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Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai wang Yanbo Liang Chao wang Yunhong Zhang hong Liu Yu Zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

响应面法优化超声提取波罗蜜叶中总黄酮的工艺

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中药材 2011年第7期34卷 1125-1129页

作者：汪洪武刘艳清汪远红肇庆学院化学化工学院广东肇庆526061 肇庆市结核病防治所广东肇庆526020

目的:以乙醇为提取剂,用超声辅助法从波罗蜜叶中提取总黄酮。方法:通过单因素试验分别考察乙醇体积分数、浸提时间和液料比对波罗蜜黄酮提取量的影响,确定各因素的适宜水平。在此基础上,利用Design-Ex-pert软件Box-Behnken中心组合设计... 详细信息

目的:以乙醇为提取剂,用超声辅助法从波罗蜜叶中提取总黄酮。方法:通过单因素试验分别考察乙醇体积分数、浸提时间和液料比对波罗蜜黄酮提取量的影响,确定各因素的适宜水平。在此基础上,利用Design-Ex-pert软件Box-Behnken中心组合设计法设计响应面分析乙醇体积分数、超声时间和液料比3个因素对总黄酮提取率的影响,并通过方差分析回归建立数学模型。结果:波罗蜜叶黄酮超声提取的最佳工艺为:乙醇体积分数为69.4%,超声32 min,液料比为22.6∶1 mL/g,在此条件下,黄酮提取量达到7.55 mg/g。结论:Box-Behnken设计结合响应面分析法可以很好地对波罗蜜叶总黄酮超声提取工艺进行优化。

关键词：波罗蜜黄酮响应面分析工艺优化

Preparation of recombinant human bone morphogenetic protein-2 loaded dextran-based microspheres and their characteristics

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Acta Pharmacologica Sinica 2005年第9期26卷 1093-1103页

作者： Fa-ming CHEN~(2,3) Zhi-fen wu~3 Qin-tao wang~3 hong wu~4 Yong-jie ZHANG~2 Xin NIE~2 Yan JIN~(2,5)2 Center for Tissue Engineering,College of Stomatology 3 Department of Periodontology and Mucosal Diseases,College of Stomatology 4 Department of Chemistry,Faculty of Preclinical Medicine,the Fourth Military Medical University,Xi-an 710032,China Center for Tissue Engineering College of Stomatology the Fourth Military Medical University Xi-an China Department of Periodontology and Mucosal Diseases College of Stomatology the Fourth Military Medical University Xi-an China Department of Chemistry Faculty of Preclinical Medicine the Fourth Military Medical University Xi-an China

Aim:To prepare new pharmaceutical forms with sustained delivery properties ofrecombinant human bone morphogenetic protein-2（rhBMP2）for tissue engineer-ing and guided tissue regeneration（GTR）***:rhBMP2-1oaded dextran-based hydrogel microspheres（rhBMP2-MPs）,which aimed to keep rhBMP2 bioac-tivity and to achieve long-term sustained release of rhBMP2,were prepared bydouble-phase emulsified condensation *** physical,chemicalperformances and biological characteristics of those microspheres were studiedboth in vitro and in ***:The microspheres' average diameter was30.33±4.32μm with 75.4% ranging from 20 μm to 40 μm and the drug loading andencapsulation efficiency were 7.82% and 82.25%,*** rhBMP2-releasing profiles in vitro showed that rhBMP2release could be maintained morethan 10 *** rhBMP2-MPs,with good swelling and biodegradation behavior,could be kept for 6 months at below 4 ℃ without significant characteristic changeor bioactivity *** studies showed that rhBMP2-MPs could promotethe proliferation of periodontal ligament cells（PDLCs）approximately 10 d,whilethe bioactivity of concentrated rhBMP2solution could keep no more than 3 *** electron microscope showed that rhBMP2-MPs could be enchased intothe porous structure of calcium phosphate ceremic（CPC）and the eugonic growthof PDLCs in CPC/rhBMP2-MPs *** experiments indicated that us-ing CPC/rhBMP2-MPs scaffolds could gain more periodontal tissue regenerationthan using rhBMP2compound firsthand with CPC（CPC/rhBMP2）.Conclusion:By encapsulating rhBMP2into dextran-based microspheres,a small quantity ofrhBMP2could achieve equivalent effects to the concentrated rhBMP2solutionand at the same time,could prolong rhBMP2retention both in vitro and in vivo.

