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Digital measuring the ocular morphological parameters of guinea pig eye in vivo with Python

International Journal of Ophthalmology(English edition) 2024年第2期17卷 239-246页

作者： Yue Di Zhong-Bao Qiao Hai-Yun Ye Xin-Yue Li Wen-Ting Luo wang-yi fang Tong Qiao Department of Ophthalmology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China

AIM:To quantitatively measure ocular morphological parameters of guinea pig with Python ***:Thirty-six eyeballs of eighteen 3-weekold guinea pigs were measured with keratometer and photographed to obtain the horizontal,coronal,and sagittal planes *** corresponding photo pixels-actual length ratio was acquired by a proportional *** edge coordinates were identified artificially by ginput *** and conic curve fitting were applied to fit the contour of the eyeball in the sagittal,coronal and horizontal *** curvature,curvature radius,eccentricity,tilt angle,corneal diameter,and binocular separation angle were calculated according to the geometric ***,the eyeballs were removed,canny edge detection was applied to identify the contour of eyeball in *** results were compared between in vivo and in ***:Regarding the corneal curvature and curvature radius on the horizontal and sagittal planes,no significant differences were observed among results in vivo,in vitro,and the *** horizontal and vertical binocular separation angles were 130.6°±6.39°and 129.8°±9.58°*** the corneal curvature radius and eccentricity in vivo,significant differences were observed between horizontal and vertical ***:The Graphical interface window of Python makes up the deficiency of edge detection,which requires too much definition in *** are significant differences between guinea pig and human beings,such as exotropic eye position,oblique oval eyeball,and obvious discrepancy of *** study helps evaluate objectively the ocular morphological parameters of small experimental animals in emmetropization research.

关键词： ocular morphological parameters guinea pig digital measurement Python

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絮凝-电化学氧化协同工艺处理兰炭废水

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中国环境科学 2024年第4期44卷 2063-2072页

作者：王亚宋永辉李金城尹宁董萍王一帆龙江李弯弯西安建筑科技大学陕西省黄金与资源重点实验室陕西西安710055 长安大学水利与环境学院陕西西安710054 陕西新能星炭能源有限公司陕西西安710199

采用絮凝-电化学氧化协同工艺处理兰炭废水,探究了反应过程中絮凝剂投加量、反应时间、初始pH值、外加电压以及NaCl添加量对化学需氧量(COD)和氨氮(NH_(3)-N)去除的影响及絮凝-电化学氧化协同作用机制.结果表明,随着絮凝剂聚合氯化铝铁(... 详细信息

采用絮凝-电化学氧化协同工艺处理兰炭废水,探究了反应过程中絮凝剂投加量、反应时间、初始pH值、外加电压以及NaCl添加量对化学需氧量(COD)和氨氮(NH_(3)-N)去除的影响及絮凝-电化学氧化协同作用机制.结果表明,随着絮凝剂聚合氯化铝铁(PAFC)投加量和外加电压的增加,兰炭废水中COD和NH_(3)-N的去除率逐渐升高.当PAFC投加量为50g/L、电压6V、反应时间4h,初始pH=9,NaCl添加量30g/L时,COD和NH_(3)-N去除率分别为82.37%和100%,更换极板进行二次电解COD去除率可达100%.兰炭废水中有机污染物主要是苯酚类､醇类和酰胺类物质,处理后酚类物质含量大幅减少,酮类、醇类和酸类物质相对占比有所增加.絮凝-电化学氧化过程中,PAFC既是絮凝剂又是Cl^(-)的提供者,其水解产生的Cl^(-)与NaCl引入的Cl^(-)在电场作用下向阳极定向迁移.阳极表面发生氧化反应产生的有效氯(Cl_(2)/ClO^(-))将兰炭废水中有机污染物氧化成中间产物氯酚,与絮凝剂中Al^(3+)的水解产物Al(OH)^(2+)、Al(OH)^(+)_(2)及Al(OH)_(3)通过静电和吸附作用结合形成絮凝体被去除.废水中剩余少量的氯酚及酰胺、环己二醇等有机污染物及NH_(3)-N则在ClO^(-)的间接氧化作用下转化为N_(2)、CO_(2)和H_(2)O得以去除.

