检索结果-南通市图书馆

Journal of Behavioral and Brain Science 2022年第12期12卷 640-657页

作者： Masahiro sano Hikaru Iwashita Atsuhiko Hattori Atsuhiko Chiba Department of Materials and Life Sciences Faculty of Science and Technology Sophia University Tokyo Japan Department of Biology College of Liberal Arts and Sciences Tokyo Medical and Dental University Chiba Japan

Melatonin (MEL) has been reported to have acute enhancing effects on some aspects of cognition. Recently, we revealed that N1-acetyl-5-methoxyquinuramine (AMK), a brain metabolite of MEL, is much more potent than MEL in converting short-term memory (STM) to long-term memory (LTM) with a single administration immediately after the acquisition trial of the novel object recognition (NOR) task. These data suggest that the memory-enhancing effects of MEL may be mediated by mechanisms independent of the activation of MEL MT1 and MT2 receptors. In the present study, we examined the contribution of MT1 and MT2 receptor-mediated and non-receptor-mediated mechanisms to the acute memory-enhancing effects of MEL using NOR task. Mice were administered with either MEL, AMK, or a highly selective MT1/MT2 receptor agonist ramelteon (RAM) immediately after the acquisition trial and the effects of varying doses of these drugs on both STM and LTM performance were compared. We found that both AMK and RAM were more potent than MEL in both facilitating STM and promoting LTM formation. We also found that pretreatment with luzindole, a MT1/MT2 receptor antagonist, markedly suppressed only the effects of RAM. These results suggest that acutely administered MEL enhances NOR memory through both MT1 and MT2 receptor-mediated and non-receptor-mediated mechanisms.

关键词： Melatonin N1-Acetyl-5-Methoxykynuramine Ramelteon Novel Object Recognition Memory Melatonin Receptors

Size does not determine the grade of malignancy of early invasive colorectal cancer

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第22期15卷 2708-2713页

作者： Takahisa Matsuda Yutaka Saito Takahiro Fujii Toshio Uraoka Takeshi Nakajima Nozomu Kobayashi Fabian Emura Akiko Ono Tadakazu Shimoda Hiroaki Ikematsu Kuang-I Fu Yasushi sano Takahiro Fujimori Endoscopy Division National Cancer Center Hospital Clinical Laboratory Division National Cancer Center Hospital Division of Digestive Endoscopy and Gastrointestinal Oncology National Cancer Center Hospital East Department of Surgical and Molecular Pathology Dokkyo University School of Medicine

AIM： To clarify the clinicopathological characteristics of small and large early invasive colorectal cancers （EI-CRCs）, and to determine whether malignancy grade depends on size. METHODS： A total of 583 consecutive EI-CRCs treated by endoscopic mucosal resection or surgery at the National Cancer Center Hospital between 1980 and 2004 were enrolled in this study. Lesions were classified into two groups based on size： small （≤10 ram） and large （〉10 ram）. Clinicopathological features, incidence of lymph node metastasis （LNM） and risk factors for LNM, such as depth of invasion, lymphovascular invasion （LVI） and poorly differentiated adenocarcinoma （PDA） were analyzed in all resected specimens. RESULTS： There were 120 （21%） small and 463 （79%） large lesions. Histopathological analysis of the small lesion group revealed submucosal deep cancer （sin： 1〉1000 μm） in 90 （75%） cases, LVI in 26 （22%） cases, and PDA in 12 （10%） cases. Similarly, the large lesion group exhibited submucosal deep cancer in 380 （82%） cases, LVI in 125 （27%） cases, and PDA in 79 （17%） cases. The rate of LNM was 11.2% and 12.1% in the small and large lesion groups, ***： Small EI-CRC demonstrated the same aggressiveness and malignant potential as large cancer.

关键词： Colorectal cancer Submucosal invasion Lymph node metastasis Endoscopic mucosal resection

Prediction of the Site Index for a Subtropical Broad-Leaved Forest on Okinawa Island Using Topographic Factor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Forestry 2018年第3期8卷 267-282页

作者： Asako Miyamoto Ryuichi Terazono Makoto sano Akira Shimizu Forestry and Forest Products Research Institute Tsukuba Japan Okinawa Prefecture Forest Resources Research Centre Nago Japan Kyushu Research Center Forest and Forest Products Research Institute Kumamoto Japan

Subtropical “Yambaru” forest, situated in the northern part of Okinawa Island of Japan, has a precious ecosystem inhabited by many endemic species. However, this region is also the center for forestry on Okinawa. Therefore, sustainable forestry activities should take into consideration the natural environment. To contribute to sustainable forest management in the region, we conducted prediction of the site index at fine-scale resolution by using multiple regression analysis with easily calculated topographic factors. For the multiple regression analysis with site index as a dependent variable, three topographic factors (the effective relief, openness, and elevation) were adopted as independent variables. Approximately 68% of the variance was explained, and the effective relief was the variable with the greatest influence. This means that it is possible to predict forest productivity at a finer scale of resolution than ever before. For sustainable forest management of sites where environmental conservation and forestry are conflicting, it is useful to estimate the site index at the finest scale of resolution practically available in the field. It might be possible to improve estimation accuracy by examining further environmental factors in the future.

