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Metabolic mechanism of dietary factors and effect of dietary types associated with hyperuricemia: A review

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Food Science and Human Wellness 2024年

作者： Kaina Qiao Xuewei Zhou Lili zhang wangang zhang Baoguo Sun Yuyu zhang College of Food Science and Technology Nanjing Agricultural University Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University) Ministry of Education Key Laboratory of Flavor Science of China General Chamber of Commerce Beijing Technology and Business University Food Laboratory of Zhongyuan Beijing Technology and Business University

Globally， hyperuricemia is a growing health， social， and economic problem which could cause gout， chronic kidney diseases and other diseases. There are increasing evidences that a sensible diet makes sense to reduce the risk of hyperuricemia. This review aims to explore the metabolic mechanism of dietary factors and effects of dietary types associated with hyperuricemia. Recommendations for dietary modification to prevent hyperuricemia are as following: decreasing intake of animal organs， seafood， sugar-sweetened， and alcohol beverages is essential; choosing water or unsweetened tea and coffee instead of sweetened beverages is beneficial; and increasing intake of vegetables， reduced-fat dairy products， foods containing fiber， micronutrients and unsaturated fatty acids is helpful. In addition， consumption of fruits and legumes in moderation is advantageous， and low-fructose of fruits and low-purine of non-soy beans are recommended. Moreover， personalized diet needs to be emphasized for hyperuricemic patients accompanied with diverse metabolic diseases.

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Protein S-nitrosylation regulates the energy metabolism of early postmortem pork using the in vitro model

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Food Materials Research 2022年第1期2卷 38-45页

作者： Wenwei Lu Qin Hou wangang zhang Key Laboratory of Meat Processing and Quality Control Ministry of Education ChinaJiangsu Collaborative Innovation Center of Meat Production and ProcessingQuality and Safety ControlCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China

This research aimed to investigate the regulation of energy metabolism by protein S-nitrosylation utilizing the in vitro muscle glycolysis model.Longissimus thoracis(LT)muscles homogenates were treated with nitric oxide donor NOR-3((±)-(E)-4-Ethyl-2-(E)-hydroxyimino-5-nitro-3-hexenamide)and control(0.1 M K_(2)HPO_(4))under different pH conditions(6.5,6.0 and 5.5)in vitro buffer system for 24 h,respectively.Results indicated that the NOR-3 treatment group had a significantly higher pH decline rate than the control group and resulted in a higher lactate accumulation and glycogen degradation at 24 h compared with the control group(p<0.05).Moreover,NOR-3 treatment significantly increased the activities along with S-nitrosylation levels of lactate dehydrogenase and glycogen phosphorylase at pH 6.5 in a concentration-dependent manner(p<0.05).In addition,low pH could weaken the NOR-3 treatment effect and inhibit glycolysis rate.Thus,protein S-nitrosylation could play a role in regulating postmortem glycolysis in vitro model even at low pH conditions.

关键词： metabolism postmortem treatment

A gene expression estimator of intramuscular fat percentage for use in both cattle and sheep

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Journal of Animal Science and Biotechnology 2014年第4期5卷 379-390页

作者： Bing Guo Kritaya Kongsuwan Paul L Greenwood Guanghong Zhou wangang zhang Brian P Dalrymple Key Laboratory of Meat Processing and Quality Control Synergetic Innovation Center of Food Safety and NutritionCollege of Food Science and TechnologyNanjing Agriculture University CSIRO Animal Food and Health SciencesSt.Lucia QLD 4067Australia National Institute of Animal Health 50/2 KasetklangLadyaoBangkok 10900Thailand CSIRO Animal Food and Health SciencesArmidale NSW 2350Australia NSW Department of primary Industries Armidale NSW 2350Australia