关键词：兰炭废水絮凝电解电化学氧化协同作用聚合氯化铝铁(PAFC)

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Performance of iron-air battery with iron nanoparticle-encapsulated C-N composite electrode

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Frontiers in Energy 2024年第1期18卷 42-53页

作者： Can fang Xiangmei TANG Jiaoyan wang Qingfeng yi School of Chemistry and Chemical Engineering Hunan University of Science and TechnologyXiangtan 411201China Hunan Provincial Key Laboratory of Advanced Materials for New Energy Storage and Conversion Xiangtan 411201China

Highly efficient and stable iron electrodes are of great significant to the development of iron-air battery(IAB).In this paper,iron nanoparticle-encapsulated C–N composite(NanoFe@CN)was synthesized by pyrolysis using polyaniline as the C–N *** performance of the NanoFe@CN in different electrolytes(alkaline,neutral,and quasi-neutral)was investigated via cyclic voltammetry(CV).The IAB was assembled with NanoFe@CN as the anode and IrO_(2)+Pt/C as the *** effects of different discharging/charging current densities and electrolytes on the battery performance were also *** K_(2)SO_(4)electrolyte can effectively suppress the passivation of iron electrode,and the battery showed a good cycling stability during 180 charging/discharging *** to the pure nano-iron(NanoFe)battery,the NanoFe@CN battery has a more stable cycling stability either in KOH or NH_(4)Cl+KCl electrolyte.

关键词： energy storage and conversion metallic composites nanocomposites iron-air battery iron anode

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Treatment of multisystem inflammatory syndrome in children

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World Journal of Pediatrics 2024年第4期20卷 325-339页

作者： Tong Tong yi-Hua Jin Min wang fang-Qi Gong Department of Cardiology Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNo.3333 Binsheng RoadHangzhou 310052China

Background Multisystem inflammatory syndrome in children(MIS-C),a relatively uncommon but severe pediatric complication,is associated with coronavirus disease 2019(COVID-19).A variety of treatment approaches,including intravenous immunoglobulins(IVIGs),glucocorticoids(GCs)and biologic agents,such as anakinra and infliximab,have been described for the management of COVID-19-related *** therapy is also ***,a well-developed treatment system has not been established,and many issues remain *** recently published articles related to the treatment of MIS-C have been ***,in this review,we identified relevant articles published recently and summarized the treatment of MIS-C more comprehensively and *** sources We reviewed the literature on the treatment of MIS-C through 20 September *** PubMed/Medline,Web of Science,EMBASE,and Cochrane Library databases were searched with the combination of the terms"multisystem inflammatory syndrome","MIS-C","PIMS-TS","therapy","treatment","drug","IVIG","GCs","intravenous immunoglobulin","corticosteroids","biological agent",and"aspirin".Results The severity of MIS-C varies,and different treatment schemes should be used according to the specific *** research and data collection are vital to better understand the pathophysiology and optimal management of *** MIS-Cis a disease involving multiple systems and has great *** the accumulation of additional experience,we have garnered fresh insights into its treatment ***,there remains a critical need for greater standardization in treatment protocols,alongside the pressing necessity for more robust and meticulously conducted studies to deepen our understanding of these protocols.

关键词： Coronavirus disease 2019-Corticosteroids Intravenous immunoglobulin Multisystem inflammatory syndrome in children-Treatment

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Surgical treatment of Pitt-Hopkins syndrome associated with strabismus and early-onset myopia:Two case reports

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World Journal of Clinical Cases 2022年第34期10卷 12734-12741页

作者： ying Huang Yue Di Xiao-Xiao Zhang Xin-Yue Li wang-yi fang Tong Qiao Department of Ophthalmology Shanghai Children's HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200062China

BACKGROUND Pitt-Hopkins syndrome(PTHS;MIM#610954)is a rare genetic neurological *** and strabismus have been reported in approximately 50%of PTHS *** studies have reported details about the required surgery for PTHS with strabismus and early-onset ***,we retrospectively reviewed the surgical management of two patients with PTHS combined with strabismus and/or early-onset *** SUMMARY A 5-year-old girl presented with congenital esotropia and left eye myopia,and the second girl was a 5-year-old girl who presented with intermittent *** testing performed on both patients showed a mutation in transcription factor 4,which is a diagnostic marker of *** first girl underwent bilateral medial rectus recession combined with posterior scleral reinforcement(PSR)in the left eye and the second patient underwent bilateral lateral rectus recession strabismus *** made key innovations in surgical timing and strategy,and the results were *** combination of strabismus and PSR surgery is an innovative strategy for patients with both strabismus and early-onset *** Early treatment of strabismus and myopia positively influence motor development and should be included in rehabilitation programs for patients with PTHS.

