement rehabilitation strategies

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Journal of Traffic and Transportation Engineering(English Edition) 2017年第2期4卷 178-184页

作者： Kang-Won wayne lee Kathleen Wilson Syed Amir Hassan Department of Civil and Environmental Engineering University of Rhode Island Kingston R1 02881 USA Rhode Island Department of Transportation Prouid-ence RI 02903 USA

Five test sections with different additives and strategies were established to rehabilitate a State-maintained highway more effectively in Rhode Island （RI）： control, calcium chloride, asphalt emulsion, Portland cement and geogrid. Resilient moduli of subgrade soils and subbase materials before and after full depth rehabilitation were employed as input pa- rameters to predict the performance of pavement structures using AASHTOWare Pave- ment ME Design （Pavement ME） software in terms of rutting, cracking and roughness. It was attempted to use Level i input （which includes traffic full spectrum data, climate data and structural layer properties） for Pavement ME. Traffic data was obtained from a Weigh- in-Motion （WIM} instrument and Providence station was used for collecting climatic data. Volumetric properties, dynamic modulus and creep compliance were used as input pa- rameters for 19 mm （0.75 in.} warm mix asphalt （WMA） base and 12.S mm （0.5 in.） WMA surface layer. The results indicated that all test sections observed AC top-down （longitu- dinal） cracking except Portland cement section which passed for all criteria. The order in terms of performance （best to worst） for all test sections by Pavement ME was Portland cement, calcium chloride, control, geogrid, and asphalt emulsion. It was also observed that all test sections passed for both bottom up and top down fatigue cracking by increasing thickness of either of the two top asphalt layers. Test sections with five different base/ subbase materials were evaluated in last two years through visual condition survey and measurements of deflection and roughness to confirm the prediction, but there was no serious distress and roughness. Thus these experiments allowed selecting the best reha- bilitation/reconstruction techniques for the particular and/or similar highway, and a framework was formulated to select an optimal technique and/or strategy for future rehabilitation/reconstruction projects. Finally, guidelines for lo

关键词： Full depth rehabilitation Resilient modulus AASHTOWare pavement ME design Surface distress

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Cold In-Place Recycling as a Sustainable Pavement Practice

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Journal of Civil Engineering and Architecture 2014年第6期8卷 680-692页

作者： Kang-Won wayne lee Max Mueller Ajay Singh Department of Civil and Environmental Engineering University of Rhode Island Kingston 02881 USA

Pavement rehabilitation and reconstruction methods with CIR （cold in-place recycling） are alternatives that can effectively reduce the high stresses and waste produced by conventional pavement strategies. An attempt was made to predict the performance, particularly low-temperature cracking resistance characteristics of CIR mixtures. These were prepared with the mix design procedure developed at the URI （University of Rhode Island） for the FHWA （Federal Highway Administration） to reduce wide variations in the application of CIR mixtures production. This standard was applied to RAP （reclaimed asphalt pavement） to produce CIR mixtures with CSS-Ih asphalt emulsion as the additive. By adjusting the number of gyrations of the SGC （Superpave gyratory compactor） for compaction, the field density of 130 pcf was represented accurately. To secure a base line, HMA （hot mix asphalt） samples were produced according to the Superpave volumetric mix design procedure. The specimens were tested using the IDT （indirect tensile） tester according to the procedure of AASHTO T 322 procedure at temperatures of-20, -10 and 0 ℃ （-4, 14, and 32°F, respectively）. The obtained results for the creep compliance and tensile strength were used as input data for the MEPDG （mechanistic empirical pavement design guide）. The analysis results indicated that no thermal or low-temperature cracking is expected over the entire analysis period of 20 years for both HMA and CIR mixtures. Thus, it appears that CIR is a sustainable rehabilitation technique which is also suitable for colder climates, and it is recommended to conduct further investigation of load-related distresses such as rutting and fatigue cracking.

关键词： Cold in-place recycling sustainable pavement asphalt pavement pavement rehabilitation and reconstruction Superpavegyratory compactor indirect tensile test.

