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新建裂解炉COT偏差大的原因分析及处理措施

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化工机械 2024年第2期51卷 310-316,322页

作者：王晓博中国石化海南炼油化工有限公司

针对新建裂解炉投料开车后出现COT偏差大的问题,通过优化COT控制方案、调整热电偶安装高度、落实施工质量、更换热电偶本体保温等方式,对裂解炉贴壁式热电偶进行了整改优化,最终达到操作要求。

关键词：裂解炉 COT偏差贴壁式热电偶保温

分析达格列净片联合麝香保心丸治疗射血分数降低心力衰竭急性发作期的临床疗效

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中国现代药物应用 2024年第13期18卷 19-22页

作者：王小波成武县人民医院药剂科 274200

目的对射血分数降低心力衰竭急性发作期患者使用达格列净片联合麝香保心丸进行治疗的效果做出分析。方法选择160例心力衰竭患者,该类患者均处在急性发作期,且射血分数降低,在随机抽样法方式下将患者划分成常规组和研究组,各80例。常规... 详细信息

目的对射血分数降低心力衰竭急性发作期患者使用达格列净片联合麝香保心丸进行治疗的效果做出分析。方法选择160例心力衰竭患者,该类患者均处在急性发作期,且射血分数降低,在随机抽样法方式下将患者划分成常规组和研究组,各80例。常规组患者使用达格列净片治疗,研究组使用达格列净片联合麝香保心丸治疗。对比分析两组患者的治疗效果、心室功能水平、心力衰竭标志物、中医证候积分。结果研究组治疗总有效率为98.75%,高于常规组的90.00%(χ^(2)=5.768,P<0.05)。研究组左室收缩末期内径、左室射血分数、左室舒张末内径分别为(35.13±2.08)mm、(58.71±2.87)%、(52.85±2.56)mm,均优于常规组的(39.56±2.51)mm、(43.10±2.43)%、(56.81±3.13)mm(t=12.154、37.127、8.759,P<0.05)。研究组N末端脑钠肽前体、血浆内脑钠肽水平分别为(1510.36±160.35)、(601.40±98.87)ng/L,均优于常规组的(2219.63±152.58)、(829.53±121.36)ng/L(t=28.660、13.035,P<0.05)。研究组治疗1、2周的中医证候积分分别为(16.08±6.84)、(11.27±9.71)分,均低于常规组的(24.28±10.39)、(20.25±13.26)分(t=5.896、4.887,P<0.05)。结论为射血分数降低心力衰竭急性发作期患者使用达格列净片联合麝香保心丸进行治疗,能够改善患者心室功能,降低患者心力衰竭标志物水平,提升治疗效果,临床应用价值较高。

关键词：达格列净片麝香保心丸射血分数心力衰竭急性发作期疗效

对行PCI患者应用尼可地尔联合氯吡格雷或替格瑞洛的临床效果对比

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中国实用医药 2024年第15期19卷 6-10页

作者：王小波成武县人民医院药剂科 274200

目的探究行经皮冠状动脉介入治疗(PCI)患者联合使用尼可地尔与氯吡格雷或替格瑞洛治疗的临床效果。方法从行PCI治疗的患者中随机抽取100例,并以抽签法分为氯吡格雷组与替格瑞洛组,各50例。两组患者均给予尼可地尔治疗,在此基础上,氯吡... 详细信息

目的探究行经皮冠状动脉介入治疗(PCI)患者联合使用尼可地尔与氯吡格雷或替格瑞洛治疗的临床效果。方法从行PCI治疗的患者中随机抽取100例,并以抽签法分为氯吡格雷组与替格瑞洛组,各50例。两组患者均给予尼可地尔治疗,在此基础上,氯吡格雷组使用氯吡格雷治疗,替格瑞洛组使用替格瑞洛治疗。对比两组患者心功能指标[左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)以及左心室射血分数(LVEF)]、心血管不良事件发生率、TIMI血流分级以及炎性细胞因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)以及C反应蛋白(CRP)]水平。结果术后1周,两组患者LVEDD、LVESD、LVEF均有改善,且替格瑞洛组患者LVEDD(46.14±4.05)mm与LVESD(30.01±3.07)mm均低于氯吡格雷组的(52.03±3.37)、(35.66±3.25)mm,而LVEF(59.38±4.37)%比氯吡格雷组的(50.75±4.06)%更高,组间有统计学差异(P<0.05)。替格瑞洛组心血管不良事件发生率4.00%低于氯吡格雷组的16.00%,组间有统计学差异(P<0.05)。术后1周,替格瑞洛组患者TNF-α、CRP、IL-6水平分别为(3.32±0.66)ng/ml、(3.44±0.87)mg/L、(2.04±0.66)ng/L,显著低于氯吡格雷组的(4.01±0.81)ng/ml、(4.22±1.63)mg/L、(3.05±0.83)ng/L,组间有统计学差异(P<0.05)。替格瑞洛组患者血流分级明显优于氯吡格雷组,组间有统计学差异(Z=3.313,P=0.001<0.05)。结论在尼可地尔基础上使用替格瑞洛或者氯吡格雷均有显著效果,可改善PCI手术患者心功能并预防心血管不良事件发生,但替格瑞洛对患者心功能指标改善更佳,可减轻患者炎性反应,且使用安全性较高,更有利于患者预后效果提升。