关键词： Pitt-Hopkins syndrome Transcription factor 4 Strabismus Myopia Surgery Case report

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郑州地区HBsAg-HBV DNA+献血者的乙肝血清学特征分析

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医药论坛杂志 2024年第13期45卷 1409-1413页

作者：王艺芳魏旖辉赵磊陈明军魏跃光吕永磊河南省红十字血液中心郑州450012

目的了解郑州地区HBsAg无反应性HBV DNA反应性(HBsAg-HBV DNA+)献血者乙肝血清学标志物特征。方法2017年9月—2019年12月本研究采用2个不同厂家ELISA检测试剂同时进行HBsAg、抗-HCV和抗-HIV1/2(ELISA双反应性的标本除外)ELISA检测后的... 详细信息

目的了解郑州地区HBsAg无反应性HBV DNA反应性(HBsAg-HBV DNA+)献血者乙肝血清学标志物特征。方法2017年9月—2019年12月本研究采用2个不同厂家ELISA检测试剂同时进行HBsAg、抗-HCV和抗-HIV1/2(ELISA双反应性的标本除外)ELISA检测后的血液标本,进行核酸检测(nucleic acid testing,NAT),并收集HBsAg-HBV DNA+标本采用化学发光法检测进行乙肝血清学补充试验。结果经ELISA检测后有562666例进行了核酸检测,其中351例为HBV DNA反应性,经核酸检测后HBV残余风险降低至6.24/万。351例HBsAg-HBV DNA+标本经化学发光法检测发现,其中5例标本为HBsAg阳性;346例标本为HBsAg-HBV DNA+,其中有30例(8.67%)可能为“窗口期”感染,316例(91.33%)可能为“隐匿性”HBV感染(occult hepatitis B virus infection,OBI);乙肝血清学模式以单独HBcAb阳性(33.33%),HBsAb、HBcAb共阳性(20.51%)及HBeAb、HBcAb共阳性(17.09%)三种模式为主;60.40%HBsAb定量值100 IU/L。HBsAb阳性组的HBV DNA复检反应性率37.41%明显低于HBsAb阴性组59.43%(χ^(2)=16.292,P26岁年龄段HBcAb阳性人群、HBsAb阴性人群都可能存在较高的输血传播HBV的风险。核酸检测的应用能有效降低经输血传播HBV的残余风险,提高血液的安全性。

关键词：核酸检测窗口期隐匿性HBV感染血液安全

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Flexible,efficient,and accurate tests for epidemics

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Science China Mathematics 2024年第8期67卷 1881-1898页

作者： Linjiajie fang Bing-yi Jing Shen Ling Qiyue wang Qing Yang Data Science and Analytics Thrust The Hong Kong University of Science and TechnologyHong KongChina Department of Statistics and Data Science Southern University of Science and TechnologyShenzhen 518055China Department of Mathematics and Statistics Dalhousie UniversityHalifaxNS B 3H 4R 2Canada Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina

Group testing involves discovering a small subset of distinguished subjects from a large population while efficiently reducing the total number of *** has been widely used for industrial testing,information technology,and biology,especially epidemic ***,in reality,are noisy for the presence of false *** tests are accurate but time-consuming,while others are cheaper but less *** which test to use is constrained by various considerations,such as availability,cost,accuracy,and *** this paper,we propose flexible,efficient,and accurate tests(FEATs).FEATs are based on group testing with simple but careful designs by incorporating ideas such as close contact cliques and repeated *** could dramatically improve the efficiency or accuracy of existing *** example,for accurate but slow tests,the FEAT can improve efficiency multiple times without compromising *** the other hand,for fast but inaccurate tests,the FEAT can sharply reduce the false-negative rate(FNR)and significantly increase *** justifications are *** point out some scenarios where the FEAT can be effectively employed.