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Exploration of Mutation and DNA Methylation of Polo-Like Kinase 1 (PLK1) in Colorectal Cancer

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Open Journal of Pathology 2017年第3期7卷 45-57页

作者： wayne Ng Joo-Shik Shin Bin Wang Cheok Soon lee Discipline of Pathology Western Sydney University Sydney Australia Centre for Oncology Education and Research Translation Ingham Institute for Applied Medical Research Sydney Australia South Western Sydney Clinical School University of New South Wales (UNSW) Sydney Australia

Polo-like kinase 1 (PLK1) is a serine/threonine kinase that plays critical roles in cell cycling and DNA damage response. Overexpression of PLK1 is associated with the poorer prognosis of cancers, including colorectal cancer (CRC). Although the downstream pathways of the overexpression that lead to oncogenesis have been extensively studied, little is known about the factors that cause the overexpression of PLK1 in CRC. DNA methylation was reported to be affecting the expression of PLK1 in some cancers. The study aims to investigate the contribution of genetic mutation and DNA methylation of the PLK1 gene to the overexpression of PLK1 in CRC. The study involves data mining from Catalogue of Somatic Mutations in Cancer (COSMIC) and UniProtKB, Sanger sequencing on DNA from the cell lines HCT116, SW48, Colo320DM and T84 to analyse the possible mutation of PLK1. Other than that methylation status of the PLK1 promoter in CRC are also analysed by using mass spectrometry (MS) and pyrosequencing. Data from the COSMIC show the low incidences of PLK1 mutation for CRC (3.02%) with 46 mutations identified. One of the mutation p.R337Q (c.1010G > A) is located in the D-box which is an important motif for protein ubiquitination and eventually proteasomal degradation. Hence this mutation may potentially result in stabilisation of the PLK1 protein. Mutations are detected at the upstream silencer region, the promoter region and Exon1 in HCT116 but are not located at the protein binding or functioning site. Similarly, the same mutation at promoter region is detected in SW48. Differential trends of changes in methylation status of PLK1 in the IR treated CRC cell lines detected by MS reveal the possible association between the methylation and the radiosensitivity. Furthermore, pyrosequencing shows that PLK1 methylation status in tumour tissues with high expression of PLK1 is not significantly different from those with no PLK1 expression. In conclusion, mutation of PLK1 gene is infrequent

关键词： PLK1 CRC Mutation DNA Methylation Sequencing

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Investigation of Novel Methods To Harvest Solar Energy from Asphalt Pavements

Investigation of Novel Methods To Harvest Solar Energy from ...

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ISAP2012重载沥青路面和桥面铺装专题会议

作者： lee Kang-Won wayne ang Sze Chang Correia Andrew Rhode Island Transportation Research Center University of Rhode Island Chemistry Department University of Rhode Island Civil and Environmental Engineering University of Rhode Island

＜正＞To investigate novel methods to harvest solar energy from road pavements,a research team from the University of Rhode Island（URI） proposed to conduct a pilot study with Rhode Island（RI） typical pavement structure with hot mix asphalt（HMA）（lee et al.2009）.A practical method to harvest solar energy would be embedding highly conductive water pipes underneath asphalt pavements,and taking advantage of their untapped solar *** heated,this water can be used as-is to heat buildings or can be passed through a generator to produce *** other

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Evaluating the Technical and Economic Feasibility of Adding a Power Recovery System to the Steam Condenser of a Lignite Coal-Fired Power Plant

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Journal of Power and Energy Engineering 2022年第11期10卷 16-34页

作者： Joshua Wilmer wayne Seames Dimitri Bazile Kay lee Smith Benjamin Koster Grady Mauch Lucas Weimer Department of Chemical Engineering University of North Dakota Grand Forks ND USA

Steam is the typical working fluid to drive turbo-generators in coal-fired power plants. It is an effective working fluid, but some of its energy is extracted in an unusable form when condensed. A Power Recovery Cycle (PRC) using a more volatile Secondary Working Fluid (SWF) added to the steam cycle could improve energy efficiency. PRCs have been applied to the flue gas and for combined cycle systems but not to traditional plant steam cycles. This paper details an analysis of adding a steam cycle PRC to a 500 MW lignite coal-fired power plant. A validated model of the plant was developed and PRCs using the three most attractive SWFs, benzene, methanol and hydrazine, were then added to the model. Adding a benzene, methanol, or hydrazine steam cycle PRC will produce an additional 59, 34, and 49 MW, respectively. An AACE Class 4 factored broad capital cost estimate and comparable operating costs and revenue estimates were developed to evaluate PRC feasibility. The benzene, methanol, and hydrazine processes had 2019 Net Present Values (NPVs) @12% of -$32, -$59, and +$35 million ± 40%, respectively. Thus, a PRC may be profitable at current or modest increases to U.S. Upper Midwest electricity prices of around $0.0667/kWh.

