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Human umbilical cord derived mesenchymal stem cells in peripheral nerve regeneration

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World Journal of stem Cells 2020年第4期12卷 288-302页

作者： Christine Bojanic Kendrick To Bridget Zhang Christopher Mak wasim s khan Department of Plastic and Reconstructive surgery Cambridge University Hospitals NHS TrustCambridge CB20QQUnited Kingdom Division of Trauma and Orthopaedic surgery Addenbrooke's HospitalUniversity of CambridgeCambridge CB20QQUnited Kingdom school of Clinical Medicine University of CambridgeCambridge CB20QQUnited Kingdom

BACKGROUND Peripheral nerve injury can occur as a result of trauma or disease and carries significant morbidity including sensory and motor *** body has limited ability for nerve regeneration and functional *** untreated,nerve lesions can cause lifelong *** treatment options such as neurorrhaphy and neurolysis have high failure *** reconstruction with autograft carries donor site morbidity and often provide suboptimal *** stem cells(MsCs)are known to have promising regenerative potential and have gained attention as a treatment option for nerve *** is however,unclear whether it can be effectively used for nerve *** To evaluate the evidence for the use of human umbilical cord derived MsCs(UCMsCs)in peripheral nerve *** We carried out a systematic literature review in accordance with the PRIsMA protocol.A literature search was performed from conception to september 2019 using PubMed,EMBAsE and Web of *** results of eligible studies were appraised.A risk of bias analysis was carried out using Cochrane’s RoB 2.0 *** Fourteen studies were included in this review.A total of 279 subjects,including both human and animal were treated with *** studies obtained UCMsCs from a third-party source and the remainder were harvested by the *** of the 14 studies,thirteen conducted xenogenic transplantation into nerve injury *** studies reported significant improvement in nerve regeneration in the UCMsC treated groups compared with the various different controls and untreated *** The evidence summarised in this PRIsMA systematic review of in vivo studies supports the notion that human UCMsC transplantation is an effective treatment option for peripheral nerve injury.

关键词： Umbilical cord Mesenchymal stem cells Transplantation Peripheral nerve regeneration

systematic review on the use of autologous matrix-induced chondrogenesis for the repair of articular cartilage defects in patients

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World Journal of Orthopedics 2017年第7期8卷 588-601页

作者： Nafisa shaikh Matthew K T seah wasim s khan sAs Facility Faculty of Science University of TechnologySydney Department of Trauma and Orthopaedics Addenbrookes Hospital University College London Institute of Orthopaedics and Musculoskeletal sciences Royal National Orthopaedic Hospital

AIM To systematically review the results of studies looking at autologous matrix-induced chondrogenesis(AMIC) in humans. METHODs A literature search was performed, adhering to the PRIsMA guidelines, to review any studies using such techniques in humans. Our initial search retrieved 297 articles listed on MEDLINE, Google scholar, CINHal and EMBAsE. From these studies, 15 studies meeting the eligibility criteria were selected and formed the basis of our systematic *** The study designs, surgical techniques and outcome measures varied between the studies. Although all studies reported improvements in patient outcome measures, this was not necessarily correlated with magnetic resonance imaging findings. Although there were many additional procedures performed, when AMIC was performed in isolation, the results tended to peak at 24 mo before declining. CONCLUsION Although short-term studies suggest improved patient reported outcomes with a variety of scaffolds, surgical techniques and rehabilitation regimes, the literature remains equivocal on whether the defect size and location, and patient factors affect the outcome. Patientbenefit appears to be maintained in the short-tomedium term but more high level studies with extensive and robust validated outcome measures should be conducted to evaluate the medium-and long-term effect of the AMIC procedure.

