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High-Efficiency Preparation of 2,5-Diformylfuran with a Keto-ABNO Catalyst Under Mild Conditions

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Transactions of Tianjin University 2019年第2期25卷 118-123页

作者： Le Li yuefei wang Wei Qi Rongxin Su Zhimin He State Key Laboratory of Chemical Engineering School of Chemical Engineering and Technology Tianjin University Tianjin Key Laboratory of Membrane Science and Desalination Technology Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

In this paper, we report a new catalytic system for realizing the rapid and efficient oxidation of 5-hydroxymethylfurfural(HMF). First, we used 9-azabicyclo [3.3.1]nonan-3-one-N-oxyl(keto-ABNO) as a catalyst for the aerobic oxidation of 5-hydroxymethylfurfural(HMF) to 2,5-diformylfuran(DFF) in acetic acid. Then, we systematically studied the important reaction parameters, including the solvent, co-catalyst, and temperature. The results demonstrate that the acidic solvent used is crucial for the efficient oxidation of HMF to DFF. Under optimal conditions, we achieved a 93.4% yield of DFF within half an hour at room temperature. We also proposed the possible mechanism for this system.

关键词： Biomass 5-Hydroxymethylfurfural 2,5-Diformylfuran 9-Azabicyclo[3.3.1]nonan-3-one-N-oxyl Homogeneous catalysis

霍山黄芽提取物对棕榈酸诱导下细胞脂质积累和炎症反应的影响

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浙江大学学报（农业与生命科学版） 2024年第4期50卷 633-645页

作者：左欣欣陈蔚丁乐佳施羽萱周继红刘仲华王岳飞浙江大学农业与生物技术学院茶叶研究所浙江杭州310058 湖南农业大学茶学教育部重点实验室/国家植物功能成分利用工程技术研究中心/植物功能成分利用省部共建协同创新中心湖南长沙410128

本研究比较分析了4个不同等级(特一级、特二级、一级、二级)霍山黄芽的主要生化成分和抗氧化活性差异,并选取特一级霍山黄芽,基于棕榈酸诱导的小鼠正常肝细胞AML-12(alpha mouse liver 12)、小鼠神经小胶质细胞BV-2、人肾皮质近曲小管... 详细信息

本研究比较分析了4个不同等级(特一级、特二级、一级、二级)霍山黄芽的主要生化成分和抗氧化活性差异,并选取特一级霍山黄芽,基于棕榈酸诱导的小鼠正常肝细胞AML-12(alpha mouse liver 12)、小鼠神经小胶质细胞BV-2、人肾皮质近曲小管上皮细胞HK-2(human kidney-2)、人胃腺癌细胞(human gastric adenocarcinoma,AGS)细胞模型,研究霍山黄芽提取物(Huoshanhuangya tea extract, HTE)对脂质积累和促炎细胞因子的影响。结果表明:特一级霍山黄芽的可溶性糖质量分数最低,咖啡碱质量分数、儿茶素类质量分数与游离氨基酸总量最高,且抗氧化活性最强;一定质量浓度的HTE处理后,棕榈酸诱导的AML-12、BV-2、HK-2、AGS细胞的细胞活力显著增加,棕榈酸诱导的脂质积累得到改善,棕榈酸诱导的AML-12、BV-2、HK-2细胞中肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)的释放水平明显降低。进一步探究其作用机制发现,HTE使BV-2细胞中炎症信号通路Toll样受体4(Toll-like receptor 4, TLR4)和核因子-κB RelA(nuclear factor-κB RelA, NF-κB p65)基因的表达下调,表明其可能通过抑制TLR4/NF-κB信号通路的活化来缓解棕榈酸诱导的BV-2细胞炎症损伤。

关键词：黄茶饱和脂肪酸抗氧化活性脂质积累促炎细胞因子

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补骨脂抗肿瘤作用机制研究进展

中草药 2024年第10期55卷 3529-3538页

作者：刘改廷勾文峰许飞飞郭江红王跃飞李祎亮侯文彬天津中医药大学天津301617 北京协和医学院&中国医学科学院放射医学研究所天津市放射医学与分子核医学重点实验室天津300192

补骨脂Psoraleae Fructus具有温肾助阳、纳气平喘、温脾止泻等功能,常用于心血管疾病、肾炎、骨质疏松症、癌症和白斑病等的治疗。现代研究表明,补骨脂中主要含有香豆素类、黄酮类、单萜酚类等多种化合物,其中含有多种抗肿瘤活性成分,... 详细信息

