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Nitrogen-doped fluorescence carbon dots as multi-mechanism detection for iodide and curcumin in biological and food samples

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Bioactive Materials 2021年第6期6卷 1541-1554页

作者： Xiaodan Tang Hongmei Yu Brian Bui Lingyun wang Christina xing Shaoyan wang Mingli Chen Zhizhi Hu Wei Chen School of Chemical Engineering University of Science and Technology LiaoningLiaoningAnshan114051China Department of Physics The University of Texas at ArlingtonArlingtonTX76019-0059USA School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou510641China Research Center for Analytical Sciences Department of ChemistryCollege of SciencesNortheastern UniversityBox332Shenyang110819China

Iodine ion is one of the most indispensable anions in living organisms,particularly being an important substance for the synthesis of thyroid *** is a yellow-orange polyphenol compound derived from the rhizome of Curcuma longa L.,which has been commonly used as a spice and natural coloring agent,food additives,cosmetics as well as Chinese ***,excess curcumin may cause DNA inactivation,lead to a decrease in intracellular ATP levels,and trigger the tissue ***,quantitative detection of iodine and curcumin is of great significance in the fields of food and life ***,we develop nitrogen-doped fluorescent carbon dots(NCDs)as a multi-mechanism detection for iodide and curcumin in actual complex biological and food samples,which was prepared by a one-step solid-phase synthesis using tartaric acid and urea as precursors without adding any other *** assembled NCDs-Hg^(2+) fluorescence-enhanced sensor for the quantitative detection of I^(-) was established based on a fluorescence“turn-off-on”mechanism in a linear range of 0.3-15μM with a detection limit of 69.4 nM and successfully quantified trace amounts of I^(-) in water samples and urine ***,the as-synthesized NCDs also can be used as a fluorescent quenched sensor for curcumin detection based on the synergistic internal filtration effect(IFE)and static quenching,achieving a good linear range of 0.1-20μM with a satisfactory detection limit of 29.8 *** results indicate that carbon dots are potential sensing materials for iodine and curcumin detection for the good of our health.

关键词： Nitrogen-doped carbon dots Iodine ion Curcumin Internal filtration effect Solid-phase thermal method Disease Detection

Chloridion-induced dual tunable fabrication of oxygen-deficient Bi_(2)WO_(6) atomic layers for deep oxidation of NO

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Chinese Journal of Catalysis 2021年第6期42卷 1013-1023页

作者： Xianglong Yang Shengyao wang Ting Chen Nan Yang Kai Jiang Pei wang shu Li xing Ding Hao Chen College of Science Key Laboratory of Environment Correlative Dietology of Ministry of EducationHuazhong Agricultural UniversityWuhan 430070HubeiChina

Engineering an efficient interface is a trustworthy strategy for designing advanced photocatalytic systems for solar energy ***,oxygen-deficient Bi_(2)WO_(6)atomic layers without organic residues were successfully fabricated via a facile solvothermal strategy by the multifunctional regulatory mechanism of introduced *** DFT calculations and speciation determination revealed that chloridion displayed a more pronounced effect in the controllable synthesis of oxygen-deficient Bi_(2)WO_(6)atomic layers without organic residues:ultrathinning and *** built-in multi-cooperative interface endowed Bi_(2)WO_(6)with intriguing photoelectrochemical properties,O_(2) activation ability,and ultrahigh activity in visible-light powered deep oxidation of NO.A reasonable photocatalytic mechanism was proposed based on in situ infrared spectroscopy analysis and theoretical *** believe that this multi-cooperative interface engineering of oxygen-deficient Bi_(2)WO_(6)atomic layers without organic residues could provide new insights into the design of two-dimensional(2D)layered materials with efficient active sites and pave the way for efficient NO photooxidation systems.

