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Piezoelectric film promotes skin wound healing with enhanced collagen deposition and vessels regeneration via upregulation of PI3K/AKT

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Nano Research 2024年第8期17卷 7461-7478页

作者： Qi Xu wufei Dai Peizhe li Qinglin li Zhen Gao Xiaoli wu Wei liu Wenbo wang Department of Plastic and Reconstructive Surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Research Institute of Plastic Surgery Shandong Second Medical UniversityWeifang 261000China Department of Surgery Air Force Medical CenterPLABeijing 100142China

Skin wounds are common in accidental injuries,and the intricacies of wound repair are closely linked to endogenous electric *** stimulation plays a pivotal role in the restorative processes of skin injuries,encompassing collagen deposition,angiogenesis,inflammation,and *** electrical stimulation therapy replicates and enhances the effects of endogenous wound electric fields by applying an external electric field to the wound site,thereby promoting skin wound *** this study,we developed a self-powered repetitive mechanical impacts-electrical stimulation(RMI-ES)system utilizing a BaTiO_(3)/polydimethylsiloxane(PDMS)piezoelectric composite *** to conventional electrical stimulation devices,the fabricated piezoelectric composite film efficiently harvests energy from the pressure applied by the stimulation device and the tensile force occurring during natural rat *** results demonstrated that piezoelectric stimulation generated by the composite membrane expedited the cell cycle,promoting fibroblast ***,piezoelectric stimulation induced favorable changes in fibroblast gene expression,including increased expression of transforming growth factor-β1(TGF-β1),connective tissue growth factor(CTGF),collagen 1,collagen 3,vascular endothelial growth factor(VEGF),and alpha-smooth muscle actin(α-SMA),while reducing interleukin-6(IL-6)*** analysis revealed that piezoelectric stimulation may induce fibroblast migration,proliferation,and collagen expression by influencing PI3K/AKT serine/threonine kinase(AKT)*** confirmation through the addition of the PI3K inhibitor LY2.4002.validated that piezoelectric stimulation can regulate the repair process after skin injury through the ***,in vivo results demonstrated that the electric field at the wound site effectively promoted wound healing,reduced inflammation,and stimulated collagen deposition and ne

关键词： BaTiO3/polydimethylsiloxane(PDMS)nano-composite membrane piezoelectrical stimulation skin wound healing collagen deposition PI3K/AKT serine/threonine kinase(AKT)signaling pathway

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Mesoporous amorphous FeOOH-encapsulated BiO_(2.x) photocatalyst with harnessing broad spectrum toward activation of persulfate for tetracycline degradation

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Chinese Journal of Chemical Engineering 2024年第7期71卷 235-248页

作者： Pengfei wu Zhaolong liu li wu Yingkun Zhang Bing wang Zhanghao Cheng Wenquan Cui Xiangyang Lv Qingling liu Tianjin Key Laboratory of Indoor Air Environmental Quality Control School of Environmental Science and EngineeringTianjin UniversityTianjin 300350China Hebei Pollution Control Technology Innovation Center of Steel and Coking Industry Department of Environmental and Chemical EngineeringHebei College of Industry and TechnologyShijiazhuang 050091China Hebei Key Laboratory of Environmental Photocatalytic and Electrocatalytic Materials College of Chemical EngineeringNorth China University of Science and TechnologyTangshan 063210China Hebei Academy of Product Quality Supervision&Inspection Shijiazhuang 050227China

