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Consensus on safety management of novel hormonal therapy for advanced prostate cancer

UroPrecision 2023年第2期1卷 53-71,I0005页

作者： Sujun Han Shudong Cheng Degang Ding Jianming Guo Zhisong He Baiye Jin Zhigang Ji Tianxin Lin Yuanjie Niu weijun Qin Benkang Shi Jinkai Shao Xi'nan Sheng Qiang wei Xin wang Xinghuan wang Shujie Xia Wanhai Xu Qing Zou Xiongbing Zu Renu Eapen Chi‐Fai Ng Hirotsugu Uemura Hiroji Uemura Cheol Kwak Jae Young Joung Marniza Saad Edmund Chiong Nianzeng Xing National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina The First People's Hospital of Jinzhong JinzhongChina Henan Provincial People's Hospital ZhengzhouChina zhongshan Hospital Fudan UniversityShanghaiChina Peking university First Hospital BeijingChina The First Affiliated Hospital Zhejiang University School of MedicineHangzhouChina Peking Union Medical college Hospital BeijingChina Sun Yat‐sen Memorial Hospital Sun Yat‐sen UniversityGuangzhouChina The Second Hospital of Tianjin Medical university TianjinChina Xijing Hospital of Air Force Military Medical university Xi'anChina Qilu Hospital of Shandong university JinanChina Shanxi Provincial People's Hospital TaiyuanChina Beijing Cancer Hospital BeijingChina West china Hospital Sichuan UniversityChengduChina Zhongnan Hospital of Wuhan university WuhanChina Shanghai General Hospital ShanghaiChina Fourth Affiliated Hospital of Harbin Medical university HarbinChina Jiangsu Cancer Hospital NanjingChina Xiangya Hospital of Central South university ChangshaChina Peter MacCallum Cancer Centre VictoriaAustralia The Chinese university of Hong Kong Hong KongChina Kindai university Faculty of Medicine Graduate school of Medical Sciences OsakaJapan Yokohama City university Medical Center KanagawaJapan Seoul National university Hospital SeoulKorea National Cancer Center Gyeonggi‐doKorea university of Malaya Medical Centre Wilayah PersekutuanMalaysia National university Hospital SingaporeSingapore

Prostate cancer(PCa)is one of the most prevalent malignant tumors in men,accompanied by high incidence and mortality *** hormonal therapy(NHT)has emerged as the primary treatment for advanced PCa,providing noticeable clinical ***,the diverse range of adverse events(AEs)associated with NHT may influence both treatment efficacy and patients'quality of *** light of the latest international clinical research evidence and recommendations from domestic and foreign guidelines,this consensus aims to provide a comprehensive overview of the common AEs experienced during NHT for advanced PCa ***,it seeks to develop a hierarchical approach to more efficiently manage AEs,presenting valuable insights for clinical medication and adverse reaction management.

关键词： adverse event novel hormonal therapy prostate cancer safety management

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Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients

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Chinese Medical Journal 2013年第12期126卷 2276-2280页

作者： ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan wang Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying wang Li SHI wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin wang Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan wang Rong ZHANG Jing-hong wang Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao Department of Nephrology State key Laboratory of Kidney Disease Chinese PLA General Hospital Beijing 100853 China Nephrology Institute of the Chinese People's Liberation Army Chinese People's Liberation Army Key Laboratory of Nephrology Beijing 100853 China Department of Nephrology West China Hospital of Sichuan University Chengdu Sichuan 610041 China Department of Nephrology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China Department of Nephrology Zhongshan Hospital Fudan University Shanghai 200032 China Department of Nephrology First Affiiated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China Department of Nephrology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China Department of Nephrology First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China Department of Nephrology First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Nephrology First Afftiated Hospital of China Medical University Shenyang Liaoning 110001 China Department of Nephrology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China Department of Nephrology Second Xiangya Hospital Central South University Changsha Hunan 410000 China Department of Nephrology First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Nephrology First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital) Nanjing Jiangsu 210029 China Department of Nephrology Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China Department of Nephrology Guangdong Provincial People's Hospital Guangzhou Guangdong 510030 China Department of Nephrology Affliated Xiehe Hospital Tongji Medical College Huazhong Science and Technology University Wuhan Hubei 430022 China Department of Nephrology Daping Hospital Third Military Medi

