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Measurement of Br(n,γ)cross sections up to stellar s-process temperatures at the CSNS Back‑n

Nuclear Science and Techniques 2023年第11期34卷 226-241页

作者： Gao‑Le Yang Zhen‑Dong An Wei Jiang Xian‑Kai Li Wei‑Wei Qiu Zheng‑Fa Liao Zi‑Yue Zhuang xiao‑Ping Zhang Sheng‑Li Chen Chen‑Chen Guo Er‑Xi xiao xiao Fang Xin‑Xiang Li Xin‑Rong Hu Bing Jiang Jin‑Cheng wang Jie Ren Wen luo zhi‑Chao Zhu Hao‑Yang Lan Zong‑Wei Cao Xu Ma Ying‑Du Liu Pu‑Sen wang Yi Yang Ping Su Xian‑Gai Deng Wan‑Bing He Chun‑wang Ma Yu‑Ting wang zhi‑Tao Dai Peng‑qin He Ren‑Guang Tang Tao Zhou Jing wang Han Yi Yue Zhang Yong‑Hao Chen Rui‑Rui Fan Ke‑qing Gao Qiang Li Kang Sun zhi‑Xin Tan Min‑Hao Gu Han‑Tao Jing Jing‑Yu Tang School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China CNSA Macao Center for Space Exploration and Science Macao 999078China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of South ChinaHengyang 421001China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411100China Key Laboratory of Nuclear Physics and Ion‑beam Application(MOE) Institute of Modern PhysicsDepartment of Nuclear Science and TechnologyFudan UniversityShanghai 200433China Institute of Particle and Nuclear Physics Henan Normal UniversityXinxiang 453007China School of Physics Henan Normal UniversityXinxiang 453007China Shenzhen Center Cancer hospitalChinese Academy of Medical SciencesShenzhen 518100China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China

The neutron capture cross sections(n,γ)of bromine were obtained using the time-of-flight technique at the Back-n facility of the China Spallation Neutron ***γ-rays originating from neutron-induced capture events were detected using four C_(6)D_(6) *** pulse-height weighting technique and double-bunch unfolding method based on Bayesian theory were used in the data *** deductions,normalization,and corrections were carefully considered to obtain reliable measurement *** multilevel R-matrix Bayesian code SAMMY was used to extract the resonance parameters in the resolved resonance region(RRR).The average cross sections in the unresolved resonance region(URR)were obtained from 10 to 400 *** experimental results were compared with data from several evaluated libraries and previous experi-ments in the RRR and *** TALYS code was used to describe the average cross sections in the *** astrophysical Maxwell average cross sections(MACSs)of ^(79,81)Br from kT=5 to 100 keV were calculated over a sufficiently wide range of neutron *** a thermal energy of kT=30 keV,the MACS value for ^(79)Br 682±68 mb was in good agreement with the KADoNiS v1.0 recommended *** contrast,the value of 293±29 mb for ^(81)Br was substantially higher than that of the evaluated database and the KADoNiS v1.0 recommended value.

关键词： Time-of-flight technique Neutron capture cross sections Maxwell average cross sections

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Electroacupuncture at Dazhui(GV14) and Mingmen(GV4) protects against spinal cord injury:the role of the Wnt/β-catenin signaling pathway

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Neural Regeneration Research 2016年第12期11卷 2004-2011页

作者： Xin wang Su-hua Shi Hai-jiang Yao quan-kai Jing Yu-ping Mo Wei Lv Liang-yu Song xiao-chen Yuan zhi-gang Li Li-na qin School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese Medicine Department of Rehabilitation The Third Affiliated Hospital of Beijing University of Chinese Medicine Treatment Center of Traditional Chinese Medicine Beijing Bo’ai HospitalChinese Rehabilitation Research CenterSchool of Rehabilitation MedicineCapital Medical University Department of Rehabilitation The Third People’s Hospital of Shenzhen Institute of Microcirculation Chinese Academy of Medical Sciences & Peking Union Medical College

