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Simultaneous enhancement in mechanical and corrosion properties of Al-Mg-Si alloys using machine learning

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Journal of Materials Science & Technology 2023年第36期167卷 1-13页

作者： Xinming Feng zhilei wang Lei Jiang Fan Zhao Zhihao Zhang Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Key Laboratory for Advanced Materials Processing(MOE) University of Science and Technology BeijingBeijing 100083China Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China

Al-Mg-Si alloys with high strength and good corrosion resistance are regarded as desirable materials for all-aluminum ***,the traditional trial-and-error experimental methods are insufficient to address the trade-offbetween strength and corrosion *** this work,a non-dominated sorting genetic machine-learning algorithm(NSGA-II)was employed to optimize the chemical composition,so as to simultaneously improve the strength and corrosion *** high-performance Al-Mg-Si alloys with low Mg,Si,and Cu contents were successfully developed,where the yield strength(YS),ultimate tensile strength(UTS),and the elongation(δ)reached 375-380 MPa,410-416 MPa,and 13.7%-15.2%,*** with higher-Cu-content 6013 alloy,the YS and UTS of the present alloys increase by about 60 MPa,and the intergranular corrosion resistance is also significantly ***-ture characterization demonstrated thatβ’’and QP phases introduced a significant synergistic precipita-tion strengthening effect;the dispersoids formed by trace Mn,Cr,Fe,Zr,and Ti contributed dispersion strengthening effect;and the good pitting corrosion resistance is attributed to lower Mg and Si contents.

关键词： Aluminum alloy Machine learning High strength Corrosion resistance

Surface crack evolution patterns in freeze-thaw damage of fissured rock bodies

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Journal of Mountain Science 2024年第9期21卷 3094-3107页

作者： KANG Zhiqiang wang zhilei SHAO Luhang FENG Jiangjiang YAO Xulong College of Mining Engineering North China University of Science and TechnologyTangshan 063200China Green Intelligent Mining Technology Innovation Center of Hebei Province North China University of Science and TechnologyTangshan 063210China Luannan Macheng Mining Co. Ltd.Shougang Group Co.LtdLuannan CountyTangshan 063500China

To explore the effects of freeze‒thaw cycles on the mechanical properties and crack evolution of fissured sandstone,biaxial compression experiments were carried out on sandstone subjected to freeze‒thaw cycles to characterize the changes in the physical and mechanical properties of fissured sandstone caused by freeze‒thaw *** crack evolution and crack change process on the surface of the fissured sandstone were recorded and analysed in detail via digital image technology(DIC).Numerical simulation was used to reveal the expansion process and damage mode of fine-scale cracks under the action of freeze‒thaw cycles,and the simulation results were compared and analysed with the experimental data to verify the reliability of the numerical *** results show that the mass loss,porosity,peak stress and elastic modulus all increase with increasing number of freeze‒thaw *** an increase in the number of freeze‒thaw cycles,a substantial change in displacement occurs around the prefabricated cracks,and a stress concentration appears at the crack *** new cracks continue to sprout at the tips of the prefabricated cracks until the microcracks gradually penetrate into the main cracks,the displacement cloud becomes obviously discontinuous,and the contours of the displacement field in the crack fracture damage area simply intersect with the prefabricated cracks to form an obvious *** damage patterns of the fractured sandstone after freeze‒thaw cycles clearly differ,forming a symmetrical"L"-shaped damage pattern at zero freeze‒thaw cycles,a symmetrical"V"-shaped damage pattern at 10 freeze‒thaw cycles,and a"V"-shaped damage pattern at 20 freeze‒thaw *** 20 freeze‒thaw cycles,a"V"-shaped destruction pattern and"L"-shaped destruction pattern are formed;after 30 freeze‒thaw cycles,an"N"-shaped destruction pattern is *** shows that the failure mode of fractured sandstone gradually becomes more complicated with an increasing number of freeze‒t

关键词： Freeze‒thaw cycles Fissured sandstone Particle flow software Rock mechanics Crack extension pattern DIC technique

A Spatial Correlation-Based Wireless Routing Algorithm

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A Spatial Correlation-Based Wireless Routing Algorithm

Asari Radix et Rhizoma consumption lacks relevance for hepatocellular carcinoma in patients:A retrospective cohort study

第25届中国控制与决策会议

作者： Lidong Zhai zhilei wang Yujia Zhu Daiyong Quan School of Information Science & Technology Southwest Jiaotong University

ISBN: (纸本)9781467355339

In this paper, a wireless routing algorithm based on spatial correlation- BSC-RA was proposed. According to the spatial correlation of nodes in wireless sensor networks and the residual power of each node, this algorithm selects the cluster- heads. These cluster-head nodes broadcast their status to other nodes in the network. Each node determines to which cluster it wants to belong and join in it. Then, data acquired by nodes is aggregated by each cluster-head and transmitted to the base station. Simulate result shows that our algorithm is able to distribute energy dissipation evenly throughout the sensor nodes, effectively prolonging the lifetime of the whole network.