Background：The expression of genes encoding proteins involved in triacyglyceride and fatty acid synthesis and storage in cattle muscle are correlated with intramuscular fat（IMF）%.Are the same genes also correlated with IMF%in sheep muscle,and can the same set of genes be used to estimate IMF%in both species？Results：The correlation between gene expression（microarray） and IMF%in the longissimus muscle（LM） of twenty sheep was calculated.An integrated analysis of this dataset with an equivalent cattle correlation dataset and a cattle differential expression dataset was undertaken.A total of 30 genes were identified to be strongly correlated with IMF%in both cattle and sheep.The overlap of genes was highly significant,8 of the 13 genes in the TAG gene set and 8 of the 13 genes in the FA gene set were in the top 100 and 500 genes respertively most correlated with IMF%in sheep,P-value = 0.Of the 30 genes,CIDEA,THRSP,ACSM1,DGAT2 and FABP4 had the highest average rank in both species.Using the data from two small groups of Brahman cattle（control and Hormone growth promotant-treated[known to decrease IMF%in muscle]） and 22 animals in total,the utility of a direct measure and different estimators of IMF%（ultrasound and gene expression） to differentiate between the two groups were examined.Directly measured IMF%and IMF%estimated from ultrasound scanning could not discriminate between the two groups.However,using gene expression to estimate IMF%discriminated between the two groups.Increasing the number of genes used to estimate IMF%from one to five significantly increased the discrimination power;but increasing the number of genes to 15 resulted in little further improvement.Conclusion：We have demonstrated the utility of a comparative approach to identify robust estimators of IMF%in the LM in cattle and sheep.We have also demonstrated a number of approaches（potentially applicable to much smaller groups of animals than conventional methods） to using gene expression to rank animals for IMF%within a single farm/treatment,or to e

关键词： Cattle Gene expression phenotype IMF% Sheep

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土壤对军用越野车辆机动性能影响分析

兵工学报 2024年第1期45卷 288-298页

作者：肖万港周云波傅耀宇张明周军葛纪桃南京理工大学机械工程学院江苏南京210094 63969部队江苏南京211113

在软地面上的机动性能是军用高机动性越野车辆的主要性能之一,对于其野外作业有重要的战略意义。为了探究不同类型松软土壤地面路况对越野车辆机动性能的影响,基于离散元法对土壤进行建模,通过土壤堆积角测试试验以及土壤圆锥指数试验... 详细信息

在软地面上的机动性能是军用高机动性越野车辆的主要性能之一,对于其野外作业有重要的战略意义。为了探究不同类型松软土壤地面路况对越野车辆机动性能的影响,基于离散元法对土壤进行建模,通过土壤堆积角测试试验以及土壤圆锥指数试验进行土壤刚度对标测试。通过DEM-MBD联合仿真方法,利用精确的土壤模型,对不可压缩干燥土壤、不可压缩湿润土壤、可压缩干燥土壤、可压缩湿润土壤4种不同类型土壤进行仿真分析,通过对比越野车辆平均速度、牵引力、驱动扭矩、轮胎沉陷量,探究土壤类型对越野车辆机动性能的影响。越野车在湿润土壤上比在干燥土壤上牵引力减少了6.98%,在不可压缩土壤上的稳定行驶速度比在可压缩土壤上稳定行驶速度高34.2%,在湿润的土壤路面上速度更加稳定。研究成果弥补了国内车辆地面力学领域土壤对整车机动性影响的空白,可为军车野外复杂地形(如沙地、雪地、泥泞等)作战时选择最优的行驶路面,提高作战效率。

关键词：军用越野车辆土壤圆锥指数离散元法多体动力学牵引力试验机动性

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浅薄层特超稠油油藏冷热交替开采技术研究

油气地质与采收率 2024年第1期31卷 103-110页

作者：张兆祥张仲平郑万刚殷方好佟彤中国石化胜利油田分公司石油工程技术研究院山东东营257000 山东省稠油开采技术重点实验室山东东营257000

针对浅薄层特超稠油油藏蒸汽吞吐开发初期面临的油层厚度薄、原油黏度高、蒸汽热损失大、吞吐有效期短等问题,提出了冷热交替大周期吞吐开发模式,有效改善开发效果。为此开展了浅薄层特超稠油油藏冷热交替开采三维物理模拟研究,结果表明... 详细信息