Background Data on the epidemiology of hypertension in Chinese non-dialysis chronic kidney disease （CKD） patients are *** aim of the present study was to investigate the prevalence,awareness,treatment,and control of hypertension in the non-dialysis CKD patients through a nationwide,multicenter study in *** The survey was performed in 61 tertiary hospitals in 31 provinces,municipalities,and autonomous regions in china （except Hong Kong,Macao,and Taiwan）.Trained physicians collected demographic and clinical data and measured blood pressure （BP） using a standardized *** was defned as systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg,and/or use of antihypertensive *** 〈140/90 mmHg and 〈130/80 mmHg were used as the 2 thresholds of hypertension *** multivariate logistic regression with adjustment for sex and age,we analyzed the association between CKD stages and uncontrolled hypertension in non-dialysis CKD *** The analysis included 8927 non-dialysis CKD *** prevalence,awareness,and treatment of hypertension in non-dialysis CKD patients were 67.3%,85.8%,and 81.0%,*** hypertensive CKD patients,33.1% and 14.1% had controlled BP to 〈140/90 mmHg and 〈130/80 mmHg,*** successive CKD stages,the prevalence of hypertension in non-dialysis CKD patients increased,but the control of hypertension decreased （P〈0.001）.When the threshold of BP 〈130/80 mmHg was considered,the risk of uncontrolled hypertension in CKD 2,3a,3b,4,and 5 stages increased 1.3,1.4,1.4,2.5,and 4.0 times compared with CKD 1 stage,respectively （P〈0.05）.Using the threshold of 〈140/90 mmHg,the risk of uncontrolled hypertension increased in advanced stages （P〈0.05）.Conclusions The prevalence of hypertension Chinese non-dialysis CKD patients was high,and the hypertension control was *** successive CKD stages,the risk of uncontrolled hypertension increased.

关键词： non-dialysis chronic kidney disease chronic kidney disease stages hypertension epidemiology

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合并心肺功能不全高龄患者右半结肠切除术的麻醉与围术期管理

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中华麻醉学杂志 2020年第8期40卷 902-906页

作者：张芳王东信薛张纲黄文起马正良尹春琳王晟李金宝肖玮王天龙黄宇光北京大学第一医院麻醉科 100032 复旦大学附属中山医院麻醉科上海200032 中山大学附属第一医院麻醉科广州510080 南京大学医学院附属鼓楼医院麻醉科 210008 首都医科大学宣武医院心内科北京100053 广东省人民医院麻醉科广州510080 上海交通大学附属第一人民医院麻醉科 201620 首都医科大学宣武医院麻醉科北京100053 中国医学科学院北京协和医学院北京协和医院麻醉科100730

一、病例介绍1.病史摘要(1)一般情况:患者女性,年龄80岁,因"右下腹疼痛2月余"入院。2月前无明显诱因出现右下腹间断疼痛,就诊于本院急诊科。腹部增强CT提示升结肠癌可能性大,病灶累及横结肠近端,累及邻近腹膜可能,伴腹腔感染。予禁食,... 详细信息

一、病例介绍1.病史摘要(1)一般情况:患者女性,年龄80岁,因"右下腹疼痛2月余"入院。2月前无明显诱因出现右下腹间断疼痛,就诊于本院急诊科。腹部增强CT提示升结肠癌可能性大,病灶累及横结肠近端,累及邻近腹膜可能,伴腹腔感染。予禁食,抗感染、抑酸治疗后入本院外科。拟全身麻醉下行腹腔镜下右半结肠切除术。

关键词：右半结肠切除术心肺功能不全病史摘要急诊科高龄患者升结肠癌近端抑酸治疗

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基于物联网的任务节点负载非对称匹配方法研究

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数字技术与应用 2020年第7期38卷 78-80页

作者：冷令吴伟斌王琳中山职业技术学院信息工程学院广东中山528400 华南农业大学工程学院广东广州510642 中山市中等专业学校广东中山528458

由于传统的任务节点负载非对称匹配方法,对任务节点负载非对称匹配指数的计算不准确,因此导致任务节点负载非对称匹配精度低。针对这一问题,进行基于物联网的任务节点负载非对称匹配方法研究。通过提取任务节点负载非对称匹配特征,计算... 详细信息

由于传统的任务节点负载非对称匹配方法,对任务节点负载非对称匹配指数的计算不准确,因此导致任务节点负载非对称匹配精度低。针对这一问题,进行基于物联网的任务节点负载非对称匹配方法研究。通过提取任务节点负载非对称匹配特征,计算任务节点负载非对称匹配指数,利用物联网建立任务节点负载非对称匹配矩阵;寻找任务节点负载非对称匹配最终执行结果,从而完成任务节点负载非对称匹配。实验结果表明,设计的匹配方法非对称匹配指数最高可达80.04,对照组仅为47.49,设计匹配方法可以实现对任务节点负载的非对称匹配。