关键词： Lignite Coal Heat Recovery Power Plant Organic Rankine Cycle Bottoming Cycle

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A RATIONAL MIX-DESIGN FOR COLD IN-PLACE RECYCLING ASPHALT IXTURES

A RATIONAL MIX-DESIGN FOR COLD IN-PLACE RECYCLING ASPHALT IX...

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ISAP2012重载沥青路面和桥面铺装专题会议

作者： K.wayne lee Todd Brayton Max Mueller Ajay Singh University of Rhode Island

＜正＞The high cost and environmental impact of traditional pavement maintenance and rehabilitation（M＆R） has led to an increase in the use of Cold In-Place Recycling（CIR） as an effective alternative to other rehabilitation ***,there was not a universally accepted or standard mix-design for ***,an attempt was made to develop a rational mix-design method for use with the CIR of asphalt pavement with the assistance from the Federal Highway Administration（FHWA）.Evaluation results of the modified Marshall Design method from the AASHTO Task Force No.38suggested that it would not be the future for CIR *** use of the Superpave

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Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma

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World Journal of Clinical Oncology 2014年第2期5卷 142-148页

作者： Erik W Larson Halloran E Peterson wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M lee Gamma Knife of Spokane Spokane WA 99204 United States Cancer Care Northwest Spokane WA 99204 United States University of Washington School of Medicine Seattle WA 98195 United States MacK ay and Meyer MDs Spokane WA 99202 United States Inland Neurosurgery and Spine Associates Spokane WA 99204 United States Spokane Brain and Spine Spokane WA 99204 United States

Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed.

关键词： Gamma Knife radiosurgery Malignant glioma Glioblastoma Salvage therapy Stereotactic radiosurgery Multimodal treatment

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Allometric relationships between primary size measures and sapwood area for six common tree species in snow-dependent ecosystems in the Southwest United States

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Journal of Forestry Research 2020年第6期31卷 2171-2180页

作者： Bhaskar Mitra Shirley A.Papuga MRoss Alexander Tyson lee Swetnam Nate Abramson School of Natural Resources and Environment University of ArizonaTucsonAZ 85721USA Department of Geology Wayne State UniversityDetroitMI 48202USA Laboratory of Tree-Ring Research University of ArizonaTucsonAZ 85721USA BIO5 Institute University of ArizonaTucsonAZ 85721USA Department of Hydrology and Water Resources University of ArizonaTucsonAZ 85721USA

High-elevation,snow-dependent,semiarid ecosystems across southwestern United States are expected to be vulnerable to climate change,including drought and fi re,with implications for various aspects of the water *** that end,much less is known about the dynamics of transpiration,an important component of the water cycle across this *** the individual-tree scale,transpiration is estimated by scaling mean sap fl ux density by the hydroactive sapwood area(SA).SA also remains a key factor in eff ectively scaling individual tree water-use to stand *** across large spatial scales is normally established by relating SA of a few trees to primary size measures,e.g.,diameter at breast height(DBH),tree height(H),or canopy diameter(CD).Considering the importance of SA in scaling transpiration,the primary objective of this study was therefore to establish six species-specifi c(aspen,maple,white fi r,ponderosa pine,Douglas fi r,Englemann spruce)allometric relationships between SA and three primary size measures(DBH,CD,or H)across two high-elevation,snow-dependent,semiarid ecosystems in New Mexico and *** on multiple statistical criteria(coeffi cient of determination,index of agreement,Nash–Sutcliff e effi-ciency)and ease of measurement in the forest,we identifi ed DBH as the primary independent variable for estimating SA across all *** on group regression analysis,we found allometric relationships to be signifi cantly(p<0.05)diff erent for the same species(ponderosa pine,Douglas-fi r)across diff erent ***,our allometric relationships provide a valuable database for estimating transpiration at diff erent spatial scales from sap fl ow data in some of our most vulnerable ecosystems.

关键词： Allometry Diameter at breast height Mountain ecosystem Sapwood area Southwestern USA

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