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透过散射介质的散斑统计特性研究

物理实验 2024年第5期44卷 47-53页

作者：林艾扬罗永锜王文皓谢欣欣杨家瑶吴欣然罗劲明张海宁嘉应学院物理与电子工程学院广东梅州514015

复杂散射介质的衍射通常会形成散斑图像,该特性使得其在激光技术、电子和光电子等领域具有重要的应用价值.搭建了透过散射介质衍射形成的散斑测量系统,研究了CCD曝光时间、衍射距离和散射面直径对散斑统计特性的影响.实验结果表明:改变... 详细信息

复杂散射介质的衍射通常会形成散斑图像,该特性使得其在激光技术、电子和光电子等领域具有重要的应用价值.搭建了透过散射介质衍射形成的散斑测量系统,研究了CCD曝光时间、衍射距离和散射面直径对散斑统计特性的影响.实验结果表明:改变光学系统参量,透过散射片的散斑特性也会随之改变;选择合适的曝光时间能够获取对比度和光强分布适中的散斑图像,其空间衍射特性可用散斑平均尺寸表征,但对于散斑特性的微小变化,则可利用相关系数和数字图像相关结果进行辅助分析.

关键词：散射介质衍射散斑统计特性

从致使动词到目的连词——海外华语中“俾”字句的来源及演变

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语言科学 2020年第3期19卷 279-288页

作者：王文豪暨南大学华文学院/海外华语研究中心广东广州510610

当前的现代汉语普通话中,目的连词"俾"基本消失,其来源致使动词"俾"的使用也极其受限,但这些用法在海外华语中却较为常见。梳理历时语料发现,古汉语中致使动词"俾",在特定条件下,经过语法化,演变为目的连词,表"以便"。

关键词：俾致使动词目的连词语法化海外华语

基于AHP理论的精准扶贫满意度评价指标体系构建

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统计与决策 2020年第15期36卷 60-64页

作者：王文豪新疆财经大学财政税务学院乌鲁木齐830012

文章在分析官方精准扶贫政策和专家咨询的基础上,运用层次分析法将反映精准扶贫满意度的指标进行层次分解,构建包含基层政府组织、扶贫政策、帮扶措施、帮扶成效4个一级测评指标和16个二级测评指标的精准扶贫满意度评价指标体系,对影响... 详细信息

文章在分析官方精准扶贫政策和专家咨询的基础上,运用层次分析法将反映精准扶贫满意度的指标进行层次分解,构建包含基层政府组织、扶贫政策、帮扶措施、帮扶成效4个一级测评指标和16个二级测评指标的精准扶贫满意度评价指标体系,对影响指标的因素进行定量分析,确定指标权重并予以排序。

关键词：精准扶贫满意度指标体系层次分析法

The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats

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International Journal of Oral Science 2024年第2期16卷 322-332页

作者： wenhao Zheng Xiaofeng Lu Guangjin Chen Yufeng Shen Xiaofei Huang Jinfeng Peng Jiajia wang Ying Yin Wencheng Song Mengru Xie Shaoling Yu Lili Chen Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina School of Stomatology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration WuhanChina Department of Stomatology The First Affiliated HospitalSchool of MedicineShihezi UniversityShiheziChina

The utilization of optimal orthodontic force is crucial to prevent undesirable side effects and ensure efficient tooth movement during orthodontic ***,the sensitivity of existing detection techniques is not sufficient,and the criteria for evaluating optimal force have not been yet ***,by employing 3D finite element analysis methodology,we found that the apical distal region(A-D region)of mesial roots is particularly sensitive to orthodontic force in ***-resistant acidic phosphatase(TRAP)-positive osteoclasts began accumulating in the A-D region under the force of 40 grams(g),leading to alveolar bone resorption and tooth *** the force reached 80 g,TRAP-positive osteoclasts started appearing on the root surface in the A-D ***,micro-computed tomography revealed a significant root resorption at 80 ***,the A-D region was identified as a major contributor to whole root *** was determined that 40 g is the minimum effective force for tooth movement with minimal side effects according to the analysis of tooth movement,inclination,and *** findings suggest that the A-D region with its changes on the root surface is an important consideration and sensitive indicator when evaluating orthodontic forces for a rat ***,our investigations into this region would aid in offering valuable implications for preventing and minimizing root resorption during patients’orthodontic treatment.

关键词： movement roots offering

Design of pH-responsive antimicrobial peptide melittin analog-camptothecin conjugates for tumor therapy

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 135-146页

作者： Sujie Huang Yuxuan Gao Ling Ma Bo Jia wenhao Zhao Yufan Yao Wenyuan Li Tongyi Lin Rui wang Jingjing Song Wei Zhang Institute of Pharmacology School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical SciencesLanzhou UniversityLanzhou 730000China State Key Laboratory of Veterinary Etiological Biology College of Veterinary MedicineLanzhou UniversityLanzhou 730000China Lanzhou University Second Hospital Lanzhou UniversityLanzhou 730000China

Melittin,a classical antimicrobial peptide,is a highly potent antitumor ***,its significant toxicity seriously hampers its application in tumor *** this study,we developed novel melittin analogs with pH-responsive,cell-penetrating and membranelytic activities by replacing arginine and lysine with *** conjugation with camptothecin(CPT),CPT-AAM-1 and CPT-AAM-2 were capable of killing tumor cells by releasing CPT at low concentrations and disrupting cell membranes at high concentrations under acidic ***,we found that the C-terminus of the melittin analogs was more suitable for drug conjugation than the ***-AAM-1 significantly suppressed melanoma growth in vivo with relatively low ***,the present study demonstrates that the development of antitumor drugs based on pH-responsive antimicrobial peptide-drug conjugates is a promising strategy.

