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“政府+市场”视角下预付式消费治理:动因、困境与提升路径

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中国市场监管研究 2024年第3期 43-49页

作者：赵玲玲王智赟中共杭州市委党校公共管理教研部杭州市市场监督管理局

预付式消费为经营者和消费者带来实惠便利的同时带动了地方经济,成为消费市场一种重要的商业运营模式。预付式消费市场出现服务质量难以保证、权利义务不对等、虚假宣传及欺诈消费等问题,成为对其治理的重要动因。配套法规相对滞后、信... 详细信息

预付式消费为经营者和消费者带来实惠便利的同时带动了地方经济,成为消费市场一种重要的商业运营模式。预付式消费市场出现服务质量难以保证、权利义务不对等、虚假宣传及欺诈消费等问题,成为对其治理的重要动因。配套法规相对滞后、信用惩戒机制不完善、预付资金纳管困难以及政府监管短板构成了预付式消费治理的现实困境。“政府+市场”治理模式能够为有效解决预付式消费监管难题提供新的治理思路,从持续完善法制建设、构建信用监管闭环、加强监管执法与刑事追诉以及破解资金纳管难题等方面提升治理效能。

关键词：政府监管预付式消费有为政府有效市场营商环境

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燃煤机组灵活性改造成本及效益分析

锅炉技术 2024年第5期55卷 65-71页

作者：高彦洁张斯文景雪晖王治云国网新疆电科院新疆乌鲁木齐830000 国网新疆电力有限公司新疆乌鲁木齐830000 上海理工大学能源与动力工程学院上海200093

当前的电力辅助服务市场机制使燃煤电厂由传统提供电能的主体性电源逐步转变为容量可靠、调节灵活性强的基础性电源.燃煤电厂现有的调峰收益基本能覆盖由于灵活性改造所带来的成本增量.分别选取燃煤电厂不同参数空冷和湿冷机组为研究对... 详细信息

当前的电力辅助服务市场机制使燃煤电厂由传统提供电能的主体性电源逐步转变为容量可靠、调节灵活性强的基础性电源.燃煤电厂现有的调峰收益基本能覆盖由于灵活性改造所带来的成本增量.分别选取燃煤电厂不同参数空冷和湿冷机组为研究对象,从技术改造成本、煤耗成本、机组寿命损耗成本、电力辅助服务市场收益以及环境收益等方面对灵活性改造收益进行分析,通过结合经典案例并给出成本和收益的经验公式,量化分析灵活性改造后的燃煤机组对电网灵活性产生的效益.

关键词：新能源消纳燃煤机组灵活性改造成本及效益

Enterovirus D68 infection upregulates SOCS3 expression to inhibit JAK-STAT3 signaling and antagonize the innate interferon response of the host

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Virologica Sinica 2023年第5期38卷 755-766页

作者： Yuling Zhang Leling Xu Zhe Zhang Xin Su zhiyun wang Tao wang School of Life Sciences Tianjin UniversityTianjin300072China School of Environmental Science and Engineering Tianjin UniversityTianjin300072China Institute of Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures Tianjin300072China

Enterovirus D68(EV-D68)can cause respiratory diseases and acute flaccid paralysis,posing a great threat to public *** are cytokines secreted by host cells that have broad-spectrum antiviral effects,inducing the expression of hundreds of interferon-stimulated genes(ISGs).EV-D68 activates ISG expression early in infection,but at a later stage,the virus suppresses ISG expression,a strategy evolved by EV-D68 to antagonize ***,we explore a host protein,suppressor of cytokine signaling 3(SOCS3),is upregulated during EV-D68 infection and antagonizes the antiviral effects of type I *** subsequently demonstrate that the structural protein of EV-D68 upregulated the expression of RFX7,a transcriptional regulator of SOCS3,leading to the upregulation of SOCS3 *** exploration revealed that SOCS3 plays its role by inhibiting the phosphorylation of signal transducer and activator of transcription 3(STAT3).The expression of SOCS3 inhibited the expression of ISG,thereby inhibiting the antiviral effect of type I interferon and promoting EV-D68 transcription,protein production,and viral ***,a truncated SOCS3,generated by deleting the kinase inhibitory region(KIR)domain,failed to promote replication and translation of *** on the above studies,we designed a short peptide named SOCS3 inhibitor,which can specifically bind and inhibit the KIR structural domain of SOCS3,significantly reducing the RNA and protein levels of *** summary,our results demonstrated a novel mechanism by which EV-D68 inhibits ISG transcription and antagonizes the antiviral responses of host type I interferon.

