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The effect of acute aerobic exercise on central arterial stiffness,wave reflections,and hemodynamics in adults with diabetes:A randomized cross-over design

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Journal of Sport and Health Science 2021年第4期10卷 499-506页

作者： Kimberley L.way Angela S.Lee Stephen M.Twigg Nathan A.Johnson Faculty of Medicine and Health Discipline of Exercise and Sports ScienceUniversity of SydneyLidcombeNSW 2141Australia charles Perkins centre University of SydneyCamperdownNSW 2006Australia Boden collaboration for Obesity NutritionExercise and Eating DisordersUniversity of SydneyCamperdownNSW 2006Australia Faculty of Medicine and Health Central Clinical SchoolUniversity of SydneyCamperdownNSW 2006Australia Department of Endocrinology Diabetes CentreRoyal Prince Alfred HospitalSydneyNSW 2050Australia

Background:Individuals with diabetes have greater central arterial stiffness,wave reflections,and hemodynamics,all of which promote the accelerated cardiovascular pathology seen in this *** aerobic exercise has been shown to be an effective strategy for reducing central arterial stiffness,wave reflections,and hemodynamics in healthy individuals;however,the effects of acute aerobic exercise in reducing these outcomes is not well established in people with ***,implementation of high-intensity interval exercise(HIIE)has shown superior improvements in cardiovascular health outcomes when compared to traditional aerobic ***,the effect of HIIE on the aforementioned outcomes in people with diabetes is not *** purpose of this study was to(i)describe the central arterial stiffness,wave reflections,and hemodynamic responses to a bout of HIIE and moderate-intensity continuous exercise(MIcE)in adults with diabetes;and(ii)compare the effects of HIIE and MIcE on the aforementioned ***:A total of 24 adult men and women(aged 29-59 years old)with type 1(n=12)and type 2(n=12)diabetes participated in a randomized cross-over *** participants completed the following protocols:(i)HIIE:cycling for 4×4 min at 85%-95%of heart rate peak(HR_(peak)),interspersed with 3 min of active recovery at 60%-70%HR_(peak);(ii)MIcE:33 min of continuous cycling at 60%-70%HR_(peak);and(iii)control(cON):lying quietly in a supine position for 30 ***:A significant group￡time effect was found for changes in central systolic blood pressure(F=3.20,p=0.01)with a transient reduction for the HIIE group but not for the MIcE or cON *** was a significant group￡time effect for changes in augmentation index at a heart rate of 75 beats/min(F=2.32,p=0.04)with a decrease following for HIIE and MIcE but not for *** all other measures of central arterial stiffness and hemodynamics,no significant changes were observed(p>0.05).conclusion:A bout of

关键词： Augmentation index central systolic blood pressure Diabetes High-intensity interval exercise

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Mutations in Hemagglutinin of a Novel Avian-Origin H7N9 Virus That Are critical for Receptor Binding Specificity

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Tsinghua Science and Technology 2013年第5期18卷 522-529页

作者： Wei hu the Department of computer Science Houghton College

A novel avian-origin H7N9 influenza virus was discovered in March in china and has caused a total of131 people infected including 39 deaths in china as of June 9, 2013. Adaptation of avian viruses to efficiently infect humans requires the viral hemagglutinin（HA） binding switches from avian to human type receptors with help of some mutations in HA. As such it is critical for pandemic assessment to discover these mutations as hallmarks of adaptation. To continue our previous study of this novel H7N9 virus, we identified two sets of mutations in HA. The first set of mutations are present in the current circulating strains of 2013 H7N9 in china, and the second set are potential mutations that were found when compared to the HAs of previous human H7 subtype. These two sets of mutations exhibited unique features. The first group of mutations, on average, enhanced the HA binding to human type receptors whereas reduced that to avian types. Further the reduction of avian binding was almost three times of the increase of the human binding. The second group increased the binding to both human and avian *** the increase in human types was almost three times of that in the avian types. Though different in their way of changing the binding preference, these two sets of mutations both contained more mutations to decrease the avian binding and increase the human binding than those that did the opposite. Our research highlighted the pandemic potential of this novel virus by showing the important mutations that could potentially help it to adapt to human hosts. Our findings offered new insights into the current state of evolution of this virus, which might be helpful for the continued surveillance of the emergence of H7N9 strains having the ability of human-to-human transmission.

关键词： H7N9 influenza receptor binding specificity mutation HA gene

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固态胶原基材料在医疗器械中的应用

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中国组织工程研究 2025年第16期29卷 3503-3512页

作者：胡张捷张宝贯张智武浙江崇山生物制品有限公司浙江省杭州市311100 上海市光明中学上海市200021

背景:胶原蛋白是细胞外基质的主要构成成分,具有稳定的三螺旋结构特性、良好的生物学特性和可加工性,是一种理想的生物医用材料,已被广泛应用于医疗器械领域。目的:分析固态胶原基材料的主要产品形态、技术特点、制备工艺和临床应用。方... 详细信息