关键词： Forest Productivity Forest Management Digital Elevation Model (DEM) Ge-ographic Information Systems (GIS)

Present Status of the Nd:YAG Thomson Scattering System Development for Time Evolution Measurement of Plasma Profile on Heliotron J

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plasma Science and Technology 2013年第3期15卷 240-243页

作者： Takashi MINAMI Shohei ARAI Naoki KENMOCHI Hiroaki YASHIRO Chihiro TAKAHASHI Shinji KOBAYASHI Tohru MIZUUCHI Shinsuke OHSHIMA Satoshi YAMAMOTO Hiroyuki OKADA Kazunobu NAGASAKI Yuji NAKAMURA Kiyoshi HANATANI Shigeru KONOSHIMA Fumimichi sano Institute of Advanced Energy Kyoto University Graduate School of Energy Science Kyoto University Pioneering Research Unit for Next Generation Kyoto University

A new high repetition rate Nd：YAG Thomson scattering system is developed for the Heliotron J helical device. A main purpose of installing the new system is the temporal evolution measurement of a plasma profile for improved confinement physics such as the edge transport barrier （H-mode） or the internal transport barrier of the helical plasma. The system has 25 spatial points with -10 mm resolution. Two high repetition Nd：YAG lasers （〉 550 m J@ 50 Hz） realize the measurement of the time evolution of the plasma profile with ~10 ms time intervals. Scattered light is collected by a large concave mirror （D----800 mm, f/2.25） with a solid angle of -100 mstr and transferred to interference filter polychromators by optical fiber bundles in a staircase form. The signal is amplified by newly designed fast preamplifiers with DC and AC output, which reduces the low frequency background noise. The signals are digitized with a multi-event QDC, fast gated integrators. The data acquisition is performed by a VME-based system operated by the CINOS.

关键词： plasma diagnostic Nd:YAG laser Thomson scattering measurement plasma improved confinement

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

原发灶不明的肿瘤

英国医学杂志中文版 2021年第4期24卷 208-218页

作者： Michael S Lee Hanna K sano 李倩(译) 高伟健(译) 张宏艳(校) Department of Gastrointestinal Medical Oncology University of Texas MD Anderson Cancer CenterHoustonTXUSA Division of Hematology/Oncology Department of MedicineUniversity of North Carolina at Chapel HillChapel HillNCUSA 解放军总医院第五医学中心肿瘤学部

原发灶不明的肿瘤(CUP)是指经组织学确诊,但根据标准评估手段和影像学检查无法确定肿瘤原发部位的转移性恶性肿瘤。CUP占全球所有确诊肿瘤的2%~5%,以早期侵袭性转移为特征。目前CUP的标准评估需要组织病理学评估和低危亚群鉴别,该亚群... 详细信息

原发灶不明的肿瘤(CUP)是指经组织学确诊,但根据标准评估手段和影像学检查无法确定肿瘤原发部位的转移性恶性肿瘤。CUP占全球所有确诊肿瘤的2%~5%,以早期侵袭性转移为特征。目前CUP的标准评估需要组织病理学评估和低危亚群鉴别,该亚群患者可以进行更加精准的治疗或预后更好。当前对高危亚群的标准治疗需要评估预后并考虑经验性化疗。组织起源分子检测法用于鉴定可能的肿瘤原发灶已经得到广泛研究,在此我们对应用该检测方法评估CUP的合理性,以及支持和反对依据进行了综述。二代测序在晚期肿瘤的广泛应用为鉴别具有治疗可行性的基因突变患者提供了可能,而且有助于后续的个体化治疗。

关键词：原发灶不明晚期肿瘤组织学确诊个体化治疗肿瘤原发部位影像学检查组织起源组织病理学

Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第11期24卷 1239-1249页

作者： Naoyuki Fujimori Takeji Umemura Takefumi Kimura Naoki Tanaka Ayumi Sugiura Tomoo Yamazaki Satoru Joshita Michiharu Komatsu Yoko Usami Kenji sano Koji Igarashi Akihiro Matsumoto Eiji Tanaka Department of Internal Medicine Division of GastroenterologyShinshu University School of MedicineMatsumoto 390-8621Japan Department of Metabolic Regulation Shinshu University Graduate School of MedicineMatsumotoJapanand Research Center for Agricultural Food IndustryShinshu UniversityMatsumoto390-8621Japan Department of Laboratory Medicine Shinshu University HospitalMatsumoto 390-8621Japan Bioscience Division TOSOH CorporationKanagawa 252-1123Japan