关键词： Enterovirus D68(EV-D68) Interferon ISG SOCS3 STAT3

25-羟维生素D_(3)、维生素C、大豆异黄酮对鸡蛋壳质量及钙代谢的影响

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饲料工业 2024年第2期45卷 66-76页

作者：程千惠汪智云王焕斌黄竹林陈橙伍志敏齐德生华中农业大学动物科学技术学院湖北武汉430070 武汉民族生物科技有限公司湖北武汉430064 武汉市动物疫病预防控制中心湖北武汉430014

为探究不同剂量组合的25-羟维生素D_(3)、维生素C、大豆异黄酮对鸡蛋壳质量及钙代谢的影响,试验采用三因素三水平正交试验设计,在基础日粮中分别添加0、10、20μg/kg 25-羟维生素D_(3),0、50、100 mg/kg维生素C,0、5、10 mg/kg大豆异黄... 详细信息

为探究不同剂量组合的25-羟维生素D_(3)、维生素C、大豆异黄酮对鸡蛋壳质量及钙代谢的影响,试验采用三因素三水平正交试验设计,在基础日粮中分别添加0、10、20μg/kg 25-羟维生素D_(3),0、50、100 mg/kg维生素C,0、5、10 mg/kg大豆异黄酮。选取972只50周龄的健康京粉一号蛋鸡,随机分为9组,每组6个重复,每个重复18羽,预试期1周,正试期6周。结果表明:(1)与0添加量相比,添加20μg/kg 25-羟维生素D_(3)可显著增加平均蛋重(P<0.05)。(2)在第5~6周,添加不同水平的25-羟维生素D_(3)、维生素C和大豆异黄酮均能显著提高蛋壳强度、蛋壳厚度(P<0.05)。(3)添加大豆异黄酮和维生素C可提高机体的抗氧化能力。(4)添加不同水平的25-羟维生素D_(3)、维生素C均可显著提高十二指肠中CaBP-D_(28k)及肾脏中CYP_(27)B_(1)表达量(P<0.05),添加5 mg/kg大豆异黄酮可显著提高子宫中ERα、CA_(2)表达量(P<0.05)。综上,(1)饲粮中添加25-羟维生素D_(3)、维生素C和大豆异黄酮均可提高蛋壳质量,最优组合为20μg/kg 25-羟维生素D_(3)、50 mg/kg维生素C和5 mg/kg大豆异黄酮。(2)25-羟维生素D_(3)通过促进十二指肠及肾脏中CaBP-D_(28k)表达,促进机体钙吸收和蛋壳钙沉积;维生素C通过提高十二指肠CaBP-D_(28k)、肾脏CYP_(27)B_(1)表达量,促进钙吸收和胫骨钙沉积;大豆异黄酮通过提高机体雌激素水平,促进子宫ERα、CA_(2)表达,促进胫骨钙沉积。

关键词： 25-羟维生素D_(3) 维生素C 大豆异黄酮蛋壳质量钙代谢

Proteasome Inhibitor PS-341 Effectively Blocks Infection by the Severe Fever with Thrombocytopenia Syndrome Virus

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Virologica Sinica 2019年第5期34卷 572-582页

作者： Sihua Liu Hongyun Liu Keke Zhang Xueping Li Yuqin Duan zhiyun wang Tao wang School of Life Sciences Tianjin UniversityTianjin 300073China School of Environmental Science and Engineering Tianjin UniversityTianjin 300073China

