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Effects of three kinds of head acupuncture therapies on regulation of brain microenvironment and rehabilitation of nerve function in rats with cerebral palsy

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Journal of Traditional Chinese Medicine 2021年第2期41卷 276-283页

作者： wang zixuan FAN Xiangwei CHEN Kaiyun YU Xuefeng GAO Jing The Fourth Clinical Medicine College of Nanchang University Nanchang 330006China Department of the Orthopaedic The Fourth Affiliated Hospital of Nanchang UniversityNanchang 330003China Department of the Drug Clinical Trial Office The Fourth Affiliated Hospital of Nanchang UniversityNanchang 330003China Department of the Orthopaedic The fourth affiliated hospital of Nanchang universityNanchang 330003China Department of Child Rehabilitation Division Huai'an maternal and child care hospital Huai'anJiangsu 223002China

OBJECTIVE:To compare and observe the effects of three kinds of cephalic acupuncture therapies commonly used in the clinic on promoting nerve function rehabilitation in the brain microenvironment of rats with cerebral ***:A negative control group,positive control group,and three cephalic acupuncture groups based on the administration of three cephalic acupuncture therapies were *** experimental rats were selected from each group at 1,2,and 3 weeks after *** function after treatment was rated according to the Basso,Beattie,and Bresnahan *** matter fiber bundles were evaluated by head diffusion tensor *** expression levels of neuron-specific enolase,microtubule-associated protein 2,and myelin basic protein in the brain tissue extract were detected by Western blot analysis and the activities of ATPases were determined using a fixed phosphorus ***:The pathological changes in brain tissue were restored and motor function scores were increased in the mice in each cephalic acupuncture group,and the expression of neuronal growth-related proteins in the brain tissue extract was significantly ***,the activities of ATPases in the lesion area were significant enhanced(P<0.05).Diffusion tensor imaging revealed that the white matter fiber bundles of mice in each cephalic acupuncture group gradually increased and *** nervous system structure was significantly ***:All three acupuncture methods promoted the rehabilitation of nerve function damaged by cerebral *** effects are likely related to the improved expression of nerve growth-related proteins,enhancement of ATPase activities,and regulation of the brain microenvironment.

关键词： cerebral palsy scalp acupuncture adenosine triphosphatases brain microenvironment

富血小板血浆在马运动系统损伤中的应用研究进展

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中国畜牧兽医 2024年第4期51卷 1784-1791页

作者：彭聪李靖汤小朋王子璇吴雨虹朱怡平中国农业大学动物医学院北京100193

马属动物尤其是运动马常发生运动系统损伤,损伤一旦发生,均会导致不同程度的跛行,且受损组织难以完全修复,常导致马运动性能大幅下降和不良预后,是运动马提前结束运动生涯最主要的原因之一。富血小板血浆(PRP)是一种再生医学制剂,通过... 详细信息

马属动物尤其是运动马常发生运动系统损伤,损伤一旦发生,均会导致不同程度的跛行,且受损组织难以完全修复,常导致马运动性能大幅下降和不良预后,是运动马提前结束运动生涯最主要的原因之一。富血小板血浆(PRP)是一种再生医学制剂,通过激活血小板释放大量生长因子促进组织修复和再生。许多研究和临床报道表明,PRP对运动损伤有一定治疗效果,最常用于治疗马属动物肌腱、韧带损伤和骨关节炎,在欧美等国家应用较多。另外,PRP还具有一定抗菌效果,有望用于治疗感染性骨关节炎。对蹄叶炎等目前缺乏有效治疗药物的疾病也表现出一定的治疗潜力。在马运动医学领域,国内对PRP作用机制和应用范围了解较少,临床实践方面缺乏有关运用PRP治疗马运动系统损伤的研究报道。笔者从PRP制备和分类、PRP在治疗马运动系统损伤中的临床应用及研究进展进行综述,总结PRP在治疗马运动系统损伤中的应用范围和发展趋势,以期为国内兽医及相关从业人员应用PRP提供参考。