Electroacupuncture at Dazhui（GV14） and Mingmen（GV4） on the Governor Vessel has been shown to exhibit curative effects on spinal cord injury; however, the underlying mechanism remains poorly understood. In this study, we established rat models of spinal cord injury using a modified Allen＇s weight-drop method. Ninety-nine male Sprague-Dawley rats were randomly divided into three equal groups： sham（only laminectomy）, SCI（induction of spinal cord injury at T10）, and EA（induction of spinal cord injury at T10 and electroacupuncture intervention at GV14 and GV4 for 20 minutes once a day）. Rats in the SCI and EA groups were further randomly divided into the following subgroups： 1-day（n = 11）, 7-day（n = 11）, and 14-day（n = 11）. At 1, 7, and 14 days after electroacupuncture treatment, the Basso, Beattie and Bresnahan locomotor rating scale showed obvious improvement in rat hind limb locomotor function, hematoxylin-eosin staining showed that the histological change of injured spinal cord tissue was obviously alleviated, and immunohistochemistry and western blot analysis showed that Wnt1, Wnt3 a, β-catenin immunoreactivity and protein expression in the injured spinal cord tissue were greatly increased compared with the sham and SCI groups. These findings suggest that electroacupuncture at GV14 and GV4 upregulates Wnt1, Wnt3 a, and β-catenin expression in the Wnt/β-catenin signaling pathway, exhibiting neuroprotective effects against spinal cord injury.

关键词： nerve regeneration spinal cord injury electroacupuncture Governor Vessel Dazhui(GV14) acupoint Mingmen(GV4) acupoint Wnt/β-cateninsignaling pathway neuroprotection neural regeneration

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Characterization of 3-inch photomultiplier tubes for the JUNO central detector

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Radiation Detection Technology and Methods 2019年第1期3卷 36-43页

作者： Nan Li Yue-kun Heng Miao He Ji-lei Xu Xuan-tong Zhang Chuan-ya Cao zhi Wu Feng-jiao luo zhi-min wang xiao-yu Yang Mei-hang Xu Zhong-hua qin Yu-zhen Yang Bao-jun Yan Shu-lin Liu State Key Laboratory of Particle Detection and Electronics Beijing 100049China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Science Beijing 100049China

Background Jiangmen Underground Neutrino Observation(JUNO)is one of the largest experimental facilities for neutrino *** its main structure,the central detector contains 20 kiloton liquid scintillator filled in an acrylic shell,and there are 18,00020-inch photomultiplier tubes(PMTs)and 25,0003-inch PMTs covering the *** As an independent photon detection system,3-inch PMTs have been required to have excellent resolution for the single photoelectron detection,high quantum efficiency,small transit time spread and low dark noise *** Two kinds of 3-inch PMTs from HZC Photonics and Hamamatsu have been investigated as candidates.A dedicated test system for 3-inch PMTs has been designed,and various characterization parameters have been *** The preliminary results show these PMTs can meet the requirements of JUNO.

关键词： PMT JUNO SPE quantum efficiency Transit time spread Dark noise

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Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1546-1558页

作者： Hao Li Xia-Ming Jiang Ning Cui Chun Yuan Shao-Fei Zhang qing-Bin Lu Zhen-Dong Yang qin-Lin Xin Ya-Bin Song xiao-Ai Zhang Hai-Zhou Liu Juan Du Xue-Juan Fan Lan Yuan Yi-Mei Yuan Zhen wang Juan wang Lan Zhang Dong-Na Zhang zhi-Bo wang Ke Dai Jie-Ying Bai Zhao-Nian Hao Hang Fan Li-Qun Fang Gengfu xiao Yang Yang Ke Peng Hong-quan wang Jian-Xiong Li Lei-Ke Zhang Wei Liu Beijing Institute of Microbiology and Epidemiology State Key Laboratory of Pathogen and BiosecurityBeijingP.R.China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhanHubeiP.R.China The 154 Hospital Peopled Liberation ArmyXinyangHenanP.R.China School of Public Health Peking UniversityBeijingP.R.China lnstitute of Molecular Medicine Peking UniversityBeijingP.R.China Rongji Medical College Huazhong University of Science and TechnologyWuhanP.R.China Department of Biostatistics and Emerging Pathogens Institute University of FloridaGainesvilleFLUSA Department of Cancer People's Liberation Army General HospitalBeijingP.R.China Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Diseases BeijingP.R.China