AIM To examine the relationship between serum autotaxin(ATX) concentrations and clinicopathological findings in non-alcoholic fatty liver disease(NAFLD) *** One hundred eighty-six NAFLD patients who had undergone liver biopsy between 2008 and 2017 were retrospectively *** samples were collected at the time of biopsy and ATX was measured by enzyme *** obtained from 160 healthy,nonobese individuals were used as *** findings were graded according to an NAFLD scoring system and correlations with serum ATX were calculated by Spearman's *** accuracy was evaluated using the area under the receiver operating characteristic curve(AUC).Cut-off values were identified by the Youden index,and the nearest clinically applicable value to the cutoff was considered the optimal threshold for clinical *** Serum ATX levels were significantly higher in NAFLD patients than in controls(0.86 mg/L vs 0.76 mg/L,P < 0.001) and correlated significantly with ballooning score and fibrosis stage(r = 0.36,P < 0.001 and r = 0.45,P < 0.001,respectively).Such tendencies were stronger in female *** were no remarkable relationships between ATX and serum alanine aminotransferase,lipid profiles,or steatosis *** AUC values of ATX for predicting the presence of fibrosis(≥ F1),significant fibrosis(≥ F2),severe fibrosis(≥ F3),and cirrhosis(F4),were all more than 0.70 in respective *** Serum ATX levels may at least partially reflect histological severity in NAFLD.

关键词： Autotaxin Non-alcoholic fatty liver disease Fibrosis Ballooning

Phylogenetic Relationships of Japanese Unionoida (Mollusca: Bivalvia) Based on Mitochondrial 16S rDNA Sequences

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Water Resource and Protection 2017年第5期9卷 493-509页

作者： Isao sano Akihisa Shirai Takaki Kondo Jun-Ichi Miyazaki Faculty of Education University of Yamanashi Yamanashi Japan Musashi High School and Junior High School Tokyo Japan Division of Natural Science Osaka Kyoiku University Osaka Japan

Japanese unionoid mussels are classified into 2 families (Margaritiferidae and Unionidae), 12 genera, and 18 species based on the morphological characteristics of both adults and larvae;however, there are some debates regarding their systematics. In this study, we determined mitochondrial 16S ribosomal DNA sequences (347-bp) for 60 specimens belonging to 18 species and constructed trees to elucidate phylogenetic relationships and evaluate the current systematics of Japanese unionoid mussels. Almost all species formed clades, except for Inversiunio yanagawensis, Sinanodonta lauta, S. japonica, and Margaritifera laevis, even though two or more specimens were collected from distant localities. All genera formed highly supported clades with the exception of the genus Sinanodonta. Phylogenetic relationships obtained in this study supported systematics based on morphological and larval traits. Therefore, the current phylogenetic relationships and systematics of Japanese unionoid mussels are stronger than they were before;now that they are corroborated by genetic data.

关键词： Systematics Molecular Barcoding Endangered Species Conservation East Asian Mussels

Usefulness of Detailed Analysis with Operative Procedure of Total Laparoscopic Hysterectomy (TLH) Done a Single Surgeon, to Master the Surgical Technique of TLH and Gain Higher Proficiency

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2022年第11期12卷 1183-1190页

作者： Tsutomu Muramoto Shin Takenaka Ryo Koike Megumi sano Kyosuke Kamijo Reproductive Center Nagano Municipal Hospital Nagano Japan Department of Obstetrics and Gynecology Showa University Fujigaoka Hospital Yokohama Japan

Objective: To analyze the relationship between the numbers of cases experienced and the operation time for a single surgeon aiming to master the TLH surgical technique. Material and Methods: Retrospective data analysis of women who underwent TLH for benign diseases between April, 2014 and March, 2016 was conducted by a single surgeon in a single hospital (Showa University of Fujigaoka Hospital). We divided the main procedures of the TLH operation into five sections, and measured the time required for each section. These cases were divided into three groups, group 1, 2, and 3. Results: There were 54 cases of TLH over two years for a single surgeon, and 21 cases that included essential operative procedures were divided into three groups of seven cases each. The average duration of the surgery (min.) was 178.3 ± 48.2 in the group 1, 128.3 ± 15.6 in the group 2, and 111.3 ± 15.9 in the group 3. A significant reduction in the required time was observed between group 1, 2, and 3 groups. As the number of cases increased, the operation time became statistically significantly shorter for every section except B and D. The skill growth rate was different at each section. Conclusion: For a single surgeon, as the number of surgical cases increased, we recognized the increased skill with the procedure in every section and the rate of skill growth differed for different sections. The difference of growth rate for each section implied that the number of operative cases required for a surgeon in each section was different.

关键词： Total Laparoscopic Hysterectomy on the Job Training Learning Curve Surgical Technique of TLH

Immunohistochemical Profile of Breast Cancer: A Retrospective Study in the Democratic Republic of Congo

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification and Pre-distortion for GaN-PA

Journal of Cancer Therapy（癌症治疗） 2024年第5期 222页

作者： Rive Lukuaku Buanza Jérémie Okumadi Lukuke Fabrice Bokambandja Lolangwa Andy Mbangama Muela Teddy Mukendi Lwambwa Fabrice Bumwana Ali sano Sire Mariama Bleuvy-Justice Fayeta Mardoche Binangu Jean Isme Ngambika David Azako Tasema Dieudonné Mvumbi

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Identification and Pre-distortion for GaN-PA