关键词： Autologous matrix-induced chondrogenesis Cartilage defects Humans,PRIsMA

Analysing the outcome of surgery for chronic Achilles tendinopathy over the last 50 years

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World Journal of Orthopedics 2015年第6期6卷 491-497页

作者： wasim s khan seema Malvankar Jagmeet s Bhamra Ioannis Pengas University College London Institute of Orthopaedics and Musculoskeletal science Royal National Orthopaedic Hospital

AIM: To determine an association between when the study was performed, the robustness of the study and the outcomes for insertional and non-insertional Achilles tendinopathy surgery. METHODs: We performed a systematic review in accordance with the PRIsMA guidelines to assess the methodology of studies investigating the outcome of surgery in chronic Achilles tendinopathy over the last 50 years to identify any trends that would account for the variable results. The Coleman Methodology scores were correlated with the reported percentage success rates and with the publication year to determine any trends using Pearson's correlation. REsULTs: We identified 62 studies published between 1964 and 2014 reporting on a total of 2923 surgically treated Achilles tendinopathies. The average followup time was 40 mo(range 5-204 mo), and the mean reported success rate was 83.5%(range 36%-100%). The Coleman Methodology scores were highly reproducible(r = 0.99, P sD 18.9, range 2-79). We found a negative correlation between reported success rate and overall methodology scores(r =-0.40, P sitive correlation between year of publication and overall methodology scores(r = 0.46, P sION: We conclude that although the success rate of surgery for chronic Acilles tendinopathy described in the literature has fallen over the last 50 years, this is probably due to a more rigorous methodology of the studies.

关键词： Achilles tendon surgery Methodology Outcome Tendinopathy

Impact of metal polluted sewage water on soil nematode assemblages in agricultural settings of Aligarh,India

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soil Ecology Letters 2024年第1期6卷 61-75页

作者： Mohammed F.s.A.Ghanem shahid Afzal Humira Nesar Zarrin Imran wasim Ahmad Nematode Biodiversity Research Lab Department of ZoologyAligarh Muslim UniversityAligarh 202002India

sewage water in agriculture threatens human health and soil ecosystems through metal *** show promise as bioindicators of soil health due to their abundance and position in soil food ***-polluted water decreased abundance of certain nematode groups and sigma Maturity *** pollution positively affected nematode groups with r-selected life *** water has been inappropriately used in agriculture,posing possible threats to human health and the soil ecosystems by its constituent pollutants,especially heavy *** evaluation of its influences on soil biomes needs to consider the response of soil *** soil organisms,nematodes are seen as the best promising candidates for bioindicators of soil *** in,we collected soil samples from fresh water irrigated field from three sites(s1,s2 and s3)and sewage water irrigated distance gradient(5 m-40 m),to assess the influence of metal(Cu,Zn,Cd,Mn,Pb)polluted water on various characteristics of nematode *** results indicated that the heavy metals decreased the abundance of C-p3 nematodes,herbivores,and predatory nematodes as well as sigma maturity index,whereas,C-p1,C-p2,bacterivore and fungivore nematodes abundance and diversity positively responded to the metal ***,nematode genera with r-selected life cycle were positively affected and those with K-selected life cycle were negatively affected by metal *** nematode community has potential to be used as indicator of pollution stress in agricultural soils to check soil health and sustainability.

关键词： heavy metals sewage irigation agriculture nematodes bioindicators

Robust design of sliding mode control for airship trajectory tracking with uncertainty and disturbance estimation

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Journal of systems Engineering and Electronics 2024年第1期35卷 242-258页

作者： wasim Muhammad ALI Ahsan CHOUDHRY Mohammad Ahmad sHAIKH Inam Ul Hasan sALEEM Faisal Department of Aeronautics and Astronautics Engineering Institute of Space TechnologyIslamabad 44000Pakistan Department of Electrical Engineering University of Engineering and TechnologyTaxila 47080Pakistan Department of Measurements and Control systems Silesian University of TechnologyGliwice 44-101Poland The Joint Doctoral school Silesian University of TechnologyGliwice 44-100Poland