背景:胶原蛋白是细胞外基质的主要构成成分,具有稳定的三螺旋结构特性、良好的生物学特性和可加工性,是一种理想的生物医用材料,已被广泛应用于医疗器械领域。目的:分析固态胶原基材料的主要产品形态、技术特点、制备工艺和临床应用。方法:应用计算机检索PubMed和中国知网数据库收录的有关固态胶原基材料在医疗器械领域应用的研究,英文检索词为“collagen,collagen sponge,collagen membrane,collagen powder,collagen gel,decellularized extracellular martix,medical device,clinical application”,中文检索词为“胶原,胶原海绵,胶原膜,胶原粉,胶原凝胶,脱细胞基质,医疗器械,临床应用”。根据纳入与排除标准对所有文章进行初筛后,保留质量和相关性较高的92篇文献进行综述。结果与结论:以动物源来源固态胶原基材料作为医疗器械制备材料,已在原料提取、制备工艺及临床应用等方面取得显著进展,海洋生物胶原和重组胶原增加了胶原来源的可选择性。固态胶原基医疗器械产品类型丰富,制备方法多样,其中交联改性是提升材料性能的重要途径,值得被深入研究。在产品开发思路上,固态胶原基医疗器械产品研究正朝着立体化和仿生化方向发展,与其他生物材料、药物复合的研究也展现出巨大潜力。尽管国内已有不少胶原基医疗器械应用于临床,但在人工皮肤、软骨修复和神经损伤修复等领域的产品开发仍显不足,需在技术和产业化上进一步突破与创新。

关键词：胶原蛋白固态胶原生物学特性医疗器械制备工艺临床应用

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Usefulness of a scoring system in the interpretation of histology in neonatal cholestasis

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World Journal of Gastroenterology 2009年第42期15卷 5326-5333页

作者： way Seah Lee Lai Meng Looi Department of Paediatrics University of Malaya Medical CentreKuala Lumpur 59100Malaysia Department of Pathology University of Malaya Medical CentreKuala Lumpur 59100Malaysia

AIM:To ascertain the usefulness of a histological scoring system devised to assist in the interpretation of liver histology in neonatal cholestasis(Nc) .METHODS:Liver biopsy specimens obtained from infants with Nc referred to a tertiary pediatric unit in Malaysia were prospectively *** first author,blinded to the final diagnosis,devised the histological diagnosis based on a 7-feature(portal ductal proliferation,bile plugs in portal ductules,portoportal bridging,lymphocytic infiltration in portal region,multinucleated hepatocytes,neutrophilic infiltration,hepatocellular swelling) ,15-point(0 to 15) scoring *** author classified the histological diagnosis as either biliary atresia(BA) or neonatal hepatitis(NH,all other diagnoses) ,and subsequently compared the author's diagnosis with the final ***:Eighty-four biopsy specimens obtained from 78 patients were *** the scoring system,BA was correctly diagnosed by the author histologically in 30 cases,labelled as NH in *** other diagnoses,BA was excluded correctly in 33 cases and mislabeled as BA in 2 *** overall sensitivity for BA was 91%,specificity 86% and accuracy 88%.With the scoring system,a score of ≥ 7 had the best diagnostic utility to differentiate BA from other intrahepatic cholestasis histologically(sensitivity 88%,specificity 94%,accuracy 92%) .Four patients with a score core ≥ 7 had ***:A 7-feature,15-point histological scoring system had good diagnostic accuracy in the interpretation of liver histology in neonatal cholestasis.

关键词： Histology scoring system Liver biopsy Neonatal cholestasis

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Attribute reduction in interval-valued information systems based on information entropies

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Frontiers of Information Technology & Electronic Engineering 2016年第9期17卷 919-928页

作者： Jian-hua DAI hu hu Guo-jie ZHENG Qing-hua hu hui-feng HAN Hong SHI School of computer Science and Technology Tianjin University college of computer Science and Technology Zhejiang University

Interval-valued data appear as a way to represent the uncertainty affecting the observed values. Dealing with interval-valued information systems is helpful to generalize the applications of rough set theory. Attribute reduction is a key issue in analysis of interval-valued data. Existing attribute reduction methods for single-valued data are unsuitable for interval-valued data. So far, there have been few studies on attribute reduction methods for interval-valued data. In this paper, we propose a framework for attribute reduction in interval-valued data from the viewpoint of information theory. Some information theory concepts, including entropy, conditional entropy, and joint entropy, are given in interval-valued information systems. Based on these concepts, we provide an information theory view for attribute reduction in interval-valued information systems. consequently, attribute reduction algorithms are proposed. Experiments show that the proposed framework is effective for attribute reduction in interval-valued information systems.