Severe fever with thrombocytopenia syndrome(SFTS)virus(SFTSV)is an emerging tick-borne virus with high fatality and an expanding ***,effective anti-SFTSV intervention remains ***(T-705)was recently reported to show in vitro and in animal model antiviral efficacy against ***,we conducted a single-blind,randomized controlled trial to assess the efficacy and safety of T-705 in treating SFTS(Chinese Clinical Trial Registry website,number ChiCTR1900023350).From May to August 2018,laboratory-confirmed SFTS patients were recruited from a designated hospital and randomly assigned to receive oral T-705 in combination with supportive care or supportive care *** outcome occurred in 9.5%(7/74)of T-705 treated patients and 18.3%(13/71)of controls(odds ratio,0.466,95%Cl,0.174-1.247).Cox regression showed a significant reduction in case fatality rate(CFR)with an adjusted hazard ratio of 0.366(95%Cl,0.142-0.944).Among the low-viral load subgroup(RT-PCR cycle threshold>26),T-705 treatment significantly reduced CFR from 11.5 to 1.6%(P=0.029),while no between-arm difference was observed in the high-viral load subgroup(RT-PCR cycle threshold<26).The T-705-treated group showed shorter viral clearance,lower incidence of hemorrhagic signs,and faster recovery of laboratory abnormities compared with the *** in vitro and animal experiments demonstrated that the antiviral efficacies of T-705 were proportionally induced by SFTSV mutation rates,particularly from two transition mutation *** mutation analyses on T-705-treated serum samples disclosed a partially consistent mutagenesis pattern as those of the in vitro or animal experiments in reducing the SFTSV viral loads,further supporting the anti-SFTSV effect of T-705,especially for the low-viral loads.

关键词： effect faster supporting

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Genetic profile of Chinese patients with Charcot-Marie-Tooth disease

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Chinese Medical Journal 2020年第21期133卷 2633-2634页

作者： zhi-Yuan Ouyang You Chen Da-Qiang qin zhi-Dong Cen xiao-Sheng Zheng Fei Xie Si Chen Hao-Tian wang De-Hao Yang Xin-Hui Chen Le-Bo wang Bao-Rong Zhang Wei luo Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Cancer Institute Key Laboratory of Cancer Prevention and InterventionChina National Ministry of EducationThe Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Department of Neurology Affiliated Hospital of Jiangsu UniversityZhenjiangJiangsu 212001China Department of Intensive Care Unit Zhejiang HospitalHangzhouZhejiang 310030China Department of Neurology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiang 310016China Chu Kochen Honors College Zhejiang UniversityHangzhouZhejiang 310058China

To the Editor:Charcot-Marie-Tooth disease(CMT)encompasses a genetically heterogeneous group of inherited neuropathies,characterized by progressive distal muscle weakness and atrophy,sensory deficits,impaired tendon reflexes,and foot deformities.[1]To date,more than 80 causative genes have been identified in CMT patients,associated with either autosomal dominant or recessive inheritance,or X-linked *** traditional classification of CMT was based on peripheral neuropathy type,as determined by nerve conduction *** more causative genes were identified and the overlap of neuropathy phenotypes became apparent,the traditional classification system proved unwieldy and ***,CMT needs to be distinguished from several entities including systemic disorders with neuropathy and other types of hereditary *** clinical practice,overlap of phenotypes can present a major challenge in reaching the correct *** study aimed to investigate the genetic profile in a cohort of Chinese CMT patients and evaluate the role of genetic testing in the diagnosis and subtyping of CMT.

关键词： Marie patients impaired

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胆汁淤积性微环境中甘氨鹅脱氧胆酸钠促进肝脏干细胞凋亡

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解剖学报 2019年第6期50卷 747-753页

作者：李志鹏王健肖程康权罗庆重庆医科大学附属儿童医院肝胆外科重庆400014 儿科研究所干细胞实验室、儿童发育疾病研究所教育部重点实验室、儿童发育重大疾病国家国际科技合作基地儿科学重庆市重点实验室重庆400014

目的探讨在胆汁淤积性肝硬化病理微环境下对肝脏干细胞存活率的影响及体外甘氨鹅脱氧胆酸钠(GCDC)对肝脏干细胞凋亡的影响。方法以Balb/c小鼠胆总管结扎模型模拟胆汁淤积性肝硬化的病理环境并回输肝脏干细胞HP14-19,检测细胞定植存活情... 详细信息