针对浅薄层特超稠油油藏蒸汽吞吐开发初期面临的油层厚度薄、原油黏度高、蒸汽热损失大、吞吐有效期短等问题,提出了冷热交替大周期吞吐开发模式,有效改善开发效果。为此开展了浅薄层特超稠油油藏冷热交替开采三维物理模拟研究,结果表明:受顶底盖层热损失影响,蒸汽吞吐温度下降迅速,峰值产量较高,但单周期生产时间较短,约100 min;降黏吞吐可以降低吞吐井附近含油饱和度,提高产油速度,降低含水率,延长吞吐周期50 min以上;提高温度可以增强降黏剂的降黏效果,第二周期开始冷热交替改善效果优于第一周期,其生产时间延长60 min,含水率降低45%,周期采出程度提高1.7%。利用数值模拟方法优化了冷热交替的注入参数,建立了该技术的政策界限:最佳转冷热交替的时机为2~3周期,注入强度为0.02 t/m;适用的油层厚度小于8 m,原油黏度小于200000 mPa•s,含油饱和度大于0.6,渗透率大于1000 mD。

关键词：冷热交替浅薄层特超稠油物理模拟生产时间

Sedimentary and reservoir architectures of MB1-2 sub-member of Middle Cretaceous Mishrif Formation of Halfaya Oilfield in Iraq

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Petroleum Exploration and Development 2020年第4期47卷 762-772页

作者： SUN Wenju QIAO Zhanfeng SHAO Guanming SUN Xiaowei GAO Jixian CAO Peng zhang Jie CHEN wangang PetroChina Research Institute of Petroleum Exploration&Development Beijing 100083China China United Coalbed Methane Corp. Ltd.Beijing 100011China PetroChina Hangzhou Research Institute of Geology Hangzhou 310023China CNPC Key Laboratory of Carbonate Reservoir Hangzhou 310023China

Based on comprehensive analysis of core,cast thin section,logging and seismic data,the sedimentary and reservoir architectures of the MB 1-2 sub-member of Mishrif Formation in Halfaya Oilfield,Iraq,are studied.The MB 1-2 sub-member of Mishrif Formation has three types of microfacies,lagoon,bioclastic shoal,and tidal channel,and facies architecture controlled by sequence stratigraphy.In the 4th-order sequence,the lagoon facies aggradated vertically,and the bioclastic shoals in lenticular shape embed in the background of lagoon,the end of the sequence is incised by the"meandering river"shape tide channel,which represents the depositional discontinuity.Three types of reservoirs including tidal channel grainstone to packstone reservoirs,bioclastic shoal grainstone to packstone reservoirs and dissolved lagoon wackestone reservoirs are developed.The reservoir architectures within tidal channel and bioclastic shoal are strickly controlled by grainy facies,whereas the dissolved lagoon reservoirs controlled by both facies and dissolution are related to the sequence boundary.The reservoir sections occur mainly in the 4 th sequence highstand systems tract(HST)and are separated by barriers formed in the transgressive systems tract(TST).Complicated facies architecture and dissolution modification resulted in strong heterogeneity within the reservoir,which showed the characteristics of"attic type"architecture.The results of this study can guide the development of similar reservoirs in the Middle East.

关键词： Iraq Halfaya Oilfield Cretaceous Mishrif Formation sedimentary microfacies reservoir architecture

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食源性抗炎活性肽的研究进展

中国食品学报 2022年第8期22卷 343-352页

作者：傅丽娟邢路娟张万刚南京农业大学食品科技学院国家肉品质量安全与工程技术研究中心南京210095

生物活性肽是蛋白质降解后产生的具有一定生理调节功能的多肽,其生物学功能体现在抗菌、抗氧化、抗炎、降血压、免疫调节等方面。其中,抗炎活性肽可通过调控细胞因子的分泌、炎性介质的合成参与机体炎症反应,从而发挥生理调节功能。慢... 详细信息

生物活性肽是蛋白质降解后产生的具有一定生理调节功能的多肽,其生物学功能体现在抗菌、抗氧化、抗炎、降血压、免疫调节等方面。其中,抗炎活性肽可通过调控细胞因子的分泌、炎性介质的合成参与机体炎症反应,从而发挥生理调节功能。慢性炎症与心血管、糖尿病等疾病的发生有直接联系。与传统抗炎药物相比,食源性抗炎活性肽具有安全、无副作用的特点,可为预防机体炎症提供新的方法。本文综述食源性抗炎活性肽的制备、炎症调节及其参与的信号通路,以期为食源性抗炎活性肽类的科学研究及产品研发提供参考。