With the growing concern about the water environment,the advanced oxidation process of persulfate activation assisted by photocatalysis has attracted considerable attention to decompose dissolved organic *** this work,to overcome the drawbacks of the photocatalytic activity reduction caused by the photo-corrosion of non-stoichiometric BiO_(2.x),a novel material with amorphous FeOOH in situ grown on layered BiO_(2.x) to form a core-shell structure similar to popcorn chicken-like morphology was produced in two simple and environmentally beneficial *** a series of degradation activity tests of hybrid materials under different conditions,the as-prepared materials exhibited remarkable degradation activity and stability toward tetracycline in the FeOOH@BiO_(2.x)/Vis/PS system due to the synergism of photocatalysis and persulfate *** results of XRD,SEM,TEM,XPS,FTIR,and BET show that the loading of FeOOH increases the specific surface area and active sites appreciably;the heterogeneous structure formed by FeOOH and BiO_(2.x) is more favorable to the effective separation of photogenerated *** optimal degradation conditions were at a catalyst addition of 0.7 g·L^(–1),a persulfate concentration of 1.0 g·L^(–1),and an initial pH of 4.5,at which the degradation rate could reach 94.7%after 90 *** influence of typical inorganic anions on degradation was also *** studies and radical quenching experiments revealed that·OH,SO_(4)^(-)·,and·O_(2.^(-)were the principal active species generated during the degradation of *** results of the 1,10-phenanthroline approach proved that the effect of dissolved iron ions on the tetracycline degradation was limited,and the interfacial reaction that occurs on the active sites on the material's surface was a critical *** work provides a novel method for producing efficient broad-spectrum Bismuth-based composite photocatalysts and photocatalytic-activated persulfate synerg

关键词： Amorphous FeOOH BiO_(2.x) Activated persulfate Photocatalytic Tetracycline degradation

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A pan‐cancer analysis of Wnt family member 7B in human cancers

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Cancer Innovation 2024年第5期3卷 84-101页

作者： Rui wang Ni‐sha wu li wang {2.‐zhao Zhang Cheng‐fang wang Yan wang Yan liang Yi Zhang Xiao‐wei Qi Department of Breast and Thyroid Surgery Southwest HospitalArmy Medical UniversityChongqingChina 2Department of InfectionChina Academy of Chinese Medical Sciences Guang'anmen HospitalBeijingChina

Background: Previous studies have highlighted the crucial role of Wnt7B inthe development of various cancers, including breast, pancreatic, and gastriccancers. However, research into the involvement of Wnt7B is often confined tospecific tumor types, with a noticeable lack of comprehensive studies spanningmultiple cancer forms. The potential of Wnt7B as a diagnostic or prognosticcancer biomarker has not been fully ***: In this study, we combined bioinformatics and immunohistochemistryanalyses to examine the expression patterns and functions of Wnt7B in cancerousand adjacent noncancerous tissues across a range of ***: Our data indicate that Wnt7B may serve as a novel prognosticbiomarker and therapeutic target in certain ***: We found significant upregulation of Wnt7B expression levels in themajority of cancer cases examined. Furthermore, Wnt7B can influence cancerprognosis by modulating the tumor microenvironment, immune cell infiltration,and tumor stemness, among other factors. Additionally, we examined theassociations between anticancer drug sensitivity and Wnt7B expression, whichcould aid in the development of more precise clinical therapies.

关键词： bioinformatics immune infiltration immunotherapy pan‐cancer analysis Wnt7B

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Role of hsa_circ_0007482.in pterygium development: insights into proliferation, apoptosis, and clinical correlations

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1387-1395页

作者： li-Yun Zhang xin liu Shuo Zheng Wen-Qun Xi Xue-Ping wu Dan-Yao Nie Hui-ling Hu Jian-Tao wang xin-Hua liu Jing Zhang Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518000Guangdong ProvinceChina

AIM:To investigate the impact of hsa_circ_0007482.on the proliferation and apoptosis of human pterygium fibroblasts(HPFs)and its correlation with the severity grades of ***:Pterygium and normal conjunctival tissues were collected from the superior area of the same patient’s eye(n=33).The correlation between pterygium severity and hsa_circ_0007482.expression using quantitative reversetranscription polymerase chain reaction(RT-qPCR)were *** distinct siRNA sequences targeting hsa_circ_0007482.along with a negative control sequence,were transfected into *** proliferation was assessed using the cell counting *** levels of Ki67,proliferating cell nuclear antigen(PCNA),Cyclin D1,Bax,B-cell lymphoma-2.Bcl-2.,and Caspase-3 were measured via *** staining was employed to detect Ki67 and vimentin *** was evaluated using flow ***:Hsa_circ_0007482.expression was significantly higher in pterygium tissues compared to normal conjunctival tissues(P2.expression and pterygium severity,thickness,and vascular *** of hsa_circ_0007482.inhibited cell proliferation,reducing the mRNA expression of Ki67,PCNA,and Cyclin D1 in ***_circ_0007482.knockdown induced apoptosis,increasing mRNA expression levels of Bax and Caspase-3,while decreasing Bcl-2.expression in ***,hsa_circ_0007482.knockdown attenuated vimentin expression in ***:The downregulation of hsa_circ_0007482.effectively hampers cell proliferation and triggers apoptosis in *** are discernible positive correlations detected between the expression of hsa_circ_0007482.and the severity of pterygium.