目的探讨在胆汁淤积性肝硬化病理微环境下对肝脏干细胞存活率的影响及体外甘氨鹅脱氧胆酸钠(GCDC)对肝脏干细胞凋亡的影响。方法以Balb/c小鼠胆总管结扎模型模拟胆汁淤积性肝硬化的病理环境并回输肝脏干细胞HP14-19,检测细胞定植存活情况;通过细胞计数试剂盒8(CCK-8)、结晶紫染色检测甘氨鹅脱氧胆酸钠对增殖的影响,流式细胞术检测细胞凋亡,通过Western blotting检测凋亡标志物Bax、Bcl-2、Caspase-3表达和磷酸化腺嘌呤核苷二磷酸依赖性蛋白激酶α(p-AMPKα)、腺嘌呤核苷二磷酸依赖性蛋白激酶α(AMPKα)等的表达。结果通过CCK-8检测和结晶紫染色发现,随着甘氨鹅脱氧胆酸钠作用浓度的增加,HP14-19细胞的增殖抑制;流式细胞术提示,GCDC处理组细胞凋亡率明显增加(P<0. 05);Western blotting检测发现,与对照组相比,实验组凋亡基因Bax、Caspase-3蛋白表达上调,抗凋亡基因Bcl-2蛋白表达下调,AMPKα活化增加(P<0. 05)。结论胆汁淤积性肝硬化所导致的胆汁淤积微环境诱导肝脏干细胞发生凋亡。

关键词：胆汁淤积性肝硬化甘氨鹅脱氧胆酸钠肝脏干细胞免疫印迹法小鼠

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评价风险评估方法有效性的DEA模型

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电子科技大学学报 2014年第4期43卷 581-584页

作者：杨晓明罗衡峰王佳昊秦志光电子科技大学计算机科学与工程学院成都611731 工业和信息化部电子第五研究所广州510610

决定信息安全评估结果是否科学有效的前提和基础是选择正确的风险评估方法,因此如何选择就成为关键。该文将模糊综合评价方法和数据包络(DEA)方法相结合,提出一种筛选评估方法的数学模型,用于评价风险评估方法的有效性。该方法充分考虑... 详细信息

决定信息安全评估结果是否科学有效的前提和基础是选择正确的风险评估方法,因此如何选择就成为关键。该文将模糊综合评价方法和数据包络(DEA)方法相结合,提出一种筛选评估方法的数学模型,用于评价风险评估方法的有效性。该方法充分考虑评价指标的客观性,从工程的角度综合计算进行风险评估活动的投入与产出,从定量的角度考察风险评估的评估效果,该方法具有良好的可操作性,为风险评估人员筛选更有效、科学、合理的评估方法提供一个具有实用价值的数学工具。

关键词： DEA模型模糊综合评价法风险评估方法有效性

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利用多重示踪技术研究正常鼠和肿瘤鼠的微量元素代谢(英文)

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原子核物理评论 2008年第3期25卷 300-304页

作者：王潇张翔秦芝孔福全赵葵中国原子能科学研究院北京102413 Department of Chemistry University of Louisville 中国科学院近代物理研究所甘肃兰州730000

利用25 MeV/u40Ar +Se中能重离子核反应,制备包含24种元素在内的多重示踪剂,通过对元素γ谱的分析,研究了正常鼠和肿瘤鼠体内微量元素的分布及代谢。Mg,Sr, Ga, As,Sc, V, Cr, Mo, Co,Fe, Y,Zr, Nb和Ru等元素在肿瘤鼠的粪便和尿液中的... 详细信息

利用25 MeV/u40Ar +Se中能重离子核反应,制备包含24种元素在内的多重示踪剂,通过对元素γ谱的分析,研究了正常鼠和肿瘤鼠体内微量元素的分布及代谢。Mg,Sr, Ga, As,Sc, V, Cr, Mo, Co,Fe, Y,Zr, Nb和Ru等元素在肿瘤鼠的粪便和尿液中的排泄时间与正常鼠不同。肿瘤鼠与正常鼠相比,Na, Mn,Fe和Co的排泄变化较大,肿瘤鼠的排泄率较正常鼠高;而Ca, Y,Zr和Mo的排泄率肿瘤鼠则较正常鼠低;在正常鼠脏器、组织和血液样品中测出了Na,Rb,Ga,Sc, As,Zn, V,Cr, Mn,Co,Fe、Y,Zr, Tc, Ru, Ag和In等17种元素,肿瘤鼠检测出了除Zn和As之外的其它15种元素。几乎所有的元素在正常鼠中的吸收均比肿瘤鼠高。大部分元素分布在肝、肾和毛皮以及实体瘤中,而Fe和Na在肿瘤组织则没有检测到。

关键词：多重示踪剂微量元素代谢肿瘤鼠

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Nucleic acids analysis

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Science China Chemistry 2021年第2期64卷 171-203页