关键词： epidemiology control blood testing testing efficiency testing accuracy

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Run-and-Tumble Dynamics and Mechanotaxis Discovered in Microglial Migration

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Research 2024年第2期2023卷 95-103页

作者： yiyu Zhang Da Wei Xiaochen wang Boyi wang Ming Li Haiping fang yi Peng Qihui Fan fangfu Ye Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejang 325000China Songshan Lake Materials Laboratory DongguanGuangdong 523808China School of Science East China University of Science and TechnologyShanghai 200237China Oujang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang 325000China

Microglia are resident macrophage cells in the central nervous system that search for pathogens or abnormal neural activities and migrate to resolve the *** effective search and targeted motion of macrophages mean dearly to maintaining a healthy brain,yet little is known about their migration *** this work,we study microglial motion with and without the presence of external *** discover that the cells are promptly attracted by the applied forces(i.e.,mechanotaxis),which is a tactic behavior as yet unconfirmed in ***,in both the explorative and the targeted migration,microglia display dynamics that is strikingly analogous to bacterial run-and-tumble motion.A closer examination reveals that microglial run-and-tumble is more sophisticated,e.g.,they display a short-term memory when tumbling and rely on active steering during runs to achieve mechanotaxis,probably via the responses of mechanosensitive ion *** differences reflect the sharp contrast between microglia and bacteria cells(eukaryotes ***)and their environments(compact tissue ***).Further analyses suggest that the reported migration dynamics has an optimal search efficiency and is shared among a subset of immune cells(human monocyte and macrophage).This work reveals a fruitful analogy between the locomotion of 2 remote systems and provides a framework for studying immune cells exploring complex environments.

关键词： analogy closer prompt

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Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy:a precise construction of structurally diverse azaspiro polycyclic scaffolds

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Science China Chemistry 2024年第2期67卷 576-586页

作者： Xiao-Bao Wu Jun-Xiu Shi yi-Ming Ou Hua-Jie Jiang yi-Jun fang Qi-Ming wang Quan Gao Jie Yu Department of Applied Chemistry Anhui Province Engineering Laboratory for Green Pesticide Development and ApplicationAnhui Province Key Laboratory of Crop Integrated Pest ManagementAnhui Agricultural UniversityHefei230036China

A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic *** diverse azaspiro polycycles bearing multiple contiguous stereocenters are obtained with excellent results(up to 99:1 e.r.,>95:5 d.r.) via sequential enantioselective four-component Ugi reactions/post-Ugi transformations with substrates containing prerequisite functional groups in the presence of anionic stereogenic-at-cobalt(Ⅲ) complexes.

关键词： asymmetric catalysis post-Ugi transformation anionic stereogenic-at-cobalt(Ⅲ)complex azaspiro polycyclic scaffold one-pot synthesis

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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1

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Frontiers of Medicine 2024年第1期18卷 180-191页

作者： fang wang Yuxing Liu yi Dong Meifang Zhao Hao Huang Jieyuan Jin Liangliang Fan Rong Xiang Department of Endocrinology The Third Xiangya Hospital of Central South UniversityChangsha410013China Department of Cellular Biology School of Life SciencesKey Laboratory of Pediatric Rare DiseasesMinistry of EducationCentral South UniversityChangsha410013China

Lipin proteins including Lipin 1–3 act as transcriptional co-activators and phosphatidic acid phosphohydrolase enzymes,which play crucial roles in lipid ***,little is known about the function of Lipin3 in triglyceride(TG)***,we identified a novel mutation(NM_001301860:p.1835A>T/p.D612V)of Lipin3 in a large family with hypertriglyceridemia(HTG)and obesity through whole-exome sequencing and Sanger *** studies revealed that the novel variant altered the half-life and stability of the Lipin3 ***,we generated Lipin3 heterozygous knockout(Lipin3-heKO)mice and cultured primary hepatocytes to explore the pathophysiological roles of Lipin3 in TG *** found that Lipin3-heKO mice exhibited obvious obesity,HTG,and non-alcoholic fatty liver *** study demonstrated that the haploinsufficiency of Lipin3 in primary hepatocytes may induce the overexpression and abnormal distribution of Lipin1 in cytosol and *** increased expression of Lipin1 in cytosol may contribute to TG anabolism,and the decreased Lipin1 in nucleoplasm can reduce PGC1α,further leading to mitochondrial dysfunction and reduced TG *** study suggested that Lipin3 was a novel disease-causing gene inducing obesity and *** also established a relationship between Lipin3 and mitochondrial dysfunction.

关键词： Lipin3 Lipin1 hypertriglyceridemia obesity mitochondrial dysfunction

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