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Next-generation vaccines for substance use disorders

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Zoological Research 2024年第3期45卷 707-708页

作者： Kaixuan wang Hongshuang wang xiaohui wang Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunJilin 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefeiAnhui 230026China

Substance use disorders(SUDs)impact an estimated 300 million people worldwide,significantly impairing both health and social *** disorders are marked by an inability to regulate substance use,despite the harmful *** affects various neurotransmitter systems,including dopamine,serotonin,γ-aminobutyric acid(GABA),and glutamate,each of which plays a role in the reward,stress,and self-control pathways of the brain(Koob&Volkow,2016).While significant advances have been made in neuroscience,our understanding of how these neurotransmitter systems interact and contribute to addiction is still *** knowledge gap represents a significant challenge in the formulation of effective treatments for *** present,the US Food and Drug Administration(FDA)has approved pharmacological treatments for alcohol,nicotine,and opioid use disorders(Vasiliu,2022);however,no such treatments have been authorized for SUDs in general,or specifically for stimulant use disorders,such as cocaine and methamphetamine ***,the FDA has not approved any new drugs for SUD treatment in the past 40 years.

关键词： disorders treatment consequences

Microglia in drug addiction:A perspective from neuroimmunopharmacology

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Zoological Research 2024年第3期45卷 704-706页

作者： Cong Lin xiaohui wang Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunJilin 130022China Beijing National Laboratory for Molecular Sciences Beijing 100190China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefeiAnhui 230026China

Drug addiction refers to a state of dependence that arises from habitual drug intake and can result in specific withdrawal symptoms upon *** most commonly abused substances include psychostimulants,cannabinoids,and *** drugs are consumed,they stimulate the release of dopamine,a neurotransmitter crucial for the pleasure and reward centers of the *** repeated drug use,the brain undergoes various changes,leading to tolerance,dependence,and addiction(Lüscher et al.,2020).The mechanisms involved in drug addiction are highly complex and involve diverse cell types within the brain.

关键词： addiction drugs intake

Understanding the Relationship Between Shrinking Cities and Land Prices:Spatial Pattern,Effectiveness,and Policy Implications

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Chinese Geographical Science 2024年第1期34卷 1-18页

作者： wang xiaohui PENG Li HUANG Kexin DENG Wei College of Geography and Resources Sichuan Normal UniversityChengdu610101China Key Laboratory of Land Resources Evaluation and Monitoring in Southwest Ministry of EducationSichuan Normal UniversityChengdu610101China

Urban shrinkage has emerged as a widespread phenomenon globally and has a significant impact on land,particularly in terms of land use and *** study focuses on 2851 county-level cities in China in 2005–2018(excluding Hong Kong,Macao,Taiwan,and‘no data’areas in Qinhai-Tibet Plateau)as the fundamental units of *** employing nighttime light(NTL)data to identify shrinking cities,the propensity score matching(PSM)model was used to quantitatively examine the impact of shrinking cities on land prices,and evaluate the magnitude of this *** findings demonstrate the following:1)there were 613 shrinking cities in China,with moderate shrinkage being the most prevalent and severe shrinkage being the least.2)Regional disparities are evident in the spatial distribution of shrinking cities,especially in areas with diverse terrain.3)The spatial pattern of land price exhibits a significant correlated to the economic and administrative levels.4)Shrinking cities significantly negatively impact on the overall land price(ATT=–0.1241,P<0.05).However,the extent of the effect varies significantly among different spatial *** study contributes novel insights into the investigation of land prices and shrinking cities,ultimately serving as a foundation for government efforts to promote the sustainable development of urban areas.

