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Targeting colorectal cancer with Herba Patriniae and Coix seed:Network pharmacology,molecular docking,and in vitro validation

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3539-3558页

作者： Cheng-Lei wang Bing-Wei Yang xin-Yan wang Xue Chen Wei-Dong li Hao-Yu Zhai Ying wu Mu-YaoCui Jia-He wu Qing-Hui Meng Nan Zhang Department of Oncology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China The First Clinical Medical College Shaanxi University of Chinese MedicineXianyang 712046Shaanxi ProvinceChina Department of Scientific Research Management Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China School of Clinical Medicine Qinghai university Xining 810000Qinghai ProvinceChina School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Herba Patriniae and Coix seed(HC)constitute a widely utilized drug combination in the clinical management of colorectal cancer(CRC)that is known for its diuretic,anti-inflammatory,and swelling-reducing *** its efficacy has been demonstrated in a clinical setting,the active compounds and their mechanisms of action in CRC treatment remain to be fully *** To identify the active,CRC-targeting components of HC and to elucidate the mechanisms of action *** Active HC components were identified and screened using *** for each component were ***-related targets were obtained from human gene *** targets between HC and CRC were identified.A“drug-ingredient-target”network was created to identify the core components and targets *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analyses were conducted to elucidate the key pathways *** docking between core targets and key components was *** vitro experiments validated core *** Nineteen active components of HC were identified,with acacetin as the primary active *** predictive analysis identified 454 targets of the active compounds in *** mapping with 2.85 CRC-related targets yielded 171 intervention targets,including 30 core *** and KEGG analyses indicated that HC may influence the phosphoinositide 3-kinase(PI3K)/Akt signaling *** docking showed that acacetin exhibited an optimal interaction with AKT1,identifying PI3K,AKT,and P53 as key genes likely targeted by HC during CRC *** inhibited HT-2. cell proliferation and migration,as well as promoted apoptosis,in *** blotting analysis revealed increased p53 and cleaved caspase-3 expression and decreased levels of p-PI3K,p-Akt,and survivin,which likely contributed to CRC *** Acacetin,the principal active compound in the HC pair,inhibited the proliferati

关键词： Colorectal cancer Baijiangcao(Herba Patriniae) Yiyiren(Coix seed) Acacetin Proliferation Migration Apoptosis Network pharmacology

Amorphous NiMo_(3)S_(13)/nickel foam integrated anode for lithium-ion batteries

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Tungsten 2024年第2期6卷 438-446页

作者： Ming-xin Shi Min wu Shan-Shan Xiao Shan-Ping liu Rui-Qi Yao Ying-Qi li Yong-Hui wang Yang-Guang li Hua-Qiao Tan Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Faculty of ChemistryNortheast Normal UniversityChangchun 130024China School of Materials Science and Engineering Jilin Jianzhu UniversityChangchun 130118China Institute Charles Gerhardt Montpellier Universite de MontpellierCentre National de la Recherche Scientifi quePlace E.Bataillon34095 Montpellier Cedex 05France

Although crystalline anode materials with long-range ordered lattice structure are in favor of facilitating the electron transfer,their structures are easily disrupted during long-term cycling due to the continuous embedding/de-embedding of lithium *** contrast,the amorphous materials have abundant defects and lithium ion storage sites,refl ecting a superior reaction kinetics and long-term cycling ***,we synthesize an integrated hybrid anode by in-situ loading amorphous NiMo_(3)S_(13)nanosheets on nickel foam *** ting from the introduction of Ni^(2.)that amorphizes the molybdenumsulfur clusters,the assembled lithium ion battery based on the integrated NiMo_(3)S_(13)/nickel foam anode delivers a specifi c capacity up to 1659 mA·h·g^(−1)at a current density of 0.6 A·g^(−1)and exhibits superior rate/cycling performance.