关键词：马富血小板血浆运动系统损伤临床应用

施肥对热带砖红壤胶林土壤水分特征曲线的影响及模型优选

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水土保持研究 2024年第1期31卷 105-116页

作者：林晓燕王晶晶吴炳孙宁松瑞王紫璇邱偲雨吴耀华海南大学热带农林学院海口570228 海南五指山森林生态系统国家定位观测研究站海南五指山572299 中国热带农业科学院橡胶研究所海口571101 西安理工大学省部共建西北旱区生态水利国家重点实验室西安710048

[目的]探明热带橡胶林施肥措施对土壤持水能力及孔隙特征的影响,并优选描述砖红壤胶林土壤水分特征曲线的模拟模型。[方法]采用沙箱排水法结合压力膜仪法测定砖红壤橡胶林5种施肥处理(有机肥混施化肥(H)、施化肥(C)、种植绿肥(G)、施专... 详细信息

[目的]探明热带橡胶林施肥措施对土壤持水能力及孔隙特征的影响,并优选描述砖红壤胶林土壤水分特征曲线的模拟模型。[方法]采用沙箱排水法结合压力膜仪法测定砖红壤橡胶林5种施肥处理(有机肥混施化肥(H)、施化肥(C)、种植绿肥(G)、施专用肥(S)及不施肥(CK))的全吸力段土壤水分特征曲线,应用Brooks-Corey(BC)、van Genuchten(VG)、Gardner和Log-Normal Distribution(LND)4种经验模型拟合,分析了不同模型的适用性及拟合精度。[结果]0—5 cm土层,在低吸力段(pF≤3.01)C处理降幅最大(0.44 cm^(3)/cm^(3));在高吸力阶段(3.01

关键词：土壤有效含水率吸湿水沙箱排水法比水容量土壤孔隙分布持水能力

维普期刊数据库博看期刊

3D肿瘤球对肿瘤浸润淋巴细胞的体外激活扩增及抗肿瘤的作用

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生物工程学报 2024年第5期40卷 1523-1535页

作者：许鑫鑫张艳梅王子萱张青李杨戴建莉高云鹤熊卓陈凛解放军医学院北京100853 中国人民解放军总医院第一医学中心普通外科医学部北京100853 清华大学机械工程系生物制造中心北京100084 北京市科学技术研究院新材料与先进制造研究所北京100089

肿瘤浸润淋巴细胞(tumor-infiltrating lymphocytes,TILs)介导的过继性免疫治疗已在多种实体瘤中取得良好疗效。然而,传统TILs体外扩增方法效率低,难以达到治疗级别的细胞数量和高肿瘤杀伤活性要求。为了研究3D肿瘤模型对TILs体外激活... 详细信息

肿瘤浸润淋巴细胞(tumor-infiltrating lymphocytes,TILs)介导的过继性免疫治疗已在多种实体瘤中取得良好疗效。然而,传统TILs体外扩增方法效率低,难以达到治疗级别的细胞数量和高肿瘤杀伤活性要求。为了研究3D肿瘤模型对TILs体外激活扩增及肿瘤杀伤活性的影响,为TILs体外扩增提供新策略,本研究从肺癌患者手术样本中获取TILs和原代肿瘤细胞,对比观察2D及3D培养条件下肺癌细胞系NCI-H1975及原代肺癌细胞对TILs激活扩增及抗肿瘤作用的影响;向3D培养原代肿瘤~+TILs中添加程序性死亡受体1(programmed cell death protein 1,PD-1)抗体,验证PD-1抗体对该体系中TILs浸润杀伤肿瘤细胞的影响。结果表明,相比于2D培养,3D培养的H1975肺癌细胞系可使TILs在一定时间内显著扩增,并提升TILs中CD3~+/CD8~+细胞的比例(61.6%);3D培养的原代肿瘤球也可刺激增加CD3~+/CD8~+TILs细胞的比例(45.5%,54.4%),诱导肿瘤上皮细胞的凋亡,使其存活率降至16.7%;进一步研究表明,PD-1抗体的引入促进3D原代肿瘤球共培养介导的TILs的增殖、提高CD3~+/CD8~+细胞的比例(50.9%,57.0%),并显著提高其抗肿瘤效力(肿瘤上皮细胞整体存活率降至9.36%)。综上所述,3D肿瘤球显著增强TILs细胞的体外激活增殖及抗肿瘤能力,且PD-1抗体进一步促进3D肿瘤球介导的TILs细胞增殖及其杀伤肿瘤的效力。