关键词： shrinking cities land price propensity score matching(PSM) relative effectiveness China

Flexible, thermal processable, self-healing, and fully bio-based starch plastics by constructing dynamic imine network

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Green Energy & Environment 2024年第10期9卷 1610-1618页

作者： Xiaoqian Zhang Haishan Zhang Guowen Zhou Zhiping Su xiaohui wang State Key Laboratory of Pulp and Paper Engineering South China University of Technology

The serious environmental threat caused by petroleum-based plastics has spurred more researches in developing substitutes from renewable *** is desirable for fabricating bioplastic due to its abundance and renewable ***,limitations such as brittleness,hydrophilicity,and thermal properties restrict its widespread *** overcome these issues,covalent adaptable network was constructed to fabricate a fully bio-based starch plastic with multiple advantages via Schiff base *** strategy endowed starch plastic with excellent thermal processability,as evidenced by a low glass transition temperature （Tg=20.15℃）.Through introducing Priamine with long carbon chains,the starch plastic demonstrated superior flexibility （elongation at break=45.2%） and waterproof capability （water contact angle=109.2°）.Besides,it possessed a good thermal stability and self-adaptability,as well as solvent resistance and chemical *** work provides a promising method to fabricate fully bio-based plastics as alternative to petroleum-based plastics.

关键词： Bioplastic Covalent adaptable networks Schiff base chemistry Thermal processability Self-healing

Configuration and Kinematics of a 3-DOF Generalized Spherical Parallel Mechanism for Ankle Rehabilitation

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 176-188页

作者： Jianjun Zhang Shuai Yang Chenglei Liu xiaohui wang Shijie Guo School of Mechanical Engineering Hebei University of TechnologyTianjin 300401China Key Laboratory of Robot Perception and Human-Machine Fusion Tianjin 300401China

The kinematic equivalent model of an existing ankle-rehabilitation robot is inconsistent with the anatomical structure of the human ankle,which influences the rehabilitation ***,this study equates the human ankle to the UR model and proposes a novel three degrees of freedom(3-DOF)generalized spherical parallel mechanism for ankle *** parallel mechanism has two spherical centers corresponding to the rotation centers of tibiotalar and subtalar *** screw theory,the mobility of the parallel mechanism,which meets the requirements of the human ankle,is *** inverse kinematics are presented,and singularities are identified based on the Jacobian *** workspaces of the parallel mechanism are obtained through the search method and compared with the motion range of the human ankle,which shows that the parallel mechanism can meet the motion demand of ankle ***,based on the motion-force transmissibility,the performance atlases are plotted in the parameter optimal design space,and the optimum parameter is obtained according to the demands of practical *** results show that the parallel mechanism can meet the motion requirements of ankle rehabilitation and has excellent kinematic performance in its rehabilitation range,which provides a theoretical basis for the prototype design and experimental verification.

关键词： Ankle rehabilitation Parallel mechanism Kinematic analysis Parameter optimization

Uncertain process-based data integration and residual lifetime evaluation of PCB in airborne equipment with ADT and field data

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Chinese Journal of Aeronautics 2024年第8期37卷 233-245页

作者： Yu wang Rui KANG Linhan GUO Xiaoyang LI Zhe LIU xiaohui wang Weifang ZHANG Schoool of Reliability and Systems Engineering Beihang UniversityBeijing 100191China

Accurately evaluating the lifespan of the Printed Circuit Board(PCB)in airborne equipment is an essential issue for aircraft design and operation in the marine atmospheric *** paper presents a novel evaluation method by fusing Accelerated Degradation Testing(ADT)data,degradation data,and life data of small samples based on the uncertainty degradation *** uncertain life model of PCB in airborne equipment is constructed by employing the uncertain distribution that considers the accelerated factor of multiple environmental conditions such as temperature,humidity,and *** addition,a degradation process model of PCB in airborne equipment is constructed by employing the uncertain process of fusing ADT data and field data,in which the performance characteristics of dynamic cumulative change are *** on minimizing the pth sample moments,an integrated method for parameter estimation of the PCB in airborne equipment is proposed by fusing the multi-source data of life,degradation,and *** engineering case illustrates the effectiveness and advantage of the proposed method.

关键词： Printed circuit board Degradation Data integration Field environment Accelerated degradation testing Parameter estimate

CONVEXITY OF THE FREE BOUNDARY FOR AN AXISYMMETRIC INCOMPRESSIBLE IMPINGING JET

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Acta Mathematica Scientia 2024年第1期44卷 234-246页

作者：王晓慧 College of Mathematics and Physics and Geomathematics Key Laboratory of Sichuan ProvinceChengdu University of TechnologyChengdu610059China

This paper is devoted to the study of the shape of the free boundary for a threedimensional axisymmetric incompressible impinging *** be more precise,we will show that the free boundary is convex to the fluid,provided... 详细信息

关键词： Euler system axisymmetric impinging jet incompressible free boundary convexity

Microstructure,elastic/mechanical and thermal properties of CrTaO_(4):A new thermal barrier material?