关键词：经皮冠状动脉介入治疗尼可地尔氯吡格雷替格瑞洛炎性因子

Photon Counting Optical Time Domain Reflectometry Applying a Single Photon Modulation Technique

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Chinese Physics Letters 2011年第7期28卷 20-22页

作者： wang xiao-bo wang Jing-Jing HE bo xiao Lian-Tuan JIA Suo-Tang State Key Laboratory of Quantum Optics and Quantum Optics Devices Laser Spectroscopy LaboratoryShanxi UniversityTaiyuan 030006

Photon-counting optical time domain reflectometry(v-OTDR)is typically used in a mode with spatial resolution in the centimeter *** we demonstrate a 1550 nm v-OTDR system to optimize the discriminate voltage of a single photon avalanche detector using a single photon modulation and demodulation technique,which shows obvious improvement in the signal *** intensity of signal is doubled when the discriminator voltage is optimized from 184 mV to 162 mV.

关键词： typically doubled system

红景天苷对血管张力调节作用及分子机制的研究进展

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中药与临床 2024年第2期15卷 96-100页

作者：陈洁王小博孟宪丽陈小睿成都中医药大学药学院/现代中药产业学院四川成都611137 成都中医药大学中医药创新研究院/交叉学科研究院四川成都611137

红景天苷是从藏药红景天根及根茎中提取的活性成分,在现代研究中发现其具有抗炎、抗氧化、调节免疫,以及保护重要脏器血管的作用。血管舒缩功能障碍是血管类疾病诊断中的常见症状,也是此类疾病继续发展的重要原因。中药在防治血管舒缩... 详细信息

红景天苷是从藏药红景天根及根茎中提取的活性成分,在现代研究中发现其具有抗炎、抗氧化、调节免疫,以及保护重要脏器血管的作用。血管舒缩功能障碍是血管类疾病诊断中的常见症状,也是此类疾病继续发展的重要原因。中药在防治血管舒缩功能障碍方面具有一定的优势,其中,红景天中的有效成分红景天苷对血管张力调节具有良好作用。本文通过内皮依赖性途径和非内皮依赖性途径对红景天苷影响血管舒缩状态的机制研究展开综述,为进一步研究红景天苷防治血管舒缩功能障碍提供理论依据。

关键词：血管舒缩功能障碍红景天苷血管内皮细胞血管平滑肌细胞作用机制

Synthesis, Crystal Structures, DNA Cleavage and DNA-binding Studies of Ho(Ⅲ) and Er(Ⅲ)Complexes Based on Macrocyclic Schiff Base

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Chinese Journal of Structural Chemistry 2020年第6期39卷 1103-1111页

作者： wang xiao-bo YU xiao-Qi HU Xue-Lei School of Chemical Engineering&Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Pharmacy Hubei University of Science and TechnologyXianningHubei 437100China Hubei Geological Research Laboratory Wuhan 430034China

Two novel macrocyclic Schiff base complexes[LnL(PhCOO)(CH3OH)](ClO4)2·(CH3OH)2(Ln=Ho,1;Ln=Er,2),in which L denotes the macrocyclic ligand,were synthesized via condensation of 2,6-diformyl-4-methyl-phenol and 1,3-diamino-2-propanol by employing benzoate as the second *** crystal structures were determined by X-ray diffraction,which showed that both complexes belong to a monoclinic system with space group P21/*** coordination polyhedron displayed a distorted bicapped trigonal prism with the coordination number of *** complexes efficiently cleaved supercoiled DNA to its nicked circular *** UV-vis absorption results and ethidium bromide(EB)fluorescence spectra indicated that the complexes bind to CT-DNA in an intercalative mode,with Ksq values to be 11830 and 10560,respectively.

关键词： macrocyclic Schiff base crystal structure CT-DNA pBR 322 fluorescence spectrum

Effect of chlorpyrifos on soil microbial populations and enzyme activities

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Journal of Environmental Sciences 2006年第1期18卷 4-5页

作者： SHAN Min FANG Hua wang xiao FENG bo CHU xiao-qiang YU Yun-long Department of Plant Protection College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China

Chlorpyrifos is an organophosphate pesticide that acts as an insecticide-acaricide by ingestion, contact, and inhalation, and is now widely used in greenhouse for the control of pests. The dissipation of chlorpyrifos in crops such as orange fruit （Martinez-Vidal et al., 1998）, tomatoes（Aysal et al., 1999）, soil and its effects on soil microbial characteristics （Singh et al., 2002） has been reported frequently. However, little information is available to describe impacts of chlorpyrifos on soil microbial population and enzyme activity in greenhouse. In this study, the effect of chlorpyrifos on soil bacteria, fungi, actinomycetes, and soil enzyme activity was investigated.