The robotic airship can provide a promising aerostatic platform for many potential *** applications require a precise autonomous trajectory tracking control for *** has a nonlinear and uncertain *** is prone to wind disturbances that offer a challenge for a trajectory tracking control *** paper addresses the airship trajectory tracking problem having time varying reference path.A lumped parameter estimation approach under model uncertainties and wind disturbances is opted against distributed *** uses extended Kalman filter(EKF)for uncertainty and disturbance *** estimated parameters are used by sliding mode controller(sMC)for ultimate control of airship trajectory *** comprehensive algorithm,EKF based sMC(EsMC),is used as a robust solution to track airship *** proposed estimator provides the estimates of wind disturbances as well as model uncertainty due to the mass matrix variations and aerodynamic model *** stability and convergence of the proposed method are investigated using the Lyapunov stability *** simulation results show that the proposed method efficiently tracks the desired *** method solves the stability,convergence,and chattering problem of sMC under model uncertainties and wind disturbances.

关键词： airship chattering extended Kalman filter(EKF) model uncertainties estimation sliding mode controller(sMC)

Understanding the Impact of H_(2) Diffusion Energy on the Formation Efficiency of H_(2) on the Interstellar Dust Grain surface

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Research in Astronomy and Astrophysics 2024年第9期24卷 190-198页

作者： Xiaoying Guo wasim Iqbal Qiang Chang Xiao-Hu Li school of Physics and Optoeletronic Engineering Shandong University of TechnologyZibo 255000China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesUrumqi 830011China

We use microscopic Monte Carlo simulation techniques to investigate the impact of H_(2)diffusion energy on the recombination efficiency of H_(2)on interstellar dust grain surfaces under diffuse and translucent cloud *** constructed five models representing different possible conditions encountered by adsorbed H and H_(2)on interstellar dust *** implemented adsorption sites with multiple binding energies for surface species;the Encounter-Desorption mechanism was also *** study focused on silicate surfaces in diffuse clouds and water ice surfaces in translucent *** results show that the recombination efficiency of H_(2)on dust surfaces decreases as H_(2)diffusion energy *** interesting finding of this work is that considering different binding sites for H and H_(2)gives rise to multiple steady phases,during which the recombination efficiency remains constant with a change in H_(2)diffusion energy.

关键词： astrochemistry atomic processes IsM:molecules

Magnesium-reinforced Electrospun synthetic-polymer Nanofibers Designed for Promoting Tissue Growth

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Journal of Bionic Engineering 2024年第3期21卷 1412-1426页

作者： Muheeb Rafiq Anjum Hamid Rather Rumysa saleem khan Taha Umair Wani Haseeb A.khan Abdullah s.Alhomida Faheem A.sheikh Nanostructured and Biomimetic Lab Department of NanotechnologyUniversity of Kashmir HazratbalSrinagarJammu and Kashmir190006India Non-Clinical Evaluation Center Biomedical Research InstituteJeonbuk National University HospitalJeonjuJeollabuk-do54907South Korea College of Pharmacy and Research Institute of Pharmaceutical sciences Gyeongsang National UniversityJinju52828South Korea Research Chair for Biomedical Applications of Nanomaterials Department of BiochemistryCollege of ScienceKing Saud UniversityRiyadh11451Saudi Arabia

The creation of 3D nanofibers offering desirable functions for bone regeneration is developed due to the latest improvisations to the electrospinning *** polymers are among the best choices for medical usage due to their lower costs,high tensile properties,and ease of spinnability compared to natural *** this communication,we report a series of interventions to polymers modified with Mg-based fillers for ideal tissue engineering *** literature survey indicated that these filler materials(e.g.,nano-sized particles)enhanced biocompatibility,antibacterial activity,tensile strength,and anti-corrosive *** review discusses electrospinning parameters,properties,and applications of the poly(ε-caprolactone),poly(lactic acid),poly(3-hydroxybutyric acid-co-3-hydroxy valeric acid),polyurethane,and poly(vinyl pyrrolidone)nanofibers when modified with Mg-based *** report encourages researchers to use synthetic polymers with Mg as fillers and validate them for tissue engineering applications.