补骨脂Psoraleae Fructus具有温肾助阳、纳气平喘、温脾止泻等功能,常用于心血管疾病、肾炎、骨质疏松症、癌症和白斑病等的治疗。现代研究表明,补骨脂中主要含有香豆素类、黄酮类、单萜酚类等多种化合物,其中含有多种抗肿瘤活性成分,包括补骨脂素、补骨脂定、补骨脂二氢黄酮、补骨脂二氢黄酮甲醚、补骨脂查耳酮和补骨脂酚等。对乳腺癌、肝癌、肺癌、胃癌、结肠癌及前列腺癌等恶性肿瘤细胞具有较好的增殖抑制作用,其作用机制主要包括增殖凋亡、周期阻滞、氧化应激、多药耐药、自噬、迁移和侵袭。通过对补骨脂中活性成分抗肿瘤的作用机制进行综述,探讨其抗肿瘤研究现状及其开发应用前景,为补骨脂抗肿瘤的研究与发展提供有用的信息。

关键词：补骨脂抗肿瘤增殖凋亡氧化应激周期阻滞多药耐药补骨脂素补骨脂定补骨脂二氢黄酮

Verbascoside exerts an anti-atherosclerotic effect by regulating liver glycerophospholipid metabolism

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Food Science and Human Wellness 2023年第6期12卷 2314-2323页

作者： Peng Lei Jialin Lü Tie Yao Peng Zhang Xin Chai yuefei wang Miaomiao Jiang State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae Ministry of EducationTianjin University of Traditional Chinese MedicineTianjin 301617China

Verbascoside,abundant in olive mill wastewater,is a phenylethanolic glycoside with a wide range of pharmacological ***(AS)is a common metabolic disease and abnormal lipid metabolism in liver is inseparable from its formation and *** this study,the anti-atherosclerotic effect of verbascoside was evaluated by establishing an atherosclerosis model based on western diet feeding of apolipoprotein E-defi cient mice for 16 *** 12 weeks of administration during the feeding period,the levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)in the plasma of mice were signifi cantly decreased,the formation of arterial plaques was delayed,and the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST)and lactate dehydrogenase(LDH)in plasma were alleviated,showing the hepatoprotective *** addition,based on untargeted lipidomic analysis,verbascoside stabilized glycerophospholipid metabolism,modulated lipid metabolism disorders and reduced lipid deposition in the liver to achieve the therapeutic effi cacy against atherosclerosis by regulating cardiolipin(CL),ether-linked phosphatidylcholine(ether-PC),lysophophatidylcholine(LPC),phosphatidylcholine(PC),oxidized phosphatidylcholine(OxPC),oxidized phosphatidylethanolamine(OxPE),triacylglycerol(TG),sphingomyelin(SM)back to normal levels.

关键词： Atherosclerosis Verbascoside Lipid deposition Lipidomics Glycerophospholipid metabolism

CMAES-WFD:Adversarial Website Fingerprinting Defense Based on Covariance Matrix Adaptation Evolution Strategy

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Computers, Materials & Continua 2024年第5期79卷 2253-2276页

作者： Di wang yuefei Zhu Jinlong Fei Maohua Guo School of Cyberspace Security Information Engineering UniversityZhengzhou450000China

Website fingerprinting,also known asWF,is a traffic analysis attack that enables local eavesdroppers to infer a user’s browsing destination,even when using the Tor anonymity *** advanced attacks based on deep neural network(DNN)can performfeature engineering and attain accuracy rates of over 98%,research has demonstrated thatDNNis vulnerable to adversarial *** a result,many researchers have explored using adversarial samples as a defense mechanism against DNN-based WF attacks and have achieved considerable ***,these methods suffer from high bandwidth overhead or require access to the target model,which is *** paper proposes CMAES-WFD,a black-box WF defense based on adversarial *** process of generating adversarial examples is transformed into a constrained optimization problem solved by utilizing the Covariance Matrix Adaptation Evolution Strategy(CMAES)optimization *** are injected into the local parts of the original traffic to control bandwidth *** to the experiment results,CMAES-WFD was able to significantly decrease the accuracy of Deep Fingerprinting(DF)and VarCnn to below 8.3%and the bandwidth overhead to a maximum of only 14.6%and 20.5%,***,for Automated Website Fingerprinting(AWF)with simple structure,CMAES-WFD reduced the classification accuracy to only 6.7%and the bandwidth overhead to less than 7.4%.Moreover,it was demonstrated that CMAES-WFD was robust against adversarial training to a certain extent.