关键词： 3D培养肿瘤模型肿瘤浸润淋巴细胞 T细胞体外扩增程序性死亡受体1

Source of the Ore-forming Adakitic Porphyry at the Beiya Super-large Au Deposit, Western Yangtze Craton: New Evidence from Zircon U-Pb Ages of the Amphibolite Xenoliths

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Acta Geologica Sinica(English Edition) 2020年第1期94卷 208-209页

作者： LIU Siqi ZHENG Yuanchuan SHEN Yang HOU Zengqian wang Lu wang zixuan State Key Laboratory of Geological Processes and Mineral Resources and School of Earth Science and ResourcesChina University of GeosciencesBeijing 100083China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China

Objective The Beiya super-large Au-rich porphyry deposit(304 t Au,2.4 g/t Au)is located within the western Yangtze craton,to the southeast of the Sanjiang Tethyan Orogen(Fig.1).The ore-forming porphyry is adakitic,characterized by high Sr/Y and La/Yb ratios coupled with low Y and Yb contents,and is generally thought to be derived from partial melting of thickened mafic lower *** lower crust underneath the western Yangtze craton is mainly composed of ancient crust with Archean ages,juvenile crust resulting from the Neoproterozoic subduction(740–1000 Ma),and late Permian juvenile crust related to the Emeishan mantle *** lower crustal end-member has played a critical role in genesis of the Beiya ore-forming porphyry can be constrained by zircon U-Pb ages of amphibolite xenoliths hosted in the ore-forming porphyry,because these xenoliths represent direct samples of the *** this study,we present new zircon U-Pb ages of these amphibolite xenoliths to have insight into the nature of the Beiya adakitic porphyry source.

关键词： Western Yangtze Craton New Evidence from Zircon U-Pb Ages of the Amphibolite Xenoliths Source of the Ore-forming Adakitic Porphyry at the Beiya Super-large Au Deposit

Petrogenesis and Physicochemical Conditions of Fertile Porphyry in Non-arc Porphyry Mineralization:A Case from Habo Porphyry Cu-Mo Deposits,SW China

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Acta Geologica Sinica(English Edition) 2023年第2期97卷 469-485页

作者： ZHANG Aiping ZHENG Yuanchuan SHEN Yang Qi Qunjia wang zixuan WU Changda wang Lu School of Earth Sciences Yunnan UniversityKunming 650500China Yunnan Key Laboratory of Sanjiang Metallogeny and Resources Exploration and Utilization Kunming 650500China School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China

The Habo deposit is a typical porphyry Cu-Mo deposit in the Ailaoshan–Red River metallogenic *** minerals in the Habo deposit typically occur as veins in the monzonite *** U-Pb dating suggests that the monzonite porphyry formed at 35.07±0.38 *** monzonite porphyry is characterized by high SiO_(2),Al_(2)O_(3),K_(2)O and Na_(2)O contents,with A/CNK ratios ranging from 0.97 to *** samples exhibit fractionated REE patterns,characterized by high(La/Yb)N ratios(9.4–13.6,average of 11.2).They show adakite-like geochemical features,high Sr concentrations(627–751 ppm,average of 700 ppm),low Y concentrations(15.13–16.86 ppm,average of 15.81 ppm)and high Sr/Y values(39.5–47.4,average of 44.3).These samples have high initial^(87)Sr/^(86)Sr ratios(0.7074–0.7076)and negativeεNd(t)values(-5.1 to-3.7),whereas the zirconεHf(t)values range from-2.2 to+0.4,suggesting that the monzonite porphyry was derived from the partial melting of a thickened juvenile lower *** oxygen fugacity,calculated on the basis of the chemical composition of the amphiboles,shows?NNO values ranging from+1.65 to+2.16(average of 1.94)and lg(fO_(2))ranging from-12.72 to-11.99(average of-12.25),indicating that the monzonite porphyry has high oxygen *** have high Ce^(4+)/Ce^(3+)ratios(29.29–164.24,average of 84.92),with high?FMQ values ranging from+0.50 to+1.51(average of 0.87)and high lg(fO_(2))values ranging from-14.72 to-12.85(average of-14.07),which also indicates that the oxygen fugacity of the magma was *** dissolved water content of the Habo monzonite porphyry is 9.5–11.5 wt%,according to the geochemical characteristics,zircon-saturation thermometry(692–794°C)and the mineral phases(amphibole,no plagioclase)in the deep magma *** with previous studies,we propose that the high oxygen fugacity and high water content of magma played key roles in controlling the formation of the Habo and other Cu-Mo-Au deposits in the Ailaoshan–Red River metallogenic be