关键词：抗炎生物活性肽食物蛋白炎症反应调节通路

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贵州侗族酸肉中优质发酵菌株的筛选及鉴定

食品与发酵工业 2023年第10期49卷 85-90页

作者：韩竞旭邢路娟张万刚南京农业大学食品科技学院国家肉品质量安全与工程技术研究中心江苏南京210095

酸肉是将猪的五花肉预处理后,加入糯米饭、盐、辣椒等辅料,装坛密封后在自然条件下厌氧发酵形成的传统肉制品。因其肉质细腻、风味独特、营养丰富等特点而广泛流传于贵州、湖南、江西等地。但由于其生产制作多为自然发酵,易受到地域、... 详细信息

酸肉是将猪的五花肉预处理后,加入糯米饭、盐、辣椒等辅料,装坛密封后在自然条件下厌氧发酵形成的传统肉制品。因其肉质细腻、风味独特、营养丰富等特点而广泛流传于贵州、湖南、江西等地。但由于其生产制作多为自然发酵,易受到地域、环境、气候、人为操作等因素影响,发酵体系中的微生物组成与发酵条件差异较大,因而导致终产品品质难以控制。在酸肉生产中引入外源发酵剂可提高生产的可控性,抑制杂菌及有害菌生长,缩短发酵周期。因此该研究采用传统培养法对自然发酵酸肉中具备优良发酵性能的菌株进行分离筛选。分离纯化后在乳酸细菌培养基(de man rogosa sharpe,MRS)和甘露醇氯化钠琼脂培养基(manitol salt agar,MSA)上分别得到575、187株菌。经初筛后得到116株乳酸菌和26株葡萄球菌。随后根据肉制品发酵剂的标准进行复筛,得到发酵性能较好的一株乳酸菌L36和一株葡萄球菌S53,经形态学观察和生理生化特征及16S rDNA序列分析后确定L36为香肠乳杆菌(Lactobacillus farciminis),具有快速产酸的特性;S53为腐生葡萄球菌(Staphylococcus saprophyticus),具有良好的脂肪酶和蛋白酶活性。2株菌种间无拮抗作用,可作为外源发酵剂用于肉制品生产中。

关键词：酸肉乳酸菌葡萄球菌分离鉴定

脂肪对不同熟化温度下乳化肠挥发性成分的影响

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食品工业科技 2023年第24期44卷 43-53页

作者：王旭李聪张万刚王颖徐宝才南京农业大学食品科技学院江苏南京210095 合肥工业大学食品与生物工程学院安徽合肥230009

为明确脂肪对不同熟化温度下(80℃,30 min、90℃,30 min、100℃,30 min和121℃,20 min)猪肉乳化香肠挥发性物质的影响,采用感官评价、电子鼻(Electronic nose,E-nose)和固相微萃取-气相色谱质谱联用技术(Solid-phase microextraction coupled-gas chromatography-mass spectrometry,SPME-GC-MS)对添加或不添加脂肪的乳化肠在不同熟化温度下挥发性物质进行分析。结果表明,添加脂肪的乳化肠,熟化条件为100℃,30 min的样品风味最好,添加脂肪可提高乳化肠脂香味、硫磺味、哈喇味和青草味的感官强度,抑制高温乳化肠肉香味和蘑菇味的感官强度;电子鼻能有效区分添加脂肪或不添加脂肪的样品,但80℃,30 min组的样品无法有效区分;添加脂肪的样品中,除100℃,30 min组和121℃,20 min组外,电子鼻能很好的将不同熟化温度的样品区分开。SPME-GC-MS结果显示,8个处理组共检测出56种挥发性化合物,己醛、庚醛、辛醛、戊醛、壬醛、1-辛烯、1-辛烯-3-醇和甲硫醇等关键化合物的含量随熟化温度的升高而增加。偏最小二乘判别分析(Partial least squares discriminant analysis,PLS-DA)筛选出己醛、戊醛和n-己酸乙烯酯是不同熟化温度乳化肠气味差异的潜在标志物。采用正交偏最小二乘判别分析(Orthogonal partial least squares discriminant analysis,OPLS-DA)筛选出添加与不添加脂肪的样品在4种熟化温度下的差异化合物分别为17种、17种、22种和25种。以上结果表明,熟化条件相同,添加脂肪的样品挥发性物质含量显著高于不添加脂肪的样品,100℃,30 min的熟化条件更有利于乳化肠风味的形成。

关键词：乳化肠熟化温度脂肪挥发性风味物质偏最小二乘判别分析(PLS-DA)