关键词： hsa_circ_0007482 circular RNA pterygium cell proliferation apoptosis

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Investigating the Potential Mechanism of Huazhi Rougan Granules Against Alcoholic liver Disease by Network Pharmacology and Experiment

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 191-203页

作者： Ying-Ying Tan Ying-Ying liu Yi-Yan Zhai Yi-Xuan wang zhi-Shan wu Antony Stalin Guo-liang Cheng Bing li Chao wu zhi-Hong Huang Shan Lu Xiao-Tian Fan Zheng Zhao Jia-Rui wu Department of Clinical Chinese Pharmacy School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijingChina Department of Bioinformatics Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengduChina Department of Traditional Chinese Medicine State Key Laboratory of Generic Manufacture Technology of Chinese Traditional MedicineLinyiChina Department of Clinical Medicine Beijing Zest Bridge Medical Technology Inc.BeijingChina

Objective: Huazhi Rougan granules(HRGs) are a promising drug to improve alcoholic liver disease(ALD), but its mechanism remains unclear. Materials and Methods: Network pharmacology, molecular docking, and animal experiments were used to reveal the potential mechanism of HRG against ALD. Results: A total of 2.5 potential targets of HRG against ALD were obtained. Functional enrichment analysis suggests that HRG could synergistically regulate various biological pathways to exert therapeutic effects on ALD. Molecular docking showed that the key targets exhibited the good binding ability with the key compounds. The in vivo experiments showed that HRG can effectively alleviate pathological changes in liver tissue, improve blood lipid levels, antioxidant stress ability, and liver function, and reduce the release of inflammatory cytokines in the liver. Conclusions: This study reflects that HRG is an effective strategy for treating ALD, providing a basis for revealing the prevention and treatment mechanisms of ALD.

关键词： Alcoholic liver disease Huazhi Rougan granules inflammatory response network pharmacology

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Electrochemical properties of spinel compound liNi_(0.5)Mn_(1.2.Ti_(0.3)O_4 as cathode materials for lithium ion batteries

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Rare Metals 2010年第6期29卷 572-575页

作者： liU Guoqiang,GUO Qingshan,li Xiaoxia,and wu Qiuyang School of Materials and Metallurgy,northeastern university,{2. 110004,china School of Materials and Metallurgy Northeastern University Shenyang China

The electrochemical properties of spinel compound liNi0.5Mn1.2.i0.3O4 were investigated in this *** chemicals liAc·2.2.,Mn（Ac）2.2.2.,Ni（Ac）2.4H2.,and Ti（OCH3）4 were used to synthesize liNi0.5Mn1.2.i0.3O4 by a simple sol-gel *** discharge capacity of the sample reached 134 mAh/g at a current rate of *** first and fifth cycle voltammogram almost overlapped,which showed that the prepared sample liNi0.5Mn1.2.i0.3O4 had excellent good cycle *** were two oxidation peaks at 4.2. V and 4.86 V,and two reduction peaks at 4.55 V and 3.88 V in the cycle voltammogram,*** electrochemical impedance spectroscopy and its fitted result,the lithium ion diffusion coefficient was measured to be approximately 7.76 × 10？11 cm2.s.