关键词： Traffic analysis deep neural network adversarial sample Tor website fingerprinting

MMCo:using multimodal deep learning to detect malicious traffic with noisy labels

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Frontiers of Computer Science 2024年第1期18卷 239-241页

作者： Qingjun YUAN Gaopeng GOU yuefei ZHU Yongjuan wang Strategic Support Force Information Engineering University Zhengzhou 450001China Institute of Information Engineering Chinese Academy of SciencesBeijing 100093China

1 Introduction The success of a deep learning-based network intrusion detection systems(NIDS)relies on large-scale,labeled,realistic traffic[1,2].However,automated labeling of realistic traffic,such as by sandbox and rule-based approaches,is prone to errors[3],which in turn affects deep learning-based *** effective schemes for learning with noisy labels(LNL)have been proposed,among which the use of parallel networks for sample selection during training has been shown to be *** is argued that parallel networks can discriminate samples from different perspectives,thus adding additional information to the training *** centerpiece is maintaining disagreement of networks.

关键词： network networks modal

The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy

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Acta Pharmaceutica Sinica B 2022年第1期12卷 50-75页

作者： Patrick Kwabena Oduro Xianxian Zheng Jinna Wei Yanze Yang yuefei wang Han Zhang Erwei Liu Xiumei Gao Mei Du Qilong wang Institute of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Component-Based Chinese Medicine Ministry of EducationTianjin 301617China Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS-STING axis is closely implicated in multiple sterile inflammatory diseases, including heart failure,myocardial infarction, cardiac hypertrophy, nonalcoholic fatty liver diseases, aortic aneurysm and dissection, obesity, etc. This is because of the massive loads of damage-associated molecular patterns(mitochondrial DNA, DNA in extracellular vesicles) liberated from recurrent injury to metabolic cellular organelles and tissues, which are sensed by the pathway. Also, the cGAS-STING pathway crosstalk with essential intracellular homeostasis processes like apoptosis, autophagy, and regulate cellular *** derailed STING signaling has become necessary for chronic inflammatory diseases. Meanwhile, excessive type I interferons signaling impact on cardiovascular and metabolic health remain entirely elusive. In this review, we summarize the intimate connection between the cGAS-STING pathway and cardiovascular and metabolic disorders. We also discuss some potential small molecule inhibitors for the pathway. This review provides insight to stimulate interest in and support future research into understanding this signaling axis in cardiovascular and metabolic tissues and diseases.

关键词： STING cGAS Cardiovascular diseases Metabolic diseases Damage-associated molecular patterns Inflammation ER stress Mitochondria

ON A MODIFIED DIFICIENCY OF MEROMORPHIC FUNCTIONS

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中国科学院大学学报(中英文) 1993年第4期 333-340页

作者： wang Shupei and wang yuefei(Department of Mathematics, University of Joensuu Institute of Mathematics, Academia Sinica)

In this paper we will introduce a new deficiency for meromorphicfunctions and obtain several sharp estimates for the upperbounds of the sums of the deficiencies.

关键词： meromorphic function deficiency entire function

Hierarchical metal-peptide assemblies with chirality-encoded spiral architecture and catalytic activity

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Science China Chemistry 2023年第1期66卷 228-241页

作者： Jiayu Liu Jiaxing Zhang Liwei Zhang yuefei wang Hao Wei Yuhe Shen Jiwei Min Xi Rong Wei Qi Rongxin Su Zhimin He School of Chemical Engineering and Technology State Key Laboratory of Chemical EngineeringTianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China Tianjin Key Laboratory of Membrane Science and Desalination Technology Tianjin 300072China

We report the coordination assembly of the ferrocene-diphenylalanine(Fc-FF)with divalent copper ions(Cu^(2+))into metalpeptide assemblies(MPAs)with hierarchical spiral *** MPA particles are composed of helically organized nanofibers which can be correlated to the logarithmic *** MPAs are hierarchically porous with abundant Fc and Cu2+active sites and show much higher catalytic activity than natural laccase toward the decolorization ***,a series of hierarchical structures of the MPAs can be synthesized by controlling the temperature and enantiomeric excess(ee).The peptide enantiomers with higher ee values will self-assemble into highly complex and ordered structures,which show higher surface area and porosity and thus enhanced catalytic activity compared with those assembled by peptides with lower ee *** results provide new insights into the vital role of chirality in directing the self-assembly of biomolecules into highly ordered complex functional structures.

关键词： peptide metal coordination spiral particles chirality catalysis