关键词： Molybdenum-sulfur clusters Amorphous Integrated anode Crystalline lithium-ion batteries

In situ tumor vaccine with optimized nanoadjuvants and lymph node targeting capacity to treat ovarian cancer and metastases

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4102-4117页

作者： Yuan li Fan Tong Yufan wang Jing wang Manqi wu Hanmei li Hongyan Guo Huile Gao Department of Obstetrics and Gynecology National Clinical Research Center for Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of PharmacySichuan UniversityChengdu 610041China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China

Tumor vaccine,a promising modality of tumor immunotherapy,needs to go through the process of tumor antigen generation and loading,antigen drainage to lymph nodes(LNs),antigen internalization by dendritic cells(DCs),DC maturation,and antigen cross-presentation to activate ***,tumor vaccines are often unable to satisfy all the steps,leading to the limitation of their application and ***,based on a smart nanogel system,an in situ nano-vaccine(CpG@Man-P/Tra/Gel)targeting LNs was constructed to induce potent anti-tumor immune effects and inhibit the recurrence and metastasis of ovarian *** CpG@Man-P/Tra/Gel exhibited MMP-2.sensitive release of trametinib(Tra)and nano-adjuvant CPG@Man-P,which generated abundant in situ depot of whole-cell tumor antigens and formed in situ nano-vaccines with CpG@*** from mannose(Man)modification,the nano-vaccines targeted to LNs,promoted the uptake of antigens by DCs,further inducing the maturation of DCs and activation of T ***,CpG@Man-P with different particle sizes were prepared and the effective size was selected to evaluate the antitumor effect and immune response in ***,combined with PD-1 blocking,the vaccine effectively inhibited primary tumor growth and induced tumor-specific immune response against tumor recurrence and metastasis of ovarian cancer.

关键词： In situ nano-vaccine Lymph node targeting MMP-2.responsive PD-1 Combination therapy CpG Ovarian cancer Metastases

Cobalt-based deep eutectic solvent modified nitrogen-doped carbon catalyst for boosting oxygen reduction reaction in zinc-air batteries

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Chinese Journal of Structural Chemistry 2024年第1期43卷 33-39页

作者： Peng wang Daijie Deng Suqin wu li Xu Institute for Energy Research School of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiang212013China

As an oxygen reduction reaction(ORR)catalyst,nitrogen-doped carbon(NC)is widely used in zinc-air batteries(ZABs).However,NC catalysts exhibit low conductivity and insufficient exposure of active ***,a Co-based deep eutectic solvent(DES)was selected to modify NC catalyst(Co-NC)to improve ORR *** functional theory(DFT)calculation shows that the modification of Co-based DES can change the electronic structure of NC and increase metallic active sites,which is beneficial to the desorption of reaction intermediates on Co-NC,further improving ORR ***-NC shows excellent ORR performances and ***,ZABs assembled with Co-NC manifest a high maximum power density of 177.4 mW cm^(-2.,a high specific capacity of 72..12.mA h g^(-1)and a charge-discharge cycle life of 500 *** study can provide practical reference for surface modified carbon-based electrocatalyst with DES to improve ORR performances.

关键词： Deep eutectic solvent Nitrogen-doped carbon Surface modification Oxygen reduction reaction Zinc-air battery

Measurement of atmospheric non-reciprocity effects for satellite-based two-way time-frequency transfer

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Photonics Research 2024年第6期12卷 1274-1282页

作者： TING ZENG QI SHEN YUAN CAO JIAN-YU GUAN MENG-ZHE liAN JIN-JIAN HAN LEI HOU JIAN LU xin-xin PENG MIN li WEI-YUE liU JIN-CAI wu YONG {2. JUAN YIN JI-GANG REN HAI-FENG JIANG QIANG ZHANG CHENG-zhi PENG JIAN-WEI PAN Hefei National Research Center for Physical Sciences at the Microscale and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China Shanghai Research Center for Quantum Science and CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaShanghai 201315China Hefei National Laboratory University of Science and Technology of ChinaHefei 230094China Faculty of Information Science and Engineering Ningbo UniversityNingbo 315211China Key Laboratory of Space Active Opto-Electronic Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China

Future optical clock networks will require high-precision optical time-frequency transfer between satellites and ground ***,due to atmospheric turbulence,satellite motion and time delay between the satellite–ground transmission links will cause spatial and temporal variations,respectively,resulting in the breakdown of the time-of-flight reciprocity on which optical two-way time-frequency transfer is ***,we experimentally simulate the atmospheric effects by two-way spatio-temporally separated links between two stationary terminals located 113 km apart and measure the effects for optical two-way time-frequency *** experiment shows that the effect on the link instability is less than 2.3×10^(−19) at 10,000 *** indicates that when the link instability of satellite-ground optical time-frequency transfer is on the order of 10^(−19),it is not necessary to consider the atmospheric non-reciprocity effects.