关键词： Antimicrobial peptide Peptide-drug conjugate Cell-penetrating activity Membrane disruption Antitumor activity

多元Al-Cu系合金凝固过程中显微偏析的计算模拟

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金属学报 2000年第5期36卷 477-482页

作者：周刚王文皓李依依中国科学院金属研究所沈阳110015

以物质守恒方程、液固界面平衡方程为基础，提出一个反映多元合金系中组元间相互作用的凝固模型，并从应用的角度出发，对该模型进行了合理的简化利用这个模型对合金元素在多元Ａｌ－Ｃｕ系合金凝固过程中的行为进行计算模拟，所得到... 详细信息

以物质守恒方程、液固界面平衡方程为基础，提出一个反映多元合金系中组元间相互作用的凝固模型，并从应用的角度出发，对该模型进行了合理的简化利用这个模型对合金元素在多元Ａｌ－Ｃｕ系合金凝固过程中的行为进行计算模拟，所得到的情况与实验结果相一致，表明这个多元系凝固模型可以为多元

关键词： Al-Cu合金计算模拟凝固显微偏析

Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein(QPCTL)with antitumor efficacy

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Signal Transduction and Targeted Therapy 2024年第1期9卷 44-46页

作者： Lei Yu Pengcheng Zhao Yaoliang Sun Zening Zheng wenhao Du Lishan Zhang Yaxu Li Longyan Xie Shilin Xu Ping wang Tongji University Cancer Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Medicinal Chemistry Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina

Dear Editor,Immune checkpoint therapies manipulating the immune system to eliminate tumor cells have shown remarkable clinical efficacy in treating various ***47,an emerging efficient immune checkpoint,is crucial for cancer cells to evade macrophagemediated phagocytosis by interaction with signal-regulatory proteinα(SIRPα).Antibodies blocking the CD47/SIRPαinteraction have been effective to promote macrophage-mediated phagocytosis in various types of cancer in mice and ***47 is not only highly expressed in tumor cells,but also normal cells,such as red blood cells(RBCs).Thus,during clinical trials involving cancer patients,anti-CD47 antibodies may promote the macrophagesmediated phagocytosis of RBCs,ultimately inducing undesirable anemia side *** contrast,small molecule inhibitors interrupting CD47/SIRPαaxis have shown potential to overcome the anemia,possibly due to their lower immunogenicity and shorter half-life compared to antibodies.1 Hence,developing the novel strategies,especially those without the anemia side effect,to intervene in CD47/SIRPαinteraction will benefit cancer immunotherapy.

关键词： anemia overcome eliminate

Insights of carbon reduction practices from Winter Olympics 2022

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Science Bulletin 2024年第13期69卷 2034-2037页

作者： Xiaoyong Liao Shuai Zhong Jie Huang Zhu Liu Ayman Elshkaki You Li Lei Shen Yingli He Li An Yidong Zhu wenhao Sun Tao Liang Jiaoe wang Jinwei Dong Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China Key Laboratory for Resources Use and Environmental Remediation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China Key Laboratory of Regional Sustainable Development Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Earth System Science Tsinghua UniversityBeijing 100084China

Concerns about the carbon emissions of mega-events revolve,mainly due to the impactful demonstration effects they ***,accurate monitoring of these emissions is crucial during such events[1].The Olympic and Paralympic Winter Games Beijing 2022(hereinafter“Winter Olympics 2022”)are recognized as the first Games to pay close attention to a wide range of emissions associated with all stages of the *** of emerging carbon reduction technologies,such as low-carbon materials and technologies,have shown promising effects on efforts to achieve carbon neutrality[2].The impacts of individual measures,such as Olympic infrastructure construction.

关键词： Winter emissions carbon

微量元素在Ni基合金凝固过程中分配行为的模拟

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金属学报 2000年第5期36卷 472-476页

作者：周刚王文皓李依依中国科学院金属研究所沈阳110015

以多元合金系在凝固过程中组元满足的液固界面平衡方程，即组元在液固相中的化学位相等为基础建立了一个反映多元系凝固偏析的简易模型，利用它对多元合金系凝固初期的特征进行了定性描述，并且对某些微量元素在Ｎｉ基合金凝固过程中的... 详细信息

以多元合金系在凝固过程中组元满足的液固界面平衡方程，即组元在液固相中的化学位相等为基础建立了一个反映多元系凝固偏析的简易模型，利用它对多元合金系凝固初期的特征进行了定性描述，并且对某些微量元素在Ｎｉ基合金凝固过程中的分配行为进行了计算模拟，得到的结果与实验结果较好地相符．从定性说明和计算模拟的角度，方便地确定出对Ｎｉ基合金凝固偏析起决定性作用的微量元素。

关键词： Ni基合金偏析模型行为模拟凝固微量元素