作者： Yongxi Zhao xiaolei Zuo Qian Li Feng Chen Yan-Ru Chen Jinqi Deng Da Han Changlong Hao Fujian Huang Yanyi Huang Guoliang Ke Hua Kuang Fan Li Jiang Li Min Li Na Li Zhenyu Lin Dingbin Liu Juewen Liu Libing Liu xiaoguo Liu Chunhua Lu Fang luo Xiuhai Mao Jiashu Sun Bo Tang Fei wang Jianbin wang Lihua wang Shu wang Lingling Wu Zai-Sheng Wu Fan Xia Chuanlai Xu Yang Yang Bi-Feng Yuan quan Yuan Chao Zhang zhi Zhu Chaoyong Yang xiao-Bing Zhang Huanghao Yang Weihong Tan Chunhai Fan Institute of Analytical Chemistry and Instrument for Life Science The Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and NanomedicineRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesInstitute of Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China Cancer Metastasis Alert and Prevention Center Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and ChemotherapyState Key Laboratory of Photocatalysis on Energy and EnvironmentCollege of ChemistryFuzhou UniversityFuzhou 350108China CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China State Key Lab of Food Science and Technology International Joint Research Laboratory for Biointerface and BiodetectionSchool of Food Science and TechnologyJiangnan UniversityWuxi 214122China Faculty of Materials Science and Chemistry Engineering Research Center of Nano-Geomaterials of Ministry of EducationChina University of GeosciencesWuhan 430074China College of Chemistry and Molecular Engineering Biomedical Pioneering Innovation Center(BIOPIC)Beijing Advanced Innovation Center for Genomics(ICG)Peking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Division of Physical Biology CAS Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China Bioimaging Center Shanghai Synchrotron Radiation FacilityZhangjiang LaboratoryShanghai Advanced

Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies, clinical diagnosis, environmental analysis, food safety and forensic *** the past decades, the field of nucleic acids analysis has been rapidly advancing with many technological *** this review, we focus on the methods developed for analyzing nucleic acids, nucleic acids-based analysis, device for nucleic acids analysis, and applications of nucleic acids analysis. The representative strategies for the development of new nucleic acids analysis in this field are summarized, and key advantages and possible limitations are discussed. Finally, a brief perspective on existing challenges and further research development is provided.

关键词： nucleic acids analysis signal amplification DNA nanotechnology aptamer biosensing

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Development of 3He-filled linear position-sensitive detector for neutron scattering instruments at CSNS

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Radiation Detection Technology and Methods 2023年第1期7卷 100-106页

作者： Lin Zhu Jian-rong Zhou Xin-feng Jiang xiao-juan Zhou Wen-qin Yang Yuan-Guang Xia Liang xiao Hong luo Bei-ju Guan Yan-feng wang Hong Xu Pei-xun Shen Hai-yun Teng Jia-jie Li Gui-an Yang Ju-ping Xu Huai-can Chen Song-lin wang Jian Zhuang Jun-rong Zhang Wen Yin zhi-jia Sun Yuan-bo Chen Tianjiao Liang Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Spallation Neutron Source Science Center Dongguan523803GuangdongChina University of Chinese Academy of Sciences Beijing100049China

Background Helium-3-filled linear position-sensitive detectors(LPSDs)have been widely applied to neutron scattering instruments in recent decades owing to the high detection efficiency,the excellent neutron/gamma discrimination,and the ability to construct the detector with large area *** than 65%of neutron instruments at the China Spallation Neutron Source(CSNS)require ^(3)He LPSDs for the building of the detector *** detector of a neutron scattering instrument is normally an array detector composed of a large number of ^(3)He ***,no appropriate substitute detector is available for the ^(3)He LPSD for operation over a short period,and its specifications need to be customized to satisfy the requirements of different *** necessitates the development of ^(3)He LPSDs with different specifications for building and upgrading the detectors of neutron scattering instruments at *** To meet the general requirements specified by the neutron instruments at CSNS,a ^(3)He LPSD was developed and its performances were investigated by using the neutron *** The neutron beam experiments for this ^(3)He LPSD,including measurements of counting rate plateau curve,position calibration,and position resolution along the tube path,were carried out at the beamline-20 of *** evaluate its performance in the instrument operation,a detector module made of this ^(3)He LPSD has been installed in the multi-physics instrument(MPI),and the comparison test with the commercial ^(3)He LPSD has been conducted at neutron scattering *** and conclusion The experimental measurements for this ^(3)He LPSD based on the neutron beam showed that it satisfies the requirements for use in neutron scattering *** reaches a plateau slope of 2.6%/100 V with a plateau range from 1750 to 1950 V and attained a minimal position resolution of 5.3 mm(FWHM),superior to the one achieved by the commercial ^(3)He *** addition,this ^(3)He

关键词： Counting rate CSNS LPSD Plateau curve Position resolution

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