关键词： Spatial correlation Cluster-head Clustering Routing

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Chinese Herbal Medicines 2022年第3期14卷 470-475页

作者： Zhi-e Fang Yuming Guo zhilei wang Tingting He Jiabo wang Zhaofang Bai Xiaohe Xiao Department of Hepatology Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China China Military Institute of Chinese Materia Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China

Objective:Although some studies have linked Asari Radix et Rhizoma(Asari Radix)administration to hepatocellular carcinoma(HCC),few studies have examined the association between the development of HCC and use of Asari Radix among patients in China's *** study aimed to evaluate the realworld association between Asari Radix and HCC in patients to strengthen the understanding of Asari Radix ***:A retrospective cohort study among hepatitis B virus(HBV)-monoinfected patients and nonHBV-monoinfected patients were *** over 18 years of age were eligible for *** records of inpatients and outpatients were inquired to distinguish Asari Radix users and *** risk of developing HCC among Asari Radix users and nonusers in the HBV cohort and the non-HBV cohort was ***:There were 49500 HBV and 133148 non-HBV patients involved in the two *** HBV patients(2901 users;46599 nonusers),the prevalence of HCC in Asari Radix users was lower than that in nonusers(145.70 vs.265.43 per 105).Among non-HBV patients(5042 users;128106 nonusers),the prevalence of HCC in Asari Radix users was lower than that in nonusers(81.62 vs.134.11 per 105).None of the hazard ratios(HRs)of Asari Radix exposure ranging from 1 g to 200 g in the two cohorts showed correlation between Asari Radix exposure and ***:An obvious irrelevancy was found between the consumption of Asari Radix and HCC development both in patients with and in those without HBV *** of Asari Radix under 200 g appears safe in terms of HCC risk in the Chinese population;further prospective studies are needed to confirm our results.

关键词： aristolochic acid Asari Radix et Rhizoma hepatitis B virus(HBV) hepatocellular carcinoma safety awareness

Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome

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Acta Pharmaceutica Sinica B 2019年第4期9卷 734-744页

作者： zhilei wang Guang Xu Yuan Gao Xiaoyan Zhan Nan Qin Shubin Fu Ruisheng Li Ming Niu Jiabo wang Youping Liu Xiaohe Xiao Zhaofang Bai School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China China Military Institute of Chinese Materia the Fifth Medical CentreChinese PLA General HospitalBeijing 100039China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China School of Pharmacy Jiangxi University of Traditional Chinese MedicineNanchang 330004China Research Center for Clinical and Translational Medicine the Fifth Medical CentreChinese PLA General HospitalBeijing 100500China Integrative Medical Center the Fifth Medical CentreChinese PLA General HospitalBeijing 100039China

Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic interventions. Cardamonin(CDN), the major active ingredient of the traditional Chinese medicinal herb Alpinia katsumadai, has exerted an excellent anti-inflammatory activity, but the mechanism underlying this role is not fully understood. Here, we show that CDN blocks canonical and noncanonical NLRP3 inflammasome activation triggered by multiple stimuli. Moreover, the suppression of CDN on inflammasome activation is specific to NLRP3, not to NLRC4 or AIM2 inflammasome. Besides, the inhibitory effect is not dependent on the expression of NF-κB-mediated inflammasome precursor proteins. We also demonstrate that CDN suppresses the NLRP3 inflammasome through blocking ASC oligomerization and speckle formation in a dose-dependent ***, CDN improves the survival of mice suffering from lethal septic shock and attenuates IL-1βproduction induced by LPS in vivo, which is shown to be NLRP3 dependent. In conclusion, our results identify CDN as a broad-spectrum and specific inhibitor of NLRP3 inflammasome and a candidate therapeutic drug for treating NLRP3 inflammasome-driven diseases.

关键词： Cardamonin NLRP3 inflammasome IL-1β Caspase-1 Septic shock

New incompatible pair of TCM:Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity under immunological stress conditions

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Frontiers of Medicine 2020年第1期14卷 68-80页

作者： Yuan Gao zhilei wang Jinfa Tang Xiaoyi Liu Wei Shi Nan Qin Xiaoyan wang Yu Pang Ruisheng Li Yaming Zhang Jiabo wang Ming Niu Zhaofang Bai Xiaohe Xiao School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China China Military Institute of Chinese Materia the Fifth Medical CentreChinese PLA General HospitalBeijing 100039China School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China The First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000China School of Pharmacy Jiangxi University of Traditional Chinese MedicineJiangxi 330004China National Institutes for Food and Drug Control Beijing 100050China Research Center for Clinical and Translational Medicine the Fifth Medical CentreChinese PLA General HospitalBeijing 100039China Integrative Medical Centre the Fifth Medical CentreChinese PLA General HospitalBeijing 100039China