关键词： breakdown transfer satellite

The marriage of immunomodulatory,angiogenic,and osteogenic capabilities in a piezoelectric hydrogel tissue engineering scafold for military medicine

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Military Medical Research 2024年第3期11卷 323-344页

作者： Ping wu lin Shen Hui-Fan liu Xiang-Hui Zou Juan Zhao Yu Huang Yu-Fan Zhu Zhao-Yu li Chao Xu li-Hua Luo zhi-Qiang Luo Min-Hao wu lin Cai Xiao-Kun li Zhou-Guang wang Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research the Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000ZhejiangChina Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Spine Surgery and Musculoskeletal Tumor Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Engineering Research Center for Nanomedicine College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Department of Overseas Education College Jimei UniversityXiamen 361021FujianChina School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou 325035ZhejiangChina

Background:Most bone-related injuries to grassroots troops are caused by training or accidental *** establish preventive measures to reduce all kinds of trauma and improve the combat effectiveness of grassroots troops,it is imperative to develop new strategies and scafolds to promote bone ***:In this study,a porous piezoelectric hydrogel bone scafold was fabricated by incorporating polydopamine(PDA)-modified ceramic hydroxyapatite(PDA-hydroxyapatite,PHA)and PDA-modified barium titanate(PDABaTiO_(3),PBT)nanoparticles into a chitosan/gelatin(Cs/Gel)*** physical and chemical properties of the Cs/Gel/PHA scafold with 0–10 wt%PBT were *** and animal experiments were performed to characterize the immunomodulatory,angiogenic,and osteogenic capabilities of the piezoelectric hydrogel scafold in vitro and in ***:The incorporation of BaTiO_(3) into the scafold improved its mechanical properties and increased self-generated *** to their endogenous piezoelectric stimulation and bioactive constituents,the prepared Cs/Gel/PHA/PBT hydrogels exhibited cytocompatibility as well as immunomodulatory,angiogenic,and osteogenic capabilities;they not only effectively induced macrophage polarization to M2.phenotype but also promoted the migration,tube formation,and angiogenic differentiation of human umbilical vein endothelial cells(HUVECs)and facilitated the migration,osteodifferentiation,and extracellular matrix(ECM)mineralization of MC3T3-E1 *** in vivo evaluations showed that these piezoelectric hydrogels with versatile capabilities significantly facilitated new bone formation in a rat large-sized cranial injury *** underlying molecular mechanism can be partly attributed to the immunomodulation of the Cs/Gel/PHA/PBT hydrogels as shown via transcriptome sequencing analysis,and the PI3K/Akt signaling axis plays an important role in regulating macrophage M2.***:The piezoelectric Cs/Gel/PHA/PBT hy

关键词： Piezoelectric hydrogel Tissue engineering scafold Immunomodulation Angiogenesis Osteogenic differentiation

In-situ study of the hydrogen peroxide photoproduction in seawater on carbon dot-based metal-free catalyst under operation condition

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Nano Research 2024年第7期17卷 5956-5964页

作者： Jiaxuan wang Jiacheng li Zenan li Jie wu Honglin Si Yangbo wu zhiyong Guo Xuepeng wang Fan liao Hui Huang Mingwang Shao Yang liu Zhenhui Kang Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products School of Material Science and Chemical EngineeringNingbo UniversityNingbo 315211China Macao Institute of Materials Science and Engineering(MIMSE) MUST-SUDA Joint Research Center for Advanced Functional MaterialsMacao University of Science and TechnologyTaipa 999078MacaoChina

Hydrogen peroxide(H_(2.O_(2.)photoproduction in seawater with metal-free photocatalysts derived from biomass materials is a green,sustainable,and ultra environmentally friendly ***,most photocatalysts are always corroded or poisoned in seawater,resulting in a significantly reduced catalytic ***,we report the metal-free photocatalysts(RUT-1 to RUT-5)with in-situ generated carbon dots(CDs)from biomass materials(Rutin)by a simple microwave-assisted pyrolysis *** visible light(λ≥42. nm,81.6 mW/cm^(2.),the optimized catalyst of RUT-4 is stable and can achieve a high H_(2.O_(2.yield of 330.36μmol/L in seawater,1.78 times higher than that in normal *** transient potential scanning(TPS)tests are developed and operated to in-situ study the H_(2.O_(2.photoproduction of RUT-4 under operation ***-4 has strong oxygen(O_(2.)absorption capacity,and the O_(2.reduction rate in seawater is higher than that in *** cations in seawater further promote the photo-charge separation and facilitate the photo-reduction *** RUT-4,the conduction band level under operating conditions only satisfies the requirement of O_(2.reduction but not for hydrogen(H2.*** work provides new insights for the in-situ study of photocatalyst under operation condition,and gives a green and sustainable path for the H_(2.O_(2.photoproduction with metal-free catalysts in seawater.