关键词：物联网任务节点负载非对称匹配方法

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VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway

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Signal Transduction and Targeted Therapy 2023年第9期8卷 4380-4393页

作者： Chunsik Lee Rongyuan Chen Guangli Sun Xialin Liu Xianchai Lin Chang He Liying Xing Lixian Liu Lasse DJensen Anil Kumar Harald FLanger Xiangrong Ren Jianing Zhang Lijuan Huang Xiangke Yin JongKyong Kim Juanhua Zhu Guanqun Huang Jiani Li weiwei Lu wei Chen Juanxi Liu Jiaxin Hu Qihang Sun weisi Lu Lekun Fang Shasha wang Haiqing Kuang Yihan Zhang Geng Tian Jia Mi Bi-Ang Kang Masashi Narazaki Aaron Prodeus Luc Schoonjans David MOrnitz Jean Gariepy Guy Eelen Mieke Dewerchin Yunlong Yang Jing-Song Ou Antonio Mora Jin Yao Chen Zhao Yizhi Liu Peter Carmeliet Yihai Cao Xuri Li State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University and Guangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060P.R.China Affiliated Eye Hospital of Nanjing Medical university Nanjing 210000China Department of Obstetrics and Gynecology Guangdong Provincial Key Laboratory of Major Obstetric DiseasesGuangdong Provincial Clinical Research Center for Obstetrics and GynecologyThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhenChina Department of Health Medical and Caring SciencesDivision of Diagnostics and Specialist MedicineLinköping University58183 LinköpingSweden Department of Cardiology AngiologyHaemostaseology and Medical Intensive CareUniversity Medical Centre MannheimMedical Faculty MannheimHeidelberg UniversityMannheimGermany DZHK(German Research Centre for Cardiovascular Research) partner site Mannheim/HeidelbergMannheimGermany European Center for Angioscience Medical Faculty MannheimHeidelberg UniversityMannheimGermany Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease Guangdong Research Institute of GastroenterologyDepartment of Colorectal SurgeryThe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Eye Institute Eye and ENT HospitalShanghai Medical CollegeFudan UniversityKey Laboratory of Myopia of State Health Ministry(Fudan University)and Shanghai Key Laboratory of Visual Impairment and Restoration200031 ShanghaiChina Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment Binzhou Medical UniversityYantai 264003P.R.China Division of Cardiac Surgery National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular DiseasesNHC key Laboratory of Assisted Circulation(Sun Yat-sen University)The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Respiratory Medicine and Clinical Imm

Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different ***,drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular *** is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying *** comprehensive in vitro and in vivo methods and models,we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly ***,we unveil that VEGF-B binds to FGFR1,induces FGFR1/VEGFR1 complex formation,and suppresses FGF2-induced Erk activation,and inhibits FGF2-driven angiogenesis and tumor *** work uncovers a previously unrecognized novel function of VEGF-B in tethering the FGF2/FGFR1 *** the anti-angiogenic nature of VEGF-B under conditions of high FGF2/FGFR1 levels,caution is warranted when modulating VEGF-B activity to treat neovascular diseases.

关键词： FGFR1 FGF2 drugs

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CACA guidelines for holistic integrative management of rectal cancer

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Holistic Integrative Oncology 2023年第1期2卷 1-31页