关键词： magmatic oxidation state water content monzonite porphyry Habo porphyry Cu-Mo deposit Ailaoshan-Red River metallogenic belt

血清标志物对老年慢性阻塞性肺疾病合并肺部感染临床诊断及预后评估的价值分析

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中国医药 2024年第7期19卷 1005-1009页

作者：王宛莹史展贺思琪王子旋王宝增首都医科大学附属北京天坛医院感染科北京100070 北京医院重症医学科北京100050 首都医科大学附属北京天坛医院呼吸科北京100070

目的探讨血清生长停滞特异性蛋白6(Gas6)、纤溶酶原激活物抑制剂1(PAI-1)和血清胆碱酯酶(S-ChE)对老年慢性阻塞性肺疾病(COPD)合并肺部感染临床诊断及预后评估的价值。方法选择首都医科大学附属北京天坛医院2021年1月至2023年1月收治的... 详细信息

目的探讨血清生长停滞特异性蛋白6(Gas6)、纤溶酶原激活物抑制剂1(PAI-1)和血清胆碱酯酶(S-ChE)对老年慢性阻塞性肺疾病(COPD)合并肺部感染临床诊断及预后评估的价值。方法选择首都医科大学附属北京天坛医院2021年1月至2023年1月收治的106例COPD合并肺部感染患者作为感染组,另纳入同期111例COPD未合并肺部感染患者作为非感染组。根据预后情况将感染组患者分为生存组(83例)与死亡组(23例)。比较非感染组和感染组患者血清Gas6、PAI-1、S-ChE水平。比较生存组和死亡组患者一般资料。采用受试者工作特征曲线分析血清Gas6、PAI-1和S-ChE对老年COPD患者发生肺部感染以及肺部感染患者发生死亡的预测价值;采用多因素Logistic回归方法分析影响老年COPD合并肺部感染患者预后的因素。结果感染组血清Gas6、PAI-1水平高于非感染组,S-ChE水平低于非感染组,差异均有统计学意义(均P<0.001)。受试者工作特征曲线分析结果显示,血清Gas6、PAI-1、S-ChE及三者联合诊断COPD患者发生肺部感染的曲线下面积分别为0.787、0.797、0.782、0.889,三者联合诊断的曲线下面积高于各自单独诊断(Z=4.527、5.435、4.167,均P<0.001)。死亡组COPD全球倡议Ⅲ级、合并糖尿病比例以及血清Gas6、PAI-1水平高于生存组,第1秒用力呼气容积占预计值百分比、第1秒用力呼气容积与用力肺活量比值以及S-ChE水平低于生存组(均P<0.05)。多因素Logistic回归分析结果显示,Gas6、PAI-1是老年COPD并发肺部感染患者发生死亡的危险因素,S-ChE是保护因素(均P<0.05)。受试者工作特征曲线分析结果显示血清Gas6、PAI-1、S-ChE三者联合诊断COPD合并肺部感染患者死亡的曲线下面积高于各自单独检测(均P<0.05)。结论老年COPD合并肺部感染患者血清Gas6、PAI-1水平升高,S-ChE水平降低,三者对疾病的临床诊断和预后评估具有一定的价值。

关键词：慢性阻塞性肺疾病肺部感染生长停滞特异性蛋白6 纤溶酶原激活物抑制剂1 血清胆碱酯酶

Efficacy of Xixiancao (Herba Siegesbeckiae Orientalis) on interactions between nuclear factor kappa-B and inflammatory cytokines in inflammatory reactions of rat synovial cells induced by sodium urate

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Journal of Traditional Chinese Medicine 2020年第5期40卷 774-781页