Severe fever with thrombocytopenia syndrome(SFTS)is an emerging hemorrhagic fever disease caused by SFTSV,a newly discovered phlebovirus that is named after the ***,no effective vaccines or drugs are available for use against SFTSV infection,as our understanding of the viral pathogenesis is ***(PS-341),a dipeptideboronic acid analog,is the first clinically approved proteasome inhibitor for use in *** this study,the antiviral efficacy of PS-341 against SFTSV infection was tested in human embryonic kidney HEK293T(293T)*** employed four different assays to analyze the antiviral ability of PS-341 and determined that PS-341 inhibited the proliferation of SFTSV in 293T cells under various treatment *** PS-341 did not affect the virus absorption,PS-341 treatment within a non-toxic concentration range resulted in a significant reduction of progeny viral titers in infected ***-luciferase reporter assays and Western blot analysis revealed that PS-341 could reverse the SFTSV-encoded nonstructural protein(NS)mediated degradation of retinoic acid-inducible gene-1(RIG-I),thereby antagonizing the inhibitory effect of NSs on interferons and blocking virus *** addition,we observed that inhibition of apoptosis promotes virus *** results indicate that targeting of cellular interferon pathways and apoptosis during acute infection might serve as the bases of future therapeutics for the treatment of SFTSV infections.

关键词： Bortezomib PS-341 Severe fever with thrombocytopenia syndrome virus(SFTSV) IFN-β Apoptosis

实时超声引导下经皮胸腔穿刺置管闭式引流术治疗气胸的效果分析

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中国社区医师 2024年第6期40卷 74-76页

作者：危内芳王志耘刘玉江湘西土家族苗族自治州民族中医院湖南吉首416000 首都医科大学附属北京友谊医院北京100050

目的:分析实时超声引导下经皮胸腔穿刺置管闭式引流术治疗气胸的效果。方法:选取2022年6月—2023年5月湘西土家族苗族自治州民族中医院收治的80例单侧气胸患者作为研究对象,依据治疗方式分为试验组与对照组,各40例。对照组行胸腔闭式引... 详细信息

目的:分析实时超声引导下经皮胸腔穿刺置管闭式引流术治疗气胸的效果。方法:选取2022年6月—2023年5月湘西土家族苗族自治州民族中医院收治的80例单侧气胸患者作为研究对象,依据治疗方式分为试验组与对照组,各40例。对照组行胸腔闭式引流术,观察组行实时超声引导下经皮胸腔穿刺置管闭式引流术。比较两组治疗前后疼痛情况、置管准确率、不良反应发生率及平均肺复张时间。结果:置管后,两组疼痛评分低于置管时,且试验组低于对照组,差异有统计学意义(P<0.001)。试验组置管准确率高于对照组,平均肺复张时间早于对照组,差异有统计学意义(P<0.05)。试验组不良反应发生率低于对照组,差异有统计学意义(P=0.033)。结论:超声引导下经皮胸腔穿刺置管闭式引流术治疗气胸效果较好,其置管准确率高,患者肺复张时间早,疼痛症状轻,不良反应发生率低。

关键词：超声引导气胸闭式引流术经皮胸腔穿刺置管

Synthesis of Bis-benzimidazolium Cyclic Receptors and Their Anion Binding Properties

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Chinese Journal of Chemistry 2013年第5期31卷 673-678页

作者： Xiaozhi Jiang Meiyun Feng Dawei Zhang Binshen wang zhiyun Dong Guohua Gao Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of Chemistry East China Normal University 3663 North Zhongshan Road Shanghai 200062 China

A series of cyclic receptors 1--5 based on bis-benzimidazolium group were designed and synthesized. Their anion recognition properties were investigated by UV-vis, fluorescent spectroscopy, 1H NMR and MALDI-TOF mass spectrometry. The UV-vis and fluorescent spectroscopic studies showed that the receptors 1--5 had different binding abilities for various anions such as fluoride, chloride, bromide, iodide and acetate. The high selectivity of the receptors for fluoride and acetate anions is attributed to their basicity. Job plot and MALDI-TOF mass spec- trometry demonstrated that the receptors form 1 ： 1 complex with fluoride. DFT calculation and 1H NMR studies indicated that the receptors bind anions through （C--H）＋…X- hydrogen bond.