关键词： bone morphogenetic proteins drug delivery system sustained-release tissue regeneration

A functional cathode sodium compensation agent for stable sodium-ion batteries

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Green Energy & Environment 2025年第1期10卷 173-182页

作者： Wei wu Zhenglin Hu Zhengfei Zhao Aoxuan wang Jiayan Luo Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China Shanghai Jiao Tong University Shaoxing Research Institute of Renewable Energy and Molecular Engineering Shaoxing312000China

Hard carbon(HC)is widely used in sodium-ion batteries(SIBs),but its performance has always been limited by lowinitial Coulombic efficiency(ICE)and cycling *** compensation agent is a favorable strategy to make up for the loss of active sodium ions consumed *** it lacks agent that effectively decomposes to increase the active sodium ions as well as regulate carbon defects for decreasing the irreversible sodium ions ***,we propose 1,2-dihydroxybenzene Na salt(NaDB)as a cathode compensation agent with high specific capacity(347.9 mAh g^(-1)),lower desodiation potential(2.4–2.8 V)and high utilization(99%).Meanwhile,its byproduct could functionalize HC with more C]O groups and promote its reversible ***,the presodiation hard carbon(pHC)anode exhibits highly reversible capacity of 204.7 mAh g^(-1) with 98%retention at 5 C rate over 1000 ***,with 5 wt%NaDB initially coated on the Na3V2(PO4)3(NVP)cathode,the capacity retention of NVP t NaDBjHC cell could increase from 22%to 89%after 1000 cycles at 1 C *** work provides a new avenue to improve reversible capacity and cycling performance of SIBs through designing functional cathode compensation agent.

关键词： Hard carbon ICE Cathode compensation agent Reversible capacity Stability

西辽河地区史前聚落的时空演变与生业模式和气候历史的相关性研究

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地球科学进展 2016年第11期31卷 1159-1171页

作者：王琳武虹贾鑫华侨大学建筑学院福建厦门361021 南京大学地理与海洋科学学院江苏南京210023

西辽河地区是中国北方农业文明的重要发源地之一。随着近年来文物普查、遗址发掘和环境考古工作的不断深入,该地区史前文化的时间序列、文化内涵和生业模式变得更加清晰。史前人类对自然资源的开发历史、生业模式变化的气候背景及其对... 详细信息

西辽河地区是中国北方农业文明的重要发源地之一。随着近年来文物普查、遗址发掘和环境考古工作的不断深入,该地区史前文化的时间序列、文化内涵和生业模式变得更加清晰。史前人类对自然资源的开发历史、生业模式变化的气候背景及其对文明进程的影响等问题引起了广泛关注。已有的工作大多采用传统环境考古手段进行遗址内调查,很少采用定量方法分析宏观尺度的遗址分布和聚集模式。在数字化大量文物普查数据的基础上,GIS的核密度分析被用来反映西辽河地区史前文化的聚集模式,并通过三维视角转换和海拔统计来反映遗址分布重心在纬向、经向及高程上的变化规律。通过对比空间分析结果和已有的生业模式研究及古气候记录,揭示了研究区史前聚落的时空分布与当时的生业模式和气候环境之间的关联,也有助于史前人地关系研究中海量遗址位置信息的理解和使用。

关键词： GIS 环境考古时空演变生业模式西辽河地区

Estimation of Chloride Diffusivity in Hydrated Tricalcium Silicate Using a Hydration-Diffusion Integrated Method