作者： wang zixuan Fan Xiangwei Xu Yier Chen Kaiyun Yu Xuefeng Sun Guicai the Fourth Clinical Medicine College Nanchang UniversityNanchang 330003China Department of the Orthopaedic the Fourth Affiliated Hospital of Nanchang UniversityNanchang 330003China Institute of Medicine Harbin Pharmaceutical Group Co.Harbin 150000China Department of the Drug Clinical Trial Office The Fourth Affiliated Hospital of Nanchang UniversityNanchang 330003China the Fourth Affiliated Hospital of Nanchang University Nanchang 330003China the First Affiliated Hospital of Nanchang University Nanchang 330000China

OBJECTIVE:To investigate the interaction between nuclear factor kappa-B(NF-κB)and inflammatory cytokines in synovial cell inflammatory responses induced by sodium urate,and to evaluate the efficacy of Xixiancao(Herba Siegesbeckiae Orientalis)on these ***:The interactions between NF-κB and inflammatory cytokines/mediators in synovial cells in acute gouty arthritis were *** observed the expressions of NF-κB,interleukin(IL)-1β,IL-8,and tumor necrosis factor alpha(TNF-α)in synovial cells at different timepoints in an in vitro model of synovial cell inflammatory responses induced by sodium urate and in an in vivo model of gouty *** in the expressions of NF-κB,IL-1β,IL-8,and TNF-αin synovial cells of all experimental groups were compared and observed after treatment with different doses of Xixiancao(Herba Siegesbeckiae Orientalis)and *** interactions between NF-κB and IL-1β,IL-8,and TNF-αwere *** changes in synovial tissues were observed in rats with acute gouty ***:Compared with the blank group,the expression levels of NF-κB,IL-1β,IL-8,and TNF-αwere increased significantly at different timepoints in the in vitro model of synovial cell inflammatory responses induced by sodium urate,and in the in vivo model of gouty *** with the model group,the expressions of NF-κB,IL-1β,IL-8,and TNF-αin synovial cells induced by sodium urate were decreased in the different Xixiancao(Herba Siegesbeckiae Orientalis)dose groups and the colchicine *** effect was more obvious in the high dose Xixiancao(Herba Siegesbeckiae Orientalis)*** expression of NF-κB in synovial cells was positively correlated with the expressions of IL-1β,IL-8,and TNF-α.Histopathological examination of synovial tissues in the high dose Xixiancao(Herba Siegesbeckiae Orientalis)group and Colchicine group showed that the characteristics of acute gouty arthritis were reduced,and there was a trend towards a positi

关键词： Arthritis,gouty NF-kappa B Cytokines Xixiancao(Herba Siegesbeckiae Orientalis)

艺术融合多元参与村庄规划的逻辑与路径探索——以益阳市富民村为例

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城市学刊 2024年第4期45卷 9-18页

作者：易纯王子轩刘彬姜美如湖南城市学院建筑与城市规划学院湖南益阳413000 数字化城乡空间规划关键技术湖南省重点实验室湖南益阳413000

艺术设计能够提升村庄本底建设环境质量,促进村庄规划落实和实施。多元参与村庄规划能够进一步为村庄提供更多有益的社会因素和发展思路,艺术设计背景下多元参与的村庄规划能更高效、更全面地促进乡村振兴。以“启蒙—发展—提质—振兴... 详细信息

艺术设计能够提升村庄本底建设环境质量,促进村庄规划落实和实施。多元参与村庄规划能够进一步为村庄提供更多有益的社会因素和发展思路,艺术设计背景下多元参与的村庄规划能更高效、更全面地促进乡村振兴。以“启蒙—发展—提质—振兴”的规划目标为导向,在理论层面建构艺术融合多元参与村庄规划设计逻辑,以益阳市富民村村庄规划设计为例,探索村庄规划设计路径。从艺术家视角下村庄艺术赋能、村民主体响应下艺术化村庄发展、企业和高校等主体创作下村庄整体统筹以及村“两委”/地方政府保障下村庄振兴推进等四个层面探讨艺术融合多元参与的村庄规划设计路径,以期为我国传统农业型村庄规划设计提供一些发展思路。

关键词：艺术设计融合多元参与村庄规划设计