关键词： cyclic ionic receptors bis-benzimidazolium anion recognition hydrogen bond

Discovery of the radio-protecting effect of Ecliptae Herba,its constituents and targeting p53-mediated apoptosis in vitro and in vivo

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Acta Pharmaceutica Sinica B 2023年第6期13卷 1216-1230页

作者： Jiang Wu Wenfeng Gou zhiyun wang Huajie Chang Deguan Li Wenbin Hou Changxiao Liu Department of Pharmaceutical Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Institute of Radiation Medicine Chinese Academy of Medical SciencesTianjin 300192China School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China Research Center for New Drug Evaluation the State Laboratory of Drug Delivery Technology and PharmacokineticsTianjin Institute of Pharmaceutical ResearchTianjin 300193China

Radiation protection drugs are often accompanied by toxicity,even amifostine,which has been the dominant radio-protecting drug for nearly 30 ***,there is no therapeutic drug for radiation-induced intestinal injury(RⅢ).This paper intends to find a safe and effective radioprotecting ingredient from natural *** radio-protecting effect of Ecliptae Herba(EHE) was discovered preliminarily by antioxidant experiments and the mouse survival rate after137Cs *** components and blood substances in vivo were identified through *** correlation network of “natural components in EHE-constituents migrating to blood-targets-pathways” was established to predict the active components and *** binding force between potential active components and targets was studied by molecular docking,and the mechanism was further analyzed by Western blotting,cellular thermal shift assay(CETSA),and Ch ***,the expression levels of Lgr5,Axin2,Ki67,lysozyme,caspase-3,caspase-8,8-OHd G,and p53 in the small intestine of mice were *** was found for the first time that EHE is active in radiation protection and that luteolin is the material basis of this *** is a promising candidate for RⅢ.Luteolin can inhibit the p53 signaling pathway and regulate the BAX/BCL2 ratio in the process of *** could also regulate the expression of multitarget proteins related to the same cell cycle.

关键词： p53 Apoptosis Luteolin Eclipta prostrata L. Radio-protecting Radiation-induced intestinal injury Radiation protection

藤茶提取液对电离辐射损伤造血系统的防护作用研究

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辐射防护 2024年第2期44卷 182-191页

作者：王志允勾文峰郭江红许飞飞李祎亮侯文彬天津中医药大学天津301617 中国医学科学院放射医学研究所天津市放射医学与分子核医学重点实验室天津300192

采用1,1-二苯基-2-苦基肼自由基(DPPH)和总抗氧化能力检测(ABTS)两种方法体外检测藤茶提取液的抗氧化能力;然后进行生存率实验,将40只雄性C57BL/6J小鼠随机分为照射组、照射+藤茶提取液低、中、高剂量组(0.8 g/kg、1.6 g/kg、2.4 g/kg)... 详细信息

采用1,1-二苯基-2-苦基肼自由基(DPPH)和总抗氧化能力检测(ABTS)两种方法体外检测藤茶提取液的抗氧化能力;然后进行生存率实验,将40只雄性C57BL/6J小鼠随机分为照射组、照射+藤茶提取液低、中、高剂量组(0.8 g/kg、1.6 g/kg、2.4 g/kg),所有小鼠均进行致死剂量7.2 Gy照射,检测藤茶提取液对照射后小鼠的生存影响;随后在电离辐射损伤造血系统实验中将50只雄性C57BL/6J小鼠随机分为5组:空白对照组、照射组、照射+藤茶提取液低、中、高剂量组,经4 Gy全身照射后,观察藤茶提取液对电离辐射后小鼠脏器指数、造血指标等的影响,并测定肝脏中总超氧化物歧化酶(T-SOD)和谷胱甘肽(GSH)的变化。实验结果表明,藤茶提取液对DPPH自由基清除率为74.35%,对ABTS自由基清除率为93.14%,能够提高7.2 Gy照射下小鼠的生存率(照射组生存率为30%,低剂量组生存率为100%,中剂量组生存率为90%,高剂量组生存率为90%),并改善4 Gy全身照射所导致造血系统损伤小鼠的脏器指数和造血指标,还能升高照射小鼠肝脏中T-SOD活力以及GSH的含量。藤茶提取液具有较强的抗氧化能力,能提高电离辐射后小鼠的生存率,并改善其引起的造血系统损伤,有望成为电离辐射导致造血系统损伤的中药防护剂。

关键词：藤茶提取液抗氧化能力造血损伤电离辐射防护