关键词： Rough set theory Interval-valued data Attribute reduction Entropy

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Investigation on Surface Plasmon Polaritons and Localized Surface Plasmon Production Mechanism in Micro-Nano Structures

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Journal of Electronic Science and Technology 2022年第1期20卷 20-29页

作者： Ling-Xi hu Min hu Sheng-Gang Liu Terahertz Research center School of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 610054 Key Laboratory of Terahertz Technology(Ministry of Education) University of Electronic Science and Technology of ChinaChengdu 610054

The simulation mechanism of surface plasmon polaritons(SPPs)and localized surface plasmon(LSP)in different structures was studied,including the Au reflection grating(Au grating),Au substrate with dielectric ribbons grating(Au substrate grating),and pure electric conductor(PEc)substrate with Au ribbons grating(Au ribbons grating).And the characteristics of the Smith-Purcell radiation in these structures were *** results show that SPPs are excited on the bottom surface of Au substrate grating grooves and LSP is stimulated on the upper surface both of Au ribbons grating grooves and Au grating *** to the irreconcilable contradiction between optimizing the grating diffraction radiation efficiency and optimizing the SPPs excitation efficiency in the Au substrate grating,only 40-times enhancement of the radiation intensity was obtained by excited ***,the LSP enhanced structure overcomes the above problem and gains much better radiation enhancement ability,with about 200-times enhancement obtained in the Au ribbons grating and more than 500-times enhancement obtained in the Au *** results presented here provide a way of developing miniature,integratable,tunable,high-power-density radiation sources from visible light to ultraviolet rays at room temperature.

关键词： coherent radiation high-power radiation localized surface plasmon(LSP) micro-nano structure Smith-Purcell radiation surface plasmon polaritons(SPPs)

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Brazil: A Leadership Role in Pushing for a Multipolar International Monetary System?——Exploring the Possible Prescriptions to the complaint from the cases of Brazil

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china's Foreign Trade 2012年第3期 66-67页

作者： Edwin way political science at Indiana University

Brazil is set to propose an 'exchange rate anti-dumping' measure to the World Trade Organization that would allow countries to retaliate against trading partners that undertake competitive devaluations of their curren... 详细信息

关键词：货币巴西国际投诉处方世界贸易组织贸易伙伴交换率

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Getting at the Pulse of the EU Debt crisis——Exploring the Roots and Possible Prescriptions to the crisis from the cases of Iceland and Greece

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china's Foreign Trade 2012年第2期 62-65页

作者： Edwin way Indiana University

The European debt crisis started with Greece in the winter of 2009. And since the outbreak of the crisis, the European commission and European central Bank, as well as the national governments have taken various finan... 详细信息

关键词：希腊冰岛脉搏处方金融危机受害者自由化

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Yolk-shell Si/c composites with multiple Si nanoparticles encapsulated into double carbon shells as lithium-ion battery anodes

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Journal of Energy chemistry 2019年第5期28卷 124-130页

作者： Le hu Bin Luo chenghao Wu Pengfei hu Lianzhou Wang Haijiao Zhang Institute of Nanochemistry and Nanobiology Shanghai UniversityShanghai 200444China Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQLD 4072Australia Laboratory of Microstructure Shanghai UniversityShanghai 200444China

The conceptual design of yolk-shell structured Si/c composites is considered to be an effective way to improve the recyclability and conductivity of Si-based anode materials. Herein, a new type of yolk-shell structured Si/c composite (denoted as TSc-PDA-B) has been intelligently designed by rational engineering and precise control. In the novel structure, the multiple Si nanoparticles with small size are successfully encapsulated into the porous carbon shells with double layers benefiting from the strong etching effect of HF. The TSc-PDA-B product prepared is evaluated as anode materials for lithium-ion batteries (LIBs). The TSc-PDA-B product exhibits an excellent lithium storage performance with a high initial capacity of 2108 mAh g^-1 at a current density of 100 mA g^-1 and superior cycling performance of 1113 mAh g^-1 over 200 cycles. The enhancement of lithium storage performance may be attributed to the construction of hybrid structure including small Si nanoparticles, high surface area, and double carbon shells, which can not only increase electrical conductiv让y and intimate electrical contact with Si nanoparticles, but also provide built-in buffer voids for Si nanoparticles to expand freely without damaging the carbon layer. The present findings can provide some scientific insights into the design and the application of advanced Si-based anode materials in energy storage fields.

关键词： Si/c composites Yolk-shell Multiple Si nanoparticles Double carbon shells Energy storage

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Synthesis of a novel diether–ester conjugated model compound for electron donors of the polypropylene catalysts

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chinese chemical Letters 2013年第12期24卷 1106-1108页

作者： Jian-Jun hu Beijing Research Institute of chemical Industry SINOPEC

A novel diether-ester conjugated electron donor model compound, 1,3-dimethoxypropan-2-yl benzoate, was synthesized via a reaction of 1,3-dimethoxypropan-2-ol and benzoyl chloride in the presence of triethyl amine and 4-dimethylaminopryidine. compared to the known routes of preparing diethers, which usually employ the reactions to O-alkylate the corresponding diols with O-alkylating reagents, the presented method here provides a new way to prepare the diether electron donor compounds. It avoids employing the traditional O-alkylation reactions, so that highly toxic O-alkylating chemicals, such as iodomethane, and very strong basic deprotonating reagents, such as alkoxides or metal hydrides, are not required. The product can be obtained in high yields without complicated purification processes. catalyst component containing the electron donor compound was prepared and used to catalyze propylene polymerization.

关键词： Ether Ester Electron donors Polypropylene catalyst

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