Epimedii Folium(EF)combined with Psoraleae Fructus(PF)is a common modern preparation,but liver injury caused by Chinese patent medicine preparations containing EF and PF has been frequently reported in recent *** pills(ZGW),which contain EF and PF,could induce immune idiosyncratic liver injury according to clinical case reports and a nonhepatotoxic dose of lipopolysaccharide(LPS)*** present study evaluated the liver injury induced by EF or PF alone or in combination and investigated the related mechanism by using the LPS *** function indexes and pathological results showed that either EF or PF alone or in combination led to liver injury in normal rats;however,EF or PF alone could lead to liver injury in LPS-treated ***,EF combined with PF could induce a greater degree of injury than that caused by EF or PF alone in LPS-treated ***,EF or PF alone or in combination enhanced the LPS-stimulated inflammatory cytokine production,implying that IL-1β,which is processed and released by activating the NLRP3 inflammasome,is a specific indicator of EF-induced immune idiosyncratic ***,EF may induce liver injury through enhancing the LPS-mediated proinflammatory cytokine production and activating the NLRP3 *** addition,the metabolomics analysis results showed that PF affected more metabolites in glycerophospholipid and sphingolipid metabolic pathways compared with EF in LPS model,suggesting that PF increased the responsiveness of the liver to LPS or other inflammatory mediators via modulation of multiple metabolic ***,EF and PF combination indicates traditional Chinese medicine incompatibility,considering that it induces idiosyncratic hepatotoxicity under immunological stress conditions.

关键词： Epimedii Folium Psoraleae Fructus idiosyncratic hepatotoxicity traditional Chinese medicine incompatibility

Icariside Ⅱ, a main compound in Epimedii Folium, induces idiosyncratic hepatotoxicity by enhancing NLRP3 inflammasome activation

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Acta Pharmaceutica Sinica B 2020年第9期10卷 1619-1633页

作者： zhilei wang Guang Xu Hongbo wang Xiaoyan Zhan Yuan Gao Nian Chen Ruisheng Li Xueai Song Yuming Guo Ruichuang Yang Ming Niu Jiabo wang Youping Liu Xiaohe Xiao Zhaofang Bai School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China China Military Institute of Chinese Materia the Fifth Medical CentreChinese PLA General HospitalBeijing 100039China Department of Hepatobiliary Surgery Center the Fifth Medical CentreChinese PLA General HospitalBeijing 100039China School of Chinese Materia Medica Capital Medical UniversityBeijing 100029China Research Center for Clinical and Translational Medicine the Fifth Medical CentreChinese PLA General HospitalBeijing 100039China Integrative Medical Center the Fifth Medical CentreChinese PLA General HospitalBeijing 100039China

Idiosyncratic drus-induced liver injury(IDILI)is an intrequent but potentially serious disease that develops the main reason for post-marketing safety warnings and withdrawals of *** Folium(EF),the widely used herbal medicine,has shown to cause idiosyncratic liver injury,but the underlying mechanisms are poorly *** evidence has indicated that most cases of IDILI are immune ***,we report that icarisideⅡ(ICSⅡ),the major active and metabolic constituent of EF,causes idiosyncratic liver injury by promoting NLRP3 inflammasome ***Ⅱexacerbates NLRP3 inflammasome activation triggered by adenosine triphosphate(ATP)and nigericin,but not silicon dioxide(SiO2),monosodium urate(MSU)crystal or cytosolic lipopolysaccharide(LPS).Additionally,the activation of NLRC4 and AIM2 inflammasomes is not affected by ICSⅡ.Mechanistically,synergistic induction of mitochondrial reactive oxygen species(mtROS)is a crucial contributor to the enhancing effect of ICSⅡon ATP-or nigericin-induced NLRP3 inflammasome ***,in vivo data show that a combination of non-hepatotoxic doses of LPS and ICSⅡcauses the increase of aminotransferase activity,hepatic inflammation and pyroptosis,which is attenuated by Nlrp3 deficiency or pretreatment with MCC950(a specific NLRP3 inflammasome inhibitor).In conclusion,these findings demonstrate that ICSⅡcauses idiosyncratic liver injury through enhancing NLRP3 inflammasome activation and suggest that ICSⅡmay be a risk factor and responsible for EF-induced liver injury.