作者： Committee of Colorectal Cancer Society Chinese Anti-Cancer Association Guiyu wang Daiming Fan Jin Gu Kefeng Ding Xuedong Fang Lin Shen Zhongfa Xu Jianmin Xu Jianchun Cai Lianming Cai Sanjun Cai Gong Chen Jiansi Chen Longwei Cheng Yong Cheng Pan Chi Binbin Cui Guanghai Dai Chuangang Fu Yanhong Gu Guodong He Junhong Hu Jing Huang Rui Huang Zhongcheng Huang Zheng Jiang Zhigang Jie Haixing Ju Hai Li Jian Li Jun Li Ming Li Yaoping Li Yunfeng Li Guole Lin Haiying Liu Ming Liu Qian Liu Zhizhong Pan Yifan Peng Niansong Qian Meng Qiu Li Ren Yueming Sun Jianqiang Tang Qingchao Tang Yuan Tang Kaixiong Tao Min Tao Haijiang wang Meng wang Zejun wang Zhengguang wang Ziqiang wang Ziwei wang Shaozhong wei Baocai Xing Bin Xiong Ye Xu Su Yan Bin Yang Chunkang Yang Qinghua Yao Yingjiang Ye Ying Yuan Guozhi Zhang Haizeng Zhang Hongmei Zhang Zhen Zhang Yunshi Zhong Ji Zhu Yuan Zhu Yuping Zhu Shuangmei Zou Yuliuming wang Jingfang Lv Enrui Liu Ming Yang Qian Zhang weiyuan Zhang Lin Zhang Jun Luo Zhaoxu Zheng Zhixun Zhao Zheng Liu Jinhua Tao Haiyang Huang Tianli Chen Xishan wang 不详 Department of Colorectal Cancer Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina State key Laboratory of Cancer Biology National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’anChina Department of Gastrointestinal SurgeryⅢ Peking University Cancer HospitalBeijingChina Department of Gastrointestinal Surgery Peking University Shougang HospitalBeijingChina Department of Colorectal Surgery and Oncology(Key Laboratory of Cancer Prevention and Intervention China National Ministry of EducationKey Laboratory of Molecular Biology in Medical SciencesZhejiang Provincial Clinical Research Center for CANCER)The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of Gastrointestinal and Colorectal Surgery The China-Japan Union Hospital of Jilin University(The Third Hospital of Jilin University)ChangchunChina Department of Gastrointestinal Oncology Key laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital&InstituteBeijingChina Gastrointestinal Department of The Third Affiliated Hospital of Shandong First Medical university TaianShandongChina Department of Colorectal Surgery Zhongshan Hospital Fudan UniversityShanghaiChina Shanghai Engineering Research Center of Colorectal Cancer Minimally Invasive Technology ShanghaiChina zhongshan Hospital Xiamen university XiamenChina Department of Abdominal Oncology Surgery Ganzhou Cancer HospitalGanzhouJiangxiChina Fudan university Shanghai Cancer Center ShanghaiChina Department of colorectal surgery Sun Yat-sen University Cancer CenterGuangzhouChina Guangxi Medical university Cancer Hospital NanningChina Jilin Cancer Hospital ChangchunChina Department of Gastrointestinal Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Colorectal Surgery Fujian Medical University Union HospitalFuzhou

Purpose Colorectal cancer is a common malignant tumor *** china,the ratio of rectal cancer to coloncancer in terms of incidence is close to 1:*** rectal cancer accounts for more than half of all cases of rectal *** recent years,the proportion of rectal cancer has trended downward,however the incidence of rectal cancer inyounger adults is *** CACA Guidelines for Holistic Integrative Management of Rectal Cancer were editedto help improve the diagnosis and comprehensive treatment in *** This guideline has been prepared by consensuses reached by the CACA Committee of Colorectal CancerSociety,based on a careful review of the latest evidence including china’s studies,and referred to domestic and internationalrelative guidelines,also considered china’s specific national conditions and clinical *** The CACA Guidelines for Holistic Integrative Management of Rectal Cancer include the epidemiology of rectalcancer,prevention and screening,diagnosis,treatment of nonmetastatic and metastatic rectal cancer,follow-up,and whole-course rehabilitation *** Committee of Colorectal Cancer Society,Chinese Anti-Cancer Association,standardizes the diagnosisand treatment of rectal cancer in china through the formulation of the CACA Guidelines.

关键词： Rectal cancer Guideline Screening Diagnosis Treatment Rehabilitation management Holistic integrative medicine

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Nutritional Assessment of Gynecological Cancer Patients in china

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Journal of Nutritional Oncology 2017年第3期2卷 145-152页

作者： Wen Ying Li Guo Lan Gao Chun Hua Song Chang wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua wang Jing Wu Ying He Jia Jun Yang Fu Xiang Zhou Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Jian Xiong Wu Chun Ling Zhou wei wang Qi Luo ong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Zhen Ming Fu Hong Xia Xu wei Li Han Ping Shi Investigation on nutrition status and its clinical outcome of common cancers (INSCOC) group Department of Obstetrics and Gynecology Aviation General HospitalChaoyang DistrictBeijingChina Department of Nutrition and Metabolism of Oncology Affiliated Provincial Hospital of Anhui Medical UniversityHefeiAnhui 230031China Department of Clinical Nutrition the First Hospital of Hefei Medical UniversityShijiazhuangHebei 050031China Department of Gastrointestinal Surgery Institute of Gastroenterologythe First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Department of Clinical Nutrition the First People’s Hospital of KashiXinjiang 844000China zhongshan Chenxinghai Hospital(Affiliated zhongshanChenxinghai Hospital of Guangdong Medical university) ZhongshanGuangdong 528400China Department of Clinical Nutrition Chongqing General HospitalChongqing 40014China Department of Colorectal and Anal Surgery Huizhou Municipal Central HospitalHuizhouGuangdong 516001China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China Department of Oncology Xingtai People’s HospitalHebei Medical UniversityXingtaiHebei 054031China The First Department of Tumor Hospital of Harbin Medical university HarbinHeilongjiang 150085China college of Medicine Chinese Academy of SciencesHuairou DistrictBeijingChina Department of Nutrition Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Oncology Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhouHenan 450008China Department of General Surgery Xiangya HospitalCentral South UniversityChangshaHunan 410008China Comprehensive Oncology Department Cancer HospitalChinese Academy of Medical SciencesBeijing 100021China Abdominal Surgery Department Cancer Institute and HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100021China The Fourth Affiliated Hospital Harbin Medical UniversityHarbinHeilongjiang 150001China Cancer Center the First People’s Hospital of

Background Malnutrition is common among cancer patients,but few studies have evaluated the nutritional status among gynecological cancer patients in *** study aimed to assess the nutritional status of women with gynecological cancer using the patient-generated subjective global assessment(PG-SGA).Methods Data for gynecological cancer patients treated at 44 tertiary hospitals were retrieved from a multicenter study on tumor *** R Software was used for statistical *** analyses of PG-SGA scores were performed using the Chi-squared test for categorical variables and the Wilcoxon-rank sum test or Kruskal-Wallis test for continuous variables,as *** significance level was *** Data for 1962 women with three types of gynecological cancer(cervical,uterine and ovarian cancer)were used for the data *** median PG-SGA score was 4(interquartile range,IQR:1,8),the median participants’age was 51(IQR:46,59)years old,and the patients had a median BMI of 22.9(IQR:20.7,25.4).The percentages of women who had a medical co-morbidity,or had undergone any radical resection,chemotherapy,or radiotherapy were approximately 27.7%,55.4%,52.5%,and 30.2%,*** levels of serum albumin and high density lipoprotein cholesterol(HDL-C)were 40.1g/L(IQR:36.8,43.1)and 1.2mmol/L(IQR:1.0,1.5),*** identified risk factors for malnutrition based on the PG-SGA score were age(0.05±0.01,p=0.002),BMI(-0.34±0.04,p<0.001),having a medical co-morbidity(0.95±0.33,p=0.004),receiving radiotherapy(1.52±0.31,p<0.001),the serum albumin level(-0.18±0.03,p<0.001),and the HDL-C(-1.12±0.35,p=0.001)as indicated by a linear regression *** A higher PG-SGA score is positively associated with the age of the patient,having a medical co-morbidity,and receiving radiotherapy,and is negatively related to the patients’BMI and serum albumin and HDL-C levels.

关键词： Albumin Gynecological cancer HDL-C Malnutrition Patient-generated Subjective Global Assessment

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Sex differences in the scored Patient-Generated Subjective Global Assessment in 19,528 cancer patients

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Journal of Nutritional Oncology 2023年第1期8卷 38-46页

作者： wang Yan-Li Wu Tian-Tian Fu Zhen-Ming Guo Zeng-Qing Lin Yuan Shi Ying-Ying Hu Wen Ba Yi Li Su-Yi Li Zeng-Ning wang Kun-Hua Wu Jing He Ying Yang Jia-Jun Xie Cong-Hua Zhou Fu-Xiang Song Xin-Xia Chen Gong-Yan Ma Wen-Jun Luo Su-Xia Chen Zi-Hua Cong Ming-Hua Ma Hu Zhou Chun-Ling wang wei Luo Qi Shi Yong-Mei Qi Yu-Mei Jiang Hai-Ping Guan Wen-Xian Chen Jun-Qiang Chen Jia-Xin Fang Yu Zhou Lan Feng Yong-Dong Tan Rong-Shao Li Tao Ou Jun-Wen Zhao Qing-Chuan Wu Jian-Xiong Lin Xin Yang Liu-Qing Zhang Qi Jia Ping-Ping Li wei Xu Hong-Xia Shi Han-Ping Song Chun-Hua The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group Chinese Society of Nutritional Oncology Department of Epidemiology and Statistics College of Public HealthZhengzhou UniversityZhengzhouHenanChina Cancer Center Renmin Hospital of Wuhan UniversityWuhanHubeiChina Department of Medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianChina Department of Gastrointestinal Surgery Affiliated Tumor Hospital of Guangxi Medical UniversityNanningGuangxiChina Department of Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Clinical Nutrition West China Hospital of Sichuan UniversityChengduSichuanChina Department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Cancer Prevention and TherapyTianjinChina Department of Nutrition and Metabolism of Oncology Affiliated Provincial Hospital of Anhui Medical UniversityHefeiAnhuiChina Department of Clinical Nutrition The First Hospital of Hebei Medical UniversityShijiazhuangHebeiChina Department of Gastrointestinal Surgery Institute of GastroenterologyThe First Affiliated Hospital of Kunming Medical UniversityKunmingYunnanChina zhongshan Chenxinghai Hospital(Affiliated zhongshan Chenxinghai Hospital of Guangdong Medical university) ZhongshanGuangdongChina Department of Clinical Nutrition The First People's Hospital of KashiKashiXinjiangChina Department of Clinical Nutrition Chongqing General HospitalChongqingChina Department of Colorectal and Anal Surgery Huizhou Municipal Central HospitalHuizhouGuangdongChina Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina Department of Oncology Xingtai People’s HospitalHebei Medical UniversityXingtaiHebeiChina The First Department of the Tumor Hospital of Harbin Medical university HarbinHeilongjiangChina Department of Nutrition Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdongChina Department of Oncology Affiliated

Background:The scored Patient-Generated Subjective Global Assessment(PG-SGA)has been widely used to assess the nutritional status of cancer *** purpose of this study is to compare the differences in PG-SGA scores and the 7 domain scores of the PG-SGA in male and female cancer ***:This study was conducted at 72 hospitals from July 2013 to December 2018,a part of the Investigation on Nutritional Status and its Clinical Outcomes of Common *** PG-SGA was recorded to evaluate the nutritional status of patients.A total of 19,528 patients with 13 common malignancies were included in this *** t test and the χ^(2) test were applied to analyze the sex diferences in the 7 domain *** Cancer Genome Atlas(TCGA)database was used to analyze the expression levels of symptom-related ***:There were significant sex dfferences in the PG-SGA(P=0.032),notably in patients with gastric cancer(male vs female:9.09±4.86 vs 9.58±5.07,P=0.005)and esophageal cancer(9.64±4.90 vs 10.46±4.96,P=0.011)and the average total PG-SGA of female patients was slightly higher than that of male patients(7.64±4.98 vs 7.77±5.14).The differences were mainly related to the weight,eating,symptom,as well as activity and physical function scores in the stratified *** causes of the sex differences were the rates of nausea,vomiting,dry mouth,and other symptoms,in both gastric and esophageal cancer *** of the TCGA database suggested that most of the related genes were sex neutral,except for genes related to dysphagia in gastric cancer(VEGFC was higher in female patients,VEGFA and VEGFB higher in male patients).Conclusions:There are sex differences in the PG-SGA scores in patients with various tumor types(female patients generally had higher scores than male patients),with differences mainly in the weight,eating,symptom,as well as activity and physical function *** sex differences in PG-SGA scores might be due to the differences i

关键词： PG-SGA Sex differences Malnutrition Cancer patients TCGA database

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Search for electron-antineutrinos associated with gravitational-wave events GW150914,GW151012,GW151226,GW170104,GW170608,GW170814,and GW170817 at Daya Bay

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Chinese Physics C 2021年第5期45卷 190-201页

作者： F.P.An A.B.Balantekin H.R.Band M.Bishai S.Blyth G.F.Cao J.Cao J.F.Chang Y.Chang H.S.Chen S.M.Chen Y.Chen Y.X.Chen J.Cheng Z.K.Cheng J.J.Cherwinka M.C.Chu J.P.Cummings O.Dalager F.S.Deng Y.Y.Ding M.V.Diwan T.Dohnal J.Dove M.Dvorak D.A.Dwyer J.P.Gallo M.Gonchar G.H.Gong H.Gong W.Q.Gu J.Y.Guo L.Guo X.H.Guo Y.H.Guo Z.Guo R.W.Hackenburg S.Hans M.He K.M.Heeger Y.K.Heng A.Higuera Y.K.Hor Y.B.Hsiung B.Z.Hu J.R.Hu T.Hu Z.J.Hu H.X.Huang X.T.Huang Y.B.Huang P.Huber D.E.Jaffe K.L.Jen X.L.Ji X.P.Ji R.A.Johnson D.Jones L.Kang S.H.Kettell S.Kohn M.Kramer T.J.Langford J.Lee J.H.C.Lee R.T.Lei R.Leitner J.K.C.Leung F.Li J.J.Li Q.J.Li S.Li S.C.Li W.D.Li X.N.Li X.Q.Li Y.F.Li Z.B.Li H.Liang C.J.Lin G.L.Lin S.Lin J.J.Ling J.M.Link L.Littenberg B.R.Littlejohn J.C.Liu J.L.Liu C.Lu H.Q.Lu J.S.Lu K.B.Luk X.B.Ma X.Y.Ma Y.Q.Ma C.Marshall D.A.Martinez Caicedo K.T.MeDonald R.D.McKeown Y.Meng J.Napolitano D.Naumov E.Naumova J.P.Ochoa-Ricoux A.OIshevskiy H.-R.Pan J.Park S.Patton J.C.Peng C.S.J.Pun F.Z.Qi M.Qi X.Qian N.Raper J.Ren C.Morales Reveco R.Rosero B.Roskovec X.C.Ruan H.Steiner J.L.Sun T.Tmej K.Treskov W.-H.Tse C.E.Tull B.Viren V.Vorobel C.H.wang J.wang M.wang N.Y.wang R.G.wang W.wang W.wang X.wang Y.wang Y.F.wang Z.wang Z.wang Z.M.wang H.Y.wei L.H.wei L.J.Wen K.Whisnant C.G.White H.L.H.Wong E.Worcester D.R.Wu F.L.Wu Q.Wu W.J.Wu D.M.Xia Z.Q.Xie Z.Z.Xing J.L.Xu T.Xu T.Xue C.G.Yang L.Yang Y.Z.Yang H.F.Yao M.Ye M.Yeh B.L.Young H.Z.Yu Z.Y.Yu B.B.Yue S.Zeng Y.Zeng L.Zhan C.Zhang F.Y.Zhang H.H.Zhang J.W.Zhang Q.M.Zhang X.T.Zhang Y.M.Zhang Y.X.Zhang Y.Y.Zhang Z.J.Zhang Z.P.Zhang Z.Y.Zhang J.Zhao L.Zhou H.L.Zhuang J.H.Zou Instiute of Modern Physics East China University of Science and TechnologyShanghai 200237 university of Wisconsin MadisonWisconsin 53706 Wright Laboratory and Department of Physics Yale UniversityNew HavenConnecticut 06520 Brookhaven National Laboratory UptonNew York 11973 Department of Physics National Taiwan UniversityTaipei Institute of High Energy Physics Beijing 100049 National United university Miao-Li Department of Engineering Physics Tsinghua UniversityBejing 100084 Shenzhen university Shenzhen 518060 Sun Yat-Sen(zhongshan)university Guangzhou North china Electric Power university Bejjing 102206 Chinese university of Hong Kong Hong Kong 999077 Siena college LoudonvilleNew York 12211 Department of Physics and Astronomy University of CaliforniaIrvineCaliformia 92697 university of Science and Technology of china Hefei 230026 Charles university Faculty of Mathematics and PhysicsPrague Department of Physics University of llinois at Urbana-ChampaignUrbanaIlinois 61801 Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720 Department of Physics Illinois Institute of TechnologyChicagoIllinois 60616 Joint Institute for Nuclear Research DubnaMoscow Region Beijing Normal university Beijing 100875 Department of Nuclear Science and Technology School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049 Department of Physics University of HoustonHoustonTexas 77204 china Institute of Atomic Energy Beijing 102413 Shandong university Jinan 250100 Guangxi university Nanning 530004 Center for Neutrino Physics Virginia TechBlacksburgVirginia 24061 Institute of Physics National Chiao-Tung UniversityHsinchu Department of Physics University of CincinnatiCincinnatiOhio 45221 Department of Physies Collge of Science and TechnologyTemple UniversityPhiladelphiaPennsylvania 19122 Dongguan university of Technology Dongguan 523808 Department of Physics University of CaliforniaBerkeleyCalifornia 94720 Department of Physics The University of Hong KongPokfulamHong Kong 999077 school

The establishment of a possible connection between neutrino emission and gravitational-wave(GW)bursts is important to our understanding of the physical processes that occur when black holes or neutron stars *** the Daya Bay experiment,using the data collected from December 2011 to August 2017,a search was per-formed for electron-antineutrino signals that coincided with detected GW events,including GW150914,GW151012,GW151226,GW170104,GW170608,GW 170814,and GW *** used three time windows of±10,±500,and±1000 s relative to the occurrence of the GW events and a neutrino energy range of 1.8 to 100 MeV to search for correlated neutrino *** detected electron-antineutrino candidates were consistent with the expected background rates for all the three time *** monochromatic spectra,we found upper limits(90%confidence level)of the electron-antineutrino fluence of(1.13-2.44)×10^(11)cm^(-2)at 5 MeV to 8.0×10^(7)cm^(-2)at 100 MeV for the three time w *** the assumption of a Fermi-Dirac spectrum,the upper limits were found to be(5.4-7.0)×10^(9)cm^(2)for the three time windows.

关键词： grav itational waves electron-antineutrinos fluence upper limit

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International guideline on natural orifice specimen extraction surgery(NOSES)for colorectal cancer(2023 version)

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Holistic Integrative Oncology 2023年第1期2卷 93-100页

作者： Zheng Liu Xu Guan Mingguang Zhang Xiyue Hu Ming Yang Junge Bai Jun Li Shaojun Yu Kefeng Ding Qingsi He Liang Kang Dan Ma Chuangang Fu Junhong Hu Ye wei Donghui Sun Gang Yu Songbing He Changyou wang Yanwei Gao Guiyu wang Hongliang Yao Jian Peng Yangchun Zheng Bo Jiang Taiyuan Li Zhiguo Xiong Xuejun Sun Zhenning wang William Meng William Tzu-Liang Chen Ming-Yin Shen John H.Marks Charles A.Ternent Darcy DShaw Jim SKhan Petr Tsarkov Inna Tulina Sergey Efetov Joaquim Manuel da Costa Pereira Fernanda Nogueira Ricardo Escalante Joel Leroy Avanish Saklani Audrius Dulskas Cuneyt Kayaalp Atsushi Nishimura Kay Uehara Woo-Yong Lee Sang-Hoo Kim Suk-Hwan Lee Xishan wang Committee of Colorectal Cancer Society Chinese Anti-Cancer Association International NOSES Alliance Department of Colorectal Surgery National Cancer CenterNational Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100021China Department of Colorectal Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of General Surgery Shandong University Qilu HospitalJinanShandongChina Department of Colorectal Surgery The Sixth Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina Department of General Surgery Xinqiao HospitalThird Military Medical UniversityChongqingChina Department of Gastrointestinal Surgery Shanghai East HospitalTongji University School of MedicineShanghaiChina Department of Anorectal Surgery First Affiliated HospitalZhengzhou UniversityZhengzhouHenanChina Department of General Surgery Zhongshan HospitalFudan UniversityShanghaiChina Department of Gastric and Colorectal Surgery Jilin University First HospitalChangchunChina Department of General Surgery Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityJinanChina Department of General Surgery the First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Affiliated Hospital of North china university of Science and Technology TangshanHebeiChina Inner Mongolia Autonomous Region People’s Hospital HuhhotInner Mongolia Autonomous RegionChina Department of Colorectal Cancer Surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of General Surgery The Second Xiangya HospitalCentral South UniversityChangshaHunanChina Department of General Surgery Xiangya HospitalCentral South UniversityChangshaChina Department of Gastrointestinal Surgery Sichuan Cancer HospitalChengduChina Department of Colorectal and Anal Surgery Shanxi Cancer HospitalTaiyuanShanxiChina Department of General Surgery The First Affiliated Hospital of Nanchang UniversityNanchangChina Department of Gastrointestinal Surgery Hubei Provincial Cancer Hosp

Purpose In recent years,natural orifice specimen extraction surgery(NOSES)has gained widespread attention as an alternative *** the safety and feasibility of NOSES have been well documented,many questions remain open for *** aim of this guideline is to provide more evidence for the promotion of *** This guideline has been prepared by the CACA Committee of Colorectal Cancer Society and the International NOSES Alliance,based on the latest *** The guideline on NOSES for colorectal cancer include the definition,classification,technology requirement,indications,technical difficulties and clinical *** The guideline provides a full introduction of the theoretical and technical aspects of NOSES for colorectal cancer which will beneficial to development of NOSES.

关键词： Colorectal cancer Guideline Treatment Surgery Holistic integrative medicine Natural orifice specimen extraction surgery

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