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Overall and cause-specific survival for mucoepidermoid carcinoma of the major salivary glands:Analysis of 2210 patients

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World Journal of Clinical Oncology 2020年第12期11卷 1029-1044页

作者： Zachary C taylor Erin A Kaya Jeffrey D Bunn Zachary D Guss Brian J Mitchell Robert K Fairbanks wayne t lamoreaux Aaron E Wagner Ben J Peressini Christopher M Lee Department of Radiation Oncology Cancer Care NorthwestSpokaneWA 99202United States MD Program Elson S.Floyd College of MedicineSpokaneWA 99202United States Surgery Spokane EarNoseand ThroatSpokaneWA 99201United States Department of Biostatistics DataWorks NorthwestLLCCoeur D'AleneID 83815United States

BACKGROUND Mucoepidermoid carcinoma(MEC)is a rare malignancy of the head and neck;however,it accounts for a majority of the tumors of the salivary *** study used a national population-based registry to describe the pre-treatment and treatment-related prognostic factors that influence survival in patients with MEC of the major salivary *** our knowledge,this is the largest populationbased study examining predictors of both overall and cause-specific survival of MEC of the major salivary *** to identify prognostic factors influencing overall survival(OS)and cause-specific survival(CSS)of patients with MEC of the major salivary *** We used the Surveillance,Epidemiology and End-Results Database of the National Cancer Institute to investigate a variety of factors that could influence survival of patients diagnosed with mucoepidermoid carcinoma of the major salivary glands.A total of 2210 patients diagnosed with MEC of the major salivary glands during the years of 1975-2016 were *** primary endpoints were OS and *** regression analysis was used to perform univariate and multivariate analyses of clinical variables such as age at diagnosis,diagnosis year,sex,race,tumor size,stage,grade,treatment with or without surgical excision,and adjuvant radiotherapy *** A total of 2210 patients diagnosed with MEC of the major salivary glands met inclusion *** this study,95%of patients underwent surgical excision and 41%received adjuvant radiation *** OS time for Grade I,II,and III/IV was 401 mo(±48.25,95%CI),340 mo(±33.68,95%CI)and 55 mo(±11.05,95%CI),*** analysis revealed that lack of surgical excision was associated with decreased OS[hazard ratio(HR)4.26,Pthat patients with localized disease had improved OS compared to both regional and distant disease(HR 3.07 and 6.96,respectively,Ptionally,univariate analysis demonstrated that male sex,age over 50 at diagnosis,G

关键词： Mucoepidermoid carcinoma Salivary gland neoplasia Surveillance,Epidemiology and End-Results Head and neck cancer Prognostic factors Major salivary glands

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Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma

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World Journal of Clinical Oncology 2014年第2期5卷 142-148页

作者： Erik W Larson Halloran E Peterson wayne t lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee Gamma Knife of Spokane Spokane WA 99204 United States Cancer Care Northwest Spokane WA 99204 United States University of Washington School of Medicine Seattle WA 98195 United States MacK ay and Meyer MDs Spokane WA 99202 United States Inland Neurosurgery and Spine Associates Spokane WA 99204 United States Spokane Brain and Spine Spokane WA 99204 United States

Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. this study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. this report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). three studies identified median progression-free survival(range:4.6-14.9 mo). two showed median time to recurrence of GBM. two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). the greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed.

关键词： Gamma Knife radiosurgery Malignant glioma Glioblastoma Salvage therapy Stereotactic radiosurgery Multimodal treatment

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