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Journal of Advanced Ceramics 2024年第3期13卷 373-387页

作者： Shuang Zhang xiaohui wang Chao Zhang Huimin Xiang Yingwei Li Cheng Fang Mingliang Li Hailong wang Yanchun Zhou School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Civil Engineering Wuhan UniversityWuhan 430072China

CrTaO_(4)(or Cr_(0.5)Ta_(0.5)O_(2))has been unexpectedly found to play a decisive role in improving the oxidation resistance of Cr and Ta-containing refractory high-entropy alloys(RHEAs).This rarely encountered complex oxide can effectively prevent the outward diffusion of metal cations from the ***,the oxidation kinetics of CrTaO_(4)-forming RHEAs is comparable to that of the well-known oxidation resistant Cr_(2)O_(3)-and Al_(2)O_(3)-forming Ni-based ***,CrTaO_(4)has been ignored and its mechanical and thermal properties have yet to be *** fill this research gap and explore the untapped potential for its applications,here we report for the first time the microstructure,mechanical and thermal properties of CrTaO_(4)prepared by hot-press sintering of solid-state reaction synthesized *** the HAADF and ABF-STEM techniques,rutile crystal structure was confirmed and short range ordering was directly *** addition,segregation of Ta and Cr was ***,CrTaO_(4)exhibits elastic/mechanical properties similar to those of yttria stabilized zirconia(YSZ)with Young’s modulus,shear modulus,and bulk modulus of 268,107,and 181 GPa,respectively,and Vickers hardness,flexural strength,and fracture toughness of 12.2±0.44 GPa,142±14 MPa,and 1.87±0.074 MPa·m^(1/2).The analogous elastic/mechanical properties of CrTaO_(4)to those of YSZ has spurred inquiries to lucrative leverage it as a new thermal barrier *** measured melting point of CrTaO_(4)is 2103±20 *** anisotropic thermal expansion coefficients areα_(a)=(5.68±0.10)×10^(-6)K^(-1),α_(c)=(7.81±0.11)×10^(-6)K^(-1),with an average thermal expansion coefficient of(6.39±0.11)×10^(-6)K^(-1).The room temperature thermal conductivity of CrTaO_(4)is 1.31 W·m^(-1)·K^(-1)and declines to 0.66 W·m^(-1)·K^(-1)at 1473 K,which are lower than most of the currently well-known thermal barrier *** the perspective of matched thermal expansion coefficient,CrTaO_(4)per

关键词： microstructure synthesis thermal conductivity thermal expansion coefficient melting point CrTaO_(4) mechanical and thermal properties

Rate-limiting factors in hydrate decomposition through depressurization across various scales:A mini-review

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Chinese Journal of Chemical Engineering 2024年第3期67卷 206-219页

作者： Xian Sun Peng Xiao Qinfeng Shi Lingban wang Zhenbin Xu Yuhao Bu xiaohui wang Yifei Sun Changyu Sun Guangjin Chen State Key Laboratory of Heavy Oil Processing China University of Petroleum(Beijing)Beijing 102249China Jining University Jining 273115China

Natural gas hydrate is an energy resource for methane that has a carbon quantity twice more than all traditional fossil fuels ***,their practical application in the field has been limited due to the challenges of long-term preparation,high costs and associated *** studies,on the other hand,offer a safe and cost-effective means of exploring the mechanisms of hydrate dissociation and optimizing exploitation *** hydrate decomposition is a complicated process along with intrinsic kinetics,mass transfer and heat transfer,which are the influencing factors for hydrate decomposition *** identification of the rate-limiting factor for hydrate dissociation during depressurization varies with the scale of the reservoir,making it challenging to extrapolate findings from laboratory experiments to the actual *** review aims to summarize current knowledge of investigations on hydrate decomposition on the subject of the research scale(core scale,middle scale,large scale and field tests)and to analyze determining factors for decomposition rate,considering the various research scales and their associated influencing factors.

关键词： Gas hydrate Rate-limiting factors Research scale Depressurization Decomposition