关键词： carbon dots hydrogen peroxide photocatalysis transient potential scanning in-situ study operation condition

Migration mechanism and risk assessment of perand polyfluoroalkyl substances in the Ya'Er Lake oxidation pond area,china

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Journal of Environmental Sciences 2024年第2期136卷 301-312页

作者： Chang li Huifang Zhong Jing wu lingyi Meng Yingjun wang Chunyang liao Yawei wang Yujian He university of Chinese Academy of Sciences Beijing 100049China Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China china National Environmental Monitoring Centre Beijing 100012China Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances Institute of Environment and HealthJianghan UniversityWuhan 430056China

The migration mechanisms,sources,and environmental risks of 2. legacy and emerging perfluorinated and polyfluoroalkyl species present in an oxidation pond(Ya'Er Lake)were investigated for treating sewage based on the analysis of their occurrence and *** concentration of per-and polyfluoroalkyl substances(PFAS)in pond area was between0.30 and 63.2.ng/g dw(dry weight),with the overall average concentration of 8.00 ng/g ***,the PFAS concentrations in the surface sediments near the sewage outlet in Pond-1(50.2.ng/g dw)and Pond-5(average 15.1 ng/g dw)were 1–2.orders of magnitude higher than those in other *** general,the legacy PFAS,i.e.,perfluorooctane sulfonic acid was considered to be the major pollutant in the polluted area,on average,accounting for 73.0%of the total concentration of PFAS *** evaluating the regional distribution of different PFAS homologs,the short-chain PFAS pollutants with lower K_(ow)were found to migrate farther in both horizontal and vertical *** sewage outlets in Pond-1 and Pond-5are the main pollution sources in polluted area and the emerging PFAS pollutants in Pond-5have replaced the legacy PFAS pollutants as the main *** on positive matrix factorization analysis,three main industrial sources of PFAS pollutants in the study area were identified:protective coating,fire-fighting,and food packaging ***,the environmental risk assessment results showed that most study areas exhibited medium environmental risk(0.01≤Risk quotient(RQ)1),indicating that the ecological environment risks in this area need further attention.

关键词： Perfluoroalkyl substances Distribution Migration mechanism Risk assessment

Tanshinone IIA inhibits endothelin-1 production in TNF-α-induced brain microvascular endothelial cells through suppression of endothelin-con-verting enzyme-1 synthesis

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Acta Pharmacologica Sinica 2007年第8期28卷 1116-1122页

作者： Chao TANG~1 An-hua wu~(1,3) Hong-li XUE~2.Yurl-jie wang~1 ~1Department of Neurosurgery,the First Affiliated Hospital,china Medical {2. ~2.epartment of Neurosurgery,General Hospital of shenyang Military Command,shenyang 110001,china. Department of Neurosurgery the First Affiliated Hospital China Medical University Shenyang 110001 China Department of Neurosurgery General Hospital of Shenyang Military Command Shenyang 110001 China

Aim:To investigate the effects of tanshinone ⅡA（Tan ⅡA）on the regulation ofthe production of endothelin（ET）-1（including large ET-1）,mRNA levels of ET-1,endothelin-converting enzyme-1（ECE-1）,endothelin-A receptor（ETA）andendothelin-B receptor（ETB）induced by TNF-α in rat brain microvascular endo-thelial cells（BMVEC）.Methods:The ET-1 release（including large ET-1）into theculture medium was determined by enzyme *** levels of ET-1,ECE- 1,ETA,and ETBmRNA were measured by *** receptor bind-ing was also ***:The induction of ET-1 release by TNF-α from cul-tured BMVEC was dose-dependently reduced by Tan IIA,but large ET-1 levelsprogressively increased in response to Tan ⅡA;the mRNA expression of ET-1 *** ⅡA also caused a decrease in ETAreceptor mRNA and ECE-1expression in a dose-dependent *** receptor binding was unal-tered in BMVEC stimulated with TNF-α alone or a combination of TNF-α and TanⅡ***:These findings suggest that Tan ⅡA may inhibit ET-1 produc-tion in TNF-α-induced BMVEC through the suppression of ECE-1 synthesis.

关键词： tanshinone IIA endothelin-1 TNF-α brain microvascular endothelial cells