关键词： lithium batteries cathode materials sol-gel process electrochemical properties

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Hydrogen production from hydrolysis of NaBH_(4) solution over Co-Fe-B@g-C_(3)N_(4)/NF thin film catalyst

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Rare Metals 2024年第6期43卷 2648-2659页

作者： Yan wang Jia-xin Ma Jian Ren Di Zhang Feng-Yan Xu Ke Zhang Zhong-Qiu Cao Qiu-Ju Sun Guo-De li Shi-Wei wu Hong-Hui Chen College of Chemistry and Chemical Engineering Shenyang Normal UniversityShenyang 110034China Experimental Center Shenyang Normal UniversityShenyang 110034China Hunan Shande Energy Storage New Materials Research Institute limited Company Changde 415000China

In this study,the double loaded Co-Fe-B@g-C_(3)N_(4)/NF(NF:Ni foam)thin film catalysts were prepared for the first time via chemical deposition method at room *** optimizing the reducing agent concentration to 0.9 mol·L^(-1),the as-obtained Co-Fe-B@g-C_(3)N_(4)/NF exhibited the twisted ribbon structure with more distinct three-dimensional hierarchy and the smaller particle size,showing the good catalytic property for the hydrolysis of NaBH_(4)*** H_(2.generation rate of Co-Fe-B@g-C_(3)N_(4)/NF and binary Co-B@g-C_(3)N_(4)/NF under visible light irradiation surpassed the value under natural *** apparent activation energy of Co-Fe-B@g-C_(3)N_(4)/NF(45.0 kJ·mol^(-1))under visible light irradiation was obviously reduced when compared with the natural condition(48.4 kJ·mol^(-1))and binary Co-B@g-C_(3)N_(4)/NF(60.6 kJ·mol^(-1))under visible light ***,the catalytic performance of the optimized Co-Fe-B@g-C_(3)N_(4)/NF thin film catalyst was superior to most of the reported non-noble metal and even noble metal ***,it illustrated that the catalytic H_(2.production performance of Co-Fe-B@g-C_(3)N_(4)/NF thin film was distinctly improved after the introduction of light and multicomponent recombination.

关键词： Sodium borohydride Co-Fe-B@g-C_(3)N_(4)/NF catalyst Chemical deposition Hydrogen production

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High-rate CH_(4)-to-C_(2.H_(6) photoconversion enabled by Au/ZnO porous nanosheets under oxygen-free system

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Science china Chemistry 2024年第3期67卷 869-875页

作者： Kai Zheng Xiaojing Zhang Jun Hu Chengbin Xu Juncheng Zhu Jing li Mingyu wu Shan Zhu li li Shumin wang Yumei Lv xin He Ming Zuo Chengyuan liu Yang Pan Junfa Zhu Yongfu Sun Yi Xie Hefei National Laboratory for Physical Sciences at Microscale National Synchrotron Radiation LaboratoryUniversity of Science and Technology of ChinaHefei 230026China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China State Grid Anhui Electric Power Research Institute Hefei 230601China

Photocatalytic CH_(4) coupling into high-valued C_(2.H_(6) is highly attractive,whereas the photosynthetic rate,especially under oxygen-free system,is still ***,we designed the negatively charged metal supported on metal oxide nanosheets to activate the inert C-H bond in CH_(4)and hence accelerate CH_(4) coupling *** an example,the synthetic Au/ZnO porous nanosheets exhibit the C_(2.H_(6) photosynthetic rate of 1,12..6μmol g^(-1)_(cat)h^(-1)and the CH_(4) conversion rate of 2.374.6μmol g^(-1)_(cat)h^(-1) under oxygen-free system,2.orders of magnitude higher than those of previously reported *** virtue of several in situ spectroscopic techniques,it is established that the generated Au^(δ-)and O^-species together polarized the C-H bond,while the Au^(δ-)and O^-species jointly stabilized the CH_(3) intermediates,which favored the coupling of CH_(3) intermediate to photosynthesize C_(2.H_(6) instead of overoxidation into CO_(x).Thus,the design of dual active species is beneficial for achieving high-efficient CH_(4)-to-C_(2.H_(6) photoconversion.