关键词： chlorpyrifos microorganism soil enzyme

miR-34a和米铂共载阳离子脂质体的构建及抗肿瘤活性研究

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中国医药生物技术 2024年第5期19卷 410-419页

作者：王丹孟月王晓葳王雪蕾王晓波苏嘉怡夏桂民中国医学科学院北京协和医学院医药生物技术研究所制剂研究室北京100050

目的构建共载miR-34a和米铂阳离子脂质体,以协同增效,用于肿瘤的化疗。方法采用薄膜分散法制备米铂阳离子脂质体(MCL),将MCL与miR-34a共孵育,构建共载miR-34a和米铂的阳离子脂质体(MCL/miR-34a)。以粒径及多分散系数、电位、米铂含量... 详细信息

目的构建共载miR-34a和米铂阳离子脂质体,以协同增效,用于肿瘤的化疗。方法采用薄膜分散法制备米铂阳离子脂质体(MCL),将MCL与miR-34a共孵育,构建共载miR-34a和米铂的阳离子脂质体(MCL/miR-34a)。以粒径及多分散系数、电位、米铂含量和抗肿瘤活性为指标,对辅助磷脂(DOPE、DOPC、DMPC、DSPC、PC-98T)的种类、阳离子磷脂DOTAP/DOPE比、N/P、DSPE-mPEG2000及胆固醇用量进行筛选;选用磺酰罗丹明B染色法在细胞(人乳腺癌细胞系MDA-MB-231、人肝癌细胞系HepG2、人口腔表皮样癌细胞系KB和人胰腺癌细胞系As PC-1)水平评价MCL/miR-34a的抗肿瘤活性。结果构建的MCL/miR-34a粒径均匀[(200±23)nm]且分布窄(PDI=0.242±0.01)、电位适宜[(45±8)m V]、包封率高(miR-34a的包封率99.2%,米铂的包封率99.8%),细胞水平上抗肿瘤活性显著优于单药米铂或mi R-34a。结论成功构建的MCL/miR-34a可显著提高miR-34a和米铂的体外抗肿瘤活性,为核酸药物与小分子化疗药物共同递送提供新策略。

关键词：阳离子脂质体米铂 miR-34a 抗肿瘤活性

Changes in speciation,mobility and bioavailability of Cd,Cr and As during the transformation process of pig manure by black soldier fly larvae(Hermetia illucens)

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Journal of Integrative Agriculture 2021年第5期20卷 1157-1166页

作者： wang xiao-bo WU Nan CAI Rui-jie GENG Wei-na XU xiao-yan College of Agronomy and Resource and Environment Tianjin Agricultural UniversityTianjin 300384P.R.China College of Engineering and Technology Tianjin Agricultural UniversityTianjin 300384P.R.China

The black soldier fly larvae(BSFL)(Hermetia illucens)are a good candidate for poultry and livestock manure *** harvested insect bodies and feces can be used as animal feed and organic ***,heavy metals have a negative impact on the transformation process of the manure by *** we evaluated the effects of Cd,Cr and As in pig manure on the growth of BSFL,as well as the mobility and changes in speciation of the metals during the transformation *** results showed that As significantly reduced the weight of BSFL,but Cr and Cd had no significant effects on BSFL *** bioaccumulation factors(BAFs)at various concentrations of Cd(2.8–3.7)were significantly higher than those of Cr(0.44–0.62)and As(0.43–0.45).The heavy metals in pig manure were mainly transferred to BSFL feces,and the distribution percentages of Cd,Cr and As in the BSFL feces were 52.6–62.0%,90.3–94.2%and 93.0–93.3%,*** concentrations in BSFL feces were significantly lower than those in the pig manure,while there were no significant differences in the concentrations of Cr and As between BSFL feces and pig manure(except for the treatment with the addition of 150 mg Cr kg^(–1)).The metal speciation(weak acid soluble,reducible,oxidizable and residual fractions)in BSFL feces obviously changed when compared with pig *** BSFL feces,the reducible proportion of Cr decreased while the oxidizable proportion *** mainly existed in the weak acid soluble and reducible states in pig manure and BSFL *** As,the proportions of weak acid soluble and reducible states decreased in BSFL *** the BSFL transformation process,the bioavailable fraction of Cr decreased by 17.3–23.1%,but those of Cd and As did not change significantly,except for As in the CK *** findings contribute to our understanding of the roles of BSFL during the biotransformation process of livestock manure as well as the safe utilization of transformed products.

关键词： black soldier fly heavy metal mobility speciation pig manure