关键词： Bone regeneration Magnesium Nanofibers Tissue engineering

Acceleration of solar wind particles due to inertial Alfvén waves

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Communications in Theoretical Physics 2024年第6期76卷 137-141页

作者： Kiran Batool Imran A khan M shamir Abdul Kabir s Ayaz Theoretical Physics Department National Centre for PhysicsIslamabad 44000Pakistan Department of space sciences Institute of Space TechnologyIslamabad 44000Pakistan space and Astrophysics Research Lab(sARL) National Center of GIS and Space Applications(NCGSA)Islamabad 44000Pakistan salam Chair Department of PhysicsGC University LahoreKatchery RoadLahorePunjab 54000Pakistan Department of space science and CsPAR University of Alabama in HuntsvilleHuntsvilleAL 35899United States of America

Gaining an understanding of the effects and dynamics of the solar wind is crucial for the study of space weather,Earth's magnetosphere,spacecraft protection,the dynamics of the solar system,and various other *** show that Alfvén waves effectively transfer energy to resonant *** study demonstrates how inertial Alfvén waves deliver their energy to resonant plasma particles in different solar environments under certain *** analysis shows that inertial Alfvén waves experience more rapid damping with increasing parallel wavenumber,ambient magnetic field strength,and particle number density,coupled with a decrease in *** rate of energy transfer to resonant particles intensifies with higher temperatures and reduced parallel wavenumber and particle number *** with higher initial velocities actively participate in Landau damping,especially in regions with a stronger ambient magnetic field.

关键词： solar wind inertial Alfven waves resonant particles

sentiment Analysis of Low-Resource Language Literature Using Data Processing and Deep Learning

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Computers, Materials & Continua 2024年第4期79卷 713-733页

作者： Aizaz Ali Maqbool khan Khalil khan Rehan Ullah khan Abdulrahman Aloraini Department of IT and Computer science Pak-Austria Fachhochschule:Institute of Applied Sciences and TechnologyHaripur22620Pakistan software Competence Center Hagenberg Softwarepark 32aHagenberg4232Austria Department of Computer science School of Engineering and Digital SciencesNazarbayev UniversityAstana010000Kazakhstan Department of Information Technology College of ComputerQassim UniversityP.O.Box 1162BuraydahSaudi Arabia

sentiment analysis, a crucial task in discerning emotional tones within the text, plays a pivotal role in understandingpublic opinion and user sentiment across diverse *** numerous scholars conduct sentiment analysisin widely spoken languages such as English, Chinese, Arabic, Roman Arabic, and more, we come to grapplingwith resource-poor languages like Urdu literature which becomes a challenge. Urdu is a uniquely crafted language,characterized by a script that amalgamates elements from diverse languages, including Arabic, Parsi, Pashtu,Turkish, Punjabi, saraiki, and more. As Urdu literature, characterized by distinct character sets and linguisticfeatures, presents an additional hurdle due to the lack of accessible datasets, rendering sentiment analysis aformidable undertaking. The limited availability of resources has fueled increased interest among researchers,prompting a deeper exploration into Urdu sentiment analysis. This research is dedicated to Urdu languagesentiment analysis, employing sophisticated deep learning models on an extensive dataset categorized into fivelabels: Positive, Negative, Neutral, Mixed, and Ambiguous. The primary objective is to discern sentiments andemotions within the Urdu language, despite the absence of well-curated datasets. To tackle this challenge, theinitial step involves the creation of a comprehensive Urdu dataset by aggregating data from various sources such asnewspapers, articles, and socialmedia comments. subsequent to this data collection, a thorough process of cleaningand preprocessing is implemented to ensure the quality of the data. The study leverages two well-known deeplearningmodels, namely Convolutional Neural Networks (CNN) and Recurrent Neural Networks (RNN), for bothtraining and evaluating sentiment analysis performance. Additionally, the study explores hyperparameter tuning tooptimize the models’ efficacy. Evaluation metrics such as precision, recall, and the F1-score are employed to assessthe effectiv

关键词： Urdu sentiment analysis convolutional neural networks recurrent neural network deep learning natural language processing neural networks