关键词： dual surface-active sites selective methane coupling ethane room temperature

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Universal architecture and defect engineering dual strategy for hierarchical antimony phosphate composite toward fast and durable sodium storage

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Journal of Energy Chemistry 2024年第3期90卷 110-119,I0004页

作者： Jiawei wu Gaoyu wang Wei Zhang lixiang wang Jian Peng Qinghua li {2.xin liang Wenbo Fan Jiazhao wang Shaoming Huang School of Materials and Energy Guangzhou Key Laboratory of Low-Dimensional Materials and Energy Storage DevicesGuangdong University of TechnologyGuangzhou 510006GuangdongChina School of Mechanical and Electrical Engineering Jiaxing Nanhu UniversityJiaxing 314001ZhejiangChina Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongInnovation CampusSquires WayNorth WollongongNSW2522Australia

Antimony(Sb)-ba sed anode materials are feasible candidates for sodium-ion batteries(SIBs) due to their high theoretical specific capacity and excellent electrical ***,they still suffer from volume distortion,structural collapse,and ionic conduction interruption upon ***,a hierarchical array-like nanofiber structure was designed to address these limitations by combining architecture engineering and anion tuning strategy,in which SbPO_(4-x) with oxygen vacancy nanosheet arrays are anchored on the surface of interwoven carbon nanofibers(SbPO_(4-x)@CNFs).In particular,bulky PO_(4)^(3-) anions mitigate the large volume distortion and generate Na_(3)PO_(4) with high ionic conductivity,collectively improving cyclic stability and ionic transport *** abundant oxygen vacancies substantially boost the intrinsic electronic conductivity of SbPO_4,further accelerating the reaction *** addition,hierarchical fibrous structures provide abundant active sites,construct efficient conducting networks,and enhance the electron/ion transport *** from the advanced structural design,the SbPO_(4-x)@CNFs electrodes exhibit outstanding cycling stability(1000 cycles at 1.0 A g^(-1) with capacity decay of 0.05% per cycle) and rapid sodium storage performance(2.3.8 mA h g^(-1) at 5.0 A g^(-1)).Importantly,systematic in-/ex-situ techniques have revealed the "multi-step conversion-alloying" reaction process and the "battery-capacitor dual-mode" sodium-storage *** work provides valuable insights into the design of anode materials for advanced SIBs with elevated stability and superior rate performance.

关键词： SbPO_(4) anodes Hierarchical nanostructures Oxygen vacancy Stress dispersion Sodium-ion batteries

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Enhanced hydrogen evolution reaction in FePt film with remanence due to decrease in domain walls

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Rare Metals 2024年第3期43卷 1108-1115页

作者： Hong Hong Dong-Xue liu Jun li Jun-Ming li li-Qian wu Bo Yang Qing-Qi Cao Dun-Hui wang National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced MicrostructuresJiangsu Provincial Key Laboratory for NanotechnologySchool of PhysicsNanjing UniversityNanjing210093China Hangzhou Dianzi university Hangzhou310018China Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Material Science and EngineeringNortheastern UniversityShenyang110819China

As an effective strategy to improve the properties of electrocatalysts,magnetic field-assisted electrocatalytic water splitting has attracted increasing attention ***,the corresponding enhancements mostly depend on the exertion of an external magnetic field during electrochemical reactions,which results in a high cost of industrial production,and makes the magnetic field manipulation of electrocatalysis become a challenging *** this work,instead of the external magnetic field,a bias magnetic field is self-supplied by the remanence state of a ferromagnetic electrocatalyst of *** to the assistance of this bias magnetic field,the FePt film in the remanence state shows the overpotential of 2.9 mV during hydrogen evolution reaction,which is much lower than that in its demagnetization state(2.3 mV).Our findings demonstrate that the remanence in ferromagnetic electrocatalysts can improve the catalytic performance,which is attributed to the decrease in domain walls.

关键词： Remanence Magnetic domains Electrocatalysis Hydrogen evolution reaction(HER)

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