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Journal of wuhan University of Technology(Materials Science) 2025年第1期40卷 49-64页

作者： wang Xin SHEN Dejian TAO Sijie LIU Ruixin wu Shengxing College of Civil and Transportation Engineering Hohai UniversityNanjing 210098China

This study aims to develop a chloride diffusion simulation method that considers the hydration microstructure and pore solution properties during the hydration of tricalcium silicate(C3S).The method combines the hydration simulation,thermodynamic calculation,and finite element analysis to examine the effects of pore solution,including effect of electrochemical potential,effect of chemical activity,and effect of mechanical interactions between ions,on the chloride effective diffusion coefficient of hydrated C3S *** results indicate that the effect of electrochemical potential on chloride diffusion becomes stronger with increasing hydration age due to the increase in the content of hydrated calcium silicate;as the hydration age increases,the effect of chemical activity on chloride diffusion weakens when the number of diffusible elements decreases;the effect of mechanical interactions between ions on chloride diffusion decreases with the increase of hydration age.

关键词： tricalcium silicate simulation method chloride diffusion coefficient pore solution

第16届世界杯前4名球队整体阵容组合结构特点的研究

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西安体育学院学报 1999年第3期16卷 50-53页

作者：王洪武西安体育学院足球教研室陕西西安710068

通过对第１６届世界杯前４名球队整体阵容组合的结构特点方面进行了较系统、深入的分析与研究，揭示了现今世界足球优秀球队在整体阵容组合的本质特征，为丰富我国的足球理论水平，为我国各级球队的整体组合，提供了有一定价值的... 详细信息

通过对第１６届世界杯前４名球队整体阵容组合的结构特点方面进行了较系统、深入的分析与研究，揭示了现今世界足球优秀球队在整体阵容组合的本质特征，为丰富我国的足球理论水平，为我国各级球队的整体组合，提供了有一定价值的依据。

关键词：世界杯前4名球队阵容组合结构特点

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考虑时间价值的路内停车巡航行为建模

交通运输系统工程与信息 2015年第4期15卷 187-191,221页

作者：丁浣郭宏伟张余杰王武宏北京理工大学交通工程系北京100081

停车者在到达目的地后可能以低速寻找路内停车位,这种巡航行为不仅造成交通拥堵,还增加了能源消耗和环境负担.基于停车者停车选择行为,综合分析停车持续时间、停车后到达目的地的步行时间及停车费用等因素的关系,并且考虑时间价值的影响... 详细信息

停车者在到达目的地后可能以低速寻找路内停车位,这种巡航行为不仅造成交通拥堵,还增加了能源消耗和环境负担.基于停车者停车选择行为,综合分析停车持续时间、停车后到达目的地的步行时间及停车费用等因素的关系,并且考虑时间价值的影响,建立了路内巡航停车行为模型.模型以停车选择过程的时间价值为基础,定量化描述停车价格对路内停车巡航行为的影响.结果显示,停车价格对调节巡航时间具有杠杆作用,非工作出行的巡航时间要长于工作出行.模型有助于解析影响巡航停车行为的关键决策变量,利用变量间的相关关系实现停车价格的优化调整,从而引导停车选择行为实现路内停车与路外停车的平衡.

关键词：城市交通路内停车巡航停车价格优化城市交通管理停车选择行为

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小议“虚不受补”

中国中医基础医学杂志 2015年第12期21卷 1483-1484页

作者：王波王洪武中国人民解放军第309医院北京100091 天津中医药大学中医学院天津300193

受《内经》所论"传化之府受五脏之浊气"的启发,对临床"虚不受补"理论进行分析,提出临床虚不受补可能是由于脏腑功能虚弱导致五脏浊气久留体内、因虚致实,补益药不能与正气相接反助邪生患。强调临床治疗需明辨虚实,以免出现虚虚实实的错误。

关键词：素问五藏别论浊气虚不受补