关键词： Epimedii Folium IcarisideⅡ Idiosyncratic drug-induced liver injury NLRP3 inflammasome Reactive oxygen species Mitochondria

Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity

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Frontiers of Medicine 2021年第4期15卷 594-607页

作者： Nan Qin Guang Xu Yan wang Xiaoyan Zhan Yuan Gao zhilei wang Shubin Fu Wei Shi Xiaorong Hou Chunyu wang Ruisheng Li Yan Liu Jiabo wang Haiping Zhao Xiaohe Xiao Zhaofang Bai China Military Institute of Chinese Materia the Fifth Medical CentreChinese PLA General HospitalBeijing 100039China Department of Pharmacy Nantong Hospital of Traditional Chinese MedicineNantong 226300China School of Pharmacy Henan University of Chinese MedicineZhengzhou 450046China School of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China Research Center for Clinical and Translational Medicine the Fifth Medical CentreChinese PLA General HospitalBeijing 100039China School of Traditional Chinese Medicine Jiangxi University of Traditional Chinese MedicineNanchang 330004China Integrative Medical Centre the Fifth Medical CentreChinese PLA General HospitalBeijing 100039China

Psoraleae Fructus(PF)is a well-known traditional herbal medicine in China,and it is widely used for osteoporosis,vitiligo,and other diseases in clinical ***,liver injury caused by PF and its preparations has been frequently reported in recent *** previous studies have demonstrated that PF could cause idiosyncratic drug-induced liver injury(IDILI),but the mechanism underlying its hepatotoxicity remains *** paper reports that bavachin isolated from PF enhances the specific stimuli-induced activation of the NLRP3 inflammasome and leads to *** boosts the secretion of IL-ip and caspase-1 caused by ATP or nigericin but not those induced by poly(I:C),monosodium urate crystal,or intracellular *** does not affect AIM2 or NLRC4 inflammasome ***,bavachin specifically increases the production of nigericin-induced mitochondrial reactive oxygen species among the most important upstream events in the activation of the NLRP3 *** increases the levels of aspartate transaminase and alanine aminotransferase in serum and hepatocyte injury accompanied by the secretion of IL-ip via a mouse model of lipopolysaccharide-mediated susceptibility to *** results suggest that bavachin specifically enhances the ATP-or nigericin-induced activation of the NLRP3 *** also potentially contributes to PF-induced idiosyncratic ***,bavachin and PF should be evaded among patients with diseases linked to the ATP-or nigericin-mediated activation of the NLRP3 inflammasome,which may be a dangerous factor for liver injury.

关键词： Psoraleae Fructus bavachin idiosyncratic drug-induced liver injury caspase-1 IL-lp NLRP3 inflammasome

Berberine enhances the anti-hepatocellular carcinoma effect of NK92-MI cells through inhibiting IFN-gamma-mediated PD-L1 expression

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Liver Research 2022年第3期6卷 167-174页

作者： Kunyuan wang Chengxin Gu Ganxiang Yu Jiaen Lin zhilei wang Qianting Lu Yangzhi Xu Dan Zhao Xiaofeng Jiang Weijian Mai Shiming Liu Hui Yang Department of Gastroenterology The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Hepatobiliary Surgery The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Guangzhou Institute of Cardiovascular Disease The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina

Background and aims:Berberine is one of the most promising clinically tested natural alkaloids,and immunotherapy using natural killer(NK)cells is a potentially effective treatment for hepatocellular carcinoma(HCC).This study aims to elucidate the effect of berberine on the anti-HCC effect of NK92-MI *** and methods:Human HCC SMMC-7721 and Hep3B cells were co-incubated with NK92-MI cells,berberine(60 or 80 mmol/L),or their combination for 36 *** evaluate the killing effect of NK92-MI cells on HCC cells,the release of lactate dehydrogenase(LDH)in HCC cells was *** anti-tumor effects of berberine,NK92-MI cells,and their combinations were evaluated by MTS,EdU,Tunel,and Western blot assays.A male BALB/c nude mouse subcutaneous tumor model was used to investigate the anti-HCC effect of berberine and NK92-MI cells in ***:The LDH assay showed that berberine enhanced the cytotoxicity of NK92-MI cells on HCC *** combination of berberine and NK92-MI cells demonstrated more obvious anti-HCC effect than did the berberine or NK92-MI single treatment in inhibiting cell proliferation and inducing apoptosis both in vitro and in ***,the expression of programmed cell death-ligand 1(PD-L1)in HCC cells was upregulated after co-culture with NK-92MI ***-L1 expression was knocked down,thereby inhibiting the proliferation and promoting apoptosis of HCC cells,and inhibited by berberine that blocked the secretion of interferon gamma(IFN-g),thereby enhancing the anti-tumor effect of NK92-MI ***:Current data show that the immunomodulatory role of berberine is to enhance the cytotoxic effect of NK92-MI cells and inhibit tumor immune escape by reducing the expression of *** study provides a rationale for the clinical application of berberine in combination with NK cells for the treatment of HCC.

关键词： Berberine Hepatocellular carcinoma(HCC) NK92-MI cells Interferon gamma(IFN-g) Programmed cell death-ligand 1(PD-L1)