关键词： Oxygen vacancy Bi_(2)WO_(6)atomic layers Chloridion Photocatalysis NO oxidation

血清Irisin、PTX3及MALAT1水平与糖尿病视网膜病变病情程度的关系及联合诊断价值

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眼科新进展 2024年第6期44卷 470-475页

作者：李博刘明远李幸张新桥曹婷婷王曦李朝霞柏玲沧州市中心医院眼一科河北省沧州市061017 沧州市中心医院麻醉一科河北省沧州市061017 沧州市中心医院呼吸与危重症医学二科河北省沧州市061017 南华大学附属第一医院眼科湖南省衡阳市421009

目的研究血清鸢尾素(Irisin)、长正五聚蛋白3(PTX3)、人肺腺癌转移相关转录本1(MALAT1)水平与糖尿病视网膜病变(DR)病情程度的关系及联合诊断的价值。方法选取2022年4月至2023年4月沧州市中心医院2型糖尿病(T2DM)合并DR患者85例设为DR组... 详细信息

目的研究血清鸢尾素(Irisin)、长正五聚蛋白3(PTX3)、人肺腺癌转移相关转录本1(MALAT1)水平与糖尿病视网膜病变(DR)病情程度的关系及联合诊断的价值。方法选取2022年4月至2023年4月沧州市中心医院2型糖尿病(T2DM)合并DR患者85例设为DR组,85例单纯T2DM患者设为非DR组,同时期85例健康志愿者设为对照组。将DR组患者以是否处于增生型DR为标准分为增生型组(38例)与非增生型组(47例)。收集DR组患者病例临床资料,包括性别、舒张压、年龄、收缩压、病程、空腹血糖(FPG)、体质量指数、糖化血红蛋白(HbA1c)、吸烟史、甘油三酯(TG)、饮酒史、收缩期峰值流速、舒张末期峰值流速、阻力指数、空腹胰岛素(FINS)、糖尿病家族史、总胆固醇(TC)、胰岛素抵抗指数(HOMA-IR)。酶联免疫吸附法检测各组患者血清Irisin、PTX3水平,实时荧光定量PCR法检测血清MALAT1水平。采用Pearson相关性分析检测血清Irisin、PTX3及MALAT1水平与DR患者病情程度的相关性。Logistic回归分析DR患者病情程度的影响因素。受者工作特征曲线(ROC曲线)分析血清Irisin、PTX3及MALAT1单独诊断DR的价值。ROC曲线、净重新分类指数(NRI)及综合判别改善指数(IDI)分析含与不含血清Irisin、PTX3及MALAT1方案诊断DR的价值。结果3组患者血清Irisin、PTX3、MALAT1水平比较,差异均有统计学意义(均为P<0.001)。增生型组患者病程长于非增生型组,收缩期峰值流速、舒张末期峰值流速、血清Irisin水平均低于非增生型组,阻力指数、FPG、HbA1c、TG、FINS、HOMA-IR及血清PTX3、MALAT1水平均高于非增生型组,差异均有统计学意义(均为P<0.05)。DR患者血清Irisin水平与DR病情程度呈负相关(r=-0.512,P<0.001),PTX3、MALAT1水平与DR病情程度均呈正相关(r=0.497、0.573,均为P<0.05)。Logistic回归分析结果显示,病程、FPG、HbA1c、TG、FINS、HOMA-IR、收缩期峰值流速、舒张末期峰值流速、阻力指数及血清Irisin、PTX3、MALAT1水平均为DR病情程度加重的影响因素(均为P<0.05)。血清Irisin、PTX3、MALAT1诊断DR的曲线下面积(AUC)分别为0.743、0.811、0.773。与常规诊断方案比较,含有血清Irisin、PTX3、MALAT1水平的新诊断方案的AUC明显增大(Z=2.708,P=0.007),NRI、IDI分别为0.039(95%CI:0.022~0.069)、0.026(95%CI:0.014~0.047)(均为P<0.05)。结论DR患者血清Irisin水平降低,PTX3、MALAT1水平升高,且与患者DR病情程度密切相关,含有血清Irisin、PTX3、MALAT1指标的诊断方案具有较高的诊断价值。

关键词： Irisin PTX3 MALAT1 糖尿病视网膜病变病情程度诊断价值

高速铁路大跨度连续斜拉桥上梁端一体化装置性能研究

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铁道标准设计 2024年第4期68卷 63-69,87页

作者：周智强邢书科王兆刚孙洪斌董昆灵杨荣山西南交通大学高速铁路线路工程教育部重点实验室成都610031 中铁上海工程局集团有限公司上海201906 山东省路桥集团有限公司济南250101 山东铁路投资控股集团有限公司济南250101

目前大跨度斜拉桥上铺设无缝线路,梁端处需设置梁端伸缩装置和钢轨伸缩调节器以降低钢轨产生较大的附加应力,但此结构无法协调较大的梁轨相对位移,应用范围有限。为此,提出了一种梁端一体化装置结构,能适用于较大的梁缝伸缩情况且伸缩... 详细信息

目前大跨度斜拉桥上铺设无缝线路,梁端处需设置梁端伸缩装置和钢轨伸缩调节器以降低钢轨产生较大的附加应力,但此结构无法协调较大的梁轨相对位移,应用范围有限。为此,提出了一种梁端一体化装置结构,能适用于较大的梁缝伸缩情况且伸缩阻力较小,经过现场应用效果良好。针对时速350 km下高速列车能够平稳通过大跨度斜拉桥无缝线路梁端的要求,建立了相关三维梁端车-线-桥耦合模型,确定了轮轨接触关系,验证该结构在大跨度斜拉桥下对于高速列车平稳运行的适用性。结果表明:温度和梁端转角作用下钢轨会产生一定变形,钢轨垂向变形大于横向变形,最大垂向位移达到15.71 mm。对比仅施加德国低干扰不平顺谱,叠加温度或梁端转角变形后行车过程中的梁端一体化装置动力响应增大,且对钢枕振动垂向加速度的影响较为明显,从38.92 m·s^(-2)上升至48.69 m·s^(-2),增加25.1%。相比之下,极限拉伸状态比极限压缩状态下行车过程中的梁端一体化装置结构响应大,钢枕垂向加速度从40.64 m·s^(-2)上升至62.39 m·s^(-2),增加53.5%,应在高温拉伸状态下对梁端一体化装置性能进行定期检测。梁端一体化装置在以上工况下的响应均满足标准规范要求,本研究可为其在列车高速运行通过大跨度斜拉桥梁端时的铺设提供参考。

关键词：高速铁路铁路桥连续斜拉桥无缝线路钢轨伸缩调节器梁端一体化装置车-线-桥耦合轮轨接触关系动力响应

Expressions of matrix metalloproteinases 1 and 3 and their tissue inhibitors in the conjunctival tissue and fibroblasts cultured from conjunctivochalasis

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 555-559页

作者： Min-Hong Xiang xing-Ru Zhang Zhen-Yong Zhang Qing-Song Li Han-Min wang Zhu-Mei Han Huan-Ming Zhou Yuan-Ling Jia xing-xing Chen Department of Ophthalmology Putuo HospitalShanghai University of Traditional Chinese Medicine Liqun Hospital Putuo District

AIM：To investigate the expression of matrix metalloproteinases 1 and 3（MMP-1 and MMP-3） and their tissue inhibitors of metalloproteinases 1 and 3（ TIMP-1 and TIMP-3） in the conjunctiva of eyes with conjunctivochalasis（CCh）.METHODS：The conjunctival tissue was obtained from the CCh patients and controls,the MMPs/TIMPs expression concentration was determined by enzyme-linked immunosorbent assay（ELISA） and immunofluorescence *** expression levels of MMPs/TIMPs in the CCh fibroblasts were determined by analyzing its concentration in the cellular supernatant that was abstracted from the in vitro cultured CCh ***：MMP-1 and MMP-3 levels determined by ELISA were both significantly higher in the CCh group than that in the control group（P= 0.042,0.022,respectively）,so was the levels of TIMP-1（P= 0.010）.No significant difference in the expression of TIMP-3 in conjunctiva was found between the two groups（P= 0.298）.The expression of MMP-1 and MMP-3 were both up-regulated significantly in the CCh group（P= 0.040,0.001,respectively） on immunofluorescence ***-1 and MMP-3 expression in the fibroblasts were both significantly higher in the CCh group than that in the control group（P= 0.027,0.001,respectively）,while neither the TIMP-1 nor TIMP-3 expression was significantly different between the two groups（P= 0.421,0.237,respectively）.CONCLUSION：The overexpression of MMP-1 and MMP-3 in conjunctival tissue and fibroblasts may play an important role in the pathogenesis and development of CCh.

关键词： conjunctivochalasis relaxed conjunctiva fibroblast matrix metaUoproteinase tissue inhibitor of matrix metalloproteinase

神经网络算法在切割索侵彻性能预测中的应用研究

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火工品 2024年第3期 22-29页

作者：王友刘名兴尹鑫李柠芮庞强宏雷新宇胡强先明春四川航天川南火工技术有限公司四川泸州646000

基于难以通过型面直接准确预测切割索侵彻性能,以及神经网络算法大力发展的现状,本文对神经网络算法在切割索侵彻性能预测领域的应用情况进行了综述。在对常用神经网络计算方法进行分析后,重点对BP神经网络和卷积神经网络算法原理及其... 详细信息

基于难以通过型面直接准确预测切割索侵彻性能,以及神经网络算法大力发展的现状,本文对神经网络算法在切割索侵彻性能预测领域的应用情况进行了综述。在对常用神经网络计算方法进行分析后,重点对BP神经网络和卷积神经网络算法原理及其在切割索性能预测中的应用进行分析梳理和归纳总结,系统性地对两种神经网络算法的数据集处理、网络搭建模型、参数设置和优缺点进行了剖析,为切割索性能优化和智能化预测提供支撑。

关键词：切割索侵彻性能 BP神经网络卷积神经网络

儿童颈项部腧穴三维数字可视化系统研发与应用

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中国组织工程研究 2025年第9期29卷 1834-1840页

作者：奥晓静李琨刘宇航杨潇暄王星李志军任小燕张少杰内蒙古医科大学中医学院内蒙古自治区呼和浩特市010110 内蒙古医科大学基础医学院解剖学教研室内蒙古自治区呼和浩特市010110 内蒙古医科大学研究生院内蒙古自治区呼和浩特市010000 内蒙古触点数字科技有限公司内蒙古自治区呼和浩特市010020 内蒙古医科大学数字医学中心内蒙古自治区呼和浩特市010059 内蒙古医科大学附属医院内分泌科内蒙古自治区呼和浩特市010059

背景:目前已有成人腧穴三维数字化、可视化系统的相关研究,但基于真实儿童数字化断层解剖数据集对儿童腧穴可视化相关的研究报道并不多见。目的:设计研发儿童颈项部腧穴数字三维可视化系统,为针灸学、经络腧穴学教学、针灸临床、针刺施... 详细信息

背景:目前已有成人腧穴三维数字化、可视化系统的相关研究,但基于真实儿童数字化断层解剖数据集对儿童腧穴可视化相关的研究报道并不多见。目的:设计研发儿童颈项部腧穴数字三维可视化系统,为针灸学、经络腧穴学教学、针灸临床、针刺施术手法练习及针刺安全性研究提供依据,并为研发儿童腧穴仿真系统提供基础。方法:基于真实学龄前男童断层解剖数据集,运用PhotoShop 2021与Digihuman Reconstruction System软件完成儿童颈项部三维数字化虚拟解剖模型及内部多器官三维重建;通过Unity数据库语言编制风府、风池等11个腧穴的数据库;在Unity3D软件中整合儿童颈项部解剖立体模型、腧穴数据库及编写针刺操作代码,成功创建集仿真腧穴定位、三维腧穴解剖、针刺训练、临床教学及针刺安全性研究等多功能于一体的儿童颈项部腧穴三维数字可视化系统。结果与结论:①该研究基于真实儿童标本,采用手动逐层分割断面图像法以最大程度确保3D模型精度。使用3D软件Digihuman Reconstruction System提取和保存独立分割数据,与PhotoShop 2021软件共同完成儿童颈项部外层皮肤与其内部骨性结构、颈部脊髓、血管和神经、肌肉及韧带等数十个三维重建解剖结构模型。于MeshLab软件中完成各独立结构基本形态和整体轮廓完整性核验工作,并利用3-maticresearch13.0软件进行最终精细化调校及解剖位置确认,成功模拟还原学龄前儿童颈项部真实解剖形态。②依据并参考中华人民共和国国家标准收集整理儿童颈项部常用腧穴的名称、所属经脉、定位、局部解剖、进针层次、针刺方法、针刺意外与预防、腧穴主治、二维解剖断层图像等8个方面内容形成腧穴数据库。③运用Unity3D软件将儿童颈项部三维模型、针刺模拟操作和腧穴数据库三者整合,成功构建三维数字儿童颈项部腧穴可视化系统。该系统可显示儿童颈项部腧穴的信息、二维三维解剖结构,并实现了儿童颈项部腧穴的二维、三维针刺模拟功能及针刺安全性研究功能。基于真实儿童标本超薄断层解剖数据集,构建了首个儿童颈项部腧穴三维数字化、可视化系统,较既往腧穴系统更贴合亚洲儿童的解剖形态学发育特点,在针刺安全性研究、临床教学及针刺模拟训练等领域具有极高的应用价值。

关键词：腧穴三维可视化断层解剖仿真系统儿童

Growth-inhibiting effects of taxol on human liver cancer in vitro and in nude mice

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World Journal of Gastroenterology 2000年第2期6卷 210-215页

作者： Jin Hui Yuan Ru Ping Zhang Ru Gang Zhang Li Xia Guo xing wang wang Dan Luo Yong Xie Hong Xie Shanghai Institute of Cell Biology Chinese Academy of SciencesShanghai 200031China Hong Kong University of Science and Technology Hong KongChina

AIM To investigate the effects of taxol onSMMC-7721 human hepatoma and *** In vitro cell growth was assessedby trypan blue exclusion *** model was established by seedingSMMC-7721 cells subcutaneously into Balb/c(nu/nu)nude *** vivo tumor growth wasdetermined by measurement of tumor diameterwith Vernier *** syntheses of DNA,RNA and protein were analyzed by incorporationof ~3H-thymidine,~3H-uridine and ~*** light and electronmicroscopes to observe the morphologicalchanges of cells including mitosis *** Taxol was effective against SMMC-7721 human hepatoma cell growth in the rangesof 2.5 nmol/L-10 nmol/L with mitotic arrestand apoptosis in ***,RNA and proteinsyntheses in cells were also obviouslysuppressed by in vitro treatment of taxol for72 *** at 2.5 nmol/L reduced ~3H-thymidineuptake to about 34% of the control value(P<0.05).Increasing the dose of taxol to20 nmol/L resulted in a greater decrease in ~3H-thymidine incorporation to 60% of the controlvalue(P<0.01).At a concentration of 20 nmol/L,the ~3H-uridine and ~3H-leucine uptakeswere reduced to 52%(P<0.05)and 63%(P<0.01),*** vivo,taxolsignificantly inhibited SMMC-7721 tumor growthat 10 mg/kg,i.p.,once daily for 10 d.A morethan 90% decrease in tumor volume wasobserved by day 11(P<0.01)similarly withmitotic arrest and cell *** Taxol has a marked anticanceractivity in SMMC-7721 human hepatoma both invitro and in nude *** mechanisms might beassociated with mitotic arrest,subsequently,apoptosis of the hepatoma *** obvioustoxicity was observed with in vivoadministration of taxoi.

关键词： paclitaxel liver neoplasms apoptosis mitoics in vitro DNA RNA microscopy wection mice nude

Enhanced performance of AlGaN-based ultraviolet light-emitting diodes with linearly graded AlGaN inserting layer in electron blocking layer

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Chinese Physics B 2019年第5期28卷 361-365页

作者： Guang Li Lin-Yuan wang Wei-Dong Song Jian Jiang xing-Jun Luo Jia-Qi Guo Long-Fei He Kang Zhang Qi-Bao Wu shu-Ti Li Guangdong Engineering Research Center of Optoelectronic Functional Materials and Devices Institute of Opto-Electronic Materials and Technology South China Normal University Guangdong Institute of Semiconductor Industrial Technology Guangdong Academy of Sciences School of Intelligent Manufacture and Equipment Shenzhen Institute of Information Technology

The conventional stationary Al content Al GaN electron blocking layer(EBL) in ultraviolet light-emitting diode(UV LED) is optimized by employing a linearly graded Al Ga N inserting layer which is 2.0 nm Al_(0.3) Ga_(0.7) N/5.0 nm Alx Ga_(1-x) N/8.0 nm Al_(0.3) Ga_(0.7) N with decreasing value of x. The results indicate that the internal quantum efficiency is significantly improved and the efficiency droop is mitigated by using the proposed structure. These improvements are attributed to the increase of the effective barrier height for electrons and the reduction of the effective barrier height for holes,which result in an increased hole injection efficiency and a decreased electron leakage into the p-type region. In addition,the linearly graded AlGaN inserting layer can generate more holes in EBL due to the polarization-induced hole doping and a tunneling effect probably occurs to enhance the hole transportation to the active regions, which will be beneficial to the radiative recombination.

关键词： ultraviolet light-emitting diode